SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF61_LEIMA

TriTrypDb:

LmjF.35.2370 , LMJLV39_350030500 , LMJSD75_350029900

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.623
CLV_C14_Caspase3-7	240	244	PF00656	0.634
CLV_C14_Caspase3-7	295	299	PF00656	0.496
CLV_C14_Caspase3-7	422	426	PF00656	0.667
CLV_C14_Caspase3-7	591	595	PF00656	0.744
CLV_NRD_NRD_1	13	15	PF00675	0.610
CLV_NRD_NRD_1	136	138	PF00675	0.442
CLV_NRD_NRD_1	492	494	PF00675	0.584
CLV_NRD_NRD_1	622	624	PF00675	0.546
CLV_NRD_NRD_1	646	648	PF00675	0.525
CLV_NRD_NRD_1	653	655	PF00675	0.571
CLV_PCSK_FUR_1	416	420	PF00082	0.732
CLV_PCSK_FUR_1	490	494	PF00082	0.744
CLV_PCSK_FUR_1	502	506	PF00082	0.592
CLV_PCSK_KEX2_1	13	15	PF00082	0.610
CLV_PCSK_KEX2_1	136	138	PF00082	0.442
CLV_PCSK_KEX2_1	418	420	PF00082	0.621
CLV_PCSK_KEX2_1	492	494	PF00082	0.597
CLV_PCSK_KEX2_1	504	506	PF00082	0.725
CLV_PCSK_KEX2_1	622	624	PF00082	0.546
CLV_PCSK_KEX2_1	645	647	PF00082	0.530
CLV_PCSK_KEX2_1	653	655	PF00082	0.571
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.739
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.622
CLV_PCSK_SKI1_1	13	17	PF00082	0.612
CLV_PCSK_SKI1_1	33	37	PF00082	0.286
CLV_PCSK_SKI1_1	403	407	PF00082	0.571
CLV_PCSK_SKI1_1	505	509	PF00082	0.702
CLV_PCSK_SKI1_1	653	657	PF00082	0.557
CLV_PCSK_SKI1_1	694	698	PF00082	0.409
DEG_APCC_DBOX_1	169	177	PF00400	0.712
DEG_APCC_DBOX_1	601	609	PF00400	0.732
DEG_APCC_DBOX_1	644	652	PF00400	0.523
DEG_Nend_UBRbox_2	1	3	PF02207	0.550
DEG_SCF_FBW7_1	155	162	PF00400	0.457
DEG_SCF_FBW7_2	438	445	PF00400	0.604
DEG_SPOP_SBC_1	343	347	PF00917	0.712
DEG_SPOP_SBC_1	460	464	PF00917	0.572
DOC_CDC14_PxL_1	527	535	PF14671	0.716
DOC_CKS1_1	439	444	PF01111	0.607
DOC_CKS1_1	522	527	PF01111	0.618
DOC_CYCLIN_RxL_1	647	657	PF00134	0.537
DOC_CYCLIN_yClb1_LxF_4	552	557	PF00134	0.719
DOC_CYCLIN_yCln2_LP_2	689	695	PF00134	0.420
DOC_MAPK_gen_1	170	179	PF00069	0.603
DOC_MAPK_gen_1	733	741	PF00069	0.531
DOC_MAPK_MEF2A_6	369	378	PF00069	0.537
DOC_MAPK_MEF2A_6	733	741	PF00069	0.413
DOC_MAPK_RevD_3	1	14	PF00069	0.516
DOC_PP2B_LxvP_1	257	260	PF13499	0.596
DOC_PP2B_LxvP_1	689	692	PF13499	0.427
DOC_PP4_FxxP_1	695	698	PF00568	0.403
DOC_USP7_MATH_1	132	136	PF00917	0.522
DOC_USP7_MATH_1	178	182	PF00917	0.674
DOC_USP7_MATH_1	205	209	PF00917	0.720
DOC_USP7_MATH_1	214	218	PF00917	0.498
DOC_USP7_MATH_1	220	224	PF00917	0.632
DOC_USP7_MATH_1	237	241	PF00917	0.619
DOC_USP7_MATH_1	344	348	PF00917	0.706
DOC_USP7_MATH_1	394	398	PF00917	0.571
DOC_USP7_MATH_1	444	448	PF00917	0.601
DOC_USP7_MATH_1	450	454	PF00917	0.700
DOC_USP7_MATH_1	460	464	PF00917	0.528
DOC_USP7_MATH_1	497	501	PF00917	0.713
DOC_USP7_MATH_1	535	539	PF00917	0.547
DOC_USP7_MATH_1	545	549	PF00917	0.626
DOC_USP7_MATH_1	562	566	PF00917	0.560
