Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF70_LEIMA

TriTrypDb:

LmjF.35.2470 , LMJLV39_350031400 , LMJSD75_350030900

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.748
CLV_NRD_NRD_1	150	152	PF00675	0.665
CLV_NRD_NRD_1	183	185	PF00675	0.598
CLV_NRD_NRD_1	217	219	PF00675	0.621
CLV_NRD_NRD_1	380	382	PF00675	0.560
CLV_NRD_NRD_1	443	445	PF00675	0.677
CLV_NRD_NRD_1	448	450	PF00675	0.640
CLV_NRD_NRD_1	463	465	PF00675	0.307
CLV_NRD_NRD_1	60	62	PF00675	0.560
CLV_PCSK_FUR_1	444	448	PF00082	0.662
CLV_PCSK_KEX2_1	134	136	PF00082	0.585
CLV_PCSK_KEX2_1	149	151	PF00082	0.670
CLV_PCSK_KEX2_1	183	185	PF00082	0.579
CLV_PCSK_KEX2_1	380	382	PF00082	0.560
CLV_PCSK_KEX2_1	443	445	PF00082	0.677
CLV_PCSK_KEX2_1	446	448	PF00082	0.654
CLV_PCSK_KEX2_1	463	465	PF00082	0.307
CLV_PCSK_KEX2_1	474	476	PF00082	0.502
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.585
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.670
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.579
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.564
CLV_PCSK_PC7_1	179	185	PF00082	0.593
CLV_PCSK_PC7_1	376	382	PF00082	0.535
CLV_PCSK_PC7_1	443	449	PF00082	0.763
CLV_PCSK_SKI1_1	112	116	PF00082	0.616
CLV_PCSK_SKI1_1	122	126	PF00082	0.573
CLV_PCSK_SKI1_1	288	292	PF00082	0.680
CLV_PCSK_SKI1_1	366	370	PF00082	0.534
CLV_PCSK_SKI1_1	394	398	PF00082	0.537
CLV_PCSK_SKI1_1	4	8	PF00082	0.441
CLV_PCSK_SKI1_1	401	405	PF00082	0.554
CLV_PCSK_SKI1_1	480	484	PF00082	0.624
CLV_PCSK_SKI1_1	490	494	PF00082	0.627
DEG_APCC_DBOX_1	111	119	PF00400	0.625
DEG_Nend_UBRbox_1	1	4	PF02207	0.457
DEG_SPOP_SBC_1	98	102	PF00917	0.485
DOC_CKS1_1	13	18	PF01111	0.440
DOC_CYCLIN_RxL_1	397	405	PF00134	0.498
DOC_CYCLIN_yClb1_LxF_4	478	483	PF00134	0.657
DOC_MAPK_DCC_7	185	195	PF00069	0.798
DOC_MAPK_gen_1	187	195	PF00069	0.704
DOC_MAPK_gen_1	2	10	PF00069	0.448
DOC_MAPK_gen_1	474	483	PF00069	0.642
DOC_MAPK_MEF2A_6	187	195	PF00069	0.704
DOC_MAPK_MEF2A_6	2	10	PF00069	0.448
DOC_MAPK_RevD_3	193	209	PF00069	0.774
DOC_PP1_RVXF_1	478	484	PF00149	0.657
DOC_PP2B_LxvP_1	14	17	PF13499	0.433
DOC_PP2B_LxvP_1	41	44	PF13499	0.432
DOC_USP7_MATH_1	171	175	PF00917	0.661
DOC_USP7_MATH_1	243	247	PF00917	0.668
DOC_USP7_MATH_1	271	275	PF00917	0.660
DOC_USP7_MATH_1	435	439	PF00917	0.675
DOC_USP7_MATH_1	69	73	PF00917	0.507
DOC_USP7_MATH_1	86	90	PF00917	0.480
DOC_USP7_MATH_1	98	102	PF00917	0.461
DOC_USP7_UBL2_3	122	126	PF12436	0.674
DOC_USP7_UBL2_3	129	133	PF12436	0.545
DOC_USP7_UBL2_3	183	187	PF12436	0.713
DOC_USP7_UBL2_3	221	225	PF12436	0.706
DOC_USP7_UBL2_3	229	233	PF12436	0.632
DOC_USP7_UBL2_3	355	359	PF12436	0.519
DOC_WW_Pin1_4	12	17	PF00397	0.439
DOC_WW_Pin1_4	45	50	PF00397	0.464
LIG_14-3-3_CanoR_1	24	29	PF00244	0.452
LIG_14-3-3_CanoR_1	448	454	PF00244	0.622
LIG_14-3-3_CanoR_1	85	91	PF00244	0.475
LIG_14-3-3_CanoR_1	99	105	PF00244	0.457
LIG_Actin_WH2_2	350	367	PF00022	0.634
LIG_BRCT_BRCA1_1	26	30	PF00533	0.453
LIG_FHA_1	239	245	PF00498	0.739
LIG_FHA_1	276	282	PF00498	0.575
LIG_FHA_1	420	426	PF00498	0.676
LIG_FHA_2	105	111	PF00498	0.730
LIG_FHA_2	198	204	PF00498	0.685
LIG_FHA_2	258	264	PF00498	0.815
LIG_FHA_2	280	286	PF00498	0.611
LIG_FHA_2	416	422	PF00498	0.515
LIG_FHA_2	450	456	PF00498	0.582
LIG_Integrin_RGD_1	296	298	PF01839	0.616
LIG_LIR_Gen_1	27	38	PF02991	0.445
LIG_LIR_Gen_1	452	461	PF02991	0.539
LIG_LIR_Nem_3	27	33	PF02991	0.447
LIG_LIR_Nem_3	452	456	PF02991	0.558
