NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF24_LEIMA

TriTrypDb:

LmjF.35.2020 , LMJLV39_350026700 , LMJSD75_350026000

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AF24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF24

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	2
GO:0006744	ubiquinone biosynthetic process	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0042180	cellular ketone metabolic process	3	2
GO:0042181	ketone biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901004	ubiquinone-6 metabolic process	6	2
GO:1901006	ubiquinone-6 biosynthetic process	7	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901661	quinone metabolic process	4	2
GO:1901663	quinone biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0044877	protein-containing complex binding	2	2
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.503
CLV_C14_Caspase3-7	98	102	PF00656	0.323
CLV_PCSK_FUR_1	166	170	PF00082	0.345
CLV_PCSK_KEX2_1	168	170	PF00082	0.347
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.347
CLV_PCSK_SKI1_1	200	204	PF00082	0.391
CLV_PCSK_SKI1_1	206	210	PF00082	0.442
CLV_PCSK_SKI1_1	235	239	PF00082	0.342
CLV_PCSK_SKI1_1	271	275	PF00082	0.486
CLV_PCSK_SKI1_1	279	283	PF00082	0.467
CLV_PCSK_SKI1_1	94	98	PF00082	0.308
DEG_APCC_DBOX_1	338	346	PF00400	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.506
DOC_ANK_TNKS_1	69	76	PF00023	0.434
DOC_CYCLIN_RxL_1	232	243	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.331
DOC_MAPK_gen_1	138	148	PF00069	0.307
DOC_MAPK_gen_1	166	175	PF00069	0.330
DOC_MAPK_gen_1	200	210	PF00069	0.377
DOC_PP1_RVXF_1	277	283	PF00149	0.469
DOC_PP1_SILK_1	143	148	PF00149	0.310
DOC_PP4_FxxP_1	335	338	PF00568	0.340
DOC_USP7_MATH_1	233	237	PF00917	0.355
DOC_WW_Pin1_4	157	162	PF00397	0.357
LIG_14-3-3_CanoR_1	254	261	PF00244	0.355
LIG_14-3-3_CanoR_1	271	276	PF00244	0.248
LIG_14-3-3_CanoR_1	67	77	PF00244	0.498
LIG_deltaCOP1_diTrp_1	131	139	PF00928	0.291
LIG_deltaCOP1_diTrp_1	310	316	PF00928	0.313
LIG_deltaCOP1_diTrp_1	331	335	PF00928	0.332
LIG_EH1_1	90	98	PF00400	0.315
LIG_FHA_1	179	185	PF00498	0.323
LIG_FHA_1	21	27	PF00498	0.442
LIG_FHA_1	255	261	PF00498	0.391
LIG_FHA_1	272	278	PF00498	0.312
LIG_FHA_1	32	38	PF00498	0.323
LIG_FHA_1	49	55	PF00498	0.444
LIG_FHA_2	254	260	PF00498	0.327
LIG_FHA_2	81	87	PF00498	0.347
LIG_LIR_Apic_2	333	338	PF02991	0.352
LIG_LIR_Gen_1	331	338	PF02991	0.335
LIG_LIR_Nem_3	195	201	PF02991	0.342
LIG_LIR_Nem_3	331	335	PF02991	0.332
LIG_SH2_CRK	50	54	PF00017	0.423
LIG_SH2_GRB2like	116	119	PF00017	0.443
LIG_SH2_SRC	116	119	PF00017	0.425
LIG_SH2_STAP1	198	202	PF00017	0.327
LIG_SH2_STAP1	50	54	PF00017	0.423
LIG_SH2_STAT5	201	204	PF00017	0.329
LIG_SH2_STAT5	207	210	PF00017	0.388
LIG_SH2_STAT5	349	352	PF00017	0.394
LIG_SH2_STAT5	362	365	PF00017	0.462
LIG_SH2_STAT5	50	53	PF00017	0.396
LIG_SH3_3	127	133	PF00018	0.291
LIG_SH3_3	208	214	PF00018	0.387
LIG_SH3_3	272	278	PF00018	0.495
LIG_SH3_5	361	365	PF00018	0.595
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.330
LIG_TRAF2_1	109	112	PF00917	0.343
LIG_WRC_WIRS_1	28	33	PF05994	0.296
MOD_CDC14_SPxK_1	160	163	PF00782	0.347
MOD_CDK_SPxK_1	157	163	PF00069	0.358
MOD_CK1_1	121	127	PF00069	0.358
MOD_CK2_1	80	86	PF00069	0.351
MOD_GlcNHglycan	59	62	PF01048	0.430
MOD_GlcNHglycan	71	74	PF01048	0.417
MOD_GSK3_1	27	34	PF00069	0.345
MOD_GSK3_1	350	357	PF00069	0.410
MOD_GSK3_1	57	64	PF00069	0.490
MOD_GSK3_1	69	76	PF00069	0.501
MOD_NEK2_1	10	15	PF00069	0.608
MOD_NEK2_1	146	151	PF00069	0.352
MOD_NEK2_1	196	201	PF00069	0.365
MOD_NEK2_1	253	258	PF00069	0.344
MOD_NEK2_1	299	304	PF00069	0.534
MOD_NEK2_1	31	36	PF00069	0.339
MOD_NEK2_1	350	355	PF00069	0.425
MOD_PIKK_1	116	122	PF00454	0.413
MOD_PKA_2	185	191	PF00069	0.297
MOD_PKA_2	253	259	PF00069	0.333
MOD_PKA_2	69	75	PF00069	0.547
MOD_Plk_1	194	200	PF00069	0.373
MOD_Plk_4	118	124	PF00069	0.442
MOD_Plk_4	149	155	PF00069	0.327
MOD_Plk_4	180	186	PF00069	0.297
MOD_Plk_4	350	356	PF00069	0.392
MOD_Plk_4	49	55	PF00069	0.304
MOD_ProDKin_1	157	163	PF00069	0.358
MOD_SUMO_rev_2	340	350	PF00179	0.376
TRG_DiLeu_BaEn_2	345	351	PF01217	0.382
TRG_ENDOCYTIC_2	207	210	PF00928	0.407
TRG_ENDOCYTIC_2	50	53	PF00928	0.323
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H6	Leptomonas seymouri	91%	99%
A0A0S4JN30	Bodo saltans	73%	99%
A0A1X0P631	Trypanosomatidae	85%	99%
A0A3S7X967	Leishmania donovani	98%	100%
A4HMM2	Leishmania braziliensis	96%	100%
A4IBA0	Leishmania infantum	98%	100%
C9ZZM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	99%
E9B680	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P0CB81	Pongo abelii	24%	98%
P0CB82	Pongo pygmaeus	24%	98%
P25284	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	98%
P34943	Bos taurus	27%	97%
Q0MQB3	Gorilla gorilla gorilla	24%	98%
Q0MQB4	Pan troglodytes	24%	98%
Q16795	Homo sapiens	24%	98%
Q559Z0	Dictyostelium discoideum	26%	100%
Q5BK63	Rattus norvegicus	26%	98%
Q9DC69	Mus musculus	27%	98%
V5ATG2	Trypanosoma cruzi	84%	99%