Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF22_LEIMA

TriTrypDb:

LmjF.35.2000 , LMJLV39_350026500 , LMJSD75_350025800

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	621	625	PF00656	0.482
CLV_NRD_NRD_1	15	17	PF00675	0.547
CLV_NRD_NRD_1	217	219	PF00675	0.518
CLV_NRD_NRD_1	3	5	PF00675	0.555
CLV_NRD_NRD_1	436	438	PF00675	0.602
CLV_NRD_NRD_1	565	567	PF00675	0.792
CLV_NRD_NRD_1	643	645	PF00675	0.488
CLV_NRD_NRD_1	658	660	PF00675	0.473
CLV_NRD_NRD_1	777	779	PF00675	0.486
CLV_NRD_NRD_1	871	873	PF00675	0.551
CLV_PCSK_FUR_1	352	356	PF00082	0.555
CLV_PCSK_FUR_1	434	438	PF00082	0.598
CLV_PCSK_KEX2_1	15	17	PF00082	0.607
CLV_PCSK_KEX2_1	217	219	PF00082	0.518
CLV_PCSK_KEX2_1	354	356	PF00082	0.555
CLV_PCSK_KEX2_1	436	438	PF00082	0.602
CLV_PCSK_KEX2_1	565	567	PF00082	0.744
CLV_PCSK_KEX2_1	585	587	PF00082	0.496
CLV_PCSK_KEX2_1	658	660	PF00082	0.473
CLV_PCSK_KEX2_1	776	778	PF00082	0.447
CLV_PCSK_KEX2_1	871	873	PF00082	0.550
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.533
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.585
CLV_PCSK_PC7_1	773	779	PF00082	0.511
CLV_PCSK_SKI1_1	18	22	PF00082	0.618
CLV_PCSK_SKI1_1	241	245	PF00082	0.513
CLV_PCSK_SKI1_1	256	260	PF00082	0.381
CLV_PCSK_SKI1_1	565	569	PF00082	0.655
CLV_PCSK_SKI1_1	632	636	PF00082	0.363
CLV_PCSK_SKI1_1	685	689	PF00082	0.383
CLV_PCSK_SKI1_1	851	855	PF00082	0.546
CLV_PCSK_SKI1_1	87	91	PF00082	0.731
CLV_PCSK_SKI1_1	97	101	PF00082	0.551
DEG_APCC_DBOX_1	684	692	PF00400	0.380
DEG_Nend_Nbox_1	1	3	PF02207	0.565
DEG_SCF_FBW7_2	88	94	PF00400	0.635
DEG_SPOP_SBC_1	743	747	PF00917	0.710
DOC_ANK_TNKS_1	802	809	PF00023	0.579
DOC_CDC14_PxL_1	717	725	PF14671	0.392
DOC_CKS1_1	789	794	PF01111	0.513
DOC_CKS1_1	834	839	PF01111	0.537
DOC_CKS1_1	88	93	PF01111	0.691
DOC_CYCLIN_yClb3_PxF_3	322	328	PF00134	0.563
DOC_MAPK_gen_1	644	652	PF00069	0.586
DOC_MAPK_gen_1	668	676	PF00069	0.415
DOC_MAPK_gen_1	773	781	PF00069	0.517
DOC_MAPK_MEF2A_6	230	239	PF00069	0.548
DOC_MAPK_MEF2A_6	304	313	PF00069	0.475
DOC_MAPK_MEF2A_6	34	42	PF00069	0.518
DOC_MAPK_MEF2A_6	644	652	PF00069	0.685
DOC_MAPK_MEF2A_6	698	707	PF00069	0.385
DOC_MAPK_NFAT4_5	645	653	PF00069	0.571
DOC_PP1_RVXF_1	352	359	PF00149	0.551
