DUF4205 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4205), putative

Species:

Leishmania major

UniProt:

E9AF29_LEIMA

TriTrypDb:

LmjF.35.2070 , LMJLV39_350027200 , LMJSD75_350026500

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF29

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.709
CLV_C14_Caspase3-7	310	314	PF00656	0.661
CLV_C14_Caspase3-7	431	435	PF00656	0.280
CLV_C14_Caspase3-7	510	514	PF00656	0.464
CLV_NRD_NRD_1	138	140	PF00675	0.668
CLV_NRD_NRD_1	37	39	PF00675	0.517
CLV_NRD_NRD_1	97	99	PF00675	0.558
CLV_PCSK_KEX2_1	37	39	PF00082	0.517
CLV_PCSK_KEX2_1	398	400	PF00082	0.436
CLV_PCSK_KEX2_1	97	99	PF00082	0.558
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.436
CLV_PCSK_SKI1_1	347	351	PF00082	0.513
CLV_PCSK_SKI1_1	38	42	PF00082	0.630
CLV_PCSK_SKI1_1	4	8	PF00082	0.674
CLV_PCSK_SKI1_1	421	425	PF00082	0.411
CLV_PCSK_SKI1_1	477	481	PF00082	0.472
CLV_PCSK_SKI1_1	539	543	PF00082	0.436
CLV_PCSK_SKI1_1	621	625	PF00082	0.411
CLV_PCSK_SKI1_1	672	676	PF00082	0.402
CLV_Separin_Metazoa	466	470	PF03568	0.389
DEG_APCC_DBOX_1	37	45	PF00400	0.627
DEG_APCC_DBOX_1	525	533	PF00400	0.513
DEG_SCF_TRCP1_1	513	518	PF00400	0.397
DOC_ANK_TNKS_1	76	83	PF00023	0.561
DOC_CDC14_PxL_1	9	17	PF14671	0.675
DOC_MAPK_gen_1	480	489	PF00069	0.347
DOC_MAPK_MEF2A_6	516	523	PF00069	0.436
DOC_PP1_RVXF_1	537	544	PF00149	0.389
DOC_PP1_RVXF_1	655	662	PF00149	0.436
DOC_PP2B_LxvP_1	519	522	PF13499	0.513
DOC_PP2B_LxvP_1	614	617	PF13499	0.474
DOC_USP7_MATH_1	147	151	PF00917	0.642
DOC_USP7_MATH_1	241	245	PF00917	0.796
DOC_USP7_MATH_1	289	293	PF00917	0.786
DOC_USP7_MATH_1	302	306	PF00917	0.722
DOC_USP7_MATH_1	584	588	PF00917	0.392
DOC_USP7_MATH_1	62	66	PF00917	0.632
DOC_USP7_MATH_1	681	685	PF00917	0.411
DOC_USP7_MATH_1	687	691	PF00917	0.411
DOC_USP7_UBL2_3	140	144	PF12436	0.696
DOC_WW_Pin1_4	214	219	PF00397	0.683
DOC_WW_Pin1_4	256	261	PF00397	0.806
DOC_WW_Pin1_4	585	590	PF00397	0.411
LIG_14-3-3_CanoR_1	139	147	PF00244	0.711
LIG_14-3-3_CanoR_1	179	185	PF00244	0.832
LIG_14-3-3_CanoR_1	255	260	PF00244	0.651
LIG_14-3-3_CanoR_1	526	530	PF00244	0.433
LIG_14-3-3_CanoR_1	578	586	PF00244	0.280
LIG_14-3-3_CanoR_1	61	70	PF00244	0.641
LIG_14-3-3_CanoR_1	672	678	PF00244	0.524
LIG_Actin_WH2_2	2	18	PF00022	0.640
LIG_Actin_WH2_2	454	471	PF00022	0.436
LIG_BRCT_BRCA1_1	487	491	PF00533	0.513
