Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF34_LEIMA

TriTrypDb:

LmjF.35.2110 , LMJLV39_350027700 , LMJSD75_350027000

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.543
CLV_C14_Caspase3-7	181	185	PF00656	0.683
CLV_NRD_NRD_1	158	160	PF00675	0.667
CLV_NRD_NRD_1	178	180	PF00675	0.828
CLV_NRD_NRD_1	203	205	PF00675	0.699
CLV_PCSK_KEX2_1	177	179	PF00082	0.837
CLV_PCSK_KEX2_1	203	205	PF00082	0.699
CLV_PCSK_KEX2_1	212	214	PF00082	0.740
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.740
CLV_PCSK_SKI1_1	295	299	PF00082	0.498
DEG_SPOP_SBC_1	106	110	PF00917	0.692
DEG_SPOP_SBC_1	197	201	PF00917	0.635
DEG_SPOP_SBC_1	256	260	PF00917	0.416
DEG_SPOP_SBC_1	361	365	PF00917	0.455
DOC_CYCLIN_RxL_1	348	357	PF00134	0.495
DOC_MAPK_gen_1	280	287	PF00069	0.487
DOC_PP1_RVXF_1	109	116	PF00149	0.697
DOC_PP4_FxxP_1	249	252	PF00568	0.615
DOC_USP7_MATH_1	106	110	PF00917	0.617
DOC_USP7_MATH_1	148	152	PF00917	0.581
DOC_USP7_MATH_1	197	201	PF00917	0.694
DOC_USP7_MATH_1	207	211	PF00917	0.658
DOC_USP7_MATH_1	256	260	PF00917	0.468
DOC_USP7_MATH_1	33	37	PF00917	0.611
DOC_USP7_MATH_1	361	365	PF00917	0.492
DOC_USP7_MATH_1	386	390	PF00917	0.708
DOC_USP7_MATH_1	450	454	PF00917	0.684
DOC_USP7_MATH_1	98	102	PF00917	0.629
DOC_WW_Pin1_4	222	227	PF00397	0.714
DOC_WW_Pin1_4	231	236	PF00397	0.583
DOC_WW_Pin1_4	362	367	PF00397	0.650
DOC_WW_Pin1_4	374	379	PF00397	0.534
DOC_WW_Pin1_4	62	67	PF00397	0.552
LIG_14-3-3_CanoR_1	187	197	PF00244	0.684
LIG_14-3-3_CanoR_1	213	217	PF00244	0.767
LIG_14-3-3_CanoR_1	228	236	PF00244	0.547
LIG_14-3-3_CanoR_1	319	328	PF00244	0.467
LIG_14-3-3_CanoR_1	374	378	PF00244	0.529
LIG_14-3-3_CanoR_1	438	446	PF00244	0.652
LIG_14-3-3_CanoR_1	451	455	PF00244	0.532
LIG_Actin_WH2_2	338	356	PF00022	0.479
LIG_BRCT_BRCA1_1	35	39	PF00533	0.561
LIG_BRCT_BRCA1_1	87	91	PF00533	0.463
LIG_Clathr_ClatBox_1	410	414	PF01394	0.525
LIG_DLG_GKlike_1	159	166	PF00625	0.664
LIG_FHA_1	108	114	PF00498	0.698
LIG_FHA_1	246	252	PF00498	0.614
LIG_FHA_1	32	38	PF00498	0.608
LIG_FHA_1	70	76	PF00498	0.540
LIG_FHA_2	125	131	PF00498	0.689
LIG_FHA_2	215	221	PF00498	0.635
LIG_FHA_2	235	241	PF00498	0.497
LIG_FHA_2	321	327	PF00498	0.469
LIG_LIR_Apic_2	246	252	PF02991	0.614
LIG_LIR_Apic_2	389	395	PF02991	0.577
LIG_LIR_Gen_1	18	29	PF02991	0.568
LIG_LIR_Nem_3	18	24	PF02991	0.564
LIG_LIR_Nem_3	275	279	PF02991	0.498
LIG_LIR_Nem_3	42	47	PF02991	0.548
LIG_LIR_Nem_3	88	94	PF02991	0.470
LIG_LYPXL_yS_3	44	47	PF13949	0.566
LIG_NRBOX	3	9	PF00104	0.545
LIG_Pex14_2	249	253	PF04695	0.514
LIG_Rb_pABgroove_1	161	169	PF01858	0.671
LIG_SH2_NCK_1	392	396	PF00017	0.570
LIG_SH2_NCK_1	429	433	PF00017	0.648
LIG_SH2_SRC	392	395	PF00017	0.635
LIG_SH2_STAP1	429	433	PF00017	0.648
LIG_SH2_STAT5	334	337	PF00017	0.337
LIG_SH2_STAT5	68	71	PF00017	0.497
LIG_SH2_STAT5	89	92	PF00017	0.531
LIG_SH3_1	392	398	PF00018	0.554
LIG_SH3_3	10	16	PF00018	0.560
LIG_SH3_3	392	398	PF00018	0.580
LIG_SH3_3	43	49	PF00018	0.576
LIG_SH3_3	80	86	PF00018	0.485
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.532
LIG_SUMO_SIM_anti_2	53	60	PF11976	0.630
LIG_SUMO_SIM_par_1	232	240	PF11976	0.634
LIG_TRAF2_1	323	326	PF00917	0.497
