SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Variant SH3 domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AF28_LEIMA

TriTrypDb:

LmjF.35.2060 , LMJLV39_350027100 , LMJSD75_350026400

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.731
CLV_C14_Caspase3-7	400	404	PF00656	0.713
CLV_C14_Caspase3-7	438	442	PF00656	0.756
CLV_NRD_NRD_1	237	239	PF00675	0.794
CLV_NRD_NRD_1	302	304	PF00675	0.341
CLV_NRD_NRD_1	316	318	PF00675	0.344
CLV_NRD_NRD_1	447	449	PF00675	0.739
CLV_NRD_NRD_1	451	453	PF00675	0.757
CLV_NRD_NRD_1	5	7	PF00675	0.822
CLV_PCSK_FUR_1	153	157	PF00082	0.514
CLV_PCSK_FUR_1	314	318	PF00082	0.333
CLV_PCSK_KEX2_1	155	157	PF00082	0.518
CLV_PCSK_KEX2_1	302	304	PF00082	0.357
CLV_PCSK_KEX2_1	316	318	PF00082	0.357
CLV_PCSK_KEX2_1	447	449	PF00082	0.790
CLV_PCSK_KEX2_1	451	453	PF00082	0.749
CLV_PCSK_KEX2_1	476	478	PF00082	0.719
CLV_PCSK_KEX2_1	5	7	PF00082	0.771
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.518
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.507
CLV_PCSK_PC7_1	447	453	PF00082	0.735
CLV_PCSK_SKI1_1	140	144	PF00082	0.452
CLV_PCSK_SKI1_1	317	321	PF00082	0.357
CLV_PCSK_SKI1_1	425	429	PF00082	0.794
CLV_PCSK_SKI1_1	476	480	PF00082	0.713
DEG_Nend_UBRbox_2	1	3	PF02207	0.660
DOC_CKS1_1	392	397	PF01111	0.687
DOC_CKS1_1	99	104	PF01111	0.600
DOC_CYCLIN_yClb5_NLxxxL_5	425	431	PF00134	0.676
DOC_PP4_FxxP_1	222	225	PF00568	0.723
DOC_USP7_MATH_1	115	119	PF00917	0.762
DOC_USP7_MATH_1	125	129	PF00917	0.659
DOC_USP7_MATH_1	228	232	PF00917	0.793
DOC_USP7_MATH_1	399	403	PF00917	0.561
DOC_USP7_MATH_1	460	464	PF00917	0.703
DOC_USP7_MATH_2	395	401	PF00917	0.704
DOC_WW_Pin1_4	121	126	PF00397	0.703
DOC_WW_Pin1_4	128	133	PF00397	0.615
DOC_WW_Pin1_4	194	199	PF00397	0.391
DOC_WW_Pin1_4	391	396	PF00397	0.677
DOC_WW_Pin1_4	98	103	PF00397	0.576
LIG_14-3-3_CanoR_1	153	159	PF00244	0.676
LIG_14-3-3_CanoR_1	193	198	PF00244	0.357
LIG_14-3-3_CanoR_1	340	345	PF00244	0.567
LIG_14-3-3_CanoR_1	429	435	PF00244	0.728
LIG_14-3-3_CanoR_1	46	53	PF00244	0.685
LIG_14-3-3_CanoR_1	461	465	PF00244	0.718
LIG_BIR_III_2	245	249	PF00653	0.610
LIG_BRCT_BRCA1_1	218	222	PF00533	0.714
LIG_FHA_1	107	113	PF00498	0.751
LIG_FHA_1	137	143	PF00498	0.558
LIG_FHA_1	266	272	PF00498	0.550
LIG_FHA_1	426	432	PF00498	0.736
LIG_FHA_1	47	53	PF00498	0.604
LIG_FHA_2	392	398	PF00498	0.606
LIG_FHA_2	436	442	PF00498	0.781
LIG_FHA_2	464	470	PF00498	0.716
LIG_LIR_Apic_2	219	225	PF02991	0.715
LIG_LIR_Apic_2	322	327	PF02991	0.564
LIG_LIR_Gen_1	383	392	PF02991	0.552
LIG_LIR_Gen_1	66	75	PF02991	0.438
LIG_LIR_Nem_3	383	388	PF02991	0.546
LIG_LIR_Nem_3	66	70	PF02991	0.399
LIG_LIR_Nem_3	92	98	PF02991	0.357
LIG_Pex14_2	266	270	PF04695	0.614
LIG_SH2_CRK	324	328	PF00017	0.568
LIG_SH2_NCK_1	324	328	PF00017	0.568
LIG_SH2_STAP1	171	175	PF00017	0.391
LIG_SH2_STAP1	345	349	PF00017	0.614
LIG_SH2_STAP1	351	355	PF00017	0.503
LIG_SH2_STAT3	161	164	PF00017	0.650
LIG_SH2_STAT3	171	174	PF00017	0.438
LIG_SH2_STAT5	324	327	PF00017	0.617
LIG_SH2_STAT5	98	101	PF00017	0.562
