ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AF50_LEIMA

TriTrypDb:

LmjF.35.2260 , LMJLV39_350029400 , LMJSD75_350028800

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF50

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.494
CLV_C14_Caspase3-7	282	286	PF00656	0.297
CLV_C14_Caspase3-7	315	319	PF00656	0.282
CLV_C14_Caspase3-7	513	517	PF00656	0.447
CLV_NRD_NRD_1	29	31	PF00675	0.467
CLV_NRD_NRD_1	519	521	PF00675	0.485
CLV_PCSK_KEX2_1	29	31	PF00082	0.467
CLV_PCSK_KEX2_1	519	521	PF00082	0.426
CLV_PCSK_SKI1_1	122	126	PF00082	0.316
CLV_PCSK_SKI1_1	172	176	PF00082	0.371
CLV_PCSK_SKI1_1	314	318	PF00082	0.322
CLV_PCSK_SKI1_1	378	382	PF00082	0.330
CLV_PCSK_SKI1_1	519	523	PF00082	0.468
DEG_APCC_DBOX_1	102	110	PF00400	0.410
DEG_SCF_FBW7_2	43	49	PF00400	0.329
DEG_SIAH_1	142	150	PF03145	0.319
DOC_CKS1_1	148	153	PF01111	0.537
DOC_CKS1_1	43	48	PF01111	0.426
DOC_CYCLIN_RxL_1	311	319	PF00134	0.396
DOC_CYCLIN_RxL_1	365	374	PF00134	0.360
DOC_CYCLIN_yClb5_NLxxxL_5	368	376	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.425
DOC_MAPK_DCC_7	103	111	PF00069	0.393
DOC_MAPK_gen_1	29	38	PF00069	0.330
DOC_MAPK_gen_1	342	350	PF00069	0.279
DOC_MAPK_MEF2A_6	29	38	PF00069	0.336
DOC_MAPK_MEF2A_6	378	385	PF00069	0.263
DOC_PP1_RVXF_1	10	17	PF00149	0.392
DOC_PP2B_LxvP_1	381	384	PF13499	0.468
DOC_PP4_FxxP_1	446	449	PF00568	0.453
DOC_USP7_MATH_1	357	361	PF00917	0.311
DOC_USP7_MATH_1	412	416	PF00917	0.586
DOC_USP7_MATH_1	85	89	PF00917	0.366
DOC_USP7_MATH_2	472	478	PF00917	0.427
DOC_USP7_UBL2_3	177	181	PF12436	0.373
DOC_WW_Pin1_4	104	109	PF00397	0.457
DOC_WW_Pin1_4	133	138	PF00397	0.350
DOC_WW_Pin1_4	147	152	PF00397	0.265
DOC_WW_Pin1_4	194	199	PF00397	0.297
DOC_WW_Pin1_4	287	292	PF00397	0.311
DOC_WW_Pin1_4	410	415	PF00397	0.727
DOC_WW_Pin1_4	42	47	PF00397	0.499
LIG_14-3-3_CanoR_1	126	135	PF00244	0.470
LIG_14-3-3_CanoR_1	18	23	PF00244	0.328
LIG_14-3-3_CanoR_1	29	35	PF00244	0.399
LIG_14-3-3_CanoR_1	425	435	PF00244	0.450
LIG_Actin_WH2_2	2	20	PF00022	0.301
LIG_BRCT_BRCA1_1	164	168	PF00533	0.441
LIG_BRCT_BRCA1_1	283	287	PF00533	0.297
LIG_BRCT_BRCA1_1	442	446	PF00533	0.419
LIG_BRCT_BRCA1_2	164	170	PF00533	0.447
LIG_deltaCOP1_diTrp_1	216	222	PF00928	0.210
LIG_EVH1_2	494	498	PF00568	0.404
LIG_FHA_1	17	23	PF00498	0.341
LIG_FHA_1	35	41	PF00498	0.469
LIG_FHA_1	60	66	PF00498	0.351
LIG_FHA_2	148	154	PF00498	0.547
LIG_FHA_2	2	8	PF00498	0.395
LIG_FHA_2	208	214	PF00498	0.408
LIG_FHA_2	508	514	PF00498	0.370
LIG_GBD_Chelix_1	175	183	PF00786	0.365
LIG_LIR_Apic_2	443	449	PF02991	0.411
LIG_LIR_Gen_1	220	230	PF02991	0.253
LIG_LIR_Gen_1	231	242	PF02991	0.312
LIG_LIR_Gen_1	433	442	PF02991	0.460
LIG_LIR_Nem_3	123	128	PF02991	0.405
LIG_LIR_Nem_3	220	225	PF02991	0.253
LIG_LIR_Nem_3	231	237	PF02991	0.312
LIG_LIR_Nem_3	365	370	PF02991	0.397
LIG_LIR_Nem_3	433	439	PF02991	0.477
LIG_LIR_Nem_3	49	53	PF02991	0.354
LIG_LIR_Nem_3	88	92	PF02991	0.309
LIG_NRBOX	312	318	PF00104	0.258
LIG_PCNA_PIPBox_1	386	395	PF02747	0.368
LIG_PCNA_yPIPBox_3	118	126	PF02747	0.347
LIG_PDZ_Class_2	528	533	PF00595	0.491
LIG_Pex14_2	50	54	PF04695	0.357
LIG_Rb_LxCxE_1	123	139	PF01857	0.449