DOC_PP1_SILK_1	213	218	PF00149	0.500
DOC_PP2B_LxvP_1	547	550	PF13499	0.585
DOC_PP2B_LxvP_1	74	77	PF13499	0.587
DOC_USP7_MATH_1	160	164	PF00917	0.570
DOC_USP7_MATH_1	228	232	PF00917	0.545
DOC_USP7_MATH_1	263	267	PF00917	0.532
DOC_USP7_MATH_1	282	286	PF00917	0.368
DOC_USP7_MATH_1	288	292	PF00917	0.540
DOC_USP7_MATH_1	48	52	PF00917	0.573
DOC_USP7_MATH_1	573	577	PF00917	0.624
DOC_USP7_MATH_1	604	608	PF00917	0.558
DOC_USP7_MATH_1	75	79	PF00917	0.620
DOC_USP7_MATH_1	750	754	PF00917	0.552
DOC_USP7_MATH_1	852	856	PF00917	0.569
DOC_USP7_UBL2_3	585	589	PF12436	0.627
DOC_WW_Pin1_4	151	156	PF00397	0.535
DOC_WW_Pin1_4	203	208	PF00397	0.524
DOC_WW_Pin1_4	231	236	PF00397	0.577
DOC_WW_Pin1_4	24	29	PF00397	0.613
DOC_WW_Pin1_4	333	338	PF00397	0.602
DOC_WW_Pin1_4	380	385	PF00397	0.462
DOC_WW_Pin1_4	52	57	PF00397	0.572
DOC_WW_Pin1_4	733	738	PF00397	0.606
DOC_WW_Pin1_4	746	751	PF00397	0.569
DOC_WW_Pin1_4	788	793	PF00397	0.526
DOC_WW_Pin1_4	833	838	PF00397	0.588
DOC_WW_Pin1_4	87	92	PF00397	0.692
LIG_14-3-3_CanoR_1	209	216	PF00244	0.559
LIG_14-3-3_CanoR_1	230	235	PF00244	0.565
LIG_14-3-3_CanoR_1	267	271	PF00244	0.627
LIG_14-3-3_CanoR_1	355	359	PF00244	0.499
LIG_14-3-3_CanoR_1	632	638	PF00244	0.431
LIG_14-3-3_CanoR_1	644	649	PF00244	0.495
LIG_14-3-3_CanoR_1	716	721	PF00244	0.393
LIG_14-3-3_CanoR_1	851	857	PF00244	0.511
LIG_Actin_WH2_2	194	211	PF00022	0.594
LIG_Actin_WH2_2	495	512	PF00022	0.486
LIG_Actin_WH2_2	669	687	PF00022	0.413
LIG_BIR_III_4	271	275	PF00653	0.460
LIG_BRCT_BRCA1_1	162	166	PF00533	0.619
LIG_Clathr_ClatBox_1	327	331	PF01394	0.506
LIG_CtBP_PxDLS_1	704	709	PF00389	0.448
LIG_deltaCOP1_diTrp_1	157	161	PF00928	0.560
LIG_deltaCOP1_diTrp_1	305	312	PF00928	0.472
LIG_eIF4E_1	717	723	PF01652	0.390
LIG_FHA_1	183	189	PF00498	0.548
LIG_FHA_1	304	310	PF00498	0.542
LIG_FHA_1	389	395	PF00498	0.594
LIG_FHA_1	449	455	PF00498	0.369
LIG_FHA_1	509	515	PF00498	0.438
LIG_FHA_1	551	557	PF00498	0.770
LIG_FHA_1	633	639	PF00498	0.339
LIG_FHA_1	65	71	PF00498	0.544
LIG_FHA_1	717	723	PF00498	0.390
LIG_FHA_1	828	834	PF00498	0.578
LIG_FHA_1	859	865	PF00498	0.549
LIG_FHA_1	897	903	PF00498	0.624
LIG_FHA_1	907	913	PF00498	0.531
LIG_FHA_2	396	402	PF00498	0.449
LIG_FHA_2	517	523	PF00498	0.473
