Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF38_LEIMA

TriTrypDb:

LmjF.35.2140 , LMJLV39_350028200 , LMJSD75_350027500

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF38

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.596
CLV_MEL_PAP_1	217	223	PF00089	0.489
CLV_MEL_PAP_1	37	43	PF00089	0.574
CLV_NRD_NRD_1	39	41	PF00675	0.437
CLV_NRD_NRD_1	523	525	PF00675	0.626
CLV_NRD_NRD_1	537	539	PF00675	0.661
CLV_NRD_NRD_1	61	63	PF00675	0.585
CLV_NRD_NRD_1	68	70	PF00675	0.679
CLV_NRD_NRD_1	71	73	PF00675	0.546
CLV_PCSK_FUR_1	69	73	PF00082	0.667
CLV_PCSK_KEX2_1	39	41	PF00082	0.431
CLV_PCSK_KEX2_1	523	525	PF00082	0.586
CLV_PCSK_KEX2_1	537	539	PF00082	0.581
CLV_PCSK_KEX2_1	61	63	PF00082	0.588
CLV_PCSK_KEX2_1	70	72	PF00082	0.587
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.639
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.740
CLV_PCSK_PC7_1	57	63	PF00082	0.530
CLV_PCSK_SKI1_1	165	169	PF00082	0.498
CLV_PCSK_SKI1_1	177	181	PF00082	0.323
CLV_PCSK_SKI1_1	273	277	PF00082	0.513
CLV_PCSK_SKI1_1	356	360	PF00082	0.391
CLV_Separin_Metazoa	476	480	PF03568	0.644
DEG_APCC_DBOX_1	164	172	PF00400	0.550
DEG_SPOP_SBC_1	389	393	PF00917	0.664
DOC_CKS1_1	197	202	PF01111	0.536
DOC_CYCLIN_RxL_1	174	184	PF00134	0.501
DOC_MAPK_DCC_7	347	357	PF00069	0.410
DOC_MAPK_gen_1	220	230	PF00069	0.509
DOC_MAPK_gen_1	523	532	PF00069	0.640
DOC_MAPK_MEF2A_6	223	230	PF00069	0.383
DOC_PP2B_LxvP_1	335	338	PF13499	0.468
DOC_USP7_MATH_1	18	22	PF00917	0.540
DOC_USP7_MATH_1	299	303	PF00917	0.420
DOC_USP7_MATH_1	388	392	PF00917	0.671
DOC_USP7_MATH_1	399	403	PF00917	0.743
DOC_USP7_MATH_1	439	443	PF00917	0.786
DOC_USP7_MATH_1	450	454	PF00917	0.695
DOC_WW_Pin1_4	196	201	PF00397	0.538
DOC_WW_Pin1_4	292	297	PF00397	0.440
DOC_WW_Pin1_4	384	389	PF00397	0.497
DOC_WW_Pin1_4	414	419	PF00397	0.793
LIG_14-3-3_CanoR_1	191	196	PF00244	0.581
LIG_14-3-3_CanoR_1	211	221	PF00244	0.433
LIG_14-3-3_CanoR_1	301	305	PF00244	0.378
LIG_14-3-3_CanoR_1	524	532	PF00244	0.693
LIG_14-3-3_CanoR_1	89	94	PF00244	0.552
LIG_14-3-3_CanoR_1	97	102	PF00244	0.449
LIG_APCC_ABBA_1	171	176	PF00400	0.387
LIG_APCC_ABBA_1	8	13	PF00400	0.486
LIG_BIR_II_1	1	5	PF00653	0.505
LIG_BIR_III_2	413	417	PF00653	0.684
LIG_BRCT_BRCA1_1	37	41	PF00533	0.568
LIG_BRCT_BRCA1_1	452	456	PF00533	0.698
LIG_BRCT_BRCA1_2	452	458	PF00533	0.695
LIG_CaM_IQ_9	81	96	PF13499	0.458
LIG_DLG_GKlike_1	191	198	PF00625	0.585
LIG_eIF4E_1	174	180	PF01652	0.402
LIG_eIF4E_1	28	34	PF01652	0.565
LIG_eIF4E_1	485	491	PF01652	0.501
LIG_FHA_1	113	119	PF00498	0.323
LIG_FHA_1	202	208	PF00498	0.422
LIG_FHA_1	301	307	PF00498	0.406
LIG_FHA_1	330	336	PF00498	0.510
LIG_FHA_1	473	479	PF00498	0.461
LIG_FHA_1	96	102	PF00498	0.482
LIG_FHA_2	242	248	PF00498	0.564
LIG_FHA_2	368	374	PF00498	0.464
LIG_FHA_2	504	510	PF00498	0.531
LIG_FHA_2	531	537	PF00498	0.656
LIG_LIR_Apic_2	194	200	PF02991	0.555
LIG_LIR_Gen_1	129	138	PF02991	0.561
LIG_LIR_Gen_1	278	287	PF02991	0.413
LIG_LIR_Gen_1	516	527	PF02991	0.592
LIG_LIR_LC3C_4	224	228	PF02991	0.524
LIG_LIR_Nem_3	516	522	PF02991	0.716
LIG_NRBOX	317	323	PF00104	0.358
LIG_PTB_Apo_2	124	131	PF02174	0.429
LIG_PTB_Phospho_1	124	130	PF10480	0.435
LIG_SH2_CRK	106	110	PF00017	0.592
LIG_SH2_SRC	507	510	PF00017	0.559
LIG_SH2_STAP1	174	178	PF00017	0.491
LIG_SH2_STAT3	234	237	PF00017	0.427
LIG_SH2_STAT5	197	200	PF00017	0.508
LIG_SH2_STAT5	240	243	PF00017	0.382
LIG_SH2_STAT5	280	283	PF00017	0.422
LIG_SH2_STAT5	36	39	PF00017	0.416
LIG_SH2_STAT5	494	497	PF00017	0.423
LIG_SH2_STAT5	90	93	PF00017	0.480
LIG_SH3_2	296	301	PF14604	0.573
LIG_SH3_3	293	299	PF00018	0.551
LIG_SH3_3	362	368	PF00018	0.452
LIG_SH3_3	412	418	PF00018	0.801
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.460
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.420
LIG_SUMO_SIM_anti_2	426	432	PF11976	0.649
LIG_SUMO_SIM_par_1	226	233	PF11976	0.394
LIG_SUMO_SIM_par_1	382	387	PF11976	0.532
LIG_TRAF2_1	464	467	PF00917	0.750
LIG_TRAF2_1	469	472	PF00917	0.687
LIG_TRAF2_1	533	536	PF00917	0.680
LIG_UBA3_1	138	147	PF00899	0.594
LIG_WRC_WIRS_1	138	143	PF05994	0.547
MOD_CDK_SPK_2	414	419	PF00069	0.716
MOD_CK1_1	137	143	PF00069	0.512
MOD_CK1_1	212	218	PF00069	0.401
MOD_CK1_1	392	398	PF00069	0.712
MOD_CK1_1	531	537	PF00069	0.622
MOD_CK2_1	137	143	PF00069	0.487
MOD_CK2_1	147	153	PF00069	0.523
MOD_CK2_1	18	24	PF00069	0.557
MOD_CK2_1	263	269	PF00069	0.503
MOD_CK2_1	367	373	PF00069	0.448
MOD_CK2_1	399	405	PF00069	0.756
MOD_CK2_1	466	472	PF00069	0.719
MOD_CK2_1	503	509	PF00069	0.514
MOD_CK2_1	523	529	PF00069	0.396
MOD_CK2_1	530	536	PF00069	0.662
MOD_GlcNHglycan	121	124	PF01048	0.439
MOD_GlcNHglycan	20	23	PF01048	0.540
MOD_GlcNHglycan	211	214	PF01048	0.426
MOD_GlcNHglycan	250	253	PF01048	0.572
MOD_GlcNHglycan	30	33	PF01048	0.513
MOD_GlcNHglycan	441	444	PF01048	0.715
MOD_GlcNHglycan	446	451	PF01048	0.680
MOD_GlcNHglycan	48	51	PF01048	0.382
MOD_GlcNHglycan	525	528	PF01048	0.637
MOD_GSK3_1	133	140	PF00069	0.552
MOD_GSK3_1	203	210	PF00069	0.422
MOD_GSK3_1	271	278	PF00069	0.518
MOD_GSK3_1	316	323	PF00069	0.520
MOD_GSK3_1	327	334	PF00069	0.520
MOD_GSK3_1	337	344	PF00069	0.460
MOD_GSK3_1	384	391	PF00069	0.555
MOD_GSK3_1	399	406	PF00069	0.771
MOD_GSK3_1	446	453	PF00069	0.697
MOD_GSK3_1	499	506	PF00069	0.538
MOD_GSK3_1	61	68	PF00069	0.649
MOD_LATS_1	497	503	PF00433	0.534
MOD_N-GLC_1	126	131	PF02516	0.575
MOD_N-GLC_1	28	33	PF02516	0.570
MOD_N-GLC_1	389	394	PF02516	0.718
MOD_N-GLC_1	421	426	PF02516	0.653
MOD_NEK2_1	133	138	PF00069	0.495
MOD_NEK2_1	27	32	PF00069	0.573
MOD_NEK2_1	275	280	PF00069	0.474
MOD_NEK2_1	282	287	PF00069	0.448
MOD_NEK2_1	316	321	PF00069	0.467
MOD_NEK2_1	327	332	PF00069	0.512
MOD_PIKK_1	275	281	PF00454	0.527
MOD_PIKK_1	320	326	PF00454	0.529
MOD_PK_1	4	10	PF00069	0.536
MOD_PK_1	499	505	PF00069	0.560
MOD_PKA_1	147	153	PF00069	0.624
MOD_PKA_1	523	529	PF00069	0.693
MOD_PKA_1	61	67	PF00069	0.598
MOD_PKA_2	190	196	PF00069	0.578
MOD_PKA_2	300	306	PF00069	0.384
MOD_PKA_2	523	529	PF00069	0.655
MOD_PKA_2	61	67	PF00069	0.648
MOD_Plk_1	126	132	PF00069	0.547
MOD_Plk_1	134	140	PF00069	0.467
MOD_Plk_1	230	236	PF00069	0.413
MOD_Plk_1	528	534	PF00069	0.533
MOD_Plk_2-3	250	256	PF00069	0.566
MOD_Plk_2-3	466	472	PF00069	0.707
MOD_Plk_4	113	119	PF00069	0.409
MOD_Plk_4	134	140	PF00069	0.508
MOD_Plk_4	191	197	PF00069	0.580
MOD_Plk_4	203	209	PF00069	0.434
MOD_Plk_4	271	277	PF00069	0.409
MOD_Plk_4	300	306	PF00069	0.391
MOD_Plk_4	316	322	PF00069	0.355
MOD_Plk_4	426	432	PF00069	0.649
MOD_Plk_4	499	505	PF00069	0.621
MOD_ProDKin_1	196	202	PF00069	0.535
MOD_ProDKin_1	292	298	PF00069	0.441
MOD_ProDKin_1	384	390	PF00069	0.516
MOD_ProDKin_1	414	420	PF00069	0.790
MOD_SUMO_rev_2	140	149	PF00179	0.496
TRG_DiLeu_BaEn_1	176	181	PF01217	0.499
TRG_DiLeu_BaEn_2	372	378	PF01217	0.453
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.399
TRG_ENDOCYTIC_2	11	14	PF00928	0.415
TRG_ENDOCYTIC_2	130	133	PF00928	0.559
TRG_ENDOCYTIC_2	280	283	PF00928	0.386
TRG_ENDOCYTIC_2	519	522	PF00928	0.587
TRG_ENDOCYTIC_2	90	93	PF00928	0.460
TRG_ER_diArg_1	39	41	PF00400	0.445
TRG_ER_diArg_1	537	540	PF00400	0.698
TRG_ER_diArg_1	69	72	PF00400	0.603
TRG_NLS_MonoCore_2	68	73	PF00514	0.678
TRG_NLS_MonoExtN_4	69	74	PF00514	0.686
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9E6	Leptomonas seymouri	63%	100%
A0A1X0P5Q0	Trypanosomatidae	44%	100%
A0A3R7RFL4	Trypanosoma rangeli	46%	100%
A0A3S7X984	Leishmania donovani	95%	100%
A4HMN6	Leishmania braziliensis	85%	100%
C9ZZF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AHV5	Leishmania infantum	95%	100%
E9B693	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BTI6	Trypanosoma cruzi	45%	100%