Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AF36_LEIMA

TriTrypDb:

LmjF.35.2125 , LMJLV39_350028000 , LMJSD75_350027300

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.593
CLV_PCSK_KEX2_1	245	247	PF00082	0.512
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.512
CLV_PCSK_SKI1_1	245	249	PF00082	0.542
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.583
DOC_PP2B_LxvP_1	253	256	PF13499	0.726
DOC_USP7_MATH_1	100	104	PF00917	0.741
DOC_USP7_MATH_1	110	114	PF00917	0.630
DOC_USP7_MATH_1	136	140	PF00917	0.653
DOC_USP7_MATH_1	153	157	PF00917	0.561
DOC_USP7_MATH_1	170	174	PF00917	0.656
DOC_USP7_MATH_1	195	199	PF00917	0.774
DOC_USP7_MATH_1	23	27	PF00917	0.592
DOC_WW_Pin1_4	108	113	PF00397	0.700
DOC_WW_Pin1_4	134	139	PF00397	0.815
DOC_WW_Pin1_4	149	154	PF00397	0.572
DOC_WW_Pin1_4	186	191	PF00397	0.707
LIG_14-3-3_CanoR_1	181	191	PF00244	0.712
LIG_14-3-3_CanoR_1	50	56	PF00244	0.678
LIG_BIR_II_1	1	5	PF00653	0.829
LIG_BIR_III_2	20	24	PF00653	0.710
LIG_BRCT_BRCA1_1	103	107	PF00533	0.822
LIG_BRCT_BRCA1_1	52	56	PF00533	0.676
LIG_EVH1_2	159	163	PF00568	0.754
LIG_FHA_1	208	214	PF00498	0.787
LIG_FHA_2	174	180	PF00498	0.701
LIG_FHA_2	3	9	PF00498	0.749
LIG_LIR_Nem_3	125	130	PF02991	0.756
LIG_PTAP_UEV_1	137	142	PF05743	0.667
LIG_SH2_CRK	251	255	PF00017	0.731
LIG_SH2_SRC	79	82	PF00017	0.591
LIG_SH3_3	135	141	PF00018	0.791
LIG_SH3_3	156	162	PF00018	0.720
LIG_SH3_3	187	193	PF00018	0.683
LIG_TRAF2_1	176	179	PF00917	0.814
LIG_TRAF2_1	67	70	PF00917	0.776
MOD_CK1_1	103	109	PF00069	0.747
MOD_CK1_1	119	125	PF00069	0.594
MOD_CK1_1	173	179	PF00069	0.727
MOD_CK1_1	2	8	PF00069	0.748
MOD_CK1_1	26	32	PF00069	0.592
MOD_CK1_1	52	58	PF00069	0.833
MOD_CK2_1	173	179	PF00069	0.807
MOD_CK2_1	224	230	PF00069	0.759
MOD_GlcNHglycan	103	106	PF01048	0.667
MOD_GlcNHglycan	112	115	PF01048	0.672
MOD_GlcNHglycan	118	121	PF01048	0.563
MOD_GlcNHglycan	124	127	PF01048	0.571
MOD_GlcNHglycan	138	141	PF01048	0.551
MOD_GlcNHglycan	155	158	PF01048	0.612
MOD_GlcNHglycan	163	166	PF01048	0.703
MOD_GlcNHglycan	197	200	PF01048	0.637
MOD_GSK3_1	110	117	PF00069	0.731
MOD_GSK3_1	130	137	PF00069	0.659
MOD_GSK3_1	144	151	PF00069	0.609
MOD_GSK3_1	182	189	PF00069	0.743
MOD_GSK3_1	191	198	PF00069	0.647
MOD_GSK3_1	45	52	PF00069	0.773
MOD_NEK2_1	1	6	PF00069	0.757
MOD_NEK2_1	206	211	PF00069	0.695
MOD_NEK2_1	218	223	PF00069	0.527
MOD_PIKK_1	199	205	PF00454	0.708
MOD_PIKK_1	2	8	PF00454	0.631
MOD_PKA_2	49	55	PF00069	0.833
MOD_Plk_1	218	224	PF00069	0.742
MOD_Plk_4	144	150	PF00069	0.725
MOD_ProDKin_1	108	114	PF00069	0.701
MOD_ProDKin_1	134	140	PF00069	0.811
MOD_ProDKin_1	149	155	PF00069	0.572
MOD_ProDKin_1	186	192	PF00069	0.706
MOD_SUMO_for_1	91	94	PF00179	0.760
MOD_SUMO_rev_2	239	247	PF00179	0.559
MOD_SUMO_rev_2	84	93	PF00179	0.820
TRG_ENDOCYTIC_2	251	254	PF00928	0.611
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IPH3	Leishmania donovani	86%	100%
A4HMN4	Leishmania braziliensis	59%	94%
E9AHV3	Leishmania infantum	85%	100%
E9B691	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	96%