LIG_FHA_2	762	768	PF00498	0.490
LIG_FHA_2	816	822	PF00498	0.688
LIG_GBD_Chelix_1	420	428	PF00786	0.470
LIG_LIR_Gen_1	305	315	PF02991	0.474
LIG_LIR_Gen_1	725	734	PF02991	0.458
LIG_LIR_Nem_3	104	109	PF02991	0.487
LIG_LIR_Nem_3	305	311	PF02991	0.472
LIG_LIR_Nem_3	477	482	PF02991	0.428
LIG_LIR_Nem_3	518	523	PF02991	0.451
LIG_LIR_Nem_3	714	720	PF02991	0.423
LIG_LIR_Nem_3	725	730	PF02991	0.445
LIG_NRBOX	126	132	PF00104	0.576
LIG_NRBOX	462	468	PF00104	0.427
LIG_NRBOX	485	491	PF00104	0.356
LIG_NRBOX	633	639	PF00104	0.359
LIG_NRBOX	687	693	PF00104	0.393
LIG_PCNA_yPIPBox_3	835	846	PF02747	0.519
LIG_SH2_CRK	718	722	PF00017	0.388
LIG_SH2_NCK_1	496	500	PF00017	0.462
LIG_SH2_NCK_1	859	863	PF00017	0.515
LIG_SH2_SRC	794	797	PF00017	0.598
LIG_SH2_SRC	890	893	PF00017	0.524
LIG_SH2_STAP1	459	463	PF00017	0.342
LIG_SH2_STAP1	496	500	PF00017	0.462
LIG_SH2_STAT5	465	468	PF00017	0.372
LIG_SH2_STAT5	479	482	PF00017	0.389
LIG_SH2_STAT5	696	699	PF00017	0.481
LIG_SH2_STAT5	718	721	PF00017	0.392
LIG_SH2_STAT5	727	730	PF00017	0.408
LIG_SH3_1	85	91	PF00018	0.622
LIG_SH3_3	232	238	PF00018	0.587
LIG_SH3_3	32	38	PF00018	0.569
LIG_SH3_3	320	326	PF00018	0.557
LIG_SH3_3	432	438	PF00018	0.601
LIG_SH3_3	542	548	PF00018	0.465
LIG_SH3_3	649	655	PF00018	0.555
LIG_SH3_3	727	733	PF00018	0.499
LIG_SH3_3	786	792	PF00018	0.519
LIG_SH3_3	811	817	PF00018	0.696
LIG_SH3_3	831	837	PF00018	0.599
LIG_SH3_3	85	91	PF00018	0.633
LIG_SH3_3	899	905	PF00018	0.625
LIG_SUMO_SIM_anti_2	60	67	PF11976	0.604
LIG_SUMO_SIM_anti_2	69	74	PF11976	0.552
LIG_SUMO_SIM_par_1	635	643	PF11976	0.378
LIG_SUMO_SIM_par_1	880	886	PF11976	0.611
LIG_TRAF2_1	91	94	PF00917	0.641
LIG_TYR_ITIM	715	720	PF00017	0.398
LIG_UBA3_1	637	645	PF00899	0.411
MOD_CDC14_SPxK_1	206	209	PF00782	0.580
MOD_CDK_SPK_2	380	385	PF00069	0.449
MOD_CDK_SPxK_1	203	209	PF00069	0.584
MOD_CDK_SPxxK_3	833	840	PF00069	0.547
MOD_CK1_1	231	237	PF00069	0.572
MOD_CK1_1	254	260	PF00069	0.513
MOD_CK1_1	266	272	PF00069	0.431
MOD_CK1_1	27	33	PF00069	0.602
MOD_CK1_1	475	481	PF00069	0.483
MOD_CK1_1	491	497	PF00069	0.323
MOD_CK1_1	66	72	PF00069	0.634
MOD_CK1_1	745	751	PF00069	0.685
MOD_CK1_1	822	828	PF00069	0.637
MOD_CK1_1	855	861	PF00069	0.566
MOD_CK2_1	120	126	PF00069	0.537
