Serine protease

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Serine protease

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF20_LEIMA

TriTrypDb:

LmjF.35.1980 , LMJLV39_350026300 , LMJSD75_350025600

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.612
CLV_NRD_NRD_1	3	5	PF00675	0.722
CLV_NRD_NRD_1	303	305	PF00675	0.615
CLV_NRD_NRD_1	34	36	PF00675	0.420
CLV_NRD_NRD_1	400	402	PF00675	0.652
CLV_NRD_NRD_1	449	451	PF00675	0.599
CLV_NRD_NRD_1	549	551	PF00675	0.599
CLV_NRD_NRD_1	555	557	PF00675	0.539
CLV_NRD_NRD_1	568	570	PF00675	0.550
CLV_PCSK_FUR_1	32	36	PF00082	0.443
CLV_PCSK_FUR_1	550	554	PF00082	0.615
CLV_PCSK_KEX2_1	142	144	PF00082	0.536
CLV_PCSK_KEX2_1	3	5	PF00082	0.722
CLV_PCSK_KEX2_1	302	304	PF00082	0.624
CLV_PCSK_KEX2_1	34	36	PF00082	0.420
CLV_PCSK_KEX2_1	552	554	PF00082	0.558
CLV_PCSK_KEX2_1	555	557	PF00082	0.558
CLV_PCSK_KEX2_1	567	569	PF00082	0.498
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.555
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.581
CLV_PCSK_PC7_1	298	304	PF00082	0.748
CLV_PCSK_SKI1_1	114	118	PF00082	0.483
CLV_PCSK_SKI1_1	283	287	PF00082	0.523
CLV_PCSK_SKI1_1	338	342	PF00082	0.575
CLV_PCSK_SKI1_1	431	435	PF00082	0.589
DEG_APCC_DBOX_1	128	136	PF00400	0.417
DEG_APCC_DBOX_1	449	457	PF00400	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DEG_SCF_FBW7_1	532	539	PF00400	0.574
DOC_ANK_TNKS_1	301	308	PF00023	0.713
DOC_CKS1_1	71	76	PF01111	0.469
DOC_MAPK_DCC_7	324	332	PF00069	0.551
DOC_MAPK_gen_1	3	9	PF00069	0.643
DOC_MAPK_gen_1	321	330	PF00069	0.535
DOC_MAPK_MEF2A_6	321	330	PF00069	0.544
DOC_PP2B_LxvP_1	196	199	PF13499	0.501
DOC_USP7_MATH_1	182	186	PF00917	0.487
DOC_USP7_MATH_1	290	294	PF00917	0.734
DOC_USP7_MATH_1	543	547	PF00917	0.727
DOC_USP7_UBL2_3	24	28	PF12436	0.516
DOC_WW_Pin1_4	402	407	PF00397	0.630
DOC_WW_Pin1_4	528	533	PF00397	0.821
DOC_WW_Pin1_4	536	541	PF00397	0.552
DOC_WW_Pin1_4	70	75	PF00397	0.461
LIG_14-3-3_CanoR_1	103	108	PF00244	0.445
LIG_14-3-3_CanoR_1	291	299	PF00244	0.753
LIG_14-3-3_CanoR_1	3	8	PF00244	0.698
LIG_14-3-3_CanoR_1	450	454	PF00244	0.589
LIG_14-3-3_CanoR_1	88	95	PF00244	0.484
LIG_Actin_WH2_2	127	144	PF00022	0.501
LIG_BRCT_BRCA1_1	271	275	PF00533	0.417
LIG_BRCT_BRCA1_1	347	351	PF00533	0.606
LIG_BRCT_BRCA1_1	353	357	PF00533	0.644
LIG_Clathr_ClatBox_1	278	282	PF01394	0.424
LIG_FHA_1	166	172	PF00498	0.535
LIG_FHA_1	216	222	PF00498	0.454
LIG_FHA_1	248	254	PF00498	0.431
LIG_FHA_1	61	67	PF00498	0.432
LIG_FHA_1	85	91	PF00498	0.476
LIG_FHA_2	217	223	PF00498	0.511
