Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF52_LEIMA

TriTrypDb:

LmjF.35.2280 , LMJLV39_350029600 , LMJSD75_350029000

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.731
CLV_C14_Caspase3-7	252	256	PF00656	0.406
CLV_NRD_NRD_1	34	36	PF00675	0.754
CLV_PCSK_KEX2_1	130	132	PF00082	0.586
CLV_PCSK_KEX2_1	33	35	PF00082	0.755
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.586
CLV_PCSK_SKI1_1	264	268	PF00082	0.460
CLV_PCSK_SKI1_1	49	53	PF00082	0.719
DEG_Nend_Nbox_1	1	3	PF02207	0.739
DEG_SPOP_SBC_1	27	31	PF00917	0.796
DOC_CKS1_1	442	447	PF01111	0.478
DOC_CKS1_1	55	60	PF01111	0.630
DOC_CYCLIN_yClb5_NLxxxL_5	117	125	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.437
DOC_MAPK_gen_1	272	281	PF00069	0.377
DOC_MAPK_gen_1	296	302	PF00069	0.454
DOC_MAPK_gen_1	453	461	PF00069	0.492
DOC_MAPK_MEF2A_6	272	281	PF00069	0.392
DOC_MAPK_MEF2A_6	327	334	PF00069	0.522
DOC_MAPK_MEF2A_6	342	349	PF00069	0.383
DOC_PP1_RVXF_1	184	191	PF00149	0.444
DOC_PP2B_LxvP_1	182	185	PF13499	0.474
DOC_PP2B_LxvP_1	298	301	PF13499	0.518
DOC_PP4_FxxP_1	375	378	PF00568	0.374
DOC_PP4_FxxP_1	55	58	PF00568	0.617
DOC_PP4_FxxP_1	85	88	PF00568	0.445
DOC_USP7_MATH_1	18	22	PF00917	0.781
DOC_USP7_MATH_1	26	30	PF00917	0.762
DOC_USP7_MATH_1	448	452	PF00917	0.512
DOC_WW_Pin1_4	441	446	PF00397	0.460
DOC_WW_Pin1_4	54	59	PF00397	0.634
LIG_APCC_ABBA_1	347	352	PF00400	0.433
LIG_BIR_III_4	25	29	PF00653	0.806
LIG_BRCT_BRCA1_1	215	219	PF00533	0.561
LIG_deltaCOP1_diTrp_1	220	227	PF00928	0.430
LIG_deltaCOP1_diTrp_1	388	393	PF00928	0.451
LIG_FHA_1	104	110	PF00498	0.568
LIG_FHA_1	248	254	PF00498	0.390
LIG_FHA_1	293	299	PF00498	0.416
LIG_FHA_1	358	364	PF00498	0.403
LIG_FHA_1	398	404	PF00498	0.456
LIG_FHA_1	437	443	PF00498	0.437
LIG_FHA_1	82	88	PF00498	0.439
LIG_FHA_2	20	26	PF00498	0.574
LIG_FHA_2	216	222	PF00498	0.481
LIG_FHA_2	64	70	PF00498	0.652
LIG_IBAR_NPY_1	312	314	PF08397	0.445
LIG_LIR_Apic_2	54	58	PF02991	0.693
LIG_LIR_Apic_2	84	88	PF02991	0.451
LIG_LIR_Gen_1	116	125	PF02991	0.596
LIG_LIR_Gen_1	159	168	PF02991	0.416
LIG_LIR_Gen_1	220	230	PF02991	0.405
LIG_LIR_Gen_1	235	244	PF02991	0.339
LIG_LIR_Gen_1	311	319	PF02991	0.416
LIG_LIR_Gen_1	371	378	PF02991	0.371
LIG_LIR_Gen_1	71	80	PF02991	0.490
LIG_LIR_Nem_3	116	121	PF02991	0.598
LIG_LIR_Nem_3	159	163	PF02991	0.414
LIG_LIR_Nem_3	220	226	PF02991	0.399
LIG_LIR_Nem_3	285	291	PF02991	0.413
LIG_LIR_Nem_3	311	317	PF02991	0.421
LIG_LIR_Nem_3	371	377	PF02991	0.367
LIG_LIR_Nem_3	388	393	PF02991	0.336
LIG_LIR_Nem_3	409	414	PF02991	0.395
LIG_LIR_Nem_3	71	77	PF02991	0.509
LIG_PCNA_yPIPBox_3	364	373	PF02747	0.472
LIG_PCNA_yPIPBox_3	435	443	PF02747	0.380
LIG_Pex14_1	222	226	PF04695	0.419
LIG_PTB_Apo_2	107	114	PF02174	0.553
LIG_SH2_CRK	175	179	PF00017	0.483
LIG_SH2_CRK	74	78	PF00017	0.549
LIG_SH2_NCK_1	160	164	PF00017	0.414
LIG_SH2_NCK_1	74	78	PF00017	0.508
LIG_SH2_SRC	160	163	PF00017	0.393
LIG_SH2_SRC	343	346	PF00017	0.366