LIG_SH3_3	96	102	PF00018	0.500
LIG_TRAF2_1	69	72	PF00917	0.259
LIG_TYR_ITIM	65	70	PF00017	0.438
MOD_CK1_1	119	125	PF00069	0.751
MOD_CK1_1	128	134	PF00069	0.670
MOD_CK1_1	231	237	PF00069	0.742
MOD_CK1_1	322	328	PF00069	0.564
MOD_CK1_1	391	397	PF00069	0.766
MOD_CK1_1	455	461	PF00069	0.786
MOD_CK1_1	463	469	PF00069	0.601
MOD_CK2_1	110	116	PF00069	0.651
MOD_CK2_1	391	397	PF00069	0.757
MOD_CK2_1	399	405	PF00069	0.650
MOD_CK2_1	412	418	PF00069	0.714
MOD_Cter_Amidation	236	239	PF01082	0.561
MOD_Cter_Amidation	314	317	PF01082	0.369
MOD_Cter_Amidation	445	448	PF01082	0.567
MOD_GlcNHglycan	125	128	PF01048	0.739
MOD_GlcNHglycan	20	23	PF01048	0.700
MOD_GlcNHglycan	205	208	PF01048	0.383
MOD_GlcNHglycan	230	234	PF01048	0.797
MOD_GlcNHglycan	397	402	PF01048	0.716
MOD_GlcNHglycan	444	447	PF01048	0.711
MOD_GlcNHglycan	452	455	PF01048	0.792
MOD_GlcNHglycan	91	94	PF01048	0.361
MOD_GSK3_1	106	113	PF00069	0.678
MOD_GSK3_1	115	122	PF00069	0.674
MOD_GSK3_1	16	23	PF00069	0.809
MOD_GSK3_1	265	272	PF00069	0.557
MOD_GSK3_1	340	347	PF00069	0.563
MOD_GSK3_1	404	411	PF00069	0.724
MOD_GSK3_1	42	49	PF00069	0.687
MOD_GSK3_1	421	428	PF00069	0.712
MOD_GSK3_1	430	437	PF00069	0.667
MOD_GSK3_1	51	58	PF00069	0.627
MOD_GSK3_1	83	90	PF00069	0.379
MOD_N-GLC_1	278	283	PF02516	0.456
MOD_N-GLC_1	322	327	PF02516	0.538
MOD_N-GLC_1	425	430	PF02516	0.753
MOD_N-GLC_1	83	88	PF02516	0.438
MOD_NEK2_1	147	152	PF00069	0.536
MOD_NEK2_1	154	159	PF00069	0.599
MOD_NEK2_1	18	23	PF00069	0.597
MOD_NEK2_1	280	285	PF00069	0.454
MOD_NEK2_1	349	354	PF00069	0.585
MOD_NEK2_1	412	417	PF00069	0.786
MOD_NEK2_2	309	314	PF00069	0.391
MOD_PK_1	16	22	PF00069	0.567
MOD_PKA_2	136	142	PF00069	0.685
MOD_PKA_2	192	198	PF00069	0.357
MOD_PKA_2	237	243	PF00069	0.790
MOD_PKA_2	412	418	PF00069	0.826
MOD_PKA_2	450	456	PF00069	0.819
MOD_PKA_2	460	466	PF00069	0.763
MOD_Plk_1	16	22	PF00069	0.567
MOD_Plk_1	179	185	PF00069	0.438
MOD_Plk_1	278	284	PF00069	0.415
MOD_Plk_1	322	328	PF00069	0.538
MOD_Plk_1	388	394	PF00069	0.634
MOD_Plk_1	404	410	PF00069	0.794
MOD_Plk_1	73	79	PF00069	0.389
MOD_Plk_4	125	131	PF00069	0.715
MOD_Plk_4	179	185	PF00069	0.427
MOD_Plk_4	345	351	PF00069	0.611
MOD_Plk_4	430	436	PF00069	0.698
MOD_Plk_4	460	466	PF00069	0.706
MOD_ProDKin_1	121	127	PF00069	0.705
MOD_ProDKin_1	128	134	PF00069	0.610
MOD_ProDKin_1	194	200	PF00069	0.391
MOD_ProDKin_1	391	397	PF00069	0.680
MOD_ProDKin_1	98	104	PF00069	0.589
MOD_SUMO_rev_2	50	58	PF00179	0.680
TRG_ENDOCYTIC_2	67	70	PF00928	0.438
TRG_ER_diArg_1	302	304	PF00400	0.358
TRG_ER_diArg_1	313	316	PF00400	0.360
TRG_ER_diArg_1	339	342	PF00400	0.450
TRG_ER_diArg_1	4	6	PF00400	0.821
TRG_NLS_MonoExtN_4	235	242	PF00514	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT1	Leptomonas seymouri	51%	100%
A0A0S4JH24	Bodo saltans	37%	100%
A0A3Q8IJ10	Leishmania donovani	90%	100%
A0A422NNS8	Trypanosoma rangeli	44%	100%
A4HMM6	Leishmania braziliensis	73%	99%
A4IBA4	Leishmania infantum	91%	100%
E9B684	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%