Ribosome biogenesis protein NOP53

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nop53 (60S ribosomal biogenesis), putative

Species:

Leishmania major

UniProt:

E9AF71_LEIMA

TriTrypDb:

LmjF.35.2480 , LMJLV39_350031500 , LMJSD75_350031000

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	10
GO:0005730	nucleolus	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AF71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF71

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	10
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0022613	ribonucleoprotein complex biogenesis	4	8
GO:0042254	ribosome biogenesis	5	8
GO:0044085	cellular component biogenesis	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0008097	5S rRNA binding	6	2
GO:0019843	rRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.292
CLV_NRD_NRD_1	245	247	PF00675	0.299
CLV_NRD_NRD_1	314	316	PF00675	0.532
CLV_NRD_NRD_1	47	49	PF00675	0.329
CLV_PCSK_FUR_1	242	246	PF00082	0.308
CLV_PCSK_FUR_1	325	329	PF00082	0.541
CLV_PCSK_KEX2_1	138	140	PF00082	0.317
CLV_PCSK_KEX2_1	203	205	PF00082	0.348
CLV_PCSK_KEX2_1	209	211	PF00082	0.301
CLV_PCSK_KEX2_1	213	215	PF00082	0.299
CLV_PCSK_KEX2_1	237	239	PF00082	0.298
CLV_PCSK_KEX2_1	244	246	PF00082	0.306
CLV_PCSK_KEX2_1	314	316	PF00082	0.532
CLV_PCSK_KEX2_1	327	329	PF00082	0.580
CLV_PCSK_KEX2_1	46	48	PF00082	0.329
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.317
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.421
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.298
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.291
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.316
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.532
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.541
CLV_PCSK_PC7_1	209	215	PF00082	0.320
CLV_PCSK_SKI1_1	185	189	PF00082	0.340
CLV_PCSK_SKI1_1	195	199	PF00082	0.272
CLV_PCSK_SKI1_1	204	208	PF00082	0.355
CLV_PCSK_SKI1_1	246	250	PF00082	0.328
CLV_PCSK_SKI1_1	315	319	PF00082	0.527
CLV_PCSK_SKI1_1	91	95	PF00082	0.417
CLV_PCSK_SKI1_1	97	101	PF00082	0.384
DOC_CKS1_1	262	267	PF01111	0.400
DOC_MAPK_gen_1	244	255	PF00069	0.326
DOC_MAPK_gen_1	314	326	PF00069	0.519
DOC_MAPK_HePTP_8	216	228	PF00069	0.288
DOC_MAPK_MEF2A_6	219	228	PF00069	0.288
DOC_MAPK_MEF2A_6	58	65	PF00069	0.360
DOC_USP7_MATH_1	149	153	PF00917	0.369
DOC_USP7_UBL2_3	133	137	PF12436	0.358
DOC_USP7_UBL2_3	185	189	PF12436	0.296
DOC_USP7_UBL2_3	191	195	PF12436	0.289
DOC_USP7_UBL2_3	90	94	PF12436	0.298
DOC_WW_Pin1_4	131	136	PF00397	0.454
DOC_WW_Pin1_4	156	161	PF00397	0.477
DOC_WW_Pin1_4	261	266	PF00397	0.284
DOC_WW_Pin1_4	268	273	PF00397	0.284
DOC_WW_Pin1_4	31	36	PF00397	0.388
LIG_14-3-3_CanoR_1	139	144	PF00244	0.251
LIG_14-3-3_CanoR_1	204	212	PF00244	0.293
LIG_14-3-3_CanoR_1	294	299	PF00244	0.414
LIG_14-3-3_CanoR_1	307	313	PF00244	0.564
LIG_FHA_1	109	115	PF00498	0.245
LIG_FHA_1	14	20	PF00498	0.403
LIG_FHA_1	219	225	PF00498	0.400
LIG_FHA_1	262	268	PF00498	0.333
LIG_FHA_1	32	38	PF00498	0.366
LIG_FHA_2	117	123	PF00498	0.284
LIG_FHA_2	196	202	PF00498	0.397
LIG_FHA_2	269	275	PF00498	0.400
LIG_LIR_Apic_2	284	290	PF02991	0.567
LIG_LIR_Gen_1	95	104	PF02991	0.308
LIG_LIR_Nem_3	69	73	PF02991	0.344
LIG_MYND_1	35	39	PF01753	0.360
LIG_NRBOX	223	229	PF00104	0.400
LIG_PDZ_Class_1	334	339	PF00595	0.524
LIG_SH2_CRK	262	266	PF00017	0.400
LIG_SH2_CRK	50	54	PF00017	0.344
LIG_SH2_PTP2	287	290	PF00017	0.467
LIG_SH2_SRC	287	290	PF00017	0.467
LIG_SH2_SRC	50	53	PF00017	0.308
LIG_SH2_STAT5	110	113	PF00017	0.420
LIG_SH2_STAT5	287	290	PF00017	0.467
LIG_SH3_1	49	55	PF00018	0.344
LIG_SH3_2	42	47	PF14604	0.308
LIG_SH3_3	16	22	PF00018	0.308
LIG_SH3_3	314	320	PF00018	0.578
LIG_SH3_3	36	42	PF00018	0.331
LIG_SH3_3	49	55	PF00018	0.266
LIG_SH3_3	58	64	PF00018	0.267
LIG_SUMO_SIM_anti_2	220	228	PF11976	0.288
LIG_SUMO_SIM_par_1	264	269	PF11976	0.284
LIG_TRAF2_1	119	122	PF00917	0.284
LIG_TRAF2_1	198	201	PF00917	0.366
LIG_TRAF2_1	297	300	PF00917	0.392
LIG_UBA3_1	101	109	PF00899	0.400
MOD_CDK_SPK_2	131	136	PF00069	0.288
MOD_CDK_SPxK_1	131	137	PF00069	0.288
MOD_CDK_SPxxK_3	131	138	PF00069	0.254
MOD_CDK_SPxxK_3	268	275	PF00069	0.400
MOD_CK1_1	152	158	PF00069	0.422
MOD_CK1_1	159	165	PF00069	0.410
MOD_CK2_1	116	122	PF00069	0.284
MOD_CK2_1	195	201	PF00069	0.397
MOD_CK2_1	294	300	PF00069	0.403
MOD_GlcNHglycan	114	117	PF01048	0.298
MOD_GlcNHglycan	151	154	PF01048	0.470
MOD_GlcNHglycan	155	158	PF01048	0.489
MOD_GlcNHglycan	283	286	PF01048	0.546
MOD_GSK3_1	108	115	PF00069	0.305
MOD_GSK3_1	124	131	PF00069	0.364
MOD_GSK3_1	139	146	PF00069	0.271
MOD_GSK3_1	148	155	PF00069	0.372
MOD_GSK3_1	191	198	PF00069	0.386
MOD_N-GLC_1	112	117	PF02516	0.278
MOD_NEK2_1	276	281	PF00069	0.308
MOD_NEK2_1	308	313	PF00069	0.536
MOD_PKA_1	108	114	PF00069	0.288
MOD_PKA_1	137	143	PF00069	0.288
MOD_PKA_1	191	197	PF00069	0.316
MOD_PKA_2	308	314	PF00069	0.559
MOD_Plk_1	116	122	PF00069	0.284
MOD_ProDKin_1	131	137	PF00069	0.454
MOD_ProDKin_1	156	162	PF00069	0.477
MOD_ProDKin_1	261	267	PF00069	0.284
MOD_ProDKin_1	268	274	PF00069	0.284
MOD_ProDKin_1	31	37	PF00069	0.388
MOD_SUMO_for_1	168	171	PF00179	0.288
MOD_SUMO_for_1	320	323	PF00179	0.510
MOD_SUMO_for_1	326	329	PF00179	0.513
MOD_SUMO_for_1	93	96	PF00179	0.400
MOD_SUMO_rev_2	200	205	PF00179	0.336
MOD_SUMO_rev_2	89	99	PF00179	0.272
TRG_DiLeu_BaEn_1	223	228	PF01217	0.400
TRG_DiLeu_BaEn_1	299	304	PF01217	0.428
TRG_ENDOCYTIC_2	50	53	PF00928	0.308
TRG_ENDOCYTIC_2	70	73	PF00928	0.155
TRG_ER_diArg_1	45	48	PF00400	0.324
TRG_NLS_MonoCore_2	135	140	PF00514	0.215
TRG_NLS_MonoExtC_3	136	141	PF00514	0.235
TRG_NLS_MonoExtC_3	187	192	PF00514	0.286
TRG_NLS_MonoExtC_3	89	94	PF00514	0.360
TRG_NLS_MonoExtN_4	133	140	PF00514	0.263
TRG_NLS_MonoExtN_4	185	192	PF00514	0.285
TRG_NLS_MonoExtN_4	242	248	PF00514	0.400
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R6	Leptomonas seymouri	66%	100%
A0A0S4KHQ3	Bodo saltans	48%	100%
A0A1X0P5V5	Trypanosomatidae	54%	97%
A0A3Q8IF61	Leishmania donovani	91%	100%
A0A422NEC3	Trypanosoma rangeli	54%	100%
A4HMS1	Leishmania braziliensis	79%	100%
A4IBF7	Leishmania infantum	92%	100%
E9B6C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%