Putative calcium motive p-type ATPase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium motive p-type ATPase, putative

Species:

Leishmania major

UniProt:

E9AF31_LEIMA

TriTrypDb:

LmjF.35.2080 , LMJLV39_350027300 , LMJSD75_350026600

Length:

1109

Annotations

LeishMANIAdb annotations

Homologous to animal ER-localized Ca2+ ATPases. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Previous1Next

Expansion

Sequence features

E9AF31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF31

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006816	calcium ion transport	7	2
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0006874	intracellular calcium ion homeostasis	7	2
GO:0006875	obsolete intracellular metal ion homeostasis	6	2
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	2
GO:0030001	metal ion transport	6	2

Previous1 2 3 4Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	3
GO:0005388	P-type calcium transporter activity	4	2
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015085	calcium ion transmembrane transporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3

Previous1 2 3 4Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.530
CLV_C14_Caspase3-7	116	120	PF00656	0.517
CLV_C14_Caspase3-7	489	493	PF00656	0.573
CLV_C14_Caspase3-7	709	713	PF00656	0.616
CLV_NRD_NRD_1	1027	1029	PF00675	0.377
CLV_NRD_NRD_1	1105	1107	PF00675	0.540
CLV_NRD_NRD_1	272	274	PF00675	0.271
CLV_NRD_NRD_1	391	393	PF00675	0.321
CLV_NRD_NRD_1	688	690	PF00675	0.467
CLV_NRD_NRD_1	738	740	PF00675	0.285

Previous1 2 3 4 5…30Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y1	Leptomonas seymouri	30%	100%
A0A0N1HWG6	Leptomonas seymouri	27%	99%
A0A0N1PFH3	Leptomonas seymouri	83%	91%
A0A0S4J1M1	Bodo saltans	29%	100%
A0A0S4J5A1	Bodo saltans	50%	100%
A0A0S4JA92	Bodo saltans	27%	100%
A0A0S4JRV4	Bodo saltans	30%	100%
A0A0S4JT33	Bodo saltans	22%	100%
A0A0S4KIG5	Bodo saltans	31%	100%
A0A0S4KNQ6	Bodo saltans	27%	99%

Previous1 2 3 4 5…20Next