LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AF16_LEIMA
TriTrypDb:
LmjF.35.1945 , LMJLV39_350025900 * , LMJSD75_350025200 *
Length:
620

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF16
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 38 42 PF00656 0.538
CLV_C14_Caspase3-7 43 47 PF00656 0.436
CLV_C14_Caspase3-7 509 513 PF00656 0.639
CLV_NRD_NRD_1 152 154 PF00675 0.663
CLV_NRD_NRD_1 302 304 PF00675 0.455
CLV_NRD_NRD_1 361 363 PF00675 0.537
CLV_NRD_NRD_1 371 373 PF00675 0.493
CLV_NRD_NRD_1 395 397 PF00675 0.592
CLV_NRD_NRD_1 471 473 PF00675 0.787
CLV_NRD_NRD_1 497 499 PF00675 0.816
CLV_NRD_NRD_1 531 533 PF00675 0.651
CLV_NRD_NRD_1 536 538 PF00675 0.627
CLV_NRD_NRD_1 557 559 PF00675 0.696
CLV_NRD_NRD_1 615 617 PF00675 0.598
CLV_NRD_NRD_1 91 93 PF00675 0.386
CLV_PCSK_KEX2_1 151 153 PF00082 0.664
CLV_PCSK_KEX2_1 302 304 PF00082 0.527
CLV_PCSK_KEX2_1 361 363 PF00082 0.537
CLV_PCSK_KEX2_1 371 373 PF00082 0.493
CLV_PCSK_KEX2_1 395 397 PF00082 0.592
CLV_PCSK_KEX2_1 471 473 PF00082 0.785
CLV_PCSK_KEX2_1 497 499 PF00082 0.795
CLV_PCSK_KEX2_1 536 538 PF00082 0.644
CLV_PCSK_KEX2_1 557 559 PF00082 0.696
CLV_PCSK_KEX2_1 615 617 PF00082 0.598
CLV_PCSK_PC7_1 147 153 PF00082 0.549
CLV_PCSK_PC7_1 532 538 PF00082 0.666
CLV_PCSK_PC7_1 553 559 PF00082 0.550
CLV_PCSK_SKI1_1 133 137 PF00082 0.510
CLV_PCSK_SKI1_1 206 210 PF00082 0.350
CLV_PCSK_SKI1_1 218 222 PF00082 0.377
CLV_PCSK_SKI1_1 591 595 PF00082 0.693
CLV_PCSK_SKI1_1 616 620 PF00082 0.590
DEG_APCC_DBOX_1 287 295 PF00400 0.517
DEG_SPOP_SBC_1 265 269 PF00917 0.468
DEG_SPOP_SBC_1 462 466 PF00917 0.682
DEG_SPOP_SBC_1 61 65 PF00917 0.547
DEG_SPOP_SBC_1 84 88 PF00917 0.472
DOC_CKS1_1 134 139 PF01111 0.488
DOC_CKS1_1 476 481 PF01111 0.613
DOC_CYCLIN_yCln2_LP_2 444 450 PF00134 0.639
DOC_MAPK_gen_1 151 159 PF00069 0.642
DOC_MAPK_gen_1 340 348 PF00069 0.531
DOC_MAPK_MEF2A_6 342 350 PF00069 0.528
DOC_MIT_MIM_1 201 210 PF04212 0.464
DOC_PP4_FxxP_1 221 224 PF00568 0.414
DOC_PP4_FxxP_1 373 376 PF00568 0.640
DOC_PP4_FxxP_1 476 479 PF00568 0.619
DOC_USP7_MATH_1 135 139 PF00917 0.545
DOC_USP7_MATH_1 163 167 PF00917 0.625
DOC_USP7_MATH_1 353 357 PF00917 0.527
DOC_USP7_MATH_1 414 418 PF00917 0.716
DOC_USP7_MATH_1 45 49 PF00917 0.624
DOC_USP7_MATH_1 463 467 PF00917 0.758
DOC_USP7_MATH_1 486 490 PF00917 0.648
DOC_USP7_MATH_1 572 576 PF00917 0.629
DOC_USP7_MATH_1 593 597 PF00917 0.694
DOC_USP7_MATH_1 607 611 PF00917 0.546
DOC_USP7_MATH_1 61 65 PF00917 0.580
DOC_USP7_UBL2_3 93 97 PF12436 0.412
DOC_WW_Pin1_4 107 112 PF00397 0.465
DOC_WW_Pin1_4 133 138 PF00397 0.509
DOC_WW_Pin1_4 249 254 PF00397 0.731
DOC_WW_Pin1_4 443 448 PF00397 0.616
DOC_WW_Pin1_4 475 480 PF00397 0.620
DOC_WW_Pin1_4 5 10 PF00397 0.388
DOC_WW_Pin1_4 514 519 PF00397 0.622
DOC_WW_Pin1_4 568 573 PF00397 0.593
LIG_14-3-3_CanoR_1 16 25 PF00244 0.462
LIG_14-3-3_CanoR_1 206 211 PF00244 0.348
LIG_14-3-3_CanoR_1 27 31 PF00244 0.392
