Mitochondrial DNA polymerase catalytic subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF48_LEIMA

TriTrypDb:

LmjF.35.2240 , LMJLV39_350029200 , LMJSD75_350028500

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.732
CLV_C14_Caspase3-7	278	282	PF00656	0.489
CLV_NRD_NRD_1	119	121	PF00675	0.552
CLV_NRD_NRD_1	139	141	PF00675	0.504
CLV_NRD_NRD_1	308	310	PF00675	0.538
CLV_NRD_NRD_1	333	335	PF00675	0.353
CLV_NRD_NRD_1	35	37	PF00675	0.700
CLV_NRD_NRD_1	434	436	PF00675	0.481
CLV_NRD_NRD_1	46	48	PF00675	0.634
CLV_PCSK_FUR_1	432	436	PF00082	0.557
CLV_PCSK_FUR_1	44	48	PF00082	0.619
CLV_PCSK_KEX2_1	119	121	PF00082	0.552
CLV_PCSK_KEX2_1	143	145	PF00082	0.540
CLV_PCSK_KEX2_1	308	310	PF00082	0.518
CLV_PCSK_KEX2_1	332	334	PF00082	0.349
CLV_PCSK_KEX2_1	35	37	PF00082	0.707
CLV_PCSK_KEX2_1	432	434	PF00082	0.515
CLV_PCSK_KEX2_1	46	48	PF00082	0.634
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.612
CLV_PCSK_SKI1_1	13	17	PF00082	0.765
CLV_PCSK_SKI1_1	334	338	PF00082	0.440
DEG_APCC_DBOX_1	493	501	PF00400	0.651
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.549
DOC_MAPK_FxFP_2	326	329	PF00069	0.395
DOC_MAPK_gen_1	242	252	PF00069	0.380
DOC_MAPK_gen_1	305	313	PF00069	0.496
DOC_MAPK_MEF2A_6	461	468	PF00069	0.512
DOC_MAPK_RevD_3	106	120	PF00069	0.313
DOC_PP1_RVXF_1	503	509	PF00149	0.495
DOC_PP2B_LxvP_1	157	160	PF13499	0.641
DOC_PP4_FxxP_1	20	23	PF00568	0.551
DOC_PP4_FxxP_1	231	234	PF00568	0.524
DOC_PP4_FxxP_1	326	329	PF00568	0.395
DOC_PP4_FxxP_1	84	87	PF00568	0.445
DOC_USP7_MATH_1	132	136	PF00917	0.341
DOC_USP7_MATH_1	178	182	PF00917	0.722
DOC_USP7_MATH_1	327	331	PF00917	0.350
DOC_USP7_MATH_1	363	367	PF00917	0.424
DOC_USP7_MATH_1	514	518	PF00917	0.520
DOC_USP7_MATH_1	57	61	PF00917	0.602
DOC_WW_Pin1_4	135	140	PF00397	0.586
DOC_WW_Pin1_4	202	207	PF00397	0.381
DOC_WW_Pin1_4	208	213	PF00397	0.395
DOC_WW_Pin1_4	293	298	PF00397	0.422
DOC_WW_Pin1_4	351	356	PF00397	0.429
DOC_WW_Pin1_4	36	41	PF00397	0.707
DOC_WW_Pin1_4	424	429	PF00397	0.673
DOC_WW_Pin1_4	64	69	PF00397	0.601
LIG_14-3-3_CanoR_1	13	20	PF00244	0.726
LIG_14-3-3_CanoR_1	144	154	PF00244	0.614
LIG_14-3-3_CanoR_1	26	32	PF00244	0.631
LIG_14-3-3_CanoR_1	287	297	PF00244	0.466
LIG_14-3-3_CanoR_1	333	342	PF00244	0.392
LIG_14-3-3_CanoR_1	38	44	PF00244	0.685
LIG_14-3-3_CanoR_1	381	389	PF00244	0.493
LIG_14-3-3_CanoR_1	505	509	PF00244	0.596
LIG_Actin_WH2_2	304	320	PF00022	0.504
LIG_BIR_III_2	151	155	PF00653	0.505
LIG_BRCT_BRCA1_1	221	225	PF00533	0.384
LIG_BRCT_BRCA1_1	97	101	PF00533	0.507
LIG_BRCT_BRCA1_2	97	103	PF00533	0.403
LIG_CSL_BTD_1	425	428	PF09270	0.630
LIG_FHA_1	195	201	PF00498	0.567
LIG_FHA_1	283	289	PF00498	0.591
LIG_FHA_1	362	368	PF00498	0.492
LIG_FHA_1	406	412	PF00498	0.726
LIG_FHA_2	110	116	PF00498	0.509
LIG_FHA_2	146	152	PF00498	0.573
LIG_FHA_2	276	282	PF00498	0.455
LIG_FHA_2	297	303	PF00498	0.519
LIG_LIR_Apic_2	228	234	PF02991	0.481
LIG_LIR_Apic_2	323	329	PF02991	0.407
LIG_LIR_Gen_1	354	363	PF02991	0.392
LIG_LIR_Gen_1	366	376	PF02991	0.428
LIG_LIR_Gen_1	394	405	PF02991	0.649
LIG_LIR_Nem_3	202	207	PF02991	0.435
LIG_LIR_Nem_3	354	360	PF02991	0.414
LIG_LIR_Nem_3	394	400	PF02991	0.651
LIG_PCNA_yPIPBox_3	461	472	PF02747	0.399
LIG_PDZ_Class_1	514	519	PF00595	0.526
LIG_Pex14_2	231	235	PF04695	0.426
LIG_SH2_CRK	357	361	PF00017	0.364
LIG_SH2_SRC	274	277	PF00017	0.434
