Short-chain dehydrogenase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania major

UniProt:

E9AF39_LEIMA

TriTrypDb:

LmjF.35.2150 , LMJLV39_350028300 , LMJSD75_350027600

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AF39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.657
CLV_MEL_PAP_1	246	252	PF00089	0.626
CLV_NRD_NRD_1	132	134	PF00675	0.462
CLV_NRD_NRD_1	170	172	PF00675	0.488
CLV_NRD_NRD_1	188	190	PF00675	0.468
CLV_NRD_NRD_1	316	318	PF00675	0.556
CLV_PCSK_FUR_1	130	134	PF00082	0.530
CLV_PCSK_KEX2_1	130	132	PF00082	0.471
CLV_PCSK_KEX2_1	316	318	PF00082	0.556
CLV_PCSK_KEX2_1	79	81	PF00082	0.613
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.613
CLV_PCSK_SKI1_1	189	193	PF00082	0.471
CLV_PCSK_SKI1_1	27	31	PF00082	0.409
CLV_PCSK_SKI1_1	319	323	PF00082	0.616
CLV_PCSK_SKI1_1	53	57	PF00082	0.608
DEG_APCC_DBOX_1	380	388	PF00400	0.614
DEG_Nend_UBRbox_1	1	4	PF02207	0.664
DOC_CYCLIN_RxL_1	187	195	PF00134	0.276
DOC_MAPK_gen_1	193	203	PF00069	0.182
DOC_MAPK_MEF2A_6	196	203	PF00069	0.289
DOC_PP1_RVXF_1	188	195	PF00149	0.276
DOC_PP2B_LxvP_1	218	221	PF13499	0.248
DOC_PP2B_LxvP_1	244	247	PF13499	0.380
DOC_PP4_FxxP_1	209	212	PF00568	0.256
DOC_PP4_FxxP_1	23	26	PF00568	0.420
DOC_SPAK_OSR1_1	249	253	PF12202	0.410
DOC_USP7_MATH_1	281	285	PF00917	0.436
DOC_USP7_UBL2_3	2	6	PF12436	0.685
DOC_WW_Pin1_4	139	144	PF00397	0.319
DOC_WW_Pin1_4	385	390	PF00397	0.618
DOC_WW_Pin1_4	399	404	PF00397	0.472
LIG_14-3-3_CanoR_1	239	245	PF00244	0.404
LIG_14-3-3_CanoR_1	249	253	PF00244	0.450
LIG_BRCT_BRCA1_1	358	362	PF00533	0.401
LIG_BRCT_BRCA1_1	401	405	PF00533	0.520
LIG_BRCT_BRCA1_1	9	13	PF00533	0.551
LIG_BRCT_BRCA1_2	358	364	PF00533	0.401
LIG_EH1_1	299	307	PF00400	0.318
LIG_eIF4E_1	300	306	PF01652	0.291
LIG_FHA_1	214	220	PF00498	0.237
LIG_FHA_1	323	329	PF00498	0.325
LIG_FHA_1	411	417	PF00498	0.632
LIG_FHA_2	363	369	PF00498	0.533
LIG_FHA_2	380	386	PF00498	0.549
LIG_FHA_2	394	400	PF00498	0.602
LIG_FHA_2	54	60	PF00498	0.430
LIG_LIR_Gen_1	103	109	PF02991	0.339
LIG_LIR_Gen_1	157	166	PF02991	0.237
LIG_LIR_Gen_1	356	363	PF02991	0.432
LIG_LIR_Nem_3	103	108	PF02991	0.257
LIG_LIR_Nem_3	157	162	PF02991	0.237
LIG_LIR_Nem_3	251	256	PF02991	0.474
LIG_LIR_Nem_3	349	353	PF02991	0.390
LIG_LIR_Nem_3	356	360	PF02991	0.397
LIG_MLH1_MIPbox_1	401	405	PF16413	0.520
LIG_MLH1_MIPbox_1	9	13	PF16413	0.493
LIG_MYND_3	220	224	PF01753	0.319
LIG_NRBOX	214	220	PF00104	0.248
LIG_Pex14_2	19	23	PF04695	0.420
LIG_RPA_C_Fungi	37	49	PF08784	0.500
LIG_SH2_CRK	318	322	PF00017	0.478
LIG_SH2_SRC	139	142	PF00017	0.395
LIG_SH2_STAP1	105	109	PF00017	0.429
LIG_SH2_STAP1	329	333	PF00017	0.475
LIG_SH2_STAT5	232	235	PF00017	0.326
LIG_SH2_STAT5	404	407	PF00017	0.392
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.551
LIG_SUMO_SIM_par_1	211	217	PF11976	0.305
LIG_SUMO_SIM_par_1	80	86	PF11976	0.351
LIG_TRAF2_1	365	368	PF00917	0.426
LIG_UBA3_1	270	275	PF00899	0.418
LIG_UBA3_1	360	364	PF00899	0.328
LIG_WRC_WIRS_1	347	352	PF05994	0.368
MOD_CK1_1	142	148	PF00069	0.445
MOD_CK1_1	356	362	PF00069	0.365
MOD_CK1_1	7	13	PF00069	0.425
MOD_CK2_1	362	368	PF00069	0.419
MOD_CK2_1	379	385	PF00069	0.422
MOD_GlcNHglycan	112	115	PF01048	0.435
MOD_GlcNHglycan	284	287	PF01048	0.495
MOD_GlcNHglycan	389	392	PF01048	0.653
MOD_GlcNHglycan	8	12	PF01048	0.373
MOD_GlcNHglycan	89	92	PF01048	0.291
MOD_GSK3_1	110	117	PF00069	0.388
MOD_GSK3_1	248	255	PF00069	0.614
