FAA_hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fumarylacetoacetate (FAA) hydrolase family, putative

Species:

Leishmania major

UniProt:

E9AF68_LEIMA

TriTrypDb:

LmjF.35.2440 , LMJLV39_350031200 , LMJSD75_350030700

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AF68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF68

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	5
GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	3	2
GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	4	2
GO:0018773	acetylpyruvate hydrolase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.284
CLV_NRD_NRD_1	254	256	PF00675	0.396
CLV_NRD_NRD_1	28	30	PF00675	0.331
CLV_PCSK_KEX2_1	143	145	PF00082	0.283
CLV_PCSK_KEX2_1	254	256	PF00082	0.369
CLV_PCSK_KEX2_1	28	30	PF00082	0.343
CLV_PCSK_SKI1_1	18	22	PF00082	0.598
CLV_PCSK_SKI1_1	232	236	PF00082	0.337
DEG_APCC_DBOX_1	142	150	PF00400	0.569
DEG_APCC_DBOX_1	212	220	PF00400	0.549
DOC_PP1_RVXF_1	19	26	PF00149	0.571
DOC_PP4_FxxP_1	56	59	PF00568	0.490
DOC_USP7_MATH_1	59	63	PF00917	0.483
DOC_USP7_MATH_1	75	79	PF00917	0.459
DOC_USP7_UBL2_3	151	155	PF12436	0.520
DOC_WW_Pin1_4	105	110	PF00397	0.541
DOC_WW_Pin1_4	243	248	PF00397	0.490
DOC_WW_Pin1_4	69	74	PF00397	0.593
LIG_14-3-3_CanoR_1	211	220	PF00244	0.544
LIG_14-3-3_CanoR_1	9	13	PF00244	0.485
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BRCT_BRCA1_1	2	6	PF00533	0.505
LIG_CtBP_PxDLS_1	138	144	PF00389	0.490
LIG_EH1_1	89	97	PF00400	0.426
LIG_FHA_1	192	198	PF00498	0.593
LIG_FHA_1	229	235	PF00498	0.591
LIG_FHA_1	266	272	PF00498	0.524
LIG_FHA_1	58	64	PF00498	0.546
LIG_FHA_1	74	80	PF00498	0.569
LIG_FHA_2	140	146	PF00498	0.490
LIG_Integrin_RGD_1	255	257	PF01839	0.393
LIG_LIR_Gen_1	117	128	PF02991	0.593
LIG_LIR_Gen_1	184	193	PF02991	0.553
LIG_LIR_Gen_1	201	210	PF02991	0.569
LIG_LIR_Gen_1	231	241	PF02991	0.569
LIG_LIR_Nem_3	184	189	PF02991	0.520
LIG_LIR_Nem_3	201	206	PF02991	0.569
LIG_LIR_Nem_3	231	236	PF02991	0.569
LIG_LIR_Nem_3	51	57	PF02991	0.591
LIG_LIR_Nem_3	78	84	PF02991	0.544
LIG_LYPXL_yS_3	81	84	PF13949	0.565
LIG_REV1ctd_RIR_1	52	58	PF16727	0.520
LIG_SH2_GRB2like	120	123	PF00017	0.569
LIG_SH2_PTP2	233	236	PF00017	0.569
LIG_SH2_SRC	133	136	PF00017	0.593
LIG_SH2_STAP1	37	41	PF00017	0.490
LIG_SH2_STAT5	233	236	PF00017	0.566
LIG_SH2_STAT5	31	34	PF00017	0.503
LIG_SH3_3	165	171	PF00018	0.542
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.503
LIG_SUMO_SIM_par_1	170	177	PF11976	0.569
LIG_TRFH_1	55	59	PF08558	0.537
LIG_TYR_ITIM	79	84	PF00017	0.565
LIG_UBA3_1	185	191	PF00899	0.510
LIG_UBA3_1	226	232	PF00899	0.542
MOD_CK1_1	103	109	PF00069	0.602
MOD_CK1_1	198	204	PF00069	0.598
MOD_CK1_1	62	68	PF00069	0.494
MOD_CK2_1	219	225	PF00069	0.537
MOD_GlcNHglycan	110	113	PF01048	0.355
MOD_GlcNHglycan	247	250	PF01048	0.306
MOD_GSK3_1	191	198	PF00069	0.588
MOD_GSK3_1	228	235	PF00069	0.562
MOD_GSK3_1	241	248	PF00069	0.479
MOD_GSK3_1	57	64	PF00069	0.582
MOD_GSK3_1	69	76	PF00069	0.570
MOD_GSK3_1	99	106	PF00069	0.566
MOD_N-GLC_1	48	53	PF02516	0.404
MOD_N-GLC_1	68	73	PF02516	0.302
MOD_NEK2_1	139	144	PF00069	0.487
MOD_NEK2_1	219	224	PF00069	0.560
MOD_NEK2_1	241	246	PF00069	0.520
MOD_NEK2_1	8	13	PF00069	0.519
MOD_NEK2_2	265	270	PF00069	0.593
MOD_NEK2_2	75	80	PF00069	0.502
MOD_PKA_2	8	14	PF00069	0.485
MOD_Plk_1	73	79	PF00069	0.537
MOD_Plk_4	198	204	PF00069	0.553
MOD_Plk_4	8	14	PF00069	0.492
