Short chain dehydrogenase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania major

UniProt:

E9AF41_LEIMA

TriTrypDb:

LmjF.35.2170 , LMJLV39_350028500 , LMJSD75_350027800

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AF41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF41

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004312	fatty acid synthase activity	5	2
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	2
GO:0016491	oxidoreductase activity	2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0016740	transferase activity	2	2
GO:0016746	acyltransferase activity	3	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.759
CLV_PCSK_KEX2_1	112	114	PF00082	0.243
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.258
CLV_PCSK_SKI1_1	107	111	PF00082	0.339
CLV_PCSK_SKI1_1	381	385	PF00082	0.336
CLV_PCSK_SKI1_1	72	76	PF00082	0.264
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DOC_CDC14_PxL_1	392	400	PF14671	0.278
DOC_CYCLIN_RxL_1	167	177	PF00134	0.531
DOC_MAPK_FxFP_2	393	396	PF00069	0.411
DOC_MAPK_MEF2A_6	153	162	PF00069	0.452
DOC_MAPK_MEF2A_6	359	367	PF00069	0.630
DOC_PP1_RVXF_1	105	111	PF00149	0.436
DOC_PP1_RVXF_1	168	175	PF00149	0.525
DOC_PP2B_LxvP_1	215	218	PF13499	0.473
DOC_PP4_FxxP_1	243	246	PF00568	0.517
DOC_PP4_FxxP_1	393	396	PF00568	0.378
DOC_USP7_MATH_1	11	15	PF00917	0.360
DOC_USP7_MATH_1	124	128	PF00917	0.451
DOC_USP7_MATH_1	189	193	PF00917	0.436
DOC_USP7_MATH_1	194	198	PF00917	0.416
DOC_USP7_UBL2_3	121	125	PF12436	0.533
DOC_WW_Pin1_4	282	287	PF00397	0.608
DOC_WW_Pin1_4	329	334	PF00397	0.746
DOC_WW_Pin1_4	351	356	PF00397	0.724
DOC_WW_Pin1_4	461	466	PF00397	0.391
LIG_14-3-3_CanoR_1	103	110	PF00244	0.457
LIG_14-3-3_CanoR_1	193	199	PF00244	0.588
LIG_14-3-3_CanoR_1	226	236	PF00244	0.444
LIG_14-3-3_CanoR_1	264	270	PF00244	0.587
LIG_14-3-3_CanoR_1	317	323	PF00244	0.546
LIG_14-3-3_CanoR_1	448	455	PF00244	0.310
LIG_Actin_WH2_2	168	184	PF00022	0.551
LIG_BRCT_BRCA1_1	396	400	PF00533	0.449
LIG_BRCT_BRCA1_1	46	50	PF00533	0.344
LIG_BRCT_BRCA1_2	396	402	PF00533	0.463
LIG_DCNL_PONY_1	1	4	PF03556	0.547
LIG_deltaCOP1_diTrp_1	291	297	PF00928	0.646
LIG_eIF4E_1	210	216	PF01652	0.436
LIG_FHA_1	103	109	PF00498	0.531
LIG_FHA_1	131	137	PF00498	0.478
LIG_FHA_1	228	234	PF00498	0.555
LIG_FHA_1	310	316	PF00498	0.461
LIG_FHA_1	330	336	PF00498	0.549
LIG_FHA_1	374	380	PF00498	0.527
LIG_FHA_1	417	423	PF00498	0.390
LIG_FHA_1	462	468	PF00498	0.408
LIG_FHA_1	68	74	PF00498	0.560
LIG_FHA_1	78	84	PF00498	0.531
LIG_FHA_1	95	101	PF00498	0.436
LIG_FHA_2	341	347	PF00498	0.633
LIG_FHA_2	401	407	PF00498	0.355
LIG_FHA_2	448	454	PF00498	0.367
LIG_LIR_Apic_2	242	246	PF02991	0.514
LIG_LIR_Apic_2	390	396	PF02991	0.442
LIG_LIR_Gen_1	291	301	PF02991	0.561
LIG_LIR_Gen_1	93	102	PF02991	0.575
LIG_LIR_Nem_3	291	297	PF02991	0.583
LIG_LIR_Nem_3	377	383	PF02991	0.552
LIG_LIR_Nem_3	390	395	PF02991	0.382
LIG_LIR_Nem_3	93	99	PF02991	0.515
LIG_LYPXL_yS_3	395	398	PF13949	0.273
LIG_Pex14_1	387	391	PF04695	0.267
LIG_Pex14_2	400	404	PF04695	0.362
LIG_SH2_STAP1	85	89	PF00017	0.471
LIG_SH2_STAT5	145	148	PF00017	0.551
LIG_SH2_STAT5	210	213	PF00017	0.531
LIG_SH2_STAT5	26	29	PF00017	0.418
LIG_SH2_STAT5	288	291	PF00017	0.652
LIG_SH2_STAT5	378	381	PF00017	0.611
