Integral membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF67_LEIMA

TriTrypDb:

LmjF.35.2430 , LMJLV39_350031100 , LMJSD75_350030600

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 2
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AF67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.677
CLV_C14_Caspase3-7	387	391	PF00656	0.841
CLV_C14_Caspase3-7	455	459	PF00656	0.685
CLV_C14_Caspase3-7	542	546	PF00656	0.843
CLV_NRD_NRD_1	114	116	PF00675	0.385
CLV_NRD_NRD_1	128	130	PF00675	0.437
CLV_NRD_NRD_1	152	154	PF00675	0.516
CLV_NRD_NRD_1	174	176	PF00675	0.642
CLV_NRD_NRD_1	203	205	PF00675	0.513
CLV_NRD_NRD_1	225	227	PF00675	0.570
CLV_NRD_NRD_1	305	307	PF00675	0.538
CLV_NRD_NRD_1	411	413	PF00675	0.501
CLV_NRD_NRD_1	571	573	PF00675	0.499
CLV_NRD_NRD_1	574	576	PF00675	0.500
CLV_PCSK_FUR_1	126	130	PF00082	0.402
CLV_PCSK_FUR_1	303	307	PF00082	0.533
CLV_PCSK_FUR_1	572	576	PF00082	0.592
CLV_PCSK_KEX2_1	114	116	PF00082	0.385
CLV_PCSK_KEX2_1	128	130	PF00082	0.437
CLV_PCSK_KEX2_1	152	154	PF00082	0.516
CLV_PCSK_KEX2_1	174	176	PF00082	0.643
CLV_PCSK_KEX2_1	203	205	PF00082	0.513
CLV_PCSK_KEX2_1	224	226	PF00082	0.568
CLV_PCSK_KEX2_1	305	307	PF00082	0.538
CLV_PCSK_KEX2_1	411	413	PF00082	0.501
CLV_PCSK_KEX2_1	573	575	PF00082	0.522
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.522
CLV_PCSK_SKI1_1	153	157	PF00082	0.517
CLV_PCSK_SKI1_1	323	327	PF00082	0.620
CLV_PCSK_SKI1_1	433	437	PF00082	0.522
CLV_PCSK_SKI1_1	519	523	PF00082	0.587
CLV_PCSK_SKI1_1	653	657	PF00082	0.522
CLV_PCSK_SKI1_1	664	668	PF00082	0.545
CLV_PCSK_SKI1_1	752	756	PF00082	0.544
CLV_PCSK_SKI1_1	762	766	PF00082	0.453
CLV_PCSK_SKI1_1	770	774	PF00082	0.496
CLV_PCSK_SKI1_1	89	93	PF00082	0.590
DEG_APCC_DBOX_1	376	384	PF00400	0.754
DEG_APCC_DBOX_1	432	440	PF00400	0.720
DEG_SCF_FBW7_1	699	705	PF00400	0.740
DEG_SCF_FBW7_2	666	671	PF00400	0.749
DEG_SPOP_SBC_1	393	397	PF00917	0.712
DEG_SPOP_SBC_1	57	61	PF00917	0.489
DOC_CDC14_PxL_1	13	21	PF14671	0.598
DOC_CKS1_1	554	559	PF01111	0.732
DOC_CKS1_1	699	704	PF01111	0.737
DOC_MAPK_gen_1	203	210	PF00069	0.674
DOC_MAPK_gen_1	224	232	PF00069	0.759
DOC_MAPK_MEF2A_6	752	759	PF00069	0.726
DOC_MAPK_RevD_3	755	770	PF00069	0.698
DOC_PP2B_LxvP_1	490	493	PF13499	0.725
