U3 small nucleolar RNA-associated protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nucleolar RNA-associated protein 6, putative

Species:

Leishmania major

UniProt:

E9AF21_LEIMA

TriTrypDb:

LmjF.35.1990 , LMJLV39_350026400 , LMJSD75_350025700

Length:

1062

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	2
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	2
GO:0110165	cellular anatomical entity	1	7
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5

Expansion

Sequence features

E9AF21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF21

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016072	rRNA metabolic process	7	7
GO:0030490	maturation of SSU-rRNA	9	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0030515	snoRNA binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	609	613	PF00656	0.511
CLV_C14_Caspase3-7	665	669	PF00656	0.510
CLV_C14_Caspase3-7	793	797	PF00656	0.560
CLV_NRD_NRD_1	1046	1048	PF00675	0.430
CLV_NRD_NRD_1	141	143	PF00675	0.356
CLV_NRD_NRD_1	207	209	PF00675	0.442
CLV_NRD_NRD_1	210	212	PF00675	0.484
CLV_NRD_NRD_1	307	309	PF00675	0.374
CLV_NRD_NRD_1	402	404	PF00675	0.605
CLV_NRD_NRD_1	428	430	PF00675	0.431
CLV_NRD_NRD_1	470	472	PF00675	0.508
CLV_NRD_NRD_1	478	480	PF00675	0.452
CLV_NRD_NRD_1	518	520	PF00675	0.597
CLV_NRD_NRD_1	679	681	PF00675	0.354
CLV_NRD_NRD_1	712	714	PF00675	0.542
CLV_NRD_NRD_1	871	873	PF00675	0.372
CLV_PCSK_FUR_1	677	681	PF00082	0.389
CLV_PCSK_KEX2_1	1046	1048	PF00082	0.430
CLV_PCSK_KEX2_1	120	122	PF00082	0.360
CLV_PCSK_KEX2_1	141	143	PF00082	0.398
CLV_PCSK_KEX2_1	212	214	PF00082	0.479
CLV_PCSK_KEX2_1	401	403	PF00082	0.607
CLV_PCSK_KEX2_1	427	429	PF00082	0.632
CLV_PCSK_KEX2_1	464	466	PF00082	0.598
CLV_PCSK_KEX2_1	470	472	PF00082	0.503
CLV_PCSK_KEX2_1	478	480	PF00082	0.430
CLV_PCSK_KEX2_1	517	519	PF00082	0.602
CLV_PCSK_KEX2_1	679	681	PF00082	0.353
CLV_PCSK_KEX2_1	68	70	PF00082	0.298
CLV_PCSK_KEX2_1	711	713	PF00082	0.563
CLV_PCSK_KEX2_1	871	873	PF00082	0.372
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.360
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.454
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.688
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.532
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.602
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.284
CLV_PCSK_PC7_1	208	214	PF00082	0.470
CLV_PCSK_PC7_1	424	430	PF00082	0.452
CLV_PCSK_SKI1_1	1033	1037	PF00082	0.437
CLV_PCSK_SKI1_1	213	217	PF00082	0.607
CLV_PCSK_SKI1_1	470	474	PF00082	0.473
