Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF55_LEIMA

TriTrypDb:

LmjF.35.2310 , LMJLV39_350029900 , LMJSD75_350029300

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

E9AF55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF55

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.347
CLV_C14_Caspase3-7	227	231	PF00656	0.572
CLV_NRD_NRD_1	180	182	PF00675	0.674
CLV_NRD_NRD_1	3	5	PF00675	0.543
CLV_NRD_NRD_1	48	50	PF00675	0.555
CLV_PCSK_KEX2_1	180	182	PF00082	0.621
CLV_PCSK_KEX2_1	3	5	PF00082	0.543
CLV_PCSK_KEX2_1	48	50	PF00082	0.566
CLV_PCSK_SKI1_1	49	53	PF00082	0.565
DOC_CKS1_1	6	11	PF01111	0.752
DOC_PP4_FxxP_1	130	133	PF00568	0.432
DOC_SPAK_OSR1_1	87	91	PF12202	0.438
DOC_USP7_MATH_1	120	124	PF00917	0.563
DOC_USP7_MATH_1	154	158	PF00917	0.419
DOC_USP7_MATH_1	16	20	PF00917	0.775
DOC_USP7_MATH_1	39	43	PF00917	0.698
DOC_USP7_MATH_1	65	69	PF00917	0.625
DOC_WW_Pin1_4	5	10	PF00397	0.733
DOC_WW_Pin1_4	53	58	PF00397	0.735
DOC_WW_Pin1_4	66	71	PF00397	0.666
LIG_14-3-3_CanoR_1	134	142	PF00244	0.461
LIG_14-3-3_CanoR_1	164	174	PF00244	0.514
LIG_14-3-3_CanoR_1	180	187	PF00244	0.328
LIG_14-3-3_CanoR_1	3	7	PF00244	0.741
LIG_BRCT_BRCA1_1	126	130	PF00533	0.439
LIG_FHA_1	166	172	PF00498	0.499
LIG_FHA_1	27	33	PF00498	0.763
LIG_FHA_1	6	12	PF00498	0.754
LIG_LIR_Apic_2	127	133	PF02991	0.432
LIG_LIR_Gen_1	153	163	PF02991	0.518
LIG_LIR_Gen_1	22	32	PF02991	0.725
LIG_LIR_Nem_3	153	158	PF02991	0.465
LIG_LIR_Nem_3	22	28	PF02991	0.758
LIG_Pex14_2	187	191	PF04695	0.418
LIG_SH2_CRK	155	159	PF00017	0.468
LIG_SH2_CRK	25	29	PF00017	0.799
LIG_SH2_NCK_1	155	159	PF00017	0.468
LIG_SH2_STAT5	155	158	PF00017	0.509
LIG_SH2_STAT5	25	28	PF00017	0.802
LIG_SH3_3	170	176	PF00018	0.468
LIG_SH3_3	3	9	PF00018	0.752
LIG_UBA3_1	190	196	PF00899	0.465
MOD_CK1_1	14	20	PF00069	0.778
MOD_CK1_1	165	171	PF00069	0.518
MOD_CK2_1	134	140	PF00069	0.432
MOD_Cter_Amidation	1	4	PF01082	0.560
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.727
MOD_GlcNHglycan	122	125	PF01048	0.704
MOD_GlcNHglycan	13	16	PF01048	0.530
MOD_GlcNHglycan	136	139	PF01048	0.649
MOD_GlcNHglycan	168	171	PF01048	0.727
MOD_GlcNHglycan	206	209	PF01048	0.606
MOD_GlcNHglycan	21	24	PF01048	0.559
MOD_GlcNHglycan	222	225	PF01048	0.716
MOD_GlcNHglycan	33	36	PF01048	0.421
MOD_GlcNHglycan	39	42	PF01048	0.479
MOD_GlcNHglycan	92	95	PF01048	0.418
MOD_GSK3_1	120	127	PF00069	0.560
MOD_GSK3_1	162	169	PF00069	0.510
MOD_GSK3_1	19	26	PF00069	0.678
MOD_GSK3_1	230	237	PF00069	0.566
MOD_GSK3_1	27	34	PF00069	0.617
MOD_GSK3_1	7	14	PF00069	0.759
MOD_NEK2_1	147	152	PF00069	0.422
MOD_NEK2_1	166	171	PF00069	0.411
MOD_PIKK_1	105	111	PF00454	0.480
MOD_PKA_2	105	111	PF00069	0.467
MOD_PKA_2	179	185	PF00069	0.376
MOD_PKA_2	2	8	PF00069	0.787
MOD_PKA_2	233	239	PF00069	0.577
MOD_PKA_2	73	79	PF00069	0.726
MOD_Plk_1	125	131	PF00069	0.438
MOD_Plk_1	147	153	PF00069	0.371
MOD_Plk_4	7	13	PF00069	0.742
MOD_ProDKin_1	5	11	PF00069	0.734
MOD_ProDKin_1	53	59	PF00069	0.735
MOD_ProDKin_1	66	72	PF00069	0.664
TRG_DiLeu_BaEn_2	196	202	PF01217	0.482
TRG_ENDOCYTIC_2	155	158	PF00928	0.469
TRG_ENDOCYTIC_2	25	28	PF00928	0.802

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF73	Leptomonas seymouri	52%	100%
A0A3Q8IPJ2	Leishmania donovani	89%	100%
A4HMQ5	Leishmania braziliensis	74%	100%
A4IBC3	Leishmania infantum	89%	100%
C9ZZC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B6B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%