DOC_PP2B_LxvP_1	510	513	PF13499	0.601
DOC_PP2B_LxvP_1	607	610	PF13499	0.784
DOC_USP7_MATH_1	107	111	PF00917	0.372
DOC_USP7_MATH_1	142	146	PF00917	0.699
DOC_USP7_MATH_1	148	152	PF00917	0.671
DOC_USP7_MATH_1	176	180	PF00917	0.817
DOC_USP7_MATH_1	2	6	PF00917	0.581
DOC_USP7_MATH_1	217	221	PF00917	0.714
DOC_USP7_MATH_1	242	246	PF00917	0.710
DOC_USP7_MATH_1	260	264	PF00917	0.739
DOC_USP7_MATH_1	370	374	PF00917	0.781
DOC_USP7_MATH_1	48	52	PF00917	0.572
DOC_USP7_MATH_1	491	495	PF00917	0.779
DOC_USP7_MATH_1	513	517	PF00917	0.816
DOC_USP7_MATH_1	57	61	PF00917	0.530
DOC_USP7_MATH_1	686	690	PF00917	0.726
DOC_USP7_MATH_1	702	706	PF00917	0.707
DOC_USP7_MATH_1	73	77	PF00917	0.448
DOC_USP7_MATH_2	493	499	PF00917	0.735
DOC_USP7_UBL2_3	569	573	PF12436	0.753
DOC_WW_Pin1_4	203	208	PF00397	0.734
DOC_WW_Pin1_4	252	257	PF00397	0.751
DOC_WW_Pin1_4	333	338	PF00397	0.749
DOC_WW_Pin1_4	37	42	PF00397	0.541
DOC_WW_Pin1_4	396	401	PF00397	0.747
DOC_WW_Pin1_4	426	431	PF00397	0.666
DOC_WW_Pin1_4	500	505	PF00397	0.760
DOC_WW_Pin1_4	553	558	PF00397	0.732
DOC_WW_Pin1_4	602	607	PF00397	0.686
DOC_WW_Pin1_4	618	623	PF00397	0.710
DOC_WW_Pin1_4	664	669	PF00397	0.718
DOC_WW_Pin1_4	676	681	PF00397	0.727
DOC_WW_Pin1_4	698	703	PF00397	0.698
DOC_WW_Pin1_4	711	716	PF00397	0.724
DOC_WW_Pin1_4	742	747	PF00397	0.717
LIG_14-3-3_CanoR_1	224	232	PF00244	0.715
LIG_14-3-3_CanoR_1	261	267	PF00244	0.795
LIG_14-3-3_CanoR_1	293	302	PF00244	0.720
LIG_14-3-3_CanoR_1	33	39	PF00244	0.491
LIG_14-3-3_CanoR_1	367	376	PF00244	0.750
LIG_14-3-3_CanoR_1	385	393	PF00244	0.639
LIG_14-3-3_CanoR_1	411	420	PF00244	0.727
LIG_14-3-3_CanoR_1	572	582	PF00244	0.718
LIG_14-3-3_CanoR_1	653	661	PF00244	0.747
LIG_14-3-3_CanoR_1	72	78	PF00244	0.503
LIG_14-3-3_CanoR_1	89	95	PF00244	0.326
LIG_BRCT_BRCA1_1	651	655	PF00533	0.750
LIG_CSL_BTD_1	743	746	PF09270	0.705
LIG_FHA_1	119	125	PF00498	0.662
LIG_FHA_1	225	231	PF00498	0.755
LIG_FHA_1	344	350	PF00498	0.796
LIG_FHA_1	523	529	PF00498	0.715
LIG_FHA_1	554	560	PF00498	0.822
LIG_FHA_1	590	596	PF00498	0.736
LIG_FHA_1	677	683	PF00498	0.753
LIG_FHA_1	699	705	PF00498	0.825
LIG_FHA_1	761	767	PF00498	0.729
LIG_FHA_1	94	100	PF00498	0.438
LIG_FHA_2	283	289	PF00498	0.751
LIG_FHA_2	385	391	PF00498	0.840
LIG_FHA_2	453	459	PF00498	0.685