CLV_PCSK_SKI1_1	49	53	PF00082	0.273
CLV_PCSK_SKI1_1	611	615	PF00082	0.520
CLV_PCSK_SKI1_1	732	736	PF00082	0.501
DEG_APCC_DBOX_1	185	193	PF00400	0.300
DEG_APCC_DBOX_1	678	686	PF00400	0.364
DEG_SCF_FBW7_2	418	425	PF00400	0.508
DEG_SPOP_SBC_1	383	387	PF00917	0.489
DEG_SPOP_SBC_1	507	511	PF00917	0.590
DEG_SPOP_SBC_1	817	821	PF00917	0.503
DEG_SPOP_SBC_1	998	1002	PF00917	0.521
DOC_CKS1_1	419	424	PF01111	0.535
DOC_CKS1_1	496	501	PF01111	0.560
DOC_CYCLIN_RxL_1	45	55	PF00134	0.273
DOC_CYCLIN_yCln2_LP_2	496	502	PF00134	0.501
DOC_MAPK_gen_1	141	147	PF00069	0.368
DOC_MAPK_gen_1	677	687	PF00069	0.363
DOC_MAPK_MEF2A_6	1047	1056	PF00069	0.434
DOC_MAPK_MEF2A_6	296	303	PF00069	0.349
DOC_MAPK_MEF2A_6	433	440	PF00069	0.347
DOC_MAPK_MEF2A_6	45	54	PF00069	0.273
DOC_PP1_RVXF_1	645	652	PF00149	0.351
DOC_PP4_FxxP_1	272	275	PF00568	0.350
DOC_PP4_MxPP_1	572	575	PF00568	0.604
DOC_SPAK_OSR1_1	647	651	PF12202	0.389
DOC_USP7_MATH_1	140	144	PF00917	0.357
DOC_USP7_MATH_1	333	337	PF00917	0.509
DOC_USP7_MATH_1	434	438	PF00917	0.487
DOC_USP7_MATH_1	481	485	PF00917	0.467
DOC_USP7_MATH_1	575	579	PF00917	0.622
DOC_USP7_MATH_1	785	789	PF00917	0.606
DOC_USP7_MATH_1	817	821	PF00917	0.551
DOC_USP7_UBL2_3	212	216	PF12436	0.446
DOC_USP7_UBL2_3	96	100	PF12436	0.336
DOC_WW_Pin1_4	271	276	PF00397	0.341
DOC_WW_Pin1_4	418	423	PF00397	0.551
DOC_WW_Pin1_4	441	446	PF00397	0.466
DOC_WW_Pin1_4	495	500	PF00397	0.546
DOC_WW_Pin1_4	629	634	PF00397	0.631
LIG_14-3-3_CanoR_1	1037	1042	PF00244	0.438
LIG_14-3-3_CanoR_1	1046	1051	PF00244	0.390
LIG_14-3-3_CanoR_1	141	147	PF00244	0.401
LIG_14-3-3_CanoR_1	158	166	PF00244	0.277
LIG_14-3-3_CanoR_1	331	339	PF00244	0.517
LIG_14-3-3_CanoR_1	377	383	PF00244	0.469
LIG_14-3-3_CanoR_1	490	499	PF00244	0.501
LIG_14-3-3_CanoR_1	522	532	PF00244	0.508
LIG_14-3-3_CanoR_1	57	63	PF00244	0.250
LIG_14-3-3_CanoR_1	738	746	PF00244	0.628
LIG_14-3-3_CanoR_1	755	761	PF00244	0.347
LIG_14-3-3_CanoR_1	762	770	PF00244	0.295
LIG_14-3-3_CanoR_1	864	869	PF00244	0.346
LIG_14-3-3_CanoR_1	913	923	PF00244	0.304
LIG_APCC_ABBA_1	920	925	PF00400	0.299
LIG_BIR_II_1	1	5	PF00653	0.399
LIG_BIR_III_3	1	5	PF00653	0.399
LIG_BRCT_BRCA1_1	1002	1006	PF00533	0.504
LIG_Clathr_ClatBox_1	51	55	PF01394	0.273
LIG_deltaCOP1_diTrp_1	1019	1027	PF00928	0.340
LIG_deltaCOP1_diTrp_1	144	152	PF00928	0.327
LIG_DLG_GKlike_1	124	131	PF00625	0.339
LIG_FHA_1	1008	1014	PF00498	0.402
LIG_FHA_1	238	244	PF00498	0.516
LIG_FHA_1	30	36	PF00498	0.273
LIG_FHA_1	377	383	PF00498	0.472
LIG_FHA_1	384	390	PF00498	0.475
