Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF33_LEIMA

TriTrypDb:

LmjF.35.2100 , LMJLV39_350027600 , LMJSD75_350026900

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.677
CLV_NRD_NRD_1	171	173	PF00675	0.700
CLV_NRD_NRD_1	186	188	PF00675	0.736
CLV_NRD_NRD_1	194	196	PF00675	0.606
CLV_NRD_NRD_1	223	225	PF00675	0.593
CLV_NRD_NRD_1	284	286	PF00675	0.589
CLV_NRD_NRD_1	329	331	PF00675	0.491
CLV_NRD_NRD_1	351	353	PF00675	0.523
CLV_NRD_NRD_1	380	382	PF00675	0.525
CLV_NRD_NRD_1	451	453	PF00675	0.555
CLV_NRD_NRD_1	590	592	PF00675	0.629
CLV_PCSK_FUR_1	169	173	PF00082	0.682
CLV_PCSK_FUR_1	192	196	PF00082	0.570
CLV_PCSK_FUR_1	210	214	PF00082	0.613
CLV_PCSK_FUR_1	282	286	PF00082	0.544
CLV_PCSK_KEX2_1	169	171	PF00082	0.753
CLV_PCSK_KEX2_1	179	181	PF00082	0.657
CLV_PCSK_KEX2_1	186	188	PF00082	0.662
CLV_PCSK_KEX2_1	194	196	PF00082	0.606
CLV_PCSK_KEX2_1	212	214	PF00082	0.616
CLV_PCSK_KEX2_1	284	286	PF00082	0.553
CLV_PCSK_KEX2_1	329	331	PF00082	0.494
CLV_PCSK_KEX2_1	351	353	PF00082	0.559
CLV_PCSK_KEX2_1	380	382	PF00082	0.525
CLV_PCSK_KEX2_1	414	416	PF00082	0.546
CLV_PCSK_KEX2_1	451	453	PF00082	0.555
CLV_PCSK_KEX2_1	590	592	PF00082	0.629
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.700
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.678
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.546
CLV_PCSK_PC7_1	165	171	PF00082	0.683
CLV_PCSK_SKI1_1	179	183	PF00082	0.837
CLV_PCSK_SKI1_1	339	343	PF00082	0.490
CLV_PCSK_SKI1_1	428	432	PF00082	0.534
CLV_PCSK_SKI1_1	435	439	PF00082	0.393
CLV_PCSK_SKI1_1	46	50	PF00082	0.515
CLV_PCSK_SKI1_1	94	98	PF00082	0.581
DEG_APCC_DBOX_1	12	20	PF00400	0.654
DEG_APCC_DBOX_1	265	273	PF00400	0.507
DEG_SPOP_SBC_1	130	134	PF00917	0.549
DEG_SPOP_SBC_1	181	185	PF00917	0.707
DEG_SPOP_SBC_1	630	634	PF00917	0.587
DOC_CYCLIN_RxL_1	222	232	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.638
DOC_MAPK_gen_1	282	290	PF00069	0.547
DOC_MAPK_gen_1	292	299	PF00069	0.549
DOC_MAPK_gen_1	46	55	PF00069	0.565
DOC_MAPK_gen_1	474	483	PF00069	0.502
DOC_MAPK_gen_1	605	613	PF00069	0.586
DOC_MAPK_MEF2A_6	49	57	PF00069	0.573
DOC_PP1_RVXF_1	118	125	PF00149	0.507
DOC_PP1_RVXF_1	337	344	PF00149	0.488
DOC_PP1_RVXF_1	458	465	PF00149	0.521
DOC_PP4_FxxP_1	311	314	PF00568	0.514
DOC_PP4_FxxP_1	456	459	PF00568	0.615