LIG_FHA_2	476	482	PF00498	0.680
LIG_Integrin_RGD_1	289	291	PF01839	0.512
LIG_Integrin_RGD_1	341	343	PF01839	0.530
LIG_LIR_Apic_2	42	48	PF02991	0.479
LIG_LIR_Apic_2	576	582	PF02991	0.711
LIG_LIR_Apic_2	768	774	PF02991	0.745
LIG_LIR_Gen_1	486	493	PF02991	0.680
LIG_LIR_Gen_1	76	86	PF02991	0.452
LIG_LIR_Nem_3	125	130	PF02991	0.597
LIG_LIR_Nem_3	486	492	PF02991	0.681
LIG_LIR_Nem_3	581	586	PF02991	0.721
LIG_LIR_Nem_3	76	81	PF02991	0.508
LIG_MYND_1	585	589	PF01753	0.700
LIG_Pex14_2	351	355	PF04695	0.781
LIG_SH2_STAP1	94	98	PF00017	0.404
LIG_SH2_STAT5	119	122	PF00017	0.569
LIG_SH2_STAT5	483	486	PF00017	0.698
LIG_SH2_STAT5	489	492	PF00017	0.674
LIG_SH2_STAT5	579	582	PF00017	0.719
LIG_SH3_1	579	585	PF00018	0.704
LIG_SH3_3	318	324	PF00018	0.803
LIG_SH3_3	397	403	PF00018	0.728
LIG_SH3_3	431	437	PF00018	0.712
LIG_SH3_3	465	471	PF00018	0.786
LIG_SH3_3	551	557	PF00018	0.737
LIG_SH3_3	579	585	PF00018	0.704
LIG_SH3_3	603	609	PF00018	0.717
LIG_SH3_3	696	702	PF00018	0.718
LIG_SH3_3	703	709	PF00018	0.750
LIG_SH3_3	745	751	PF00018	0.732
LIG_SH3_5	41	45	PF00018	0.520
LIG_SH3_CIN85_PxpxPR_1	256	261	PF14604	0.754
LIG_SUMO_SIM_par_1	104	110	PF11976	0.372
LIG_SUMO_SIM_par_1	16	21	PF11976	0.697
LIG_SUMO_SIM_par_1	760	768	PF11976	0.684
LIG_TRAF2_1	220	223	PF00917	0.690
LIG_TRAF2_1	539	542	PF00917	0.708
LIG_TRAF2_1	672	675	PF00917	0.749
LIG_TRAF2_1	758	761	PF00917	0.675
LIG_TYR_ITIM	487	492	PF00017	0.682
LIG_WRC_WIRS_1	183	188	PF05994	0.666
LIG_WRC_WIRS_1	4	9	PF05994	0.652
MOD_CDK_SPK_2	256	261	PF00069	0.754
MOD_CDK_SPxxK_3	426	433	PF00069	0.670
MOD_CDK_SPxxK_3	553	560	PF00069	0.734
MOD_CK1_1	24	30	PF00069	0.519
MOD_CK1_1	282	288	PF00069	0.759
MOD_CK1_1	297	303	PF00069	0.711
MOD_CK1_1	308	314	PF00069	0.739
MOD_CK1_1	36	42	PF00069	0.456
MOD_CK1_1	386	392	PF00069	0.754
MOD_CK1_1	396	402	PF00069	0.719
MOD_CK1_1	410	416	PF00069	0.750
MOD_CK1_1	482	488	PF00069	0.768
MOD_CK1_1	53	59	PF00069	0.615
MOD_CK1_1	60	66	PF00069	0.592
MOD_CK1_1	605	611	PF00069	0.815
MOD_CK1_1	642	648	PF00069	0.753
MOD_CK1_1	659	665	PF00069	0.708
MOD_CK1_1	669	675	PF00069	0.753
MOD_CK1_1	67	73	PF00069	0.502
MOD_CK1_1	726	732	PF00069	0.738
MOD_CK2_1	132	138	PF00069	0.729
MOD_CK2_1	217	223	PF00069	0.733
MOD_CK2_1	293	299	PF00069	0.746