LIG_FHA_2	250	256	PF00498	0.467
LIG_FHA_2	295	301	PF00498	0.679
LIG_FHA_2	339	345	PF00498	0.561
LIG_FHA_2	373	379	PF00498	0.678
LIG_FHA_2	71	77	PF00498	0.442
LIG_FHA_2	92	98	PF00498	0.462
LIG_LIR_Apic_2	73	78	PF02991	0.494
LIG_LIR_Gen_1	173	182	PF02991	0.429
LIG_LIR_Gen_1	272	281	PF02991	0.396
LIG_LIR_Gen_1	407	416	PF02991	0.708
LIG_LIR_Gen_1	59	69	PF02991	0.472
LIG_LIR_Nem_3	173	177	PF02991	0.434
LIG_LIR_Nem_3	272	278	PF02991	0.391
LIG_LIR_Nem_3	30	36	PF02991	0.483
LIG_LIR_Nem_3	407	413	PF02991	0.712
LIG_LIR_Nem_3	474	480	PF02991	0.683
LIG_LIR_Nem_3	59	65	PF02991	0.488
LIG_LIR_Nem_3	76	80	PF02991	0.447
LIG_NRP_CendR_1	588	589	PF00754	0.588
LIG_Pex14_2	42	46	PF04695	0.503
LIG_PTB_Apo_2	151	158	PF02174	0.530
LIG_PTB_Apo_2	495	502	PF02174	0.725
LIG_PTB_Phospho_1	151	157	PF10480	0.553
LIG_PTB_Phospho_1	495	501	PF10480	0.620
LIG_SH2_GRB2like	345	348	PF00017	0.698
LIG_SH2_GRB2like	410	413	PF00017	0.763
LIG_SH2_NCK_1	410	414	PF00017	0.688
LIG_SH2_NCK_1	514	518	PF00017	0.699
LIG_SH2_PTP2	174	177	PF00017	0.434
LIG_SH2_SRC	410	413	PF00017	0.637
LIG_SH2_STAP1	15	19	PF00017	0.480
LIG_SH2_STAP1	270	274	PF00017	0.394
LIG_SH2_STAP1	514	518	PF00017	0.699
LIG_SH2_STAT3	81	84	PF00017	0.642
LIG_SH2_STAT5	157	160	PF00017	0.532
LIG_SH2_STAT5	174	177	PF00017	0.336
LIG_SH3_1	80	86	PF00018	0.514
LIG_SH3_2	83	88	PF14604	0.548
LIG_SH3_3	131	137	PF00018	0.429
LIG_SH3_3	534	540	PF00018	0.743
LIG_SH3_3	68	74	PF00018	0.375
LIG_SH3_3	80	86	PF00018	0.486
LIG_SH3_4	394	401	PF00018	0.669
LIG_SUMO_SIM_par_1	194	200	PF11976	0.482
LIG_SUMO_SIM_par_1	276	282	PF11976	0.420
LIG_TRAF2_1	293	296	PF00917	0.694
LIG_WRC_WIRS_1	383	388	PF05994	0.799
MOD_CK1_1	385	391	PF00069	0.735
MOD_CK1_1	531	537	PF00069	0.762
MOD_CK1_1	91	97	PF00069	0.469
MOD_CK2_1	178	184	PF00069	0.411
MOD_CK2_1	216	222	PF00069	0.487
MOD_CK2_1	249	255	PF00069	0.441
MOD_CK2_1	290	296	PF00069	0.710
MOD_GlcNHglycan	143	146	PF01048	0.521
MOD_GlcNHglycan	180	183	PF01048	0.580
MOD_GlcNHglycan	347	350	PF01048	0.612
MOD_GlcNHglycan	353	356	PF01048	0.638
MOD_GlcNHglycan	363	366	PF01048	0.554
MOD_GlcNHglycan	488	491	PF01048	0.701
MOD_GlcNHglycan	502	505	PF01048	0.635
MOD_GlcNHglycan	507	510	PF01048	0.695
MOD_GlcNHglycan	579	585	PF01048	0.560
MOD_GlcNHglycan	58	61	PF01048	0.595
MOD_GSK3_1	178	185	PF00069	0.434
MOD_GSK3_1	262	269	PF00069	0.429
MOD_GSK3_1	290	297	PF00069	0.688
MOD_GSK3_1	382	389	PF00069	0.767
MOD_GSK3_1	425	432	PF00069	0.582
MOD_GSK3_1	528	535	PF00069	0.796
MOD_GSK3_1	56	63	PF00069	0.556
MOD_GSK3_1	84	91	PF00069	0.484