LIG_14-3-3_CanoR_1 361 365 PF00244 0.545
LIG_14-3-3_CanoR_1 366 373 PF00244 0.646
LIG_14-3-3_CanoR_1 395 402 PF00244 0.581
LIG_14-3-3_CanoR_1 434 440 PF00244 0.621
LIG_14-3-3_CanoR_1 471 479 PF00244 0.698
LIG_14-3-3_CanoR_1 548 556 PF00244 0.660
LIG_14-3-3_CanoR_1 557 563 PF00244 0.604
LIG_14-3-3_CanoR_1 580 589 PF00244 0.588
LIG_14-3-3_CanoR_1 591 599 PF00244 0.637
LIG_14-3-3_CanoR_1 72 78 PF00244 0.462
LIG_14-3-3_CanoR_1 92 96 PF00244 0.387
LIG_BIR_II_1 1 5 PF00653 0.410
LIG_BRCT_BRCA1_1 472 476 PF00533 0.712
LIG_FHA_1 215 221 PF00498 0.395
LIG_FHA_1 490 496 PF00498 0.577
LIG_FHA_1 550 556 PF00498 0.646
LIG_FHA_1 78 84 PF00498 0.488
LIG_FHA_2 117 123 PF00498 0.382
LIG_FHA_2 168 174 PF00498 0.617
LIG_FHA_2 188 194 PF00498 0.473
LIG_FHA_2 472 478 PF00498 0.634
LIG_FHA_2 76 82 PF00498 0.467
LIG_IBAR_NPY_1 399 401 PF08397 0.568
LIG_Integrin_RGD_1 503 505 PF01839 0.720
LIG_LIR_Apic_2 473 479 PF02991 0.631
LIG_LIR_Gen_1 204 214 PF02991 0.367
LIG_LIR_Gen_1 94 103 PF02991 0.364
LIG_LIR_Nem_3 204 210 PF02991 0.403
LIG_LIR_Nem_3 410 416 PF02991 0.636
LIG_LIR_Nem_3 94 98 PF02991 0.412
LIG_MYND_1 447 451 PF01753 0.532
LIG_MYND_1 482 486 PF01753 0.542
LIG_SH2_CRK 103 107 PF00017 0.425
LIG_SH2_CRK 413 417 PF00017 0.628
LIG_SH2_STAP1 103 107 PF00017 0.425
LIG_SH2_STAP1 212 216 PF00017 0.401
LIG_SH2_STAT5 13 16 PF00017 0.383
LIG_SH2_STAT5 388 391 PF00017 0.640
LIG_SH2_STAT5 401 404 PF00017 0.573
LIG_SH3_3 3 9 PF00018 0.376
LIG_SH3_3 444 450 PF00018 0.687
LIG_SH3_3 476 482 PF00018 0.599
LIG_SH3_3 528 534 PF00018 0.615
LIG_SUMO_SIM_par_1 189 197 PF11976 0.466
LIG_SUMO_SIM_par_1 78 88 PF11976 0.454
MOD_CDK_SPxK_1 133 139 PF00069 0.555
MOD_CDK_SPxxK_3 5 12 PF00069 0.384
MOD_CK1_1 2 8 PF00069 0.460
MOD_CK1_1 35 41 PF00069 0.482
MOD_CK1_1 356 362 PF00069 0.492
MOD_CK1_1 378 384 PF00069 0.573
MOD_CK1_1 406 412 PF00069 0.759
MOD_CK1_1 427 433 PF00069 0.653
MOD_CK1_1 464 470 PF00069 0.650
MOD_CK1_1 489 495 PF00069 0.611
MOD_CK1_1 507 513 PF00069 0.638
MOD_CK1_1 539 545 PF00069 0.723
MOD_CK1_1 547 553 PF00069 0.627
MOD_CK1_1 575 581 PF00069 0.607
MOD_CK1_1 582 588 PF00069 0.598
MOD_CK2_1 116 122 PF00069 0.382
MOD_CK2_1 16 22 PF00069 0.385
MOD_CK2_1 187 193 PF00069 0.482
MOD_CK2_1 73 79 PF00069 0.381
MOD_GlcNHglycan 160 163 PF01048 0.661
MOD_GlcNHglycan 249 252 PF01048 0.555
MOD_GlcNHglycan 385 388 PF01048 0.598
MOD_GlcNHglycan 389 392 PF01048 0.600
MOD_GlcNHglycan 41 45 PF01048 0.621
MOD_GlcNHglycan 426 429 PF01048 0.695
MOD_GlcNHglycan 435 438 PF01048 0.616
MOD_GlcNHglycan 46 50 PF01048 0.523
MOD_GlcNHglycan 539 542 PF01048 0.666
MOD_GlcNHglycan 565 569 PF01048 0.742
MOD_GlcNHglycan 582 585 PF01048 0.485
MOD_GlcNHglycan 609 612 PF01048 0.683
MOD_GlcNHglycan 65 68 PF01048 0.707
MOD_GlcNHglycan 87 90 PF01048 0.450
MOD_GSK3_1 133 140 PF00069 0.550
MOD_GSK3_1 163 170 PF00069 0.675
MOD_GSK3_1 227 234 PF00069 0.607
