UBX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubx domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AF19_LEIMA

TriTrypDb:

LmjF.35.1970 , LMJLV39_350026200 , LMJSD75_350025500

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AF19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF19

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0030433	ubiquitin-dependent ERAD pathway	6	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0050896	response to stimulus	1	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901698	response to nitrogen compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.384
CLV_NRD_NRD_1	117	119	PF00675	0.558
CLV_NRD_NRD_1	170	172	PF00675	0.407
CLV_NRD_NRD_1	177	179	PF00675	0.390
CLV_NRD_NRD_1	188	190	PF00675	0.326
CLV_NRD_NRD_1	265	267	PF00675	0.252
CLV_NRD_NRD_1	330	332	PF00675	0.474
CLV_PCSK_KEX2_1	117	119	PF00082	0.544
CLV_PCSK_KEX2_1	177	179	PF00082	0.409
CLV_PCSK_KEX2_1	188	190	PF00082	0.360
CLV_PCSK_KEX2_1	25	27	PF00082	0.392
CLV_PCSK_KEX2_1	265	267	PF00082	0.258
CLV_PCSK_KEX2_1	330	332	PF00082	0.474
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.546
CLV_PCSK_PC7_1	113	119	PF00082	0.360
CLV_PCSK_SKI1_1	163	167	PF00082	0.489
CLV_PCSK_SKI1_1	265	269	PF00082	0.331
CLV_PCSK_SKI1_1	296	300	PF00082	0.368
CLV_PCSK_SKI1_1	52	56	PF00082	0.427
CLV_Separin_Metazoa	168	172	PF03568	0.400
DEG_APCC_DBOX_1	162	170	PF00400	0.512
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DOC_MAPK_gen_1	8	16	PF00069	0.429
DOC_MAPK_MEF2A_6	8	16	PF00069	0.429
DOC_PP2B_LxvP_1	12	15	PF13499	0.461
DOC_USP7_MATH_1	232	236	PF00917	0.528
DOC_USP7_UBL2_3	230	234	PF12436	0.577
DOC_WW_Pin1_4	38	43	PF00397	0.370
LIG_14-3-3_CanoR_1	266	276	PF00244	0.252
LIG_APCC_ABBAyCdc20_2	234	240	PF00400	0.511
LIG_BRCT_BRCA1_1	67	71	PF00533	0.491
LIG_deltaCOP1_diTrp_1	119	127	PF00928	0.472
LIG_EVH1_1	301	305	PF00568	0.384
LIG_FHA_1	100	106	PF00498	0.469
LIG_FHA_1	248	254	PF00498	0.297
LIG_FHA_1	275	281	PF00498	0.382
LIG_FHA_1	55	61	PF00498	0.377
LIG_FHA_1	7	13	PF00498	0.360
LIG_FHA_2	18	24	PF00498	0.380
LIG_FHA_2	280	286	PF00498	0.271
LIG_LIR_Gen_1	31	42	PF02991	0.438
LIG_LIR_Nem_3	277	281	PF02991	0.290
LIG_LIR_Nem_3	31	37	PF02991	0.441
LIG_LIR_Nem_3	312	318	PF02991	0.362
LIG_NRBOX	165	171	PF00104	0.454
LIG_Pex14_2	116	120	PF04695	0.413
LIG_Pex14_2	297	301	PF04695	0.384
LIG_SH2_SRC	38	41	PF00017	0.373
LIG_SH2_STAP1	263	267	PF00017	0.354
LIG_SH2_STAT5	34	37	PF00017	0.303
LIG_SH2_STAT5	38	41	PF00017	0.313
LIG_SH2_STAT5	50	53	PF00017	0.431
LIG_SH3_3	252	258	PF00018	0.350
LIG_SH3_3	299	305	PF00018	0.280
LIG_SUMO_SIM_anti_2	57	68	PF11976	0.449
LIG_SUMO_SIM_par_1	279	285	PF11976	0.364
LIG_TRAF2_1	190	193	PF00917	0.524
LIG_TRAF2_1	20	23	PF00917	0.424
LIG_TRAF2_1	217	220	PF00917	0.512
LIG_UBA3_1	165	172	PF00899	0.503
MOD_CDK_SPK_2	38	43	PF00069	0.510
MOD_CK1_1	112	118	PF00069	0.410
MOD_CK2_1	153	159	PF00069	0.490
MOD_CK2_1	17	23	PF00069	0.384
MOD_CK2_1	279	285	PF00069	0.340
MOD_GlcNHglycan	155	158	PF01048	0.452
MOD_GlcNHglycan	227	230	PF01048	0.540
MOD_GlcNHglycan	258	261	PF01048	0.372
MOD_GSK3_1	240	247	PF00069	0.525
MOD_GSK3_1	287	294	PF00069	0.360
MOD_GSK3_1	71	78	PF00069	0.513
MOD_NEK2_1	64	69	PF00069	0.385
MOD_NEK2_1	71	76	PF00069	0.318
MOD_PIKK_1	232	238	PF00454	0.424
MOD_PKA_2	112	118	PF00069	0.457
MOD_PKA_2	225	231	PF00069	0.620
MOD_Plk_1	290	296	PF00069	0.384
MOD_Plk_1	6	12	PF00069	0.345
MOD_Plk_1	65	71	PF00069	0.446
MOD_Plk_4	274	280	PF00069	0.271
MOD_Plk_4	65	71	PF00069	0.429
MOD_Plk_4	78	84	PF00069	0.345
MOD_Plk_4	99	105	PF00069	0.396
MOD_ProDKin_1	38	44	PF00069	0.371
MOD_SUMO_for_1	200	203	PF00179	0.430
MOD_SUMO_rev_2	312	321	PF00179	0.312
TRG_DiLeu_BaEn_1	59	64	PF01217	0.393
TRG_ENDOCYTIC_2	34	37	PF00928	0.309
TRG_ER_diArg_1	116	118	PF00400	0.542
TRG_ER_diArg_1	146	149	PF00400	0.426
TRG_ER_diArg_1	265	267	PF00400	0.252
TRG_ER_diArg_1	329	331	PF00400	0.331
TRG_NES_CRM1_1	271	285	PF08389	0.325
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSJ2	Leptomonas seymouri	66%	100%
A0A0S4JEV1	Bodo saltans	31%	100%
A0A1X0P6W3	Trypanosomatidae	35%	100%
A0A3R7KII9	Trypanosoma rangeli	35%	100%
A0A3S7X998	Leishmania donovani	97%	100%
A4HML7	Leishmania braziliensis	92%	100%
A4IB95	Leishmania infantum	97%	100%
C9ZZL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B675	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q28BP9	Xenopus tropicalis	25%	75%
Q2HJD0	Bos taurus	24%	75%
Q6AZH6	Xenopus laevis	25%	75%
Q6GQ69	Xenopus laevis	27%	75%
Q9M0N1	Arabidopsis thaliana	27%	69%