DOC_USP7_MATH_1	130	134	PF00917	0.587
DOC_USP7_MATH_1	181	185	PF00917	0.707
DOC_USP7_MATH_1	234	238	PF00917	0.751
DOC_USP7_MATH_1	403	407	PF00917	0.619
DOC_USP7_MATH_1	433	437	PF00917	0.507
DOC_USP7_MATH_1	582	586	PF00917	0.567
DOC_USP7_MATH_1	630	634	PF00917	0.573
DOC_USP7_MATH_1	637	641	PF00917	0.603
DOC_USP7_MATH_1	699	703	PF00917	0.733
DOC_USP7_UBL2_3	59	63	PF12436	0.520
DOC_WW_Pin1_4	132	137	PF00397	0.649
DOC_WW_Pin1_4	229	234	PF00397	0.731
DOC_WW_Pin1_4	567	572	PF00397	0.573
DOC_WW_Pin1_4	649	654	PF00397	0.658
DOC_WW_Pin1_4	680	685	PF00397	0.639
DOC_WW_Pin1_4	703	708	PF00397	0.635
LIG_14-3-3_CanoR_1	13	22	PF00244	0.470
LIG_14-3-3_CanoR_1	180	190	PF00244	0.752
LIG_14-3-3_CanoR_1	224	230	PF00244	0.716
LIG_14-3-3_CanoR_1	266	270	PF00244	0.598
LIG_14-3-3_CanoR_1	415	425	PF00244	0.591
LIG_14-3-3_CanoR_1	428	433	PF00244	0.489
LIG_14-3-3_CanoR_1	581	589	PF00244	0.550
LIG_14-3-3_CanoR_1	605	611	PF00244	0.585
LIG_APCC_ABBA_1	288	293	PF00400	0.557
LIG_APCC_ABBA_1	53	58	PF00400	0.496
LIG_APCC_ABBA_1	624	629	PF00400	0.524
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_BIR_III_3	1	5	PF00653	0.521
LIG_BRCT_BRCA1_1	307	311	PF00533	0.505
LIG_BRCT_BRCA1_1	460	464	PF00533	0.542
LIG_BRCT_BRCA1_1	631	635	PF00533	0.620
LIG_BRCT_BRCA1_1	639	643	PF00533	0.584
LIG_Clathr_ClatBox_1	296	300	PF01394	0.538
LIG_FHA_1	247	253	PF00498	0.655
LIG_FHA_1	333	339	PF00498	0.490
LIG_FHA_1	594	600	PF00498	0.644
LIG_FHA_1	676	682	PF00498	0.649
LIG_FHA_1	704	710	PF00498	0.565
LIG_FHA_2	31	37	PF00498	0.495
LIG_FHA_2	429	435	PF00498	0.524
LIG_FHA_2	437	443	PF00498	0.401
LIG_FHA_2	468	474	PF00498	0.504
LIG_Integrin_RGD_1	241	243	PF01839	0.663
LIG_LIR_Apic_2	308	314	PF02991	0.509
LIG_LIR_Gen_1	305	315	PF02991	0.511
LIG_LIR_Gen_1	84	93	PF02991	0.549
LIG_LIR_Nem_3	305	310	PF02991	0.512
LIG_LIR_Nem_3	575	579	PF02991	0.601
LIG_LIR_Nem_3	612	617	PF02991	0.623
LIG_LIR_Nem_3	80	86	PF02991	0.562
LIG_MLH1_MIPbox_1	307	311	PF16413	0.505
LIG_MYND_1	649	653	PF01753	0.689
LIG_NRBOX	491	497	PF00104	0.518
LIG_PCNA_PIPBox_1	312	321	PF02747	0.482
LIG_PDZ_Class_1	718	723	PF00595	0.653
LIG_Pex14_2	22	26	PF04695	0.466
LIG_Pex14_2	307	311	PF04695	0.505
LIG_Pex14_2	464	468	PF04695	0.477
LIG_Rb_pABgroove_1	608	616	PF01858	0.585
LIG_REV1ctd_RIR_1	308	313	PF16727	0.508
LIG_SH2_CRK	503	507	PF00017	0.431