DOC_USP7_MATH_1	586	590	PF00917	0.646
DOC_USP7_MATH_1	624	628	PF00917	0.679
DOC_USP7_MATH_1	773	777	PF00917	0.663
DOC_USP7_MATH_1	786	790	PF00917	0.446
DOC_WW_Pin1_4	155	160	PF00397	0.571
DOC_WW_Pin1_4	194	199	PF00397	0.690
DOC_WW_Pin1_4	305	310	PF00397	0.452
DOC_WW_Pin1_4	319	324	PF00397	0.496
DOC_WW_Pin1_4	345	350	PF00397	0.628
DOC_WW_Pin1_4	438	443	PF00397	0.664
DOC_WW_Pin1_4	521	526	PF00397	0.638
DOC_WW_Pin1_4	531	536	PF00397	0.549
DOC_WW_Pin1_4	538	543	PF00397	0.511
DOC_WW_Pin1_4	548	553	PF00397	0.538
DOC_WW_Pin1_4	627	632	PF00397	0.670
DOC_WW_Pin1_4	635	640	PF00397	0.514
DOC_WW_Pin1_4	800	805	PF00397	0.640
LIG_14-3-3_CanoR_1	154	161	PF00244	0.559
LIG_14-3-3_CanoR_1	315	320	PF00244	0.499
LIG_14-3-3_CanoR_1	33	38	PF00244	0.441
LIG_14-3-3_CanoR_1	419	424	PF00244	0.754
LIG_14-3-3_CanoR_1	602	608	PF00244	0.635
LIG_14-3-3_CanoR_1	736	740	PF00244	0.521
LIG_14-3-3_CanoR_1	77	82	PF00244	0.436
LIG_BIR_III_4	337	341	PF00653	0.625
LIG_BIR_III_4	425	429	PF00653	0.674
LIG_BIR_III_4	799	803	PF00653	0.554
LIG_BRCT_BRCA1_1	361	365	PF00533	0.741
LIG_CaM_IQ_9	609	625	PF13499	0.735
LIG_deltaCOP1_diTrp_1	371	378	PF00928	0.607
LIG_DLG_GKlike_1	126	133	PF00625	0.443
LIG_eIF4E_1	24	30	PF01652	0.425
LIG_eIF4E_1	43	49	PF01652	0.421
LIG_FHA_1	129	135	PF00498	0.410
LIG_FHA_1	182	188	PF00498	0.719
LIG_FHA_1	306	312	PF00498	0.464
LIG_FHA_1	522	528	PF00498	0.778
LIG_FHA_1	583	589	PF00498	0.550
LIG_FHA_1	610	616	PF00498	0.787
LIG_FHA_1	650	656	PF00498	0.545
LIG_FHA_2	410	416	PF00498	0.508
LIG_FHA_2	609	615	PF00498	0.766
LIG_FHA_2	727	733	PF00498	0.532
LIG_Integrin_RGD_1	677	679	PF01839	0.460
LIG_LIR_Gen_1	128	134	PF02991	0.422
LIG_LIR_Gen_1	158	168	PF02991	0.535
LIG_LIR_Gen_1	469	480	PF02991	0.552
LIG_LIR_Gen_1	581	588	PF02991	0.640
LIG_LIR_Gen_1	64	71	PF02991	0.425
LIG_LIR_LC3C_4	738	741	PF02991	0.398
LIG_LIR_Nem_3	128	133	PF02991	0.426
LIG_LIR_Nem_3	158	163	PF02991	0.527
LIG_LIR_Nem_3	469	475	PF02991	0.553
LIG_LIR_Nem_3	581	587	PF02991	0.601
LIG_LIR_Nem_3	61	66	PF02991	0.386
LIG_LIR_Nem_3	80	86	PF02991	0.438
LIG_MYND_1	531	535	PF01753	0.520
LIG_MYND_3	555	559	PF01753	0.667
LIG_NRBOX	315	321	PF00104	0.495
LIG_Pex14_2	66	70	PF04695	0.428
LIG_SH2_STAP1	779	783	PF00017	0.536
LIG_SH2_STAP1	90	94	PF00017	0.380
LIG_SH2_STAT3	637	640	PF00017	0.675
LIG_SH2_STAT5	408	411	PF00017	0.590
LIG_SH2_STAT5	607	610	PF00017	0.733
LIG_SH2_STAT5	669	672	PF00017	0.503
LIG_SH2_STAT5	747	750	PF00017	0.471
LIG_SH2_STAT5	79	82	PF00017	0.425
LIG_SH3_3	35	41	PF00018	0.450
LIG_SH3_3	374	380	PF00018	0.602
LIG_SH3_3	430	436	PF00018	0.696
LIG_SH3_3	536	542	PF00018	0.555
LIG_SH3_3	633	639	PF00018	0.503
LIG_SUMO_SIM_anti_2	516	524	PF11976	0.712
LIG_SUMO_SIM_anti_2	735	742	PF11976	0.413
LIG_SUMO_SIM_par_1	315	322	PF11976	0.501