MOD_ProDKin_1	105	111	PF00069	0.541
MOD_ProDKin_1	243	249	PF00069	0.490
MOD_ProDKin_1	69	75	PF00069	0.593
MOD_SUMO_rev_2	175	181	PF00179	0.545
TRG_DiLeu_BaEn_2	51	57	PF01217	0.537
TRG_ENDOCYTIC_2	120	123	PF00928	0.488
TRG_ENDOCYTIC_2	233	236	PF00928	0.569
TRG_ENDOCYTIC_2	81	84	PF00928	0.565
TRG_ER_diArg_1	253	255	PF00400	0.596
TRG_ER_diArg_1	27	29	PF00400	0.402
TRG_NES_CRM1_1	225	240	PF08389	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S1	Leptomonas seymouri	62%	100%
A0A0S4IKX8	Bodo saltans	35%	100%
A0A0S4JYH7	Bodo saltans	25%	100%
A0A1X0P5X5	Trypanosomatidae	48%	99%
A0A3R7MDA1	Trypanosoma rangeli	46%	100%
A0A3S7X9E6	Leishmania donovani	95%	100%
A0B3M8	Burkholderia cenocepacia (strain HI2424)	27%	97%
A3AJ77	Oryza sativa subsp. japonica	32%	100%
A4HMR8	Leishmania braziliensis	78%	100%
A4IBF4	Leishmania infantum	95%	100%
A9ALD1	Burkholderia multivorans (strain ATCC 17616 / 249)	29%	97%
B1K3Y3	Burkholderia cenocepacia (strain MC0-3)	27%	97%
B1Z1Y2	Burkholderia ambifaria (strain MC40-6)	28%	97%
B2RYW9	Rattus norvegicus	29%	88%
B4EKX6	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	27%	97%
E9B6C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
I6Y276	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
O06724	Bacillus subtilis (strain 168)	30%	91%
O28058	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O58377	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
O86042	Ralstonia sp.	32%	100%
P34673	Caenorhabditis elegans	31%	100%
P53889	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P76004	Escherichia coli (strain K12)	32%	100%
Q0B628	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	28%	97%
Q0QFQ3	Pseudomonas alcaligenes	26%	95%
Q10B63	Oryza sativa subsp. japonica	32%	100%
Q1BJJ1	Burkholderia cenocepacia (strain AU 1054)	27%	97%
Q2FIA7	Staphylococcus aureus (strain USA300)	27%	91%
Q2FZT4	Staphylococcus aureus (strain NCTC 8325 / PS 47)	27%	91%
Q2HJ98	Bos taurus	32%	100%
Q2KIB0	Bos taurus	30%	87%
Q2YWW3	Staphylococcus aureus (strain bovine RF122 / ET3-1)	27%	91%
Q39BA7	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	27%	97%
Q3TC72	Mus musculus	30%	88%
Q49WA8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	28%	91%
Q4L4Y4	Staphylococcus haemolyticus (strain JCSC1435)	27%	91%
Q54BF3	Dictyostelium discoideum	30%	90%
Q59050	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	30%	100%
Q5HHB6	Staphylococcus aureus (strain COL)	27%	91%
Q5HQJ3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	28%	91%
Q5RCX5	Pongo abelii	28%	87%
Q5RDW0	Pongo abelii	33%	100%
Q6AYQ8	Rattus norvegicus	32%	100%
Q6GAV8	Staphylococcus aureus (strain MSSA476)	27%	91%
Q6GIC0	Staphylococcus aureus (strain MRSA252)	27%	91%
Q6GLT8	Xenopus laevis	30%	86%
Q6P2I3	Homo sapiens	28%	87%
Q6P587	Homo sapiens	33%	100%
Q7A1B6	Staphylococcus aureus (strain MW2)	27%	91%
Q7A6H3	Staphylococcus aureus (strain N315)	27%	91%
Q86I22	Dictyostelium discoideum	34%	100%
Q8CPT8	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	91%
Q8R0F8	Mus musculus	31%	100%
Q93ZE5	Arabidopsis thaliana	34%	100%
Q96GK7	Homo sapiens	28%	87%
Q99VC2	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	91%
Q9LUR3	Arabidopsis thaliana	34%	100%
Q9P7L4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9UYW0	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
V5BTF7	Trypanosoma cruzi	45%	99%