MOD_CK2_1	129	135	PF00069	0.506
MOD_CK2_1	395	401	PF00069	0.456
MOD_CK2_1	516	522	PF00069	0.478
MOD_CK2_1	535	541	PF00069	0.291
MOD_CK2_1	633	639	PF00069	0.359
MOD_CK2_1	761	767	PF00069	0.508
MOD_CMANNOS	158	161	PF00535	0.502
MOD_Cter_Amidation	2	5	PF01082	0.590
MOD_Cter_Amidation	583	586	PF01082	0.585
MOD_GlcNHglycan	123	126	PF01048	0.468
MOD_GlcNHglycan	162	165	PF01048	0.543
MOD_GlcNHglycan	230	233	PF01048	0.618
MOD_GlcNHglycan	318	321	PF01048	0.544
MOD_GlcNHglycan	343	346	PF01048	0.628
MOD_GlcNHglycan	370	373	PF01048	0.638
MOD_GlcNHglycan	439	442	PF01048	0.647
MOD_GlcNHglycan	469	472	PF01048	0.427
MOD_GlcNHglycan	607	610	PF01048	0.482
MOD_GlcNHglycan	752	755	PF01048	0.672
MOD_GlcNHglycan	77	80	PF01048	0.626
MOD_GlcNHglycan	823	827	PF01048	0.656
MOD_GlcNHglycan	885	888	PF01048	0.652
MOD_GSK3_1	116	123	PF00069	0.462
MOD_GSK3_1	23	30	PF00069	0.632
MOD_GSK3_1	280	287	PF00069	0.529
MOD_GSK3_1	303	310	PF00069	0.499
MOD_GSK3_1	444	451	PF00069	0.573
MOD_GSK3_1	48	55	PF00069	0.585
MOD_GSK3_1	484	491	PF00069	0.529
MOD_GSK3_1	605	612	PF00069	0.478
MOD_GSK3_1	640	647	PF00069	0.466
MOD_GSK3_1	742	749	PF00069	0.748
MOD_GSK3_1	815	822	PF00069	0.654
MOD_GSK3_1	83	90	PF00069	0.643
MOD_GSK3_1	851	858	PF00069	0.531
MOD_GSK3_1	892	899	PF00069	0.606
MOD_GSK3_1	906	913	PF00069	0.501
MOD_N-GLC_1	484	489	PF02516	0.402
MOD_N-GLC_1	605	610	PF02516	0.486
MOD_NEK2_1	166	171	PF00069	0.580
MOD_NEK2_1	208	213	PF00069	0.563
MOD_NEK2_1	280	285	PF00069	0.621
MOD_NEK2_1	313	318	PF00069	0.495
MOD_NEK2_1	395	400	PF00069	0.489
MOD_NEK2_1	402	407	PF00069	0.424
MOD_NEK2_1	466	471	PF00069	0.397
MOD_NEK2_1	488	493	PF00069	0.411
MOD_NEK2_1	498	503	PF00069	0.408
MOD_NEK2_1	633	638	PF00069	0.362
MOD_NEK2_1	640	645	PF00069	0.433
MOD_NEK2_1	703	708	PF00069	0.397
MOD_NEK2_1	722	727	PF00069	0.387
MOD_NEK2_1	787	792	PF00069	0.578
MOD_PIKK_1	222	228	PF00454	0.598
MOD_PIKK_1	313	319	PF00454	0.509
MOD_PIKK_1	395	401	PF00454	0.408
MOD_PIKK_1	488	494	PF00454	0.399
MOD_PIKK_1	698	704	PF00454	0.371
MOD_PIKK_1	89	95	PF00454	0.613
MOD_PKA_1	354	360	PF00069	0.541
MOD_PKA_1	644	650	PF00069	0.538
MOD_PKA_2	208	214	PF00069	0.629
MOD_PKA_2	266	272	PF00069	0.481
MOD_PKA_2	303	309	PF00069	0.539