LIG_BRCT_BRCA1_1	657	661	PF00533	0.513
LIG_Clathr_ClatBox_1	67	71	PF01394	0.423
LIG_FHA_1	463	469	PF00498	0.492
LIG_FHA_1	526	532	PF00498	0.353
LIG_FHA_1	618	624	PF00498	0.411
LIG_FHA_1	651	657	PF00498	0.515
LIG_FHA_1	99	105	PF00498	0.581
LIG_FHA_2	195	201	PF00498	0.702
LIG_FHA_2	353	359	PF00498	0.389
LIG_FHA_2	408	414	PF00498	0.411
LIG_FHA_2	429	435	PF00498	0.376
LIG_FHA_2	643	649	PF00498	0.411
LIG_FHA_2	83	89	PF00498	0.504
LIG_GBD_Chelix_1	404	412	PF00786	0.513
LIG_GBD_Chelix_1	486	494	PF00786	0.474
LIG_LIR_Apic_2	475	481	PF02991	0.411
LIG_LIR_Gen_1	452	461	PF02991	0.411
LIG_LIR_Gen_1	488	499	PF02991	0.513
LIG_LIR_Gen_1	609	617	PF02991	0.513
LIG_LIR_Nem_3	192	196	PF02991	0.580
LIG_LIR_Nem_3	488	494	PF02991	0.513
LIG_LIR_Nem_3	609	614	PF02991	0.513
LIG_NRBOX	489	495	PF00104	0.513
LIG_REV1ctd_RIR_1	540	548	PF16727	0.513
LIG_SH2_GRB2like	592	595	PF00017	0.513
LIG_SH2_NCK_1	592	596	PF00017	0.478
LIG_SH2_STAP1	388	392	PF00017	0.411
LIG_SH2_STAP1	556	560	PF00017	0.411
LIG_SH2_STAT5	393	396	PF00017	0.411
LIG_SH2_STAT5	438	441	PF00017	0.436
LIG_SH2_STAT5	592	595	PF00017	0.387
LIG_SH3_3	110	116	PF00018	0.663
LIG_SH3_3	372	378	PF00018	0.411
LIG_SH3_3	583	589	PF00018	0.402
LIG_SH3_3	595	601	PF00018	0.342
LIG_SUMO_SIM_anti_2	635	640	PF11976	0.513
LIG_SUMO_SIM_par_1	421	427	PF11976	0.367
LIG_TRAF2_1	18	21	PF00917	0.534
LIG_TRAF2_1	218	221	PF00917	0.676
LIG_TRAF2_1	460	463	PF00917	0.389
LIG_WRC_WIRS_1	486	491	PF05994	0.513
MOD_CK1_1	180	186	PF00069	0.763
MOD_CK1_1	205	211	PF00069	0.738
MOD_CK1_1	244	250	PF00069	0.608
MOD_CK1_1	253	259	PF00069	0.626
MOD_CK1_1	436	442	PF00069	0.490
MOD_CK1_1	588	594	PF00069	0.373
MOD_CK2_1	214	220	PF00069	0.721
MOD_CK2_1	289	295	PF00069	0.770
MOD_CK2_1	345	351	PF00069	0.344
MOD_CK2_1	407	413	PF00069	0.411
MOD_CK2_1	457	463	PF00069	0.377
MOD_CK2_1	642	648	PF00069	0.457
MOD_CK2_1	82	88	PF00069	0.517
MOD_CMANNOS	603	606	PF00535	0.513
MOD_GlcNHglycan	151	154	PF01048	0.765
MOD_GlcNHglycan	184	187	PF01048	0.807
MOD_GlcNHglycan	239	242	PF01048	0.822
MOD_GlcNHglycan	308	313	PF01048	0.630
MOD_GlcNHglycan	513	516	PF01048	0.360
MOD_GlcNHglycan	523	526	PF01048	0.351
MOD_GlcNHglycan	568	571	PF01048	0.409
MOD_GlcNHglycan	582	585	PF01048	0.418
MOD_GlcNHglycan	664	667	PF01048	0.413
MOD_GlcNHglycan	689	692	PF01048	0.411
MOD_GSK3_1	135	142	PF00069	0.550
MOD_GSK3_1	147	154	PF00069	0.733