LIG_SH2_STAP1	144	148	PF00017	0.403
LIG_SH2_STAP1	175	179	PF00017	0.379
LIG_SH2_STAP1	249	253	PF00017	0.484
LIG_SH2_STAP1	83	87	PF00017	0.472
LIG_SH2_STAT5	223	226	PF00017	0.411
LIG_SH2_STAT5	238	241	PF00017	0.423
LIG_SH2_STAT5	249	252	PF00017	0.453
LIG_SH2_STAT5	260	263	PF00017	0.259
LIG_SH2_STAT5	314	317	PF00017	0.450
LIG_SH2_STAT5	372	375	PF00017	0.355
LIG_SH2_STAT5	381	384	PF00017	0.374
LIG_SH2_STAT5	392	395	PF00017	0.258
LIG_SH2_STAT5	65	68	PF00017	0.676
LIG_SH2_STAT5	83	86	PF00017	0.455
LIG_SH3_3	411	417	PF00018	0.428
LIG_SH3_3	442	448	PF00018	0.397
LIG_TRAF2_1	218	221	PF00917	0.444
LIG_TRAF2_1	66	69	PF00917	0.547
LIG_TYR_ITAM	157	178	PF00017	0.438
LIG_TYR_ITIM	158	163	PF00017	0.412
LIG_UBA3_1	178	186	PF00899	0.490
LIG_UBA3_1	315	322	PF00899	0.452
LIG_UBA3_1	331	335	PF00899	0.433
MOD_CK1_1	29	35	PF00069	0.729
MOD_CK1_1	357	363	PF00069	0.418
MOD_CK2_1	193	199	PF00069	0.560
MOD_CK2_1	215	221	PF00069	0.441
MOD_CK2_1	365	371	PF00069	0.406
MOD_CK2_1	377	383	PF00069	0.360
MOD_CK2_1	63	69	PF00069	0.508
MOD_CMANNOS	387	390	PF00535	0.369
MOD_GlcNHglycan	22	25	PF01048	0.743
MOD_GlcNHglycan	450	453	PF01048	0.403
MOD_GSK3_1	1	8	PF00069	0.746
MOD_GSK3_1	174	181	PF00069	0.453
MOD_GSK3_1	243	250	PF00069	0.359
MOD_GSK3_1	64	71	PF00069	0.674
MOD_GSK3_1	72	79	PF00069	0.577
MOD_N-GLC_1	292	297	PF02516	0.392
MOD_NEK2_1	113	118	PF00069	0.584
MOD_NEK2_1	178	183	PF00069	0.462
MOD_NEK2_1	253	258	PF00069	0.466
MOD_NEK2_1	292	297	PF00069	0.447
MOD_PIKK_1	100	106	PF00454	0.615
MOD_PKA_2	397	403	PF00069	0.568
MOD_PKA_2	43	49	PF00069	0.786
MOD_PKB_1	42	50	PF00069	0.724
MOD_Plk_1	113	119	PF00069	0.671
MOD_Plk_1	199	205	PF00069	0.482
MOD_Plk_1	213	219	PF00069	0.433
MOD_Plk_4	174	180	PF00069	0.493
MOD_Plk_4	243	249	PF00069	0.393
MOD_Plk_4	343	349	PF00069	0.410
MOD_Plk_4	56	62	PF00069	0.681
MOD_ProDKin_1	441	447	PF00069	0.461
MOD_ProDKin_1	54	60	PF00069	0.631
MOD_SUMO_for_1	111	114	PF00179	0.639
MOD_SUMO_rev_2	321	328	PF00179	0.451
TRG_DiLeu_BaEn_1	263	268	PF01217	0.510
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.503
TRG_ENDOCYTIC_2	144	147	PF00928	0.446
TRG_ENDOCYTIC_2	160	163	PF00928	0.390
TRG_ENDOCYTIC_2	175	178	PF00928	0.430
TRG_ENDOCYTIC_2	223	226	PF00928	0.392
TRG_ENDOCYTIC_2	230	233	PF00928	0.368
TRG_ENDOCYTIC_2	238	241	PF00928	0.347
TRG_ENDOCYTIC_2	314	317	PF00928	0.449
TRG_ENDOCYTIC_2	372	375	PF00928	0.366
TRG_ENDOCYTIC_2	74	77	PF00928	0.501
TRG_ER_diArg_1	33	35	PF00400	0.654
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S2	Leptomonas seymouri	87%	100%
A0A0S4JF65	Bodo saltans	58%	100%
A0A1X0P745	Trypanosomatidae	71%	100%
A0A3R7NH73	Trypanosoma rangeli	70%	100%
A0A3S7X999	Leishmania donovani	95%	100%
A4HMQ2	Leishmania braziliensis	86%	100%
A4IBC0	Leishmania infantum	95%	100%
C9ZZC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B6A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BNX6	Trypanosoma cruzi	70%	100%