40S ribosomal protein S6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S6, putative

Species:

Leishmania major

UniProt:

E9AF23_LEIMA

TriTrypDb:

LmjF.21.1780 , LMJLV39_210027300 , LMJSD75_210027500

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0005840	ribosome	5	19
GO:0032991	protein-containing complex	1	19
GO:0043226	organelle	2	19
GO:0043228	non-membrane-bounded organelle	3	19
GO:0043229	intracellular organelle	3	19
GO:0043232	intracellular non-membrane-bounded organelle	4	19
GO:0110165	cellular anatomical entity	1	19
GO:1990904	ribonucleoprotein complex	2	19

Expansion

Sequence features

E9AF23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF23

PDB structure(s): 5osg_P

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	19
GO:0006518	peptide metabolic process	4	19
GO:0006807	nitrogen compound metabolic process	2	19
GO:0008152	metabolic process	1	19
GO:0009058	biosynthetic process	2	19
GO:0009059	macromolecule biosynthetic process	4	19
GO:0009987	cellular process	1	19
GO:0019538	protein metabolic process	3	19
GO:0034641	cellular nitrogen compound metabolic process	3	19
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	19
GO:0043043	peptide biosynthetic process	5	19
GO:0043170	macromolecule metabolic process	3	19
GO:0043603	amide metabolic process	3	19
GO:0043604	amide biosynthetic process	4	19
GO:0044237	cellular metabolic process	2	19
GO:0044238	primary metabolic process	2	19
GO:0044249	cellular biosynthetic process	3	19
GO:0044260	obsolete cellular macromolecule metabolic process	3	19
GO:0044271	cellular nitrogen compound biosynthetic process	4	19
GO:0071704	organic substance metabolic process	2	19
GO:1901564	organonitrogen compound metabolic process	3	19
GO:1901566	organonitrogen compound biosynthetic process	4	19
GO:1901576	organic substance biosynthetic process	3	19