LIG_SH2_NCK_1	324	328	PF00017	0.496
LIG_SH2_NCK_1	86	90	PF00017	0.563
LIG_SH2_PTP2	576	579	PF00017	0.599
LIG_SH2_SRC	576	579	PF00017	0.599
LIG_SH2_STAT5	318	321	PF00017	0.456
LIG_SH2_STAT5	324	327	PF00017	0.459
LIG_SH2_STAT5	576	579	PF00017	0.694
LIG_SH2_STAT5	64	67	PF00017	0.458
LIG_SH2_STAT5	7	10	PF00017	0.534
LIG_SH3_3	251	257	PF00018	0.565
LIG_SH3_3	576	582	PF00018	0.731
LIG_SH3_3	678	684	PF00018	0.545
LIG_SH3_3	706	712	PF00018	0.646
LIG_SUMO_SIM_anti_2	251	256	PF11976	0.567
LIG_SUMO_SIM_par_1	436	443	PF11976	0.520
LIG_SUMO_SIM_par_1	609	615	PF11976	0.591
LIG_TRAF2_1	598	601	PF00917	0.581
LIG_TYR_ITIM	501	506	PF00017	0.483
LIG_UBA3_1	610	618	PF00899	0.621
LIG_WRC_WIRS_1	19	24	PF05994	0.543
LIG_WW_3	91	95	PF00397	0.514
MOD_CDK_SPxxK_3	229	236	PF00069	0.557
MOD_CK1_1	132	138	PF00069	0.735
MOD_CK1_1	142	148	PF00069	0.611
MOD_CK1_1	150	156	PF00069	0.541
MOD_CK1_1	161	167	PF00069	0.670
MOD_CK1_1	18	24	PF00069	0.468
MOD_CK1_1	219	225	PF00069	0.718
MOD_CK1_1	232	238	PF00069	0.556
MOD_CK1_1	3	9	PF00069	0.467
MOD_CK1_1	417	423	PF00069	0.570
MOD_CK1_1	436	442	PF00069	0.485
MOD_CK1_1	585	591	PF00069	0.694
MOD_CK1_1	703	709	PF00069	0.654
MOD_CK2_1	225	231	PF00069	0.714
MOD_CK2_1	299	305	PF00069	0.611
MOD_CK2_1	30	36	PF00069	0.488
MOD_CK2_1	391	397	PF00069	0.680
MOD_CK2_1	428	434	PF00069	0.478
MOD_CK2_1	436	442	PF00069	0.434
MOD_CK2_1	714	720	PF00069	0.557
MOD_CK2_1	84	90	PF00069	0.538
MOD_GlcNHglycan	2	5	PF01048	0.512
MOD_GlcNHglycan	325	328	PF01048	0.467
MOD_GlcNHglycan	517	520	PF01048	0.547
MOD_GlcNHglycan	545	548	PF01048	0.579
MOD_GlcNHglycan	584	587	PF01048	0.618
MOD_GlcNHglycan	620	624	PF01048	0.581
MOD_GlcNHglycan	697	700	PF01048	0.780
MOD_GlcNHglycan	703	706	PF01048	0.718
MOD_GSK3_1	132	139	PF00069	0.679
MOD_GSK3_1	14	21	PF00069	0.468
MOD_GSK3_1	142	149	PF00069	0.552
MOD_GSK3_1	150	157	PF00069	0.530
MOD_GSK3_1	219	226	PF00069	0.755
MOD_GSK3_1	367	374	PF00069	0.679
MOD_GSK3_1	413	420	PF00069	0.661
MOD_GSK3_1	581	588	PF00069	0.650
MOD_GSK3_1	649	656	PF00069	0.661
MOD_GSK3_1	675	682	PF00069	0.780
MOD_GSK3_1	695	702	PF00069	0.628
MOD_GSK3_1	714	721	PF00069	0.499
MOD_LATS_1	178	184	PF00433	0.684
MOD_NEK2_1	105	110	PF00069	0.443
MOD_NEK2_1	190	195	PF00069	0.630
MOD_NEK2_1	371	376	PF00069	0.632
MOD_NEK2_1	391	396	PF00069	0.695