LIG_FHA_1	491	497	PF00498	0.488
LIG_FHA_1	525	531	PF00498	0.472
LIG_FHA_1	557	563	PF00498	0.484
LIG_FHA_1	59	65	PF00498	0.249
LIG_FHA_1	594	600	PF00498	0.572
LIG_FHA_1	640	646	PF00498	0.355
LIG_FHA_1	856	862	PF00498	0.304
LIG_FHA_1	915	921	PF00498	0.318
LIG_FHA_2	1038	1044	PF00498	0.387
LIG_FHA_2	26	32	PF00498	0.273
LIG_FHA_2	264	270	PF00498	0.345
LIG_FHA_2	524	530	PF00498	0.574
LIG_FHA_2	545	551	PF00498	0.414
LIG_FHA_2	639	645	PF00498	0.365
LIG_FHA_2	7	13	PF00498	0.355
LIG_FHA_2	876	882	PF00498	0.355
LIG_LIR_Apic_2	269	275	PF02991	0.354
LIG_LIR_Gen_1	596	605	PF02991	0.572
LIG_LIR_Gen_1	848	857	PF02991	0.350
LIG_LIR_Gen_1	963	972	PF02991	0.390
LIG_LIR_Nem_3	1019	1024	PF02991	0.347
LIG_LIR_Nem_3	129	135	PF02991	0.463
LIG_LIR_Nem_3	151	155	PF02991	0.536
LIG_LIR_Nem_3	361	367	PF02991	0.415
LIG_LIR_Nem_3	43	47	PF02991	0.273
LIG_LIR_Nem_3	463	469	PF02991	0.495
LIG_LIR_Nem_3	596	600	PF02991	0.572
LIG_LIR_Nem_3	72	76	PF02991	0.305
LIG_LIR_Nem_3	759	764	PF02991	0.317
LIG_LIR_Nem_3	848	854	PF02991	0.365
LIG_LIR_Nem_3	963	968	PF02991	0.480
LIG_LIR_Nem_3	979	984	PF02991	0.368
LIG_MYND_3	921	925	PF01753	0.297
LIG_NRBOX	195	201	PF00104	0.429
LIG_NRBOX	281	287	PF00104	0.364
LIG_PCNA_yPIPBox_3	120	132	PF02747	0.343
LIG_PCNA_yPIPBox_3	186	200	PF02747	0.345
LIG_PCNA_yPIPBox_3	246	258	PF02747	0.460
LIG_Pex14_2	118	122	PF04695	0.331
LIG_Pex14_2	648	652	PF04695	0.344
LIG_RPA_C_Fungi	199	211	PF08784	0.430
LIG_SH2_CRK	76	80	PF00017	0.315
LIG_SH2_STAP1	378	382	PF00017	0.463
LIG_SH2_STAP1	965	969	PF00017	0.377
LIG_SH2_STAT5	1024	1027	PF00017	0.330
LIG_SH2_STAT5	22	25	PF00017	0.349
LIG_SH2_STAT5	367	370	PF00017	0.395
LIG_SH2_STAT5	378	381	PF00017	0.472
LIG_SH2_STAT5	388	391	PF00017	0.467
LIG_SH2_STAT5	73	76	PF00017	0.273
LIG_SH2_STAT5	835	838	PF00017	0.261
LIG_SH3_2	419	424	PF14604	0.494
LIG_SH3_2	630	635	PF14604	0.567
LIG_SH3_3	134	140	PF00018	0.361
LIG_SH3_3	416	422	PF00018	0.537
LIG_SH3_3	44	50	PF00018	0.323
LIG_SH3_3	549	555	PF00018	0.419
LIG_SH3_3	627	633	PF00018	0.587
LIG_SH3_3	694	700	PF00018	0.478
LIG_SH3_3	944	950	PF00018	0.475
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.393
LIG_SUMO_SIM_par_1	30	36	PF11976	0.273
LIG_SUMO_SIM_par_1	49	55	PF11976	0.273
LIG_TRAF2_1	28	31	PF00917	0.273
LIG_TRAF2_1	846	849	PF00917	0.435
LIG_UBA3_1	258	265	PF00899	0.380
LIG_UBA3_1	537	545	PF00899	0.375
LIG_UBA3_1	968	976	PF00899	0.393
LIG_WRC_WIRS_1	440	445	PF05994	0.386
LIG_WRC_WIRS_1	826	831	PF05994	0.310
MOD_CDC14_SPxK_1	632	635	PF00782	0.533
MOD_CDK_SPxK_1	418	424	PF00069	0.503
