Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AF37_LEIMA

TriTrypDb:

LmjF.35.2130 , LMJLV39_350028100 , LMJSD75_350027400

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.602
CLV_C14_Caspase3-7	301	305	PF00656	0.558
CLV_MEL_PAP_1	36	42	PF00089	0.632
CLV_NRD_NRD_1	219	221	PF00675	0.696
CLV_NRD_NRD_1	36	38	PF00675	0.546
CLV_PCSK_KEX2_1	219	221	PF00082	0.696
CLV_PCSK_KEX2_1	235	237	PF00082	0.573
CLV_PCSK_KEX2_1	38	40	PF00082	0.560
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.573
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.543
CLV_PCSK_SKI1_1	276	280	PF00082	0.661
DOC_CKS1_1	249	254	PF01111	0.649
DOC_CKS1_1	3	8	PF01111	0.603
DOC_MAPK_gen_1	377	385	PF00069	0.515
DOC_MAPK_MEF2A_6	79	86	PF00069	0.537
DOC_PP1_RVXF_1	26	32	PF00149	0.550
DOC_PP2B_PxIxI_1	434	440	PF00149	0.492
DOC_PP4_FxxP_1	136	139	PF00568	0.654
DOC_USP7_MATH_1	107	111	PF00917	0.651
DOC_USP7_MATH_1	139	143	PF00917	0.676
DOC_USP7_MATH_1	191	195	PF00917	0.581
DOC_USP7_MATH_1	200	204	PF00917	0.629
DOC_USP7_MATH_1	348	352	PF00917	0.679
DOC_USP7_MATH_1	475	479	PF00917	0.595
DOC_USP7_MATH_1	492	496	PF00917	0.585
DOC_WW_Pin1_4	142	147	PF00397	0.591
DOC_WW_Pin1_4	17	22	PF00397	0.524
DOC_WW_Pin1_4	2	7	PF00397	0.710
DOC_WW_Pin1_4	248	253	PF00397	0.604
DOC_WW_Pin1_4	302	307	PF00397	0.675
DOC_WW_Pin1_4	342	347	PF00397	0.716
LIG_14-3-3_CanoR_1	126	134	PF00244	0.550
LIG_14-3-3_CanoR_1	236	245	PF00244	0.488
LIG_14-3-3_CanoR_1	276	281	PF00244	0.644
LIG_14-3-3_CanoR_1	37	45	PF00244	0.562
LIG_14-3-3_CanoR_1	379	384	PF00244	0.532
LIG_14-3-3_CanoR_1	97	103	PF00244	0.629
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	326	330	PF00533	0.625
LIG_deltaCOP1_diTrp_1	335	341	PF00928	0.526
LIG_FHA_1	147	153	PF00498	0.574
LIG_FHA_1	31	37	PF00498	0.583
LIG_FHA_1	380	386	PF00498	0.571
LIG_FHA_1	6	12	PF00498	0.606
LIG_FHA_1	98	104	PF00498	0.631
LIG_FHA_2	112	118	PF00498	0.607
LIG_FHA_2	169	175	PF00498	0.749
LIG_LIR_Gen_1	228	237	PF02991	0.548
LIG_LIR_Gen_1	335	343	PF02991	0.528
LIG_LIR_Nem_3	228	233	PF02991	0.605
LIG_LIR_Nem_3	335	340	PF02991	0.522
LIG_LIR_Nem_3	351	357	PF02991	0.549
LIG_LIR_Nem_3	448	454	PF02991	0.600
LIG_LYPXL_yS_3	354	357	PF13949	0.520
LIG_MYND_1	9	13	PF01753	0.706
LIG_NRBOX	418	424	PF00104	0.536
LIG_NRBOX	51	57	PF00104	0.531
LIG_PCNA_yPIPBox_3	170	184	PF02747	0.551
LIG_Pex14_2	337	341	PF04695	0.521
LIG_Pex14_2	459	463	PF04695	0.537
LIG_SH2_CRK	230	234	PF00017	0.595
LIG_SH2_NCK_1	230	234	PF00017	0.604
LIG_SH2_STAP1	230	234	PF00017	0.530
LIG_SH2_STAT3	387	390	PF00017	0.500
LIG_SH2_STAT5	254	257	PF00017	0.544
LIG_SH3_3	15	21	PF00018	0.675
LIG_SH3_3	3	9	PF00018	0.653
LIG_SH3_3	340	346	PF00018	0.530
LIG_SH3_3	481	487	PF00018	0.572
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.481
LIG_SUMO_SIM_anti_2	47	54	PF11976	0.532
LIG_SUMO_SIM_par_1	47	54	PF11976	0.592
LIG_SUMO_SIM_par_1	80	85	PF11976	0.561
LIG_TRAF2_1	241	244	PF00917	0.662
LIG_TRAF2_1	32	35	PF00917	0.558