MOD_GSK3_1	53	60	PF00069	0.541
MOD_GSK3_1	83	90	PF00069	0.314
MOD_LATS_1	51	57	PF00433	0.554
MOD_N-GLC_1	340	345	PF02516	0.478
MOD_NEK2_1	192	197	PF00069	0.338
MOD_NEK2_1	240	245	PF00069	0.556
MOD_NEK2_1	288	293	PF00069	0.498
MOD_NEK2_1	305	310	PF00069	0.310
MOD_NEK2_2	329	334	PF00069	0.377
MOD_NEK2_2	370	375	PF00069	0.393
MOD_PIKK_1	114	120	PF00454	0.443
MOD_PIKK_1	290	296	PF00454	0.525
MOD_PKA_2	192	198	PF00069	0.209
MOD_PKA_2	248	254	PF00069	0.629
MOD_Plk_1	7	13	PF00069	0.455
MOD_Plk_4	142	148	PF00069	0.354
MOD_Plk_4	240	246	PF00069	0.523
MOD_Plk_4	346	352	PF00069	0.346
MOD_Plk_4	356	362	PF00069	0.328
MOD_Plk_4	411	417	PF00069	0.537
MOD_ProDKin_1	139	145	PF00069	0.401
MOD_ProDKin_1	385	391	PF00069	0.553
MOD_ProDKin_1	399	405	PF00069	0.332
MOD_SUMO_for_1	321	324	PF00179	0.562
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.324
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.501
TRG_ENDOCYTIC_2	105	108	PF00928	0.344
TRG_ENDOCYTIC_2	318	321	PF00928	0.516
TRG_ER_diArg_1	130	133	PF00400	0.371
TRG_ER_diArg_1	316	318	PF00400	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A078IS66	Brassica napus	25%	100%
A0A078ISJ6	Brassica napus	25%	100%
A0A0N0P2P0	Leptomonas seymouri	28%	100%
A0A0N0P2S5	Leptomonas seymouri	66%	98%
A0A0N0P2S7	Leptomonas seymouri	27%	86%
A0A0N1HZ81	Leptomonas seymouri	30%	79%
A0A0N1I1M5	Leptomonas seymouri	24%	89%
A0A0S4J1I6	Bodo saltans	24%	100%
A0A0S4JBQ4	Bodo saltans	27%	100%
A0A0S4JFU3	Bodo saltans	43%	100%
A0A1B7YCL6	Colletotrichum higginsianum (strain IMI 349063)	27%	100%
A0A1X0NVT8	Trypanosomatidae	28%	88%
A0A1X0P5Q9	Trypanosomatidae	48%	96%
A0A1X0P5W3	Trypanosomatidae	28%	99%
A0A2H3CZZ2	Armillaria gallica	23%	100%
A0A3Q8ID46	Leishmania donovani	29%	87%
A0A3Q8IM89	Leishmania donovani	96%	100%
A0A3R7K071	Trypanosoma rangeli	29%	91%
A0A3R7K8J6	Trypanosoma rangeli	52%	100%
A0A3R7N7S2	Trypanosoma rangeli	30%	100%
A0A3S7WQY1	Leishmania donovani	25%	100%
A0A3S7X986	Leishmania donovani	27%	91%
A0A422N2B6	Trypanosoma rangeli	28%	92%
A4H5Z1	Leishmania braziliensis	27%	100%
A4HDP3	Leishmania braziliensis	28%	100%
A4HMN7	Leishmania braziliensis	84%	100%
A4HMN9	Leishmania braziliensis	25%	91%
A4HUB6	Leishmania infantum	25%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	88%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	95%
E9AF41	Leishmania major	27%	91%
E9AH89	Leishmania infantum	29%	87%
E9AHV6	Leishmania infantum	96%	100%
E9AHV8	Leishmania infantum	26%	91%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	87%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	91%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P59837	Bos taurus	31%	100%
Q08651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q17QU7	Bos taurus	29%	100%
Q17QW3	Bos taurus	28%	100%
Q4QAE9	Leishmania major	29%	87%
Q4QHL1	Leishmania major	25%	100%
Q5F389	Gallus gallus	26%	100%
Q5R9W5	Pongo abelii	29%	100%
Q6RVV4	Pisum sativum	27%	100%
Q803A8	Danio rerio	30%	100%
Q8BYK4	Mus musculus	29%	100%
Q8N5I4	Homo sapiens	28%	100%
Q8TC12	Homo sapiens	31%	100%
Q91WL8	Mus musculus	29%	100%
Q96NR8	Homo sapiens	30%	100%
Q9ERI6	Mus musculus	28%	100%
Q9HBH5	Homo sapiens	27%	100%
Q9NZC7	Homo sapiens	29%	100%
Q9QYF1	Mus musculus	30%	100%
Q9VLU5	Drosophila melanogaster	28%	100%
V5BAF4	Trypanosoma cruzi	31%	92%
V5BJC7	Trypanosoma cruzi	54%	100%
V5BNY6	Trypanosoma cruzi	32%	100%