MOD_GSK3_1	180	187	PF00069	0.775
MOD_GSK3_1	201	208	PF00069	0.729
MOD_GSK3_1	237	244	PF00069	0.813
MOD_GSK3_1	249	256	PF00069	0.602
MOD_GSK3_1	341	348	PF00069	0.420
MOD_GSK3_1	424	431	PF00069	0.424
MOD_GSK3_1	432	439	PF00069	0.422
MOD_GSK3_1	485	492	PF00069	0.515
MOD_GSK3_1	504	511	PF00069	0.411
MOD_GSK3_1	521	528	PF00069	0.220
MOD_GSK3_1	580	587	PF00069	0.442
MOD_GSK3_1	673	680	PF00069	0.411
MOD_N-GLC_1	593	598	PF02516	0.499
MOD_N-GLC_1	632	637	PF02516	0.397
MOD_NEK2_1	184	189	PF00069	0.800
MOD_NEK2_1	201	206	PF00069	0.702
MOD_NEK2_1	251	256	PF00069	0.818
MOD_NEK2_1	341	346	PF00069	0.509
MOD_NEK2_1	40	45	PF00069	0.528
MOD_NEK2_1	424	429	PF00069	0.507
MOD_NEK2_1	468	473	PF00069	0.389
MOD_NEK2_1	489	494	PF00069	0.411
MOD_NEK2_1	534	539	PF00069	0.499
MOD_NEK2_1	590	595	PF00069	0.420
MOD_NEK2_1	652	657	PF00069	0.410
MOD_NEK2_1	677	682	PF00069	0.411
MOD_PK_1	457	463	PF00069	0.280
MOD_PKA_1	139	145	PF00069	0.700
MOD_PKA_2	135	141	PF00069	0.546
MOD_PKA_2	289	295	PF00069	0.770
MOD_PKA_2	432	438	PF00069	0.397
MOD_PKA_2	468	474	PF00069	0.411
MOD_PKA_2	515	521	PF00069	0.399
MOD_PKA_2	525	531	PF00069	0.351
MOD_PKA_2	577	583	PF00069	0.358
MOD_PKA_2	607	613	PF00069	0.513
MOD_Plk_1	433	439	PF00069	0.280
MOD_Plk_1	632	638	PF00069	0.397
MOD_Plk_2-3	642	648	PF00069	0.411
MOD_Plk_4	345	351	PF00069	0.326
MOD_Plk_4	424	430	PF00069	0.436
MOD_Plk_4	468	474	PF00069	0.411
MOD_Plk_4	485	491	PF00069	0.411
MOD_Plk_4	515	521	PF00069	0.416
MOD_Plk_4	599	605	PF00069	0.362
MOD_Plk_4	673	679	PF00069	0.411
MOD_Plk_4	82	88	PF00069	0.517
MOD_ProDKin_1	214	220	PF00069	0.682
MOD_ProDKin_1	256	262	PF00069	0.805
MOD_ProDKin_1	585	591	PF00069	0.411
MOD_SUMO_for_1	78	81	PF00179	0.563
TRG_DiLeu_BaEn_1	100	105	PF01217	0.589
TRG_DiLeu_BaEn_1	21	26	PF01217	0.514
TRG_DiLeu_LyEn_5	100	105	PF01217	0.550
TRG_ENDOCYTIC_2	119	122	PF00928	0.613
TRG_ER_diArg_1	450	453	PF00400	0.443
TRG_ER_diArg_1	97	99	PF00400	0.558
TRG_NES_CRM1_1	84	96	PF08389	0.515
TRG_NLS_MonoCore_2	144	149	PF00514	0.705
TRG_NLS_MonoExtC_3	143	148	PF00514	0.699
TRG_NLS_MonoExtN_4	144	149	PF00514	0.709
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT4	Leptomonas seymouri	54%	100%
A0A3S7X9A6	Leishmania donovani	92%	100%
A4HMM7	Leishmania braziliensis	78%	100%
A4IBA5	Leishmania infantum	92%	100%
E9B685	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%