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	19
GO:0005198	structural molecule activity	1	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.342
CLV_NRD_NRD_1	134	136	PF00675	0.467
CLV_NRD_NRD_1	144	146	PF00675	0.385
CLV_NRD_NRD_1	156	158	PF00675	0.386
CLV_NRD_NRD_1	163	165	PF00675	0.406
CLV_NRD_NRD_1	190	192	PF00675	0.443
CLV_NRD_NRD_1	209	211	PF00675	0.439
CLV_NRD_NRD_1	220	222	PF00675	0.467
CLV_NRD_NRD_1	233	235	PF00675	0.503
CLV_NRD_NRD_1	24	26	PF00675	0.282
CLV_NRD_NRD_1	96	98	PF00675	0.282
CLV_PCSK_KEX2_1	134	136	PF00082	0.467
CLV_PCSK_KEX2_1	139	141	PF00082	0.391
CLV_PCSK_KEX2_1	162	164	PF00082	0.415
CLV_PCSK_KEX2_1	190	192	PF00082	0.444
CLV_PCSK_KEX2_1	209	211	PF00082	0.434
CLV_PCSK_KEX2_1	220	222	PF00082	0.470
CLV_PCSK_KEX2_1	24	26	PF00082	0.282
CLV_PCSK_KEX2_1	79	81	PF00082	0.301
CLV_PCSK_KEX2_1	95	97	PF00082	0.282
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.391
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.282
CLV_PCSK_PC7_1	135	141	PF00082	0.412
CLV_PCSK_PC7_1	186	192	PF00082	0.519
CLV_PCSK_SKI1_1	145	149	PF00082	0.408
CLV_PCSK_SKI1_1	164	168	PF00082	0.424
CLV_PCSK_SKI1_1	181	185	PF00082	0.348
CLV_PCSK_SKI1_1	190	194	PF00082	0.426
CLV_PCSK_SKI1_1	220	224	PF00082	0.603
CLV_Separin_Metazoa	21	25	PF03568	0.326
DEG_APCC_DBOX_1	209	217	PF00400	0.413
DEG_Nend_UBRbox_1	1	4	PF02207	0.301
DOC_CKS1_1	182	187	PF01111	0.545
DOC_CYCLIN_RxL_1	139	151	PF00134	0.493
DOC_MAPK_gen_1	209	215	PF00069	0.417
DOC_MAPK_gen_1	79	85	PF00069	0.322
DOC_MAPK_RevD_3	177	191	PF00069	0.419
DOC_PP2B_LxvP_1	174	177	PF13499	0.520
DOC_USP7_UBL2_3	139	143	PF12436	0.459
DOC_USP7_UBL2_3	167	171	PF12436	0.443
DOC_USP7_UBL2_3	231	235	PF12436	0.623
DOC_WW_Pin1_4	181	186	PF00397	0.541
LIG_14-3-3_CanoR_1	73	77	PF00244	0.324
LIG_FHA_1	151	157	PF00498	0.511
LIG_FHA_1	182	188	PF00498	0.422
LIG_FHA_1	231	237	PF00498	0.585
LIG_LIR_Gen_1	211	217	PF02991	0.421
LIG_LIR_Nem_3	211	215	PF02991	0.441
LIG_LIR_Nem_3	44	49	PF02991	0.293
LIG_LIR_Nem_3	60	65	PF02991	0.338
LIG_LIR_Nem_3	87	91	PF02991	0.334
LIG_PCNA_APIM_2	156	162	PF02747	0.392
LIG_Pex14_2	42	46	PF04695	0.298
LIG_SH2_STAT5	159	162	PF00017	0.415
LIG_SH2_STAT5	212	215	PF00017	0.418
LIG_SH2_STAT5	49	52	PF00017	0.282
LIG_SH3_3	60	66	PF00018	0.331
LIG_SUMO_SIM_anti_2	107	113	PF11976	0.284
LIG_SUMO_SIM_anti_2	71	78	PF11976	0.322
LIG_WRC_WIRS_1	85	90	PF05994	0.313
MOD_CDK_SPK_2	181	186	PF00069	0.589
MOD_CDK_SPxxK_3	181	188	PF00069	0.550
MOD_CK1_1	72	78	PF00069	0.301
MOD_CK2_1	148	154	PF00069	0.506
MOD_CK2_1	202	208	PF00069	0.416
MOD_Cter_Amidation	168	171	PF01082	0.447
MOD_GlcNHglycan	167	170	PF01048	0.577
MOD_GlcNHglycan	204	207	PF01048	0.434
MOD_GSK3_1	226	233	PF00069	0.570
MOD_GSK3_1	68	75	PF00069	0.411
MOD_LATS_1	228	234	PF00433	0.633
MOD_N-GLC_1	112	117	PF02516	0.383
MOD_N-GLC_1	148	153	PF02516	0.428
MOD_N-GLC_1	9	14	PF02516	0.282
MOD_NEK2_1	148	153	PF00069	0.528
MOD_NEK2_1	215	220	PF00069	0.468
MOD_NEK2_1	69	74	PF00069	0.404
MOD_NEK2_2	84	89	PF00069	0.313
MOD_PKA_1	139	145	PF00069	0.551
MOD_PKA_1	230	236	PF00069	0.599
MOD_PKA_2	139	145	PF00069	0.551
MOD_PKA_2	202	208	PF00069	0.412
MOD_PKA_2	72	78	PF00069	0.324
MOD_PKB_1	224	232	PF00069	0.631
MOD_PKB_1	52	60	PF00069	0.444
MOD_Plk_1	112	118	PF00069	0.353
MOD_Plk_4	72	78	PF00069	0.301
MOD_ProDKin_1	181	187	PF00069	0.535
TRG_DiLeu_BaEn_1	211	216	PF01217	0.434
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.389
TRG_DiLeu_LyEn_5	211	216	PF01217	0.492
TRG_ENDOCYTIC_2	212	215	PF00928	0.418
TRG_ER_diArg_1	133	135	PF00400	0.472
TRG_ER_diArg_1	161	164	PF00400	0.412
TRG_ER_diArg_1	223	226	PF00400	0.496
TRG_ER_diArg_1	23	25	PF00400	0.282
TRG_ER_diArg_1	51	54	PF00400	0.444
TRG_ER_diArg_1	95	97	PF00400	0.282
TRG_NES_CRM1_1	17	30	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6J8	Leptomonas seymouri	92%	100%
A0A0S4IXL4	Bodo saltans	74%	100%
A0A0S4JEL0	Bodo saltans	71%	94%
A0A1D8PL99	Candida albicans (strain SC5314 / ATCC MYA-2876)	49%	100%
A0A1X0NHJ4	Trypanosomatidae	74%	100%
A0A1X0P5W5	Trypanosomatidae	72%	100%
A0A3R7K8Y0	Trypanosoma rangeli	75%	100%
A0A3S7WWY7	Leishmania donovani	99%	100%
A0A3S7X972	Leishmania donovani	100%	100%
A0A422NNU2	Trypanosoma rangeli	75%	100%
A4HLC0	Leishmania braziliensis	96%	100%
A4HMM1	Leishmania braziliensis	96%	100%
A4HZI4	Leishmania infantum	100%	100%
C9ZZM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A0Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	91%
E9AVH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O01727	Branchiostoma floridae	45%	100%
O44012	Leishmania infantum	99%	100%
O48549	Arabidopsis thaliana	44%	100%
P05752	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P0CX37	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P0CX38	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P29327	Drosophila melanogaster	49%	100%
P29345	Nicotiana tabacum	43%	100%
P39017	Xenopus laevis	47%	100%
P41798	Kluyveromyces marxianus	55%	100%
P47838	Gallus gallus	50%	100%
P51430	Arabidopsis thaliana	47%	100%
P62753	Homo sapiens	50%	100%
P62754	Mus musculus	50%	100%
P62755	Rattus norvegicus	50%	100%
Q2PQM1	Glossina morsitans morsitans	48%	100%
Q4R4K6	Macaca fascicularis	50%	100%
Q54UU3	Dictyostelium discoideum	49%	100%
Q5E995	Bos taurus	50%	100%
Q6BXH8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	50%	100%
Q6C169	Yarrowia lipolytica (strain CLIB 122 / E 150)	49%	100%
Q6CM04	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	48%	100%
Q6FJH3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	47%	100%
Q74ZK3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	52%	100%
Q8SRY0	Encephalitozoon cuniculi (strain GB-M1)	39%	100%
Q90YR8	Ictalurus punctatus	47%	100%
Q94624	Manduca sexta	45%	98%
Q95V32	Spodoptera frugiperda	46%	98%
Q9BMX5	Aplysia californica	47%	100%
Q9C0Z7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
Q9M3V8	Asparagus officinalis	48%	99%
Q9NE83	Leishmania major	100%	100%
Q9NEN6	Caenorhabditis elegans	47%	100%
Q9U761	Aedes aegypti	46%	72%
Q9U762	Aedes albopictus	47%	71%
Q9YGF2	Oncorhynchus mykiss	47%	100%
V5B8X2	Trypanosoma cruzi	75%	100%