LIG_SUMO_SIM_par_1	751	756	PF11976	0.501
LIG_SxIP_EBH_1	51	60	PF03271	0.398
LIG_TRAF2_1	141	144	PF00917	0.536
LIG_TRAF2_1	25	28	PF00917	0.432
LIG_TRAF2_1	611	614	PF00917	0.609
LIG_TRAF2_2	380	385	PF00917	0.584
LIG_TRFH_1	695	699	PF08558	0.464
LIG_WRC_WIRS_1	179	184	PF05994	0.734
LIG_WRC_WIRS_1	727	732	PF05994	0.525
LIG_WW_3	697	701	PF00397	0.473
MOD_CDC14_SPxK_1	551	554	PF00782	0.714
MOD_CDK_SPK_2	305	310	PF00069	0.452
MOD_CDK_SPxK_1	548	554	PF00069	0.720
MOD_CK1_1	181	187	PF00069	0.700
MOD_CK1_1	188	194	PF00069	0.614
MOD_CK1_1	208	214	PF00069	0.679
MOD_CK1_1	223	229	PF00069	0.606
MOD_CK1_1	318	324	PF00069	0.500
MOD_CK1_1	342	348	PF00069	0.629
MOD_CK1_1	355	361	PF00069	0.674
MOD_CK1_1	364	370	PF00069	0.672
MOD_CK1_1	453	459	PF00069	0.810
MOD_CK1_1	500	506	PF00069	0.720
MOD_CK1_1	538	544	PF00069	0.596
MOD_CK1_1	548	554	PF00069	0.575
MOD_CK1_1	589	595	PF00069	0.683
MOD_CK1_1	627	633	PF00069	0.601
MOD_CK1_1	714	720	PF00069	0.625
MOD_CK1_1	73	79	PF00069	0.467
MOD_CK2_1	287	293	PF00069	0.440
MOD_CK2_1	394	400	PF00069	0.575
MOD_CK2_1	568	574	PF00069	0.632
MOD_CK2_1	608	614	PF00069	0.728
MOD_CK2_1	684	690	PF00069	0.481
MOD_CMANNOS	381	384	PF00535	0.584
MOD_Cter_Amidation	490	493	PF01082	0.597
MOD_GlcNHglycan	117	120	PF01048	0.422
MOD_GlcNHglycan	155	158	PF01048	0.568
MOD_GlcNHglycan	187	190	PF01048	0.768
MOD_GlcNHglycan	194	197	PF01048	0.674
MOD_GlcNHglycan	207	210	PF01048	0.725
MOD_GlcNHglycan	221	225	PF01048	0.683
MOD_GlcNHglycan	234	238	PF01048	0.609
MOD_GlcNHglycan	245	248	PF01048	0.543
MOD_GlcNHglycan	257	260	PF01048	0.593
MOD_GlcNHglycan	311	314	PF01048	0.518
MOD_GlcNHglycan	341	344	PF01048	0.659
MOD_GlcNHglycan	354	357	PF01048	0.752
MOD_GlcNHglycan	463	466	PF01048	0.519
MOD_GlcNHglycan	494	497	PF01048	0.692
MOD_GlcNHglycan	499	502	PF01048	0.742
MOD_GlcNHglycan	547	550	PF01048	0.635
MOD_GlcNHglycan	562	565	PF01048	0.585
MOD_GlcNHglycan	570	573	PF01048	0.668
MOD_GlcNHglycan	574	578	PF01048	0.594
MOD_GlcNHglycan	626	629	PF01048	0.625
MOD_GlcNHglycan	63	66	PF01048	0.397
MOD_GlcNHglycan	713	716	PF01048	0.669
MOD_GlcNHglycan	768	772	PF01048	0.652
MOD_GSK3_1	128	135	PF00069	0.446
MOD_GSK3_1	155	162	PF00069	0.490
MOD_GSK3_1	181	188	PF00069	0.754
MOD_GSK3_1	190	197	PF00069	0.695
MOD_GSK3_1	226	233	PF00069	0.752
MOD_GSK3_1	255	262	PF00069	0.626
MOD_GSK3_1	305	312	PF00069	0.475
MOD_GSK3_1	315	322	PF00069	0.559
MOD_GSK3_1	339	346	PF00069	0.731
MOD_GSK3_1	355	362	PF00069	0.701
MOD_GSK3_1	363	370	PF00069	0.638
MOD_GSK3_1	394	401	PF00069	0.578
MOD_GSK3_1	49	56	PF00069	0.436
MOD_GSK3_1	531	538	PF00069	0.599
MOD_GSK3_1	558	565	PF00069	0.741
MOD_GSK3_1	578	585	PF00069	0.476
MOD_GSK3_1	586	593	PF00069	0.650
MOD_GSK3_1	603	610	PF00069	0.624
MOD_GSK3_1	635	642	PF00069	0.572
MOD_GSK3_1	69	76	PF00069	0.319
MOD_GSK3_1	735	742	PF00069	0.416
MOD_GSK3_1	767	774	PF00069	0.588
MOD_LATS_1	396	402	PF00433	0.578
MOD_N-GLC_1	115	120	PF02516	0.419
MOD_N-GLC_2	686	688	PF02516	0.613
MOD_NEK2_1	200	205	PF00069	0.711
MOD_NEK2_1	266	271	PF00069	0.556
MOD_NEK2_1	49	54	PF00069	0.520
MOD_NEK2_1	558	563	PF00069	0.679
MOD_NEK2_1	608	613	PF00069	0.756
MOD_NEK2_1	70	75	PF00069	0.473
MOD_NEK2_2	535	540	PF00069	0.525
MOD_OFUCOSY	682	688	PF10250	0.507
MOD_PIKK_1	281	287	PF00454	0.429
MOD_PIKK_1	323	329	PF00454	0.489
MOD_PIKK_1	349	355	PF00454	0.625
MOD_PIKK_1	398	404	PF00454	0.593
MOD_PIKK_1	444	450	PF00454	0.711
MOD_PIKK_1	609	615	PF00454	0.609
MOD_PK_1	419	425	PF00069	0.755
MOD_PKA_1	492	498	PF00069	0.576
MOD_PKA_2	153	159	PF00069	0.589
MOD_PKA_2	492	498	PF00069	0.675
MOD_PKA_2	567	573	PF00069	0.573
MOD_PKA_2	735	741	PF00069	0.528
MOD_PKB_1	490	498	PF00069	0.685
MOD_PKB_1	675	683	PF00069	0.478
MOD_Plk_1	466	472	PF00069	0.704
MOD_Plk_1	753	759	PF00069	0.508
MOD_Plk_2-3	514	520	PF00069	0.657
MOD_Plk_4	315	321	PF00069	0.549
MOD_Plk_4	388	394	PF00069	0.551
MOD_Plk_4	535	541	PF00069	0.525
MOD_Plk_4	55	61	PF00069	0.417
MOD_Plk_4	603	609	PF00069	0.609
MOD_Plk_4	639	645	PF00069	0.623
MOD_Plk_4	665	671	PF00069	0.464
MOD_Plk_4	735	741	PF00069	0.424
MOD_ProDKin_1	155	161	PF00069	0.567
MOD_ProDKin_1	194	200	PF00069	0.693
MOD_ProDKin_1	305	311	PF00069	0.455
MOD_ProDKin_1	319	325	PF00069	0.491
MOD_ProDKin_1	345	351	PF00069	0.633
MOD_ProDKin_1	438	444	PF00069	0.665
MOD_ProDKin_1	521	527	PF00069	0.640
MOD_ProDKin_1	531	537	PF00069	0.552
MOD_ProDKin_1	538	544	PF00069	0.514
MOD_ProDKin_1	548	554	PF00069	0.538
MOD_ProDKin_1	627	633	PF00069	0.673
MOD_ProDKin_1	635	641	PF00069	0.502
MOD_ProDKin_1	800	806	PF00069	0.631
MOD_SUMO_rev_2	258	265	PF00179	0.559
TRG_AP2beta_CARGO_1	128	137	PF09066	0.422
TRG_DiLeu_BaEn_1	518	523	PF01217	0.716
TRG_DiLeu_BaEn_1	614	619	PF01217	0.612
TRG_DiLeu_BaEn_4	518	524	PF01217	0.717
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.717
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.475
TRG_ENDOCYTIC_2	100	103	PF00928	0.521
TRG_ENDOCYTIC_2	63	66	PF00928	0.397
TRG_ER_diArg_1	13	15	PF00400	0.610
TRG_ER_diArg_1	169	172	PF00400	0.576
TRG_ER_diArg_1	268	271	PF00400	0.553
TRG_ER_diArg_1	473	476	PF00400	0.678
TRG_ER_diArg_1	490	493	PF00400	0.548
TRG_ER_diArg_1	621	623	PF00400	0.548
TRG_ER_diArg_1	644	647	PF00400	0.526
TRG_ER_diArg_1	653	655	PF00400	0.571
TRG_ER_diArg_1	699	702	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P946	Leptomonas seymouri	51%	89%
A0A3Q8IMA4	Leishmania donovani	89%	100%
A4HMR1	Leishmania braziliensis	76%	100%
A4IBE7	Leishmania infantum	90%	100%
E9B6B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%