Putative phosphoinositide-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Autophagy-related protein 24

Species:

Leishmania major

UniProt:

E9AF66_LEIMA

TriTrypDb:

LmjF.35.2420 , LMJLV39_350031000 , LMJSD75_350030500

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005768	endosome	7	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030666	endocytic vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2

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Expansion

Sequence features

E9AF66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF66

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0006898	receptor-mediated endocytosis	6	2
GO:0006914	autophagy	3	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005543	phospholipid binding	3	12
GO:0008289	lipid binding	2	12
GO:0035091	phosphatidylinositol binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.365
CLV_NRD_NRD_1	110	112	PF00675	0.335
CLV_NRD_NRD_1	236	238	PF00675	0.329
CLV_NRD_NRD_1	272	274	PF00675	0.450
CLV_NRD_NRD_1	47	49	PF00675	0.334
CLV_PCSK_FUR_1	234	238	PF00082	0.448
CLV_PCSK_KEX2_1	105	107	PF00082	0.448
CLV_PCSK_KEX2_1	110	112	PF00082	0.448
CLV_PCSK_KEX2_1	236	238	PF00082	0.334
CLV_PCSK_KEX2_1	47	49	PF00082	0.321

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBS5	Leptomonas seymouri	76%	98%
A0A0S4KLA7	Bodo saltans	34%	100%
A0A1X0P5K9	Trypanosomatidae	34%	100%
A0A3Q8IV97	Leishmania donovani	97%	100%
A0A3R7L2W7	Trypanosoma rangeli	34%	99%
A4HMR6	Leishmania braziliensis	93%	100%
A4IBF2	Leishmania infantum	97%	100%
C9ZZB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B6C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O60749	Homo sapiens	24%	80%

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