MOD_CDK_SPxxK_3	5	12	PF00069	0.571
MOD_CK1_1	108	114	PF00069	0.552
MOD_CK1_1	116	122	PF00069	0.615
MOD_CK1_1	124	130	PF00069	0.618
MOD_CK1_1	142	148	PF00069	0.524
MOD_CK1_1	17	23	PF00069	0.565
MOD_CK1_1	326	332	PF00069	0.605
MOD_CK1_1	394	400	PF00069	0.597
MOD_CK1_1	4	10	PF00069	0.679
MOD_CK1_1	41	47	PF00069	0.551
MOD_CK1_1	92	98	PF00069	0.725
MOD_CK2_1	111	117	PF00069	0.606
MOD_CK2_1	162	168	PF00069	0.646
MOD_CK2_1	295	301	PF00069	0.698
MOD_CK2_1	318	324	PF00069	0.681
MOD_CMANNOS	336	339	PF00535	0.521
MOD_CMANNOS	460	463	PF00535	0.539
MOD_GlcNHglycan	107	110	PF01048	0.593
MOD_GlcNHglycan	164	167	PF01048	0.563
MOD_GlcNHglycan	202	205	PF01048	0.726
MOD_GlcNHglycan	207	211	PF01048	0.585
MOD_GlcNHglycan	296	300	PF01048	0.621
MOD_GlcNHglycan	320	323	PF01048	0.798
MOD_GlcNHglycan	326	329	PF01048	0.638
MOD_GlcNHglycan	398	403	PF01048	0.584
MOD_GlcNHglycan	404	407	PF01048	0.572
MOD_GlcNHglycan	89	92	PF01048	0.623
MOD_GSK3_1	1	8	PF00069	0.578
MOD_GSK3_1	105	112	PF00069	0.580
MOD_GSK3_1	113	120	PF00069	0.620
MOD_GSK3_1	121	128	PF00069	0.641
MOD_GSK3_1	142	149	PF00069	0.627
MOD_GSK3_1	259	266	PF00069	0.671
MOD_GSK3_1	318	325	PF00069	0.660
MOD_GSK3_1	394	401	PF00069	0.595
MOD_GSK3_1	50	57	PF00069	0.598
MOD_GSK3_1	92	99	PF00069	0.657
MOD_N-GLC_1	97	102	PF02516	0.678
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	323	328	PF00069	0.573
MOD_NEK2_1	73	78	PF00069	0.555
MOD_NEK2_2	211	216	PF00069	0.501
MOD_NEK2_2	454	459	PF00069	0.572
MOD_PIKK_1	386	392	PF00454	0.520
MOD_PKA_1	38	44	PF00069	0.628
MOD_PKA_2	11	17	PF00069	0.672
MOD_PKA_2	125	131	PF00069	0.549
MOD_PKA_2	162	168	PF00069	0.559
MOD_PKA_2	318	324	PF00069	0.671
MOD_PKA_2	38	44	PF00069	0.628
MOD_PKA_2	96	102	PF00069	0.633
MOD_PKB_1	293	301	PF00069	0.540
MOD_PKB_1	377	385	PF00069	0.515
MOD_Plk_1	258	264	PF00069	0.577
MOD_Plk_1	41	47	PF00069	0.580
MOD_Plk_1	445	451	PF00069	0.551
MOD_Plk_2-3	168	174	PF00069	0.593
MOD_Plk_4	151	157	PF00069	0.586
MOD_Plk_4	264	270	PF00069	0.678
MOD_Plk_4	326	332	PF00069	0.702
MOD_Plk_4	418	424	PF00069	0.536
MOD_Plk_4	454	460	PF00069	0.532
MOD_Plk_4	51	57	PF00069	0.565
MOD_ProDKin_1	142	148	PF00069	0.589
MOD_ProDKin_1	17	23	PF00069	0.521
MOD_ProDKin_1	2	8	PF00069	0.710
MOD_ProDKin_1	248	254	PF00069	0.605
MOD_ProDKin_1	302	308	PF00069	0.677
MOD_ProDKin_1	342	348	PF00069	0.720
MOD_SUMO_rev_2	20	29	PF00179	0.592
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.569
TRG_ENDOCYTIC_2	230	233	PF00928	0.546
TRG_ENDOCYTIC_2	234	237	PF00928	0.521
TRG_ENDOCYTIC_2	354	357	PF00928	0.520
TRG_ER_diArg_1	218	220	PF00400	0.696
TRG_ER_diArg_1	36	39	PF00400	0.553
TRG_ER_diArg_1	376	379	PF00400	0.504
TRG_NLS_MonoExtC_3	36	42	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ3	Leptomonas seymouri	47%	99%
A0A3Q8IHZ9	Leishmania donovani	87%	100%
A4HMN5	Leishmania braziliensis	69%	100%
E9AHV4	Leishmania infantum	87%	100%
E9B692	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%