LIG_MLH1_MIPbox_1	26	30	PF16413	0.453
LIG_MYND_1	320	324	PF01753	0.601
LIG_MYND_1	38	42	PF01753	0.424
LIG_Pex14_2	120	124	PF04695	0.590
LIG_REV1ctd_RIR_1	351	360	PF16727	0.535
LIG_SH2_PTP2	390	393	PF00017	0.521
LIG_SH2_STAP1	453	457	PF00017	0.552
LIG_SH2_STAT3	457	460	PF00017	0.529
LIG_SH2_STAT5	390	393	PF00017	0.521
LIG_SH3_3	36	42	PF00018	0.432
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.457
LIG_TRAF2_1	358	361	PF00917	0.410
LIG_UBA3_1	114	122	PF00899	0.722
LIG_WRC_WIRS_1	426	431	PF05994	0.653
MOD_CDK_SPxxK_3	12	19	PF00069	0.444
MOD_CK1_1	246	252	PF00069	0.719
MOD_CK1_1	72	78	PF00069	0.469
MOD_CK2_1	104	110	PF00069	0.451
MOD_CK2_1	197	203	PF00069	0.690
MOD_CK2_1	257	263	PF00069	0.786
MOD_CK2_1	270	276	PF00069	0.678
MOD_CK2_1	279	285	PF00069	0.588
MOD_CK2_1	339	345	PF00069	0.681
MOD_CK2_1	355	361	PF00069	0.372
MOD_Cter_Amidation	147	150	PF01082	0.623
MOD_GlcNHglycan	158	161	PF01048	0.758
MOD_GlcNHglycan	173	176	PF01048	0.602
MOD_GlcNHglycan	30	33	PF01048	0.448
MOD_GlcNHglycan	341	344	PF01048	0.570
MOD_GlcNHglycan	404	407	PF01048	0.565
MOD_GlcNHglycan	71	74	PF01048	0.497
MOD_GSK3_1	197	204	PF00069	0.687
MOD_GSK3_1	228	235	PF00069	0.776
MOD_GSK3_1	24	31	PF00069	0.477
MOD_GSK3_1	271	278	PF00069	0.586
MOD_GSK3_1	415	422	PF00069	0.653
MOD_GSK3_1	459	466	PF00069	0.479
MOD_GSK3_1	61	68	PF00069	0.484
MOD_GSK3_1	8	15	PF00069	0.477
MOD_GSK3_1	93	100	PF00069	0.483
MOD_LATS_1	97	103	PF00433	0.485
MOD_N-GLC_1	24	29	PF02516	0.477
MOD_N-GLC_1	8	13	PF02516	0.478
MOD_NEK2_1	425	430	PF00069	0.621
MOD_NEK2_1	459	464	PF00069	0.520
MOD_NEK2_1	473	478	PF00069	0.580
MOD_NEK2_1	8	13	PF00069	0.452
MOD_PIKK_1	275	281	PF00454	0.744
MOD_PIKK_1	53	59	PF00454	0.469
MOD_PK_1	24	30	PF00069	0.453
MOD_PKA_1	355	361	PF00069	0.533
MOD_PKA_1	463	469	PF00069	0.469
MOD_PKA_1	61	67	PF00069	0.483
MOD_PKA_2	257	263	PF00069	0.808
MOD_PKA_2	442	448	PF00069	0.662
MOD_PKA_2	463	469	PF00069	0.588
MOD_PKA_2	98	104	PF00069	0.483
MOD_PKB_1	447	455	PF00069	0.708
MOD_Plk_1	24	30	PF00069	0.479
MOD_Plk_1	8	14	PF00069	0.476
MOD_Plk_2-3	415	421	PF00069	0.682
MOD_Plk_4	24	30	PF00069	0.453
MOD_Plk_4	318	324	PF00069	0.636
MOD_Plk_4	415	421	PF00069	0.654
MOD_Plk_4	86	92	PF00069	0.501
MOD_ProDKin_1	12	18	PF00069	0.441
MOD_ProDKin_1	45	51	PF00069	0.469
MOD_SUMO_for_1	224	227	PF00179	0.785
MOD_SUMO_rev_2	246	255	PF00179	0.788
MOD_SUMO_rev_2	330	338	PF00179	0.551
TRG_DiLeu_BaEn_1	110	115	PF01217	0.611
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.434
TRG_ENDOCYTIC_2	453	456	PF00928	0.558
TRG_ER_diArg_1	150	152	PF00400	0.630
TRG_ER_diArg_1	442	444	PF00400	0.678
TRG_ER_diArg_1	446	449	PF00400	0.651
TRG_ER_diArg_1	463	465	PF00400	0.452
TRG_NLS_Bipartite_1	133	153	PF00514	0.580
TRG_NLS_Bipartite_1	172	188	PF00514	0.680
TRG_NLS_Bipartite_1	207	223	PF00514	0.625
TRG_NLS_Bipartite_1	463	478	PF00514	0.556
TRG_NLS_MonoCore_2	183	188	PF00514	0.576
TRG_NLS_MonoCore_2	217	222	PF00514	0.688
TRG_NLS_MonoExtC_3	124	129	PF00514	0.665
TRG_NLS_MonoExtC_3	182	187	PF00514	0.580
TRG_NLS_MonoExtC_3	206	211	PF00514	0.621
TRG_NLS_MonoExtN_4	122	129	PF00514	0.670
TRG_NLS_MonoExtN_4	183	188	PF00514	0.602
TRG_NLS_MonoExtN_4	218	223	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P943	Leptomonas seymouri	64%	100%
A0A3S7X9B6	Leishmania donovani	93%	100%
A4HMS0	Leishmania braziliensis	80%	100%
A4IBF6	Leishmania infantum	93%	100%
E9B6C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%