LIG_SH2_STAT5	391	394	PF00017	0.301
LIG_SH2_STAT5	427	430	PF00017	0.354
LIG_SUMO_SIM_par_1	132	139	PF11976	0.432
LIG_TRAF2_1	451	454	PF00917	0.294
LIG_TYR_ITIM	298	303	PF00017	0.322
MOD_CDK_SPxxK_3	329	336	PF00069	0.704
MOD_CDK_SPxxK_3	461	468	PF00069	0.324
MOD_CK1_1	111	117	PF00069	0.356
MOD_CK1_1	138	144	PF00069	0.383
MOD_CK1_1	228	234	PF00069	0.318
MOD_CK1_1	239	245	PF00069	0.356
MOD_CK1_1	407	413	PF00069	0.460
MOD_CK2_1	400	406	PF00069	0.409
MOD_CK2_1	447	453	PF00069	0.481
MOD_GlcNHglycan	184	187	PF01048	0.395
MOD_GlcNHglycan	346	349	PF01048	0.658
MOD_GlcNHglycan	406	409	PF01048	0.391
MOD_GlcNHglycan	429	432	PF01048	0.452
MOD_GlcNHglycan	436	439	PF01048	0.463
MOD_GlcNHglycan	442	445	PF01048	0.373
MOD_GlcNHglycan	64	67	PF01048	0.458
MOD_GlcNHglycan	80	83	PF01048	0.350
MOD_GSK3_1	180	187	PF00069	0.360
MOD_GSK3_1	220	227	PF00069	0.291
MOD_GSK3_1	235	242	PF00069	0.334
MOD_GSK3_1	325	332	PF00069	0.618
MOD_GSK3_1	340	347	PF00069	0.693
MOD_GSK3_1	400	407	PF00069	0.429
MOD_N-GLC_1	349	354	PF02516	0.657
MOD_NEK2_1	108	113	PF00069	0.358
MOD_NEK2_1	309	314	PF00069	0.516
MOD_NEK2_1	400	405	PF00069	0.502
MOD_NEK2_1	44	49	PF00069	0.347
MOD_NEK2_2	124	129	PF00069	0.267
MOD_NEK2_2	408	413	PF00069	0.448
MOD_PIKK_1	210	216	PF00454	0.344
MOD_PIKK_1	274	280	PF00454	0.426
MOD_PK_1	448	454	PF00069	0.282
MOD_PKA_2	102	108	PF00069	0.354
MOD_PKA_2	225	231	PF00069	0.410
MOD_PKA_2	263	269	PF00069	0.553
MOD_PKA_2	447	453	PF00069	0.395
MOD_Plk_1	138	144	PF00069	0.336
MOD_Plk_1	224	230	PF00069	0.387
MOD_Plk_1	290	296	PF00069	0.436
MOD_Plk_4	11	17	PF00069	0.347
MOD_Plk_4	239	245	PF00069	0.453
MOD_Plk_4	374	380	PF00069	0.493
MOD_Plk_4	394	400	PF00069	0.298
MOD_ProDKin_1	282	288	PF00069	0.501
MOD_ProDKin_1	329	335	PF00069	0.705
MOD_ProDKin_1	351	357	PF00069	0.668
MOD_ProDKin_1	461	467	PF00069	0.484
MOD_SUMO_rev_2	177	183	PF00179	0.411
MOD_SUMO_rev_2	276	283	PF00179	0.711
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.320
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.281
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.450
TRG_ENDOCYTIC_2	22	25	PF00928	0.383
TRG_ENDOCYTIC_2	252	255	PF00928	0.528
TRG_ENDOCYTIC_2	300	303	PF00928	0.314
TRG_ENDOCYTIC_2	380	383	PF00928	0.398
TRG_ENDOCYTIC_2	395	398	PF00928	0.309
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M5	Leptomonas seymouri	62%	98%
A0A0S4IZG2	Bodo saltans	23%	100%
A0A0S4J1I6	Bodo saltans	24%	100%
A0A0S4J9U3	Bodo saltans	29%	100%
A0A1X0P5W3	Trypanosomatidae	45%	100%
A0A3Q8IM89	Leishmania donovani	27%	100%
A0A3R7K8J6	Trypanosoma rangeli	26%	100%
A0A3R7N7S2	Trypanosoma rangeli	43%	100%
A0A3S5H7D5	Leishmania donovani	23%	100%
A0A3S7X986	Leishmania donovani	95%	100%
A4HDP2	Leishmania braziliensis	24%	100%
A4HMN7	Leishmania braziliensis	25%	100%
A4HMN9	Leishmania braziliensis	83%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	97%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AF39	Leishmania major	27%	100%
E9AH88	Leishmania infantum	22%	97%
E9AHV6	Leishmania infantum	27%	100%
E9AHV8	Leishmania infantum	94%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAF0	Leishmania major	23%	100%
V5BJC7	Trypanosoma cruzi	27%	100%
V5BNY6	Trypanosoma cruzi	44%	100%