MOD_CDK_SPxK_1	629	635	PF00069	0.566
MOD_CK1_1	274	280	PF00069	0.354
MOD_CK1_1	334	340	PF00069	0.494
MOD_CK1_1	359	365	PF00069	0.380
MOD_CK1_1	396	402	PF00069	0.558
MOD_CK1_1	509	515	PF00069	0.609
MOD_CK1_1	717	723	PF00069	0.484
MOD_CK1_1	790	796	PF00069	0.630
MOD_CK1_1	803	809	PF00069	0.526
MOD_CK1_1	819	825	PF00069	0.448
MOD_CK1_1	843	849	PF00069	0.423
MOD_CK2_1	1006	1012	PF00069	0.478
MOD_CK2_1	1037	1043	PF00069	0.389
MOD_CK2_1	25	31	PF00069	0.273
MOD_CK2_1	263	269	PF00069	0.343
MOD_CK2_1	6	12	PF00069	0.353
MOD_CK2_1	762	768	PF00069	0.311
MOD_CK2_1	843	849	PF00069	0.423
MOD_CK2_1	875	881	PF00069	0.356
MOD_Cter_Amidation	869	872	PF01082	0.351
MOD_GlcNHglycan	1002	1005	PF01048	0.447
MOD_GlcNHglycan	23	26	PF01048	0.275
MOD_GlcNHglycan	240	243	PF01048	0.611
MOD_GlcNHglycan	276	279	PF01048	0.336
MOD_GlcNHglycan	314	317	PF01048	0.465
MOD_GlcNHglycan	333	336	PF01048	0.439
MOD_GlcNHglycan	393	396	PF01048	0.597
MOD_GlcNHglycan	446	449	PF01048	0.475
MOD_GlcNHglycan	483	486	PF01048	0.493
MOD_GlcNHglycan	567	570	PF01048	0.611
MOD_GlcNHglycan	624	627	PF01048	0.565
MOD_GlcNHglycan	668	671	PF01048	0.480
MOD_GlcNHglycan	701	704	PF01048	0.562
MOD_GlcNHglycan	707	710	PF01048	0.622
MOD_GlcNHglycan	716	719	PF01048	0.470
MOD_GlcNHglycan	739	742	PF01048	0.424
MOD_GlcNHglycan	764	767	PF01048	0.306
MOD_GlcNHglycan	781	784	PF01048	0.557
MOD_GlcNHglycan	789	792	PF01048	0.776
MOD_GlcNHglycan	804	808	PF01048	0.490
MOD_GlcNHglycan	837	840	PF01048	0.314
MOD_GlcNHglycan	842	845	PF01048	0.363
MOD_GlcNHglycan	931	934	PF01048	0.364
MOD_GlcNHglycan	989	992	PF01048	0.497
MOD_GSK3_1	153	160	PF00069	0.344
MOD_GSK3_1	21	28	PF00069	0.274
MOD_GSK3_1	29	36	PF00069	0.273
MOD_GSK3_1	314	321	PF00069	0.465
MOD_GSK3_1	331	338	PF00069	0.508
MOD_GSK3_1	393	400	PF00069	0.543
MOD_GSK3_1	486	493	PF00069	0.509
MOD_GSK3_1	503	510	PF00069	0.546
MOD_GSK3_1	629	636	PF00069	0.688
MOD_GSK3_1	717	724	PF00069	0.476
MOD_GSK3_1	790	797	PF00069	0.555
MOD_GSK3_1	816	823	PF00069	0.592
MOD_GSK3_1	875	882	PF00069	0.356
MOD_GSK3_1	935	942	PF00069	0.447
MOD_N-GLC_1	124	129	PF02516	0.333
MOD_N-GLC_1	513	518	PF02516	0.594
MOD_N-GLC_1	705	710	PF02516	0.524
MOD_N-GLC_1	736	741	PF02516	0.368
MOD_N-GLC_1	945	950	PF02516	0.493
MOD_NEK2_1	1006	1011	PF00069	0.459
MOD_NEK2_1	1027	1032	PF00069	0.349
MOD_NEK2_1	263	268	PF00069	0.338
MOD_NEK2_1	301	306	PF00069	0.469
MOD_NEK2_1	439	444	PF00069	0.437
MOD_NEK2_1	521	526	PF00069	0.614
MOD_NEK2_1	585	590	PF00069	0.585
MOD_NEK2_1	595	600	PF00069	0.530
MOD_NEK2_1	673	678	PF00069	0.425