MOD_CK2_1	36	42	PF00069	0.483
MOD_CK2_1	475	481	PF00069	0.726
MOD_CK2_1	482	488	PF00069	0.763
MOD_CK2_1	491	497	PF00069	0.684
MOD_CK2_1	536	542	PF00069	0.745
MOD_CK2_1	669	675	PF00069	0.726
MOD_CK2_1	755	761	PF00069	0.682
MOD_Cter_Amidation	172	175	PF01082	0.489
MOD_DYRK1A_RPxSP_1	664	668	PF00069	0.745
MOD_GlcNHglycan	140	143	PF01048	0.506
MOD_GlcNHglycan	144	147	PF01048	0.501
MOD_GlcNHglycan	156	159	PF01048	0.492
MOD_GlcNHglycan	256	259	PF01048	0.597
MOD_GlcNHglycan	262	265	PF01048	0.574
MOD_GlcNHglycan	370	373	PF01048	0.545
MOD_GlcNHglycan	413	416	PF01048	0.546
MOD_GlcNHglycan	50	53	PF01048	0.756
MOD_GlcNHglycan	62	65	PF01048	0.776
MOD_GlcNHglycan	641	644	PF01048	0.520
MOD_GlcNHglycan	668	671	PF01048	0.623
MOD_GlcNHglycan	725	728	PF01048	0.576
MOD_GSK3_1	118	125	PF00069	0.642
MOD_GSK3_1	138	145	PF00069	0.697
MOD_GSK3_1	211	218	PF00069	0.725
MOD_GSK3_1	242	249	PF00069	0.786
MOD_GSK3_1	252	259	PF00069	0.729
MOD_GSK3_1	260	267	PF00069	0.693
MOD_GSK3_1	293	300	PF00069	0.787
MOD_GSK3_1	33	40	PF00069	0.587
MOD_GSK3_1	389	396	PF00069	0.819
MOD_GSK3_1	407	414	PF00069	0.724
MOD_GSK3_1	466	473	PF00069	0.742
MOD_GSK3_1	475	482	PF00069	0.690
MOD_GSK3_1	48	55	PF00069	0.607
MOD_GSK3_1	491	498	PF00069	0.757
MOD_GSK3_1	513	520	PF00069	0.832
MOD_GSK3_1	522	529	PF00069	0.706
MOD_GSK3_1	56	63	PF00069	0.591
MOD_GSK3_1	605	612	PF00069	0.754
MOD_GSK3_1	638	645	PF00069	0.723
MOD_GSK3_1	64	71	PF00069	0.510
MOD_GSK3_1	649	656	PF00069	0.739
MOD_GSK3_1	660	667	PF00069	0.720
MOD_GSK3_1	698	705	PF00069	0.755
MOD_GSK3_1	731	738	PF00069	0.694
MOD_GSK3_1	90	97	PF00069	0.338
MOD_N-GLC_1	138	143	PF02516	0.494
MOD_N-GLC_1	246	251	PF02516	0.613
MOD_N-GLC_1	33	38	PF02516	0.751
MOD_N-GLC_1	351	356	PF02516	0.579
MOD_N-GLC_1	368	373	PF02516	0.447
MOD_N-GLC_1	645	650	PF02516	0.602
MOD_N-GLC_1	755	760	PF02516	0.513
MOD_N-GLC_2	692	694	PF02516	0.482
MOD_NEK2_1	211	216	PF00069	0.808
MOD_NEK2_1	383	388	PF00069	0.741
MOD_NEK2_1	460	465	PF00069	0.706
MOD_NEK2_1	517	522	PF00069	0.728
MOD_NEK2_1	58	63	PF00069	0.549
MOD_NEK2_1	655	660	PF00069	0.763
MOD_NEK2_1	681	686	PF00069	0.715
MOD_NEK2_1	765	770	PF00069	0.731
MOD_NEK2_2	182	187	PF00069	0.667
MOD_NEK2_2	298	303	PF00069	0.672
MOD_PIKK_1	160	166	PF00454	0.730
MOD_PIKK_1	212	218	PF00454	0.703