LIG_SH2_STAT3	340	343	PF00017	0.428
LIG_SH2_STAT5	274	277	PF00017	0.505
LIG_SH3_3	104	110	PF00018	0.369
LIG_SH3_3	170	176	PF00018	0.631
LIG_SH3_3	258	264	PF00018	0.360
LIG_SH3_3	321	327	PF00018	0.565
LIG_SH3_3	434	440	PF00018	0.635
LIG_SH3_4	461	468	PF00018	0.416
LIG_SUMO_SIM_anti_2	214	219	PF11976	0.348
LIG_SUMO_SIM_par_1	216	222	PF11976	0.372
LIG_TRFH_1	340	344	PF08558	0.492
MOD_CDK_SPK_2	135	140	PF00069	0.450
MOD_CDK_SPxK_1	135	141	PF00069	0.463
MOD_CK1_1	111	117	PF00069	0.414
MOD_CK1_1	135	141	PF00069	0.597
MOD_CK1_1	194	200	PF00069	0.638
MOD_CK1_1	202	208	PF00069	0.538
MOD_CK1_1	211	217	PF00069	0.385
MOD_CK1_1	39	45	PF00069	0.730
MOD_CK1_1	392	398	PF00069	0.649
MOD_CK1_1	476	482	PF00069	0.417
MOD_CK1_1	58	64	PF00069	0.622
MOD_CK2_1	202	208	PF00069	0.372
MOD_CK2_1	296	302	PF00069	0.580
MOD_Cter_Amidation	44	47	PF01082	0.621
MOD_GlcNHglycan	134	137	PF01048	0.550
MOD_GlcNHglycan	163	166	PF01048	0.703
MOD_GlcNHglycan	193	196	PF01048	0.663
MOD_GlcNHglycan	318	321	PF01048	0.373
MOD_GlcNHglycan	385	389	PF01048	0.605
MOD_GlcNHglycan	457	460	PF01048	0.590
MOD_GlcNHglycan	475	478	PF01048	0.326
MOD_GlcNHglycan	57	60	PF01048	0.597
MOD_GlcNHglycan	92	95	PF01048	0.509
MOD_GSK3_1	161	168	PF00069	0.723
MOD_GSK3_1	190	197	PF00069	0.618
MOD_GSK3_1	401	408	PF00069	0.571
MOD_GSK3_1	447	454	PF00069	0.449
MOD_GSK3_1	504	511	PF00069	0.761
MOD_LATS_1	142	148	PF00433	0.504
MOD_N-GLC_1	160	165	PF02516	0.609
MOD_N-GLC_1	455	460	PF02516	0.489
MOD_N-GLC_2	123	125	PF02516	0.515
MOD_NEK2_1	3	8	PF00069	0.664
MOD_NEK2_1	405	410	PF00069	0.740
MOD_NEK2_1	471	476	PF00069	0.310
MOD_NEK2_1	73	78	PF00069	0.600
MOD_NEK2_1	95	100	PF00069	0.478
MOD_NEK2_2	282	287	PF00069	0.385
MOD_PIKK_1	13	19	PF00454	0.603
MOD_PKA_1	46	52	PF00069	0.704
MOD_PKA_2	389	395	PF00069	0.457
MOD_PKA_2	46	52	PF00069	0.673
MOD_PKA_2	504	510	PF00069	0.576
MOD_PKB_1	332	340	PF00069	0.491
MOD_PKB_1	36	44	PF00069	0.592
MOD_PKB_1	379	387	PF00069	0.386
MOD_Plk_1	275	281	PF00069	0.399
MOD_Plk_1	384	390	PF00069	0.470
MOD_Plk_1	392	398	PF00069	0.518
MOD_Plk_4	152	158	PF00069	0.732
MOD_Plk_4	178	184	PF00069	0.601
MOD_Plk_4	199	205	PF00069	0.464
MOD_Plk_4	363	369	PF00069	0.424
MOD_Plk_4	392	398	PF00069	0.541
MOD_ProDKin_1	135	141	PF00069	0.599
MOD_ProDKin_1	202	208	PF00069	0.379
MOD_ProDKin_1	293	299	PF00069	0.425
MOD_ProDKin_1	351	357	PF00069	0.427
MOD_ProDKin_1	36	42	PF00069	0.710
MOD_ProDKin_1	424	430	PF00069	0.676
MOD_ProDKin_1	64	70	PF00069	0.599
TRG_DiLeu_BaEn_2	392	398	PF01217	0.541
TRG_ENDOCYTIC_2	204	207	PF00928	0.420
TRG_ENDOCYTIC_2	357	360	PF00928	0.367
TRG_ER_diArg_1	118	120	PF00400	0.400
TRG_ER_diArg_1	307	309	PF00400	0.535
TRG_ER_diArg_1	331	334	PF00400	0.382
TRG_ER_diArg_1	35	38	PF00400	0.718
TRG_ER_diArg_1	378	381	PF00400	0.520
TRG_ER_diArg_1	43	46	PF00400	0.665
TRG_ER_diArg_1	431	434	PF00400	0.540
TRG_NLS_MonoExtC_3	139	144	PF00514	0.452
TRG_NLS_MonoExtN_4	139	144	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L8	Leptomonas seymouri	46%	95%
A0A1X0P5V1	Trypanosomatidae	37%	100%
A0A3Q8IJ19	Leishmania donovani	92%	97%
A0A422NLY6	Trypanosoma rangeli	38%	100%
A4HMP7	Leishmania braziliensis	73%	100%
A4IBB6	Leishmania infantum	92%	97%
C9ZZD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B6A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DKB8	Trypanosoma cruzi	37%	100%