MOD_GSK3_1 243 250 PF00069 0.493
MOD_GSK3_1 28 35 PF00069 0.545
MOD_GSK3_1 356 363 PF00069 0.534
MOD_GSK3_1 371 378 PF00069 0.489
MOD_GSK3_1 383 390 PF00069 0.791
MOD_GSK3_1 461 468 PF00069 0.773
MOD_GSK3_1 471 478 PF00069 0.598
MOD_GSK3_1 537 544 PF00069 0.646
MOD_GSK3_1 547 554 PF00069 0.674
MOD_GSK3_1 564 571 PF00069 0.795
MOD_GSK3_1 572 579 PF00069 0.601
MOD_GSK3_1 589 596 PF00069 0.614
MOD_GSK3_1 73 80 PF00069 0.492
MOD_LATS_1 422 428 PF00433 0.571
MOD_N-GLC_1 32 37 PF02516 0.549
MOD_NEK2_1 116 121 PF00069 0.473
MOD_NEK2_1 167 172 PF00069 0.603
MOD_NEK2_1 26 31 PF00069 0.400
MOD_NEK2_1 264 269 PF00069 0.622
MOD_NEK2_1 389 394 PF00069 0.527
MOD_NEK2_1 454 459 PF00069 0.627
MOD_NEK2_1 589 594 PF00069 0.611
MOD_NEK2_1 62 67 PF00069 0.604
MOD_NEK2_1 73 78 PF00069 0.338
MOD_NEK2_1 83 88 PF00069 0.397
MOD_NEK2_2 435 440 PF00069 0.546
MOD_PIKK_1 353 359 PF00454 0.544
MOD_PIKK_1 366 372 PF00454 0.433
MOD_PKA_1 371 377 PF00069 0.563
MOD_PKA_1 471 477 PF00069 0.706
MOD_PKA_1 536 542 PF00069 0.717
MOD_PKA_2 26 32 PF00069 0.351
MOD_PKA_2 35 41 PF00069 0.451
MOD_PKA_2 360 366 PF00069 0.507
MOD_PKA_2 371 377 PF00069 0.538
MOD_PKA_2 394 400 PF00069 0.588
MOD_PKA_2 406 412 PF00069 0.733
MOD_PKA_2 433 439 PF00069 0.692
MOD_PKA_2 454 460 PF00069 0.640
MOD_PKA_2 470 476 PF00069 0.607
MOD_PKA_2 496 502 PF00069 0.715
MOD_PKA_2 536 542 PF00069 0.649
MOD_PKA_2 547 553 PF00069 0.653
MOD_PKA_2 579 585 PF00069 0.634
MOD_PKA_2 91 97 PF00069 0.387
MOD_PKB_1 243 251 PF00069 0.585
MOD_Plk_1 2 8 PF00069 0.384
MOD_Plk_1 257 263 PF00069 0.606
MOD_Plk_4 187 193 PF00069 0.482
MOD_Plk_4 2 8 PF00069 0.384
MOD_Plk_4 50 56 PF00069 0.581
MOD_ProDKin_1 107 113 PF00069 0.457
MOD_ProDKin_1 133 139 PF00069 0.519
MOD_ProDKin_1 249 255 PF00069 0.731
MOD_ProDKin_1 443 449 PF00069 0.617
MOD_ProDKin_1 475 481 PF00069 0.618
MOD_ProDKin_1 5 11 PF00069 0.390
MOD_ProDKin_1 514 520 PF00069 0.620
MOD_ProDKin_1 568 574 PF00069 0.594
TRG_DiLeu_BaEn_1 304 309 PF01217 0.451
TRG_ENDOCYTIC_2 103 106 PF00928 0.420
TRG_ENDOCYTIC_2 413 416 PF00928 0.653
TRG_ER_diArg_1 151 153 PF00400 0.619
TRG_ER_diArg_1 242 245 PF00400 0.594
TRG_ER_diArg_1 285 288 PF00400 0.516
TRG_ER_diArg_1 301 303 PF00400 0.362
TRG_ER_diArg_1 339 342 PF00400 0.478
TRG_ER_diArg_1 371 373 PF00400 0.533
TRG_ER_diArg_1 439 442 PF00400 0.640
TRG_ER_diArg_1 470 472 PF00400 0.774
TRG_ER_diArg_1 497 500 PF00400 0.634
TRG_ER_diArg_1 556 558 PF00400 0.667
TRG_ER_diArg_1 614 616 PF00400 0.594
TRG_NES_CRM1_1 320 335 PF08389 0.517
TRG_Pf-PMV_PEXEL_1 206 211 PF00026 0.348
TRG_Pf-PMV_PEXEL_1 403 408 PF00026 0.592
TRG_Pf-PMV_PEXEL_1 560 565 PF00026 0.617

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBH3 Leptomonas seymouri 45% 94%
A0A3S7X983 Leishmania donovani 90% 100%
A4HML5 Leishmania braziliensis 74% 100%
A4IB92 Leishmania infantum 91% 100%
E9B672 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS