60S ribosomal protein L32

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L32

Species:

Leishmania major

UniProt:

E9AF27_LEIMA

TriTrypDb:

LmjF.35.2050 , LMJLV39_350027000 , LMJSD75_350026300

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	22
GO:0044391	ribosomal subunit	3	3
GO:1990904	ribonucleoprotein complex	2	22
GO:0005840	ribosome	5	19
GO:0043226	organelle	2	20
GO:0043228	non-membrane-bounded organelle	3	20
GO:0043229	intracellular organelle	3	20
GO:0043232	intracellular non-membrane-bounded organelle	4	20
GO:0110165	cellular anatomical entity	1	20
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AF27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF27

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	22
GO:0006518	peptide metabolic process	4	22
GO:0006807	nitrogen compound metabolic process	2	22
GO:0008152	metabolic process	1	22
GO:0009058	biosynthetic process	2	22
GO:0009059	macromolecule biosynthetic process	4	22
GO:0009987	cellular process	1	22
GO:0019538	protein metabolic process	3	22
GO:0034641	cellular nitrogen compound metabolic process	3	22
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	22
GO:0043043	peptide biosynthetic process	5	22
GO:0043170	macromolecule metabolic process	3	22
GO:0043603	amide metabolic process	3	22
GO:0043604	amide biosynthetic process	4	22
GO:0044237	cellular metabolic process	2	22
GO:0044238	primary metabolic process	2	22
GO:0044249	cellular biosynthetic process	3	22
GO:0044260	obsolete cellular macromolecule metabolic process	3	22
GO:0044271	cellular nitrogen compound biosynthetic process	4	22
GO:0071704	organic substance metabolic process	2	22
GO:1901564	organonitrogen compound metabolic process	3	22
GO:1901566	organonitrogen compound biosynthetic process	4	22
GO:1901576	organic substance biosynthetic process	3	22

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	22
GO:0005198	structural molecule activity	1	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.337
CLV_NRD_NRD_1	110	112	PF00675	0.363
CLV_NRD_NRD_1	127	129	PF00675	0.541
CLV_NRD_NRD_1	33	35	PF00675	0.363
CLV_NRD_NRD_1	45	47	PF00675	0.363
CLV_NRD_NRD_1	90	92	PF00675	0.363
CLV_PCSK_FUR_1	14	18	PF00082	0.462
CLV_PCSK_KEX2_1	13	15	PF00082	0.516
CLV_PCSK_KEX2_1	16	18	PF00082	0.355
CLV_PCSK_KEX2_1	44	46	PF00082	0.363
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.526
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.363
CLV_PCSK_SKI1_1	16	20	PF00082	0.382
CLV_PCSK_SKI1_1	65	69	PF00082	0.371
DOC_CKS1_1	66	71	PF01111	0.370
DOC_MAPK_gen_1	111	118	PF00069	0.363
DOC_MAPK_MEF2A_6	111	120	PF00069	0.363
DOC_USP7_MATH_1	4	8	PF00917	0.599
DOC_USP7_UBL2_3	8	12	PF12436	0.516
DOC_WW_Pin1_4	38	43	PF00397	0.357
DOC_WW_Pin1_4	65	70	PF00397	0.370
LIG_FHA_1	62	68	PF00498	0.362
LIG_LIR_Apic_2	30	36	PF02991	0.364
LIG_LIR_Apic_2	64	69	PF02991	0.364
LIG_LIR_Gen_1	82	88	PF02991	0.361
LIG_LIR_Nem_3	24	29	PF02991	0.355
LIG_LIR_Nem_3	70	75	PF02991	0.363
LIG_LIR_Nem_3	82	87	PF02991	0.361
LIG_PTB_Apo_2	52	59	PF02174	0.363
LIG_PTB_Apo_2	87	94	PF02174	0.363
LIG_PTB_Phospho_1	52	58	PF10480	0.363
LIG_PTB_Phospho_1	87	93	PF10480	0.363
LIG_SH2_CRK	84	88	PF00017	0.363
LIG_SH2_CRK	93	97	PF00017	0.363
LIG_SH2_PTP2	66	69	PF00017	0.391
LIG_SH2_STAT3	47	50	PF00017	0.363
LIG_SH2_STAT5	66	69	PF00017	0.381
LIG_TRFH_1	23	27	PF08558	0.477
LIG_UBA3_1	85	92	PF00899	0.363
MOD_CDC14_SPxK_1	41	44	PF00782	0.363
MOD_CDK_SPxK_1	38	44	PF00069	0.363
MOD_CDK_SPxxK_3	38	45	PF00069	0.363
MOD_GlcNHglycan	122	125	PF01048	0.584
MOD_GlcNHglycan	69	72	PF01048	0.360
MOD_GSK3_1	12	19	PF00069	0.362
MOD_GSK3_1	57	64	PF00069	0.363
MOD_GSK3_1	67	74	PF00069	0.495
MOD_NEK2_1	120	125	PF00069	0.527
MOD_NEK2_1	29	34	PF00069	0.391
MOD_PKA_1	12	18	PF00069	0.363
MOD_PKA_2	16	22	PF00069	0.462
MOD_PKA_2	61	67	PF00069	0.362
MOD_ProDKin_1	38	44	PF00069	0.357
MOD_ProDKin_1	65	71	PF00069	0.370
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.330
TRG_ENDOCYTIC_2	23	26	PF00928	0.470
TRG_ENDOCYTIC_2	84	87	PF00928	0.363
TRG_ENDOCYTIC_2	93	96	PF00928	0.363
TRG_ER_diArg_1	20	23	PF00400	0.477
TRG_ER_diArg_1	43	46	PF00400	0.363
TRG_NLS_Bipartite_1	16	38	PF00514	0.363
TRG_NLS_MonoCore_2	33	38	PF00514	0.363
TRG_NLS_MonoExtC_3	11	16	PF00514	0.503
TRG_NLS_MonoExtC_3	33	39	PF00514	0.391
TRG_NLS_MonoExtN_4	12	17	PF00514	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P415	Leptomonas seymouri	92%	100%
A0A0N0P7H7	Leptomonas seymouri	93%	100%
A0A0S4J1B6	Bodo saltans	82%	100%
A0A0S4JEW7	Bodo saltans	82%	100%
A0A0S4JID9	Bodo saltans	82%	100%
A0A1D8PPN6	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	100%
A0A1X0P652	Trypanosomatidae	87%	100%
A0A3Q8IBA2	Leishmania donovani	91%	100%
A0A3R7M160	Trypanosoma rangeli	89%	100%
A0A3S7X954	Leishmania donovani	96%	100%
A0A422N8T9	Trypanosoma rangeli	84%	100%
A4FWA4	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	32%	99%
A4HC36	Leishmania braziliensis	83%	100%
A4HMM5	Leishmania braziliensis	92%	100%
A4HZH8	Leishmania infantum	91%	100%
A4IBA3	Leishmania infantum	96%	100%
A6UQ61	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	30%	99%
A6VH02	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	31%	99%
A9A9P7	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	31%	99%
B6YSN1	Thermococcus onnurineus (strain NA1)	33%	100%
C3MQ76	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	30%	96%
C3MVJ5	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	30%	96%
C3N5U4	Sulfolobus islandicus (strain M.16.27)	30%	96%
C3NEG0	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	30%	96%
C3NH92	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	30%	96%
C4KHH3	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	30%	96%
C5A268	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	34%	100%
C6A177	Thermococcus sibiricus (strain DSM 12597 / MM 739)	33%	100%
C9ZZN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
D0A0Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
E2RKA8	Canis lupus familiaris	48%	99%
E9AVG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B683	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O05638	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	28%	100%
O26128	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	36%	100%
O28371	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	35%	100%
O42935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
O59435	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	100%
O94008	Candida albicans	43%	100%
P04359	Drosophila melanogaster	50%	99%
P14549	Methanococcus vannielii	30%	99%
P17932	Mus musculus	44%	99%
P38061	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P49211	Arabidopsis thaliana	45%	100%
P54010	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	91%
P61127	Drosophila yakuba	50%	99%
P61128	Drosophila simulans	50%	99%
P62910	Homo sapiens	48%	99%
P62911	Mus musculus	48%	99%
P62912	Rattus norvegicus	48%	99%
P79015	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
P84311	Drosophila subobscura	48%	99%
P84312	Drosophila bifasciata	48%	99%
P84313	Drosophila madeirensis	48%	99%
P84314	Drosophila guanche	48%	99%
P84323	Drosophila pseudoobscura pseudoobscura	48%	99%
P84324	Drosophila affinis	48%	99%
P84325	Drosophila azteca	48%	99%
P84326	Drosophila miranda	48%	99%
P84327	Drosophila persimilis	48%	99%
Q236T0	Tetrahymena thermophila (strain SB210)	50%	99%
Q3SZQ6	Bos taurus	48%	99%
Q4QC11	Leishmania major	91%	100%
Q55AB5	Dictyostelium discoideum	54%	100%
Q5JJG5	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	33%	100%
Q6FS03	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	100%
Q6L1B0	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	33%	99%
Q6LXD6	Methanococcus maripaludis (strain S2 / LL)	33%	99%
Q6QAT0	Sus scrofa	48%	99%
Q74MV8	Nanoarchaeum equitans (strain Kin4-M)	34%	99%
Q751I7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	100%
Q76KA3	Macaca fascicularis	48%	99%
Q7RXY1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	47%	100%
Q8PV33	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	29%	100%
Q8SS18	Encephalitozoon cuniculi (strain GB-M1)	40%	96%
Q8TRT0	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	32%	100%
Q8TW13	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	33%	100%
Q8WRF3	Apis mellifera	44%	99%
Q8ZVV9	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	34%	88%
Q90YT6	Ictalurus punctatus	45%	99%
Q94460	Drosophila acanthoptera	50%	99%
Q962T1	Spodoptera frugiperda	49%	99%
Q975J7	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	30%	100%
Q97BV9	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	29%	100%
Q9FHG2	Arabidopsis thaliana	43%	100%
Q9HH82	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
Q9HIS4	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	33%	100%
Q9UX90	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	96%
Q9V1V2	Pyrococcus abyssi (strain GE5 / Orsay)	33%	100%
Q9YF92	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	30%	92%
V5ATH5	Trypanosoma cruzi	90%	100%