LIG_SH2_CRK	28	32	PF00017	0.407
LIG_SH2_CRK	367	371	PF00017	0.399
LIG_SH2_SRC	338	341	PF00017	0.355
LIG_SH2_STAT3	459	462	PF00017	0.537
LIG_SH2_STAT5	293	296	PF00017	0.297
LIG_SH2_STAT5	320	323	PF00017	0.357
LIG_SH2_STAT5	346	349	PF00017	0.279
LIG_SH3_3	107	113	PF00018	0.325
LIG_SH3_3	137	143	PF00018	0.463
LIG_SH3_3	190	196	PF00018	0.273
LIG_SH3_3	286	292	PF00018	0.333
LIG_SH3_3	40	46	PF00018	0.344
LIG_SH3_3	402	408	PF00018	0.566
LIG_SH3_3	466	472	PF00018	0.385
LIG_SH3_3	488	494	PF00018	0.381
LIG_SH3_3	526	532	PF00018	0.478
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.300
LIG_SxIP_EBH_1	103	115	PF03271	0.365
LIG_TRAF2_1	384	387	PF00917	0.404
LIG_WRC_WIRS_1	86	91	PF05994	0.291
MOD_CDK_SPK_2	133	138	PF00069	0.410
MOD_CDK_SPxK_1	410	416	PF00069	0.717
MOD_CK1_1	136	142	PF00069	0.476
MOD_CK1_1	202	208	PF00069	0.382
MOD_CK1_1	220	226	PF00069	0.150
MOD_CK1_1	319	325	PF00069	0.243
MOD_CK1_1	356	362	PF00069	0.352
MOD_CK2_1	1	7	PF00069	0.426
MOD_CK2_1	147	153	PF00069	0.474
MOD_CK2_1	507	513	PF00069	0.397
MOD_CK2_1	85	91	PF00069	0.304
MOD_CMANNOS	219	222	PF00535	0.330
MOD_GlcNHglycan	239	242	PF01048	0.400
MOD_GlcNHglycan	302	305	PF01048	0.349
MOD_GlcNHglycan	321	324	PF01048	0.249
MOD_GlcNHglycan	355	358	PF01048	0.358
MOD_GlcNHglycan	428	431	PF01048	0.657
MOD_GlcNHglycan	483	486	PF01048	0.399
MOD_GlcNHglycan	72	75	PF01048	0.399
MOD_GSK3_1	30	37	PF00069	0.308
MOD_GSK3_1	353	360	PF00069	0.331
MOD_GSK3_1	426	433	PF00069	0.714
MOD_N-GLC_1	104	109	PF02516	0.411
MOD_N-GLC_1	34	39	PF02516	0.263
MOD_N-GLC_2	155	157	PF02516	0.359
MOD_NEK2_1	1	6	PF00069	0.579
MOD_NEK2_1	16	21	PF00069	0.295
MOD_NEK2_1	237	242	PF00069	0.476
MOD_NEK2_1	316	321	PF00069	0.357
MOD_NEK2_1	34	39	PF00069	0.331
MOD_NEK2_1	362	367	PF00069	0.345
MOD_NEK2_1	481	486	PF00069	0.496
MOD_NEK2_1	70	75	PF00069	0.476
MOD_PK_1	18	24	PF00069	0.300
MOD_PK_1	279	285	PF00069	0.357
MOD_PKA_1	519	525	PF00069	0.419
MOD_PKA_2	17	23	PF00069	0.318
MOD_PKA_2	519	525	PF00069	0.465
MOD_Plk_1	34	40	PF00069	0.260
MOD_Plk_1	357	363	PF00069	0.393
MOD_Plk_1	474	480	PF00069	0.427
MOD_Plk_4	199	205	PF00069	0.279
MOD_Plk_4	316	322	PF00069	0.343
MOD_Plk_4	34	40	PF00069	0.308
MOD_Plk_4	357	363	PF00069	0.361
MOD_Plk_4	474	480	PF00069	0.411
MOD_ProDKin_1	104	110	PF00069	0.453
MOD_ProDKin_1	133	139	PF00069	0.352
MOD_ProDKin_1	147	153	PF00069	0.269
MOD_ProDKin_1	194	200	PF00069	0.297
MOD_ProDKin_1	287	293	PF00069	0.311
MOD_ProDKin_1	410	416	PF00069	0.729
MOD_ProDKin_1	42	48	PF00069	0.502
MOD_SUMO_for_1	58	61	PF00179	0.275
MOD_SUMO_rev_2	523	530	PF00179	0.504
TRG_DiLeu_BaEn_1	474	479	PF01217	0.432
TRG_ENDOCYTIC_2	28	31	PF00928	0.324
TRG_ENDOCYTIC_2	367	370	PF00928	0.346
TRG_ER_diArg_1	28	30	PF00400	0.452
TRG_ER_diArg_1	518	520	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P380	Leptomonas seymouri	56%	100%
A0A0S4JCU0	Bodo saltans	42%	100%
A0A1X0P6I8	Trypanosomatidae	47%	100%
A0A3Q8IG99	Leishmania donovani	88%	100%
A0A3R7KHD1	Trypanosoma rangeli	47%	100%
A4HMQ0	Leishmania braziliensis	72%	100%
A4IBB8	Leishmania infantum	88%	100%
E9B6A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BJB2	Trypanosoma cruzi	46%	100%