LIG_TRAF2_1	327	330	PF00917	0.418
LIG_UBA3_1	74	82	PF00899	0.508
MOD_CDC14_SPxK_1	225	228	PF00782	0.657
MOD_CDK_SPxK_1	222	228	PF00069	0.657
MOD_CK1_1	105	111	PF00069	0.693
MOD_CK1_1	125	131	PF00069	0.689
MOD_CK1_1	162	168	PF00069	0.669
MOD_CK1_1	180	186	PF00069	0.508
MOD_CK1_1	191	197	PF00069	0.587
MOD_CK1_1	230	236	PF00069	0.646
MOD_CK1_1	243	249	PF00069	0.551
MOD_CK1_1	257	263	PF00069	0.419
MOD_CK1_1	365	371	PF00069	0.583
MOD_CK1_1	377	383	PF00069	0.660
MOD_CK2_1	124	130	PF00069	0.692
MOD_CK2_1	214	220	PF00069	0.638
MOD_CK2_1	25	31	PF00069	0.637
MOD_CK2_1	320	326	PF00069	0.473
MOD_GlcNHglycan	100	103	PF01048	0.656
MOD_GlcNHglycan	104	107	PF01048	0.649
MOD_GlcNHglycan	146	149	PF01048	0.576
MOD_GlcNHglycan	204	207	PF01048	0.659
MOD_GlcNHglycan	367	370	PF01048	0.676
MOD_GlcNHglycan	379	382	PF01048	0.615
MOD_GlcNHglycan	39	42	PF01048	0.602
MOD_GlcNHglycan	441	444	PF01048	0.778
MOD_GlcNHglycan	446	449	PF01048	0.704
MOD_GSK3_1	102	109	PF00069	0.594
MOD_GSK3_1	144	151	PF00069	0.751
MOD_GSK3_1	188	195	PF00069	0.634
MOD_GSK3_1	198	205	PF00069	0.666
MOD_GSK3_1	227	234	PF00069	0.666
MOD_GSK3_1	241	248	PF00069	0.518
MOD_GSK3_1	252	259	PF00069	0.479
MOD_GSK3_1	33	40	PF00069	0.680
MOD_GSK3_1	361	368	PF00069	0.596
MOD_GSK3_1	373	380	PF00069	0.592
MOD_GSK3_1	446	453	PF00069	0.652
MOD_GSK3_1	93	100	PF00069	0.579
MOD_N-GLC_1	310	315	PF02516	0.546
MOD_NEK2_1	190	195	PF00069	0.815
MOD_NEK2_1	241	246	PF00069	0.553
MOD_NEK2_1	254	259	PF00069	0.422
MOD_NEK2_1	360	365	PF00069	0.597
MOD_NEK2_1	8	13	PF00069	0.547
MOD_NEK2_2	207	212	PF00069	0.554
MOD_PIKK_1	188	194	PF00454	0.706
MOD_PIKK_1	214	220	PF00454	0.678
MOD_PIKK_1	354	360	PF00454	0.446
MOD_PIKK_1	50	56	PF00454	0.571
MOD_PIKK_1	8	14	PF00454	0.441
MOD_PK_1	198	204	PF00069	0.563
MOD_PK_1	212	218	PF00069	0.669
MOD_PK_1	417	423	PF00069	0.517
MOD_PKA_1	159	165	PF00069	0.664
MOD_PKA_1	177	183	PF00069	0.534
MOD_PKA_1	212	218	PF00069	0.731
MOD_PKA_2	177	183	PF00069	0.734
MOD_PKA_2	188	194	PF00069	0.608
MOD_PKA_2	197	203	PF00069	0.498
MOD_PKA_2	212	218	PF00069	0.787
MOD_PKA_2	227	233	PF00069	0.537
MOD_PKA_2	373	379	PF00069	0.499
MOD_PKA_2	450	456	PF00069	0.574
MOD_PKA_2	98	104	PF00069	0.659
MOD_Plk_2-3	25	31	PF00069	0.587
MOD_Plk_4	162	168	PF00069	0.716
MOD_Plk_4	33	39	PF00069	0.567
MOD_Plk_4	386	392	PF00069	0.612
MOD_Plk_4	53	59	PF00069	0.401
MOD_ProDKin_1	222	228	PF00069	0.716
MOD_ProDKin_1	231	237	PF00069	0.583
MOD_ProDKin_1	362	368	PF00069	0.658
MOD_ProDKin_1	374	380	PF00069	0.535
MOD_ProDKin_1	62	68	PF00069	0.542
MOD_SUMO_rev_2	215	223	PF00179	0.651
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.465
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.501
TRG_ENDOCYTIC_2	334	337	PF00928	0.474
TRG_ENDOCYTIC_2	44	47	PF00928	0.566
TRG_ER_diArg_1	177	179	PF00400	0.835
TRG_ER_diArg_1	187	190	PF00400	0.675
TRG_ER_diArg_1	202	204	PF00400	0.538
TRG_ER_diArg_1	279	282	PF00400	0.485
TRG_NES_CRM1_1	400	414	PF08389	0.528
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X976	Leishmania donovani	89%	95%
A4HMN2	Leishmania braziliensis	71%	94%
A4IBA9	Leishmania infantum	89%	69%
E9B689	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	95%