MOD_PIKK_1	370	376	PF00454	0.723
MOD_PK_1	226	232	PF00069	0.757
MOD_PKA_1	224	230	PF00069	0.722
MOD_PKA_1	305	311	PF00069	0.742
MOD_PKA_1	411	417	PF00069	0.711
MOD_PKA_1	573	579	PF00069	0.722
MOD_PKA_2	224	230	PF00069	0.726
MOD_PKA_2	242	248	PF00069	0.735
MOD_PKA_2	260	266	PF00069	0.666
MOD_PKA_2	305	311	PF00069	0.792
MOD_PKA_2	384	390	PF00069	0.750
MOD_PKA_2	410	416	PF00069	0.753
MOD_PKA_2	573	579	PF00069	0.792
MOD_PKB_1	224	232	PF00069	0.759
MOD_PKB_1	303	311	PF00069	0.738
MOD_Plk_1	138	144	PF00069	0.696
MOD_Plk_1	298	304	PF00069	0.748
MOD_Plk_1	351	357	PF00069	0.721
MOD_Plk_1	389	395	PF00069	0.746
MOD_Plk_1	452	458	PF00069	0.787
MOD_Plk_1	536	542	PF00069	0.745
MOD_Plk_1	656	662	PF00069	0.734
MOD_Plk_1	755	761	PF00069	0.696
MOD_Plk_2-3	132	138	PF00069	0.676
MOD_Plk_2-3	21	27	PF00069	0.711
MOD_Plk_2-3	536	542	PF00069	0.745
MOD_Plk_4	182	188	PF00069	0.770
MOD_Plk_4	3	9	PF00069	0.629
MOD_Plk_4	479	485	PF00069	0.728
MOD_Plk_4	609	615	PF00069	0.724
MOD_Plk_4	656	662	PF00069	0.778
MOD_Plk_4	73	79	PF00069	0.482
MOD_Plk_4	94	100	PF00069	0.442
MOD_ProDKin_1	203	209	PF00069	0.734
MOD_ProDKin_1	252	258	PF00069	0.753
MOD_ProDKin_1	333	339	PF00069	0.749
MOD_ProDKin_1	37	43	PF00069	0.541
MOD_ProDKin_1	396	402	PF00069	0.747
MOD_ProDKin_1	426	432	PF00069	0.666
MOD_ProDKin_1	500	506	PF00069	0.759
MOD_ProDKin_1	553	559	PF00069	0.733
MOD_ProDKin_1	602	608	PF00069	0.685
MOD_ProDKin_1	618	624	PF00069	0.708
MOD_ProDKin_1	664	670	PF00069	0.719
MOD_ProDKin_1	676	682	PF00069	0.727
MOD_ProDKin_1	698	704	PF00069	0.701
MOD_ProDKin_1	711	717	PF00069	0.726
MOD_ProDKin_1	742	748	PF00069	0.714
MOD_SUMO_rev_2	530	540	PF00179	0.742
MOD_SUMO_rev_2	696	702	PF00179	0.724
TRG_DiLeu_BaEn_1	760	765	PF01217	0.658
TRG_DiLeu_BaLyEn_6	771	776	PF01217	0.679
TRG_ENDOCYTIC_2	489	492	PF00928	0.684
TRG_ER_diArg_1	113	115	PF00400	0.426
TRG_ER_diArg_1	127	129	PF00400	0.605
TRG_ER_diArg_1	224	226	PF00400	0.762
TRG_ER_diArg_1	571	574	PF00400	0.700
TRG_NLS_MonoCore_2	571	576	PF00514	0.737
TRG_NLS_MonoExtC_3	571	577	PF00514	0.734
TRG_NLS_MonoExtN_4	569	576	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH2	Leptomonas seymouri	26%	100%
A0A3S7X9B2	Leishmania donovani	86%	100%
A4HMR7	Leishmania braziliensis	54%	100%