MOD_NEK2_1	572	577	PF00069	0.632
MOD_NEK2_1	695	700	PF00069	0.611
MOD_PIKK_1	105	111	PF00454	0.443
MOD_PIKK_1	173	179	PF00454	0.703
MOD_PIKK_1	332	338	PF00454	0.485
MOD_PIKK_1	417	423	PF00454	0.607
MOD_PIKK_1	651	657	PF00454	0.670
MOD_PIKK_1	714	720	PF00454	0.649
MOD_PKA_1	171	177	PF00069	0.644
MOD_PKA_1	380	386	PF00069	0.472
MOD_PKA_1	414	420	PF00069	0.542
MOD_PKA_2	171	177	PF00069	0.708
MOD_PKA_2	223	229	PF00069	0.748
MOD_PKA_2	235	241	PF00069	0.541
MOD_PKA_2	265	271	PF00069	0.593
MOD_PKA_2	380	386	PF00069	0.495
MOD_PKA_2	414	420	PF00069	0.605
MOD_PKA_2	42	48	PF00069	0.473
MOD_PKB_1	169	177	PF00069	0.648
MOD_Plk_1	150	156	PF00069	0.675
MOD_Plk_1	433	439	PF00069	0.517
MOD_Plk_2-3	84	90	PF00069	0.600
MOD_Plk_4	142	148	PF00069	0.613
MOD_Plk_4	15	21	PF00069	0.540
MOD_Plk_4	265	271	PF00069	0.593
MOD_Plk_4	3	9	PF00069	0.540
MOD_Plk_4	367	373	PF00069	0.561
MOD_Plk_4	433	439	PF00069	0.569
MOD_Plk_4	458	464	PF00069	0.582
MOD_Plk_4	572	578	PF00069	0.598
MOD_Plk_4	684	690	PF00069	0.591
MOD_Plk_4	84	90	PF00069	0.565
MOD_ProDKin_1	132	138	PF00069	0.650
MOD_ProDKin_1	229	235	PF00069	0.730
MOD_ProDKin_1	567	573	PF00069	0.575
MOD_ProDKin_1	649	655	PF00069	0.661
MOD_ProDKin_1	680	686	PF00069	0.642
MOD_ProDKin_1	703	709	PF00069	0.639
MOD_SUMO_for_1	343	346	PF00179	0.560
MOD_SUMO_for_1	617	620	PF00179	0.609
MOD_SUMO_rev_2	31	39	PF00179	0.477
MOD_SUMO_rev_2	58	65	PF00179	0.476
TRG_DiLeu_BaEn_1	357	362	PF01217	0.576
TRG_DiLeu_BaEn_2	76	82	PF01217	0.575
TRG_ENDOCYTIC_2	318	321	PF00928	0.417
TRG_ENDOCYTIC_2	503	506	PF00928	0.426
TRG_ENDOCYTIC_2	576	579	PF00928	0.599
TRG_ENDOCYTIC_2	86	89	PF00928	0.573
TRG_ER_diArg_1	124	127	PF00400	0.541
TRG_ER_diArg_1	169	172	PF00400	0.719
TRG_ER_diArg_1	192	195	PF00400	0.682
TRG_ER_diArg_1	282	285	PF00400	0.542
TRG_ER_diArg_1	329	331	PF00400	0.494
TRG_ER_diArg_1	350	352	PF00400	0.514
TRG_ER_diArg_1	380	382	PF00400	0.561
TRG_ER_diArg_1	589	591	PF00400	0.618
TRG_NLS_Bipartite_1	165	183	PF00514	0.687
TRG_NLS_MonoExtC_3	164	169	PF00514	0.684
TRG_NLS_MonoExtN_4	163	170	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W4	Leptomonas seymouri	56%	100%
A0A3S5H7Z3	Leishmania donovani	93%	100%
A4HMN1	Leishmania braziliensis	75%	100%
A4IBA8	Leishmania infantum	93%	100%
E9B688	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%