MOD_N-GLC_1	165	170	PF02516	0.511
MOD_N-GLC_1	424	429	PF02516	0.587
MOD_N-GLC_1	434	439	PF02516	0.607
MOD_N-GLC_1	470	475	PF02516	0.733
MOD_N-GLC_1	543	548	PF02516	0.755
MOD_NEK2_1	123	128	PF00069	0.487
MOD_NEK2_1	2	7	PF00069	0.710
MOD_NEK2_1	215	220	PF00069	0.442
MOD_NEK2_1	234	239	PF00069	0.399
MOD_NEK2_1	249	254	PF00069	0.427
MOD_NEK2_1	262	267	PF00069	0.391
MOD_NEK2_1	317	322	PF00069	0.563
MOD_NEK2_1	351	356	PF00069	0.655
MOD_NEK2_1	37	42	PF00069	0.382
MOD_NEK2_1	386	391	PF00069	0.780
MOD_NEK2_1	465	470	PF00069	0.617
MOD_NEK2_1	47	52	PF00069	0.547
MOD_NEK2_1	95	100	PF00069	0.457
MOD_NEK2_2	182	187	PF00069	0.491
MOD_PIKK_1	290	296	PF00454	0.782
MOD_PIKK_1	358	364	PF00454	0.583
MOD_PIKK_1	97	103	PF00454	0.400
MOD_PK_1	3	9	PF00069	0.643
MOD_PKA_1	3	9	PF00069	0.643
MOD_PKA_2	2	8	PF00069	0.700
MOD_PKA_2	290	296	PF00069	0.760
MOD_PKA_2	449	455	PF00069	0.591
MOD_Plk_1	165	171	PF00069	0.511
MOD_Plk_1	216	222	PF00069	0.461
MOD_Plk_1	294	300	PF00069	0.633
MOD_Plk_1	37	43	PF00069	0.403
MOD_Plk_1	434	440	PF00069	0.632
MOD_Plk_1	543	549	PF00069	0.750
MOD_Plk_4	182	188	PF00069	0.495
MOD_Plk_4	234	240	PF00069	0.417
MOD_Plk_4	3	9	PF00069	0.711
MOD_Plk_4	328	334	PF00069	0.577
MOD_Plk_4	382	388	PF00069	0.721
MOD_Plk_4	465	471	PF00069	0.651
MOD_Plk_4	543	549	PF00069	0.721
MOD_ProDKin_1	402	408	PF00069	0.628
MOD_ProDKin_1	528	534	PF00069	0.821
MOD_ProDKin_1	536	542	PF00069	0.546
MOD_ProDKin_1	70	76	PF00069	0.466
MOD_SUMO_rev_2	144	150	PF00179	0.491
MOD_SUMO_rev_2	184	193	PF00179	0.554
MOD_SUMO_rev_2	255	262	PF00179	0.570
MOD_SUMO_rev_2	331	340	PF00179	0.529
MOD_SUMO_rev_2	436	443	PF00179	0.600
TRG_ENDOCYTIC_2	113	116	PF00928	0.490
TRG_ENDOCYTIC_2	174	177	PF00928	0.434
TRG_ENDOCYTIC_2	410	413	PF00928	0.646
TRG_ER_diArg_1	160	163	PF00400	0.475
TRG_ER_diArg_1	2	4	PF00400	0.659
TRG_ER_diArg_1	202	205	PF00400	0.474
TRG_ER_diArg_1	227	230	PF00400	0.592
TRG_ER_diArg_1	302	304	PF00400	0.647
TRG_ER_diArg_1	33	35	PF00400	0.438
TRG_ER_diArg_1	566	569	PF00400	0.576
TRG_NES_CRM1_1	97	108	PF08389	0.491
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	431	436	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P326	Leptomonas seymouri	79%	97%
A0A0S4JIC7	Bodo saltans	56%	100%
A0A1X0P7C6	Trypanosomatidae	68%	100%
A0A3Q8IM74	Leishmania donovani	97%	100%
A4HML8	Leishmania braziliensis	91%	100%
A4IB96	Leishmania infantum	97%	100%
C9ZZM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9B676	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5ATF8	Trypanosoma cruzi	68%	100%