MOD_NEK2_1	736	741	PF00069	0.368
MOD_NEK2_1	824	829	PF00069	0.355
MOD_NEK2_1	914	919	PF00069	0.540
MOD_NEK2_1	929	934	PF00069	0.285
MOD_PIKK_1	153	159	PF00454	0.372
MOD_PIKK_1	349	355	PF00454	0.458
MOD_PIKK_1	771	777	PF00454	0.475
MOD_PKA_1	1046	1052	PF00069	0.423
MOD_PKA_2	1046	1052	PF00069	0.405
MOD_PKA_2	140	146	PF00069	0.343
MOD_PKA_2	157	163	PF00069	0.283
MOD_PKA_2	356	362	PF00069	0.399
MOD_PKA_2	376	382	PF00069	0.382
MOD_PKA_2	521	527	PF00069	0.573
MOD_PKA_2	737	743	PF00069	0.553
MOD_PKA_2	875	881	PF00069	0.381
MOD_PKB_1	347	355	PF00069	0.436
MOD_PKB_1	862	870	PF00069	0.309
MOD_Plk_1	1027	1033	PF00069	0.363
MOD_Plk_1	29	35	PF00069	0.273
MOD_Plk_1	318	324	PF00069	0.523
MOD_Plk_1	383	389	PF00069	0.503
MOD_Plk_1	945	951	PF00069	0.426
MOD_Plk_2-3	544	550	PF00069	0.406
MOD_Plk_2-3	721	727	PF00069	0.435
MOD_Plk_4	1037	1043	PF00069	0.389
MOD_Plk_4	263	269	PF00069	0.343
MOD_Plk_4	359	365	PF00069	0.412
MOD_Plk_4	384	390	PF00069	0.480
MOD_Plk_4	393	399	PF00069	0.527
MOD_Plk_4	434	440	PF00069	0.349
MOD_Plk_4	756	762	PF00069	0.387
MOD_Plk_4	856	862	PF00069	0.304
MOD_Plk_4	977	983	PF00069	0.434
MOD_ProDKin_1	271	277	PF00069	0.340
MOD_ProDKin_1	418	424	PF00069	0.543
MOD_ProDKin_1	441	447	PF00069	0.471
MOD_ProDKin_1	495	501	PF00069	0.553
MOD_ProDKin_1	629	635	PF00069	0.632
TRG_DiLeu_BaEn_1	654	659	PF01217	0.364
TRG_DiLeu_BaEn_2	113	119	PF01217	0.328
TRG_DiLeu_BaEn_4	654	660	PF01217	0.368
TRG_DiLeu_BaEn_4	849	855	PF01217	0.385
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.349
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.273
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.485
TRG_ENDOCYTIC_2	1024	1027	PF00928	0.330
TRG_ENDOCYTIC_2	132	135	PF00928	0.502
TRG_ENDOCYTIC_2	367	370	PF00928	0.395
TRG_ENDOCYTIC_2	76	79	PF00928	0.305
TRG_ENDOCYTIC_2	965	968	PF00928	0.377
TRG_ER_diArg_1	140	142	PF00400	0.368
TRG_ER_diArg_1	347	350	PF00400	0.528
TRG_ER_diArg_1	354	357	PF00400	0.477
TRG_ER_diArg_1	427	429	PF00400	0.436
TRG_ER_diArg_1	469	471	PF00400	0.511
TRG_ER_diArg_1	477	479	PF00400	0.438
TRG_ER_diArg_1	677	680	PF00400	0.358
TRG_ER_diArg_1	711	713	PF00400	0.545
TRG_ER_diArg_1	861	864	PF00400	0.298
TRG_ER_diArg_1	871	873	PF00400	0.372
TRG_NLS_MonoExtC_3	207	212	PF00514	0.415
TRG_NLS_MonoExtN_4	208	215	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB0	Leptomonas seymouri	56%	100%
A0A3Q8II91	Leishmania donovani	92%	100%
A4HML9	Leishmania braziliensis	79%	100%
A4IB97	Leishmania infantum	92%	100%
E9B677	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%