DUF4806 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF1764), putative

Species:

Leishmania major

UniProt:

E9AF60_LEIMA

TriTrypDb:

LmjF.35.2360 , LMJLV39_350030400 , LMJSD75_350029800

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.428
CLV_PCSK_KEX2_1	162	164	PF00082	0.452
CLV_PCSK_KEX2_1	85	87	PF00082	0.707
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.707
CLV_PCSK_SKI1_1	27	31	PF00082	0.715
CLV_PCSK_SKI1_1	52	56	PF00082	0.483
CLV_Separin_Metazoa	159	163	PF03568	0.364
DEG_Nend_UBRbox_1	1	4	PF02207	0.744
DEG_SPOP_SBC_1	142	146	PF00917	0.705
DEG_SPOP_SBC_1	28	32	PF00917	0.738
DEG_SPOP_SBC_1	95	99	PF00917	0.709
DOC_PP2B_LxvP_1	65	68	PF13499	0.562
DOC_USP7_MATH_1	115	119	PF00917	0.602
DOC_USP7_MATH_1	142	146	PF00917	0.732
DOC_USP7_MATH_1	147	151	PF00917	0.706
DOC_USP7_MATH_1	15	19	PF00917	0.704
DOC_USP7_MATH_1	154	158	PF00917	0.509
DOC_USP7_MATH_1	34	38	PF00917	0.751
DOC_USP7_MATH_1	7	11	PF00917	0.758
DOC_USP7_MATH_1	96	100	PF00917	0.646
DOC_WW_Pin1_4	11	16	PF00397	0.750
DOC_WW_Pin1_4	150	155	PF00397	0.774
DOC_WW_Pin1_4	185	190	PF00397	0.370
DOC_WW_Pin1_4	32	37	PF00397	0.687
LIG_14-3-3_CanoR_1	168	173	PF00244	0.343
LIG_14-3-3_CanoR_1	8	15	PF00244	0.774
LIG_14-3-3_CanoR_1	86	94	PF00244	0.704
LIG_DLG_GKlike_1	168	175	PF00625	0.402
LIG_FHA_1	12	18	PF00498	0.790
LIG_FHA_1	36	42	PF00498	0.704
LIG_LIR_Apic_2	109	115	PF02991	0.577
LIG_LIR_Gen_1	46	56	PF02991	0.585
LIG_LIR_Nem_3	46	51	PF02991	0.513
LIG_Pex14_2	127	131	PF04695	0.607
LIG_SH3_3	186	192	PF00018	0.335
LIG_TRAF2_1	156	159	PF00917	0.639
LIG_TRAF2_1	171	174	PF00917	0.374
LIG_UBA3_1	47	55	PF00899	0.560
MOD_CK1_1	150	156	PF00069	0.709
MOD_CK1_1	18	24	PF00069	0.691
MOD_CK1_1	180	186	PF00069	0.315
MOD_CK1_1	32	38	PF00069	0.766
MOD_CK1_1	61	67	PF00069	0.566
MOD_CK1_1	97	103	PF00069	0.684
MOD_CK2_1	168	174	PF00069	0.370
MOD_GlcNHglycan	127	130	PF01048	0.602
MOD_GlcNHglycan	145	148	PF01048	0.469
MOD_GlcNHglycan	20	23	PF01048	0.593
MOD_GlcNHglycan	60	63	PF01048	0.751
MOD_GlcNHglycan	88	91	PF01048	0.702
MOD_GlcNHglycan	9	12	PF01048	0.814
MOD_GlcNHglycan	99	102	PF01048	0.653
MOD_GSK3_1	115	122	PF00069	0.610
MOD_GSK3_1	137	144	PF00069	0.728
MOD_GSK3_1	150	157	PF00069	0.551
MOD_GSK3_1	173	180	PF00069	0.402
MOD_GSK3_1	18	25	PF00069	0.594
MOD_GSK3_1	28	35	PF00069	0.654
MOD_GSK3_1	43	50	PF00069	0.513
MOD_GSK3_1	7	14	PF00069	0.760
MOD_NEK2_1	127	132	PF00069	0.612
MOD_NEK2_1	47	52	PF00069	0.627
MOD_NEK2_2	75	80	PF00069	0.594
MOD_PKA_1	85	91	PF00069	0.707
MOD_PKA_2	7	13	PF00069	0.765
MOD_PKA_2	85	91	PF00069	0.707
MOD_Plk_1	115	121	PF00069	0.617
MOD_Plk_4	127	133	PF00069	0.587
MOD_Plk_4	43	49	PF00069	0.582
MOD_ProDKin_1	11	17	PF00069	0.751
MOD_ProDKin_1	150	156	PF00069	0.773
MOD_ProDKin_1	185	191	PF00069	0.370
MOD_ProDKin_1	32	38	PF00069	0.683
MOD_SUMO_rev_2	78	87	PF00179	0.682
TRG_DiLeu_BaEn_3	173	179	PF01217	0.385
TRG_ER_diArg_1	161	163	PF00400	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8J3	Leptomonas seymouri	50%	100%
A0A1X0P736	Trypanosomatidae	34%	100%
A0A3S7X9A2	Leishmania donovani	86%	100%
A4HMR0	Leishmania braziliensis	70%	100%
E9AHW2	Leishmania infantum	88%	100%
E9B6B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%