MOD_PKA_2	354	360	PF00069	0.476
MOD_PKA_2	475	481	PF00069	0.440
MOD_PKA_2	896	902	PF00069	0.573
MOD_PKB_1	16	24	PF00069	0.626
MOD_Plk_1	263	269	PF00069	0.538
MOD_Plk_1	484	490	PF00069	0.397
MOD_Plk_1	662	668	PF00069	0.464
MOD_Plk_2-3	618	624	PF00069	0.497
MOD_Plk_2-3	761	767	PF00069	0.508
MOD_Plk_4	241	247	PF00069	0.512
MOD_Plk_4	303	309	PF00069	0.493
MOD_Plk_4	444	450	PF00069	0.563
MOD_Plk_4	475	481	PF00069	0.483
MOD_Plk_4	484	490	PF00069	0.408
MOD_Plk_4	491	497	PF00069	0.335
MOD_Plk_4	498	504	PF00069	0.308
MOD_Plk_4	508	514	PF00069	0.368
MOD_Plk_4	633	639	PF00069	0.373
MOD_Plk_4	687	693	PF00069	0.407
MOD_Plk_4	703	709	PF00069	0.400
MOD_Plk_4	722	728	PF00069	0.392
MOD_ProDKin_1	151	157	PF00069	0.536
MOD_ProDKin_1	203	209	PF00069	0.520
MOD_ProDKin_1	231	237	PF00069	0.572
MOD_ProDKin_1	24	30	PF00069	0.615
MOD_ProDKin_1	333	339	PF00069	0.603
MOD_ProDKin_1	380	386	PF00069	0.461
MOD_ProDKin_1	52	58	PF00069	0.574
MOD_ProDKin_1	733	739	PF00069	0.614
MOD_ProDKin_1	746	752	PF00069	0.568
MOD_ProDKin_1	788	794	PF00069	0.529
MOD_ProDKin_1	833	839	PF00069	0.576
MOD_ProDKin_1	87	93	PF00069	0.694
MOD_SUMO_rev_2	780	790	PF00179	0.439
TRG_DiLeu_BaEn_1	126	131	PF01217	0.517
TRG_DiLeu_BaEn_1	595	600	PF01217	0.555
TRG_DiLeu_BaEn_4	595	601	PF01217	0.534
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.506
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.446
TRG_DiLeu_BaLyEn_6	629	634	PF01217	0.398
TRG_DiLeu_BaLyEn_6	718	723	PF01217	0.384
TRG_DiLeu_LyEn_5	126	131	PF01217	0.575
TRG_ENDOCYTIC_2	106	109	PF00928	0.546
TRG_ENDOCYTIC_2	459	462	PF00928	0.345
TRG_ENDOCYTIC_2	520	523	PF00928	0.331
TRG_ENDOCYTIC_2	717	720	PF00928	0.407
TRG_ENDOCYTIC_2	727	730	PF00928	0.464
TRG_ER_diArg_1	14	16	PF00400	0.548
TRG_ER_diArg_1	216	218	PF00400	0.517
TRG_ER_diArg_1	434	437	PF00400	0.599
TRG_ER_diArg_1	473	476	PF00400	0.437
TRG_ER_diArg_1	657	659	PF00400	0.472
TRG_ER_diArg_1	775	778	PF00400	0.445
TRG_ER_diArg_1	871	873	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA60	Leptomonas seymouri	48%	99%
A0A3Q8IV80	Leishmania donovani	93%	100%
A4HMM0	Leishmania braziliensis	75%	99%
A4IB98	Leishmania infantum	94%	100%
E9B678	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%