Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AF15_LEIMA

TriTrypDb:

LmjF.35.1940 , LMJLV39_350025800 , LMJSD75_350025100

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.705
CLV_NRD_NRD_1	437	439	PF00675	0.661
CLV_PCSK_FUR_1	108	112	PF00082	0.646
CLV_PCSK_KEX2_1	110	112	PF00082	0.705
CLV_Separin_Metazoa	187	191	PF03568	0.566
CLV_Separin_Metazoa	316	320	PF03568	0.553
DEG_APCC_DBOX_1	213	221	PF00400	0.404
DEG_APCC_KENBOX_2	408	412	PF00400	0.665
DEG_SPOP_SBC_1	250	254	PF00917	0.574
DOC_MAPK_gen_1	212	220	PF00069	0.401
DOC_MAPK_gen_1	438	448	PF00069	0.622
DOC_MAPK_MEF2A_6	214	222	PF00069	0.412
DOC_PP2B_LxvP_1	135	138	PF13499	0.670
DOC_PP2B_LxvP_1	97	100	PF13499	0.640
DOC_PP4_FxxP_1	340	343	PF00568	0.576
DOC_PP4_FxxP_1	345	348	PF00568	0.548
DOC_USP7_MATH_1	119	123	PF00917	0.588
DOC_USP7_MATH_1	243	247	PF00917	0.759
DOC_USP7_MATH_1	249	253	PF00917	0.692
DOC_USP7_MATH_1	262	266	PF00917	0.704
DOC_USP7_MATH_1	267	271	PF00917	0.639
DOC_USP7_MATH_1	280	284	PF00917	0.520
DOC_USP7_MATH_1	296	300	PF00917	0.566
DOC_USP7_MATH_1	384	388	PF00917	0.518
DOC_USP7_MATH_1	59	63	PF00917	0.569
DOC_USP7_MATH_1	83	87	PF00917	0.651
DOC_USP7_MATH_1	88	92	PF00917	0.618
DOC_WW_Pin1_4	125	130	PF00397	0.640
DOC_WW_Pin1_4	141	146	PF00397	0.730
DOC_WW_Pin1_4	156	161	PF00397	0.447
DOC_WW_Pin1_4	245	250	PF00397	0.678
DOC_WW_Pin1_4	26	31	PF00397	0.496
DOC_WW_Pin1_4	271	276	PF00397	0.772
DOC_WW_Pin1_4	364	369	PF00397	0.534
DOC_WW_Pin1_4	6	11	PF00397	0.630
LIG_14-3-3_CanoR_1	380	384	PF00244	0.587
LIG_14-3-3_CanoR_1	63	73	PF00244	0.547
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BIR_III_4	58	62	PF00653	0.555
LIG_BRCT_BRCA1_1	412	416	PF00533	0.552
LIG_deltaCOP1_diTrp_1	327	333	PF00928	0.503
LIG_FHA_1	10	16	PF00498	0.603
LIG_FHA_1	110	116	PF00498	0.576
LIG_FHA_1	152	158	PF00498	0.539
LIG_FHA_1	380	386	PF00498	0.517
LIG_FHA_1	431	437	PF00498	0.576
LIG_FHA_1	94	100	PF00498	0.748
LIG_LIR_Apic_2	397	402	PF02991	0.625
LIG_LIR_Gen_1	76	85	PF02991	0.507
LIG_LIR_Nem_3	171	177	PF02991	0.507
LIG_LIR_Nem_3	246	250	PF02991	0.640
LIG_LIR_Nem_3	300	306	PF02991	0.470
LIG_LIR_Nem_3	327	332	PF02991	0.552
LIG_LIR_Nem_3	76	82	PF02991	0.489
LIG_PDZ_Class_2	443	448	PF00595	0.645
LIG_Pex14_1	329	333	PF04695	0.513
LIG_Pex14_2	206	210	PF04695	0.469
LIG_PTB_Apo_2	188	195	PF02174	0.568
LIG_SH2_CRK	247	251	PF00017	0.644
LIG_SH2_CRK	321	325	PF00017	0.474
LIG_SH2_GRB2like	73	76	PF00017	0.609
LIG_SH2_NCK_1	79	83	PF00017	0.576
LIG_SH2_STAP1	73	77	PF00017	0.517
LIG_SH2_STAT3	332	335	PF00017	0.516
LIG_SH2_STAT5	114	117	PF00017	0.688
LIG_SH2_STAT5	177	180	PF00017	0.496
LIG_SH2_STAT5	332	335	PF00017	0.516
LIG_SH2_STAT5	376	379	PF00017	0.575
LIG_SH2_STAT5	39	42	PF00017	0.478
LIG_SH3_3	140	146	PF00018	0.693
LIG_SH3_3	270	276	PF00018	0.682
LIG_SH3_3	386	392	PF00018	0.530
LIG_TRAF2_1	237	240	PF00917	0.631
LIG_WRC_WIRS_1	5	10	PF05994	0.570
MOD_CDC14_SPxK_1	248	251	PF00782	0.690
MOD_CDK_SPxK_1	245	251	PF00069	0.689
MOD_CK1_1	122	128	PF00069	0.648
MOD_CK1_1	139	145	PF00069	0.693
MOD_CK1_1	148	154	PF00069	0.585
MOD_GlcNHglycan	138	141	PF01048	0.695
MOD_GlcNHglycan	164	167	PF01048	0.562
MOD_GlcNHglycan	253	256	PF01048	0.662
MOD_GlcNHglycan	31	34	PF01048	0.744
MOD_GlcNHglycan	386	389	PF01048	0.532
MOD_GlcNHglycan	90	93	PF01048	0.629
MOD_GSK3_1	141	148	PF00069	0.702
MOD_GSK3_1	152	159	PF00069	0.511
MOD_GSK3_1	194	201	PF00069	0.566
MOD_GSK3_1	245	252	PF00069	0.630
MOD_GSK3_1	262	269	PF00069	0.603
MOD_GSK3_1	278	285	PF00069	0.664
MOD_GSK3_1	83	90	PF00069	0.630
MOD_N-GLC_1	194	199	PF02516	0.566
MOD_N-GLC_1	278	283	PF02516	0.558
MOD_N-GLC_1	410	415	PF02516	0.570
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	194	199	PF00069	0.566
MOD_NEK2_1	378	383	PF00069	0.676
MOD_PIKK_1	109	115	PF00454	0.628
MOD_PKA_1	438	444	PF00069	0.647
MOD_PKA_2	109	115	PF00069	0.628
MOD_PKA_2	119	125	PF00069	0.611
MOD_PKA_2	148	154	PF00069	0.656
MOD_PKA_2	213	219	PF00069	0.455
MOD_PKA_2	379	385	PF00069	0.588
MOD_Plk_1	194	200	PF00069	0.581
MOD_Plk_4	1	7	PF00069	0.575
MOD_Plk_4	152	158	PF00069	0.602
MOD_Plk_4	213	219	PF00069	0.494
MOD_Plk_4	430	436	PF00069	0.652
MOD_ProDKin_1	125	131	PF00069	0.638
MOD_ProDKin_1	141	147	PF00069	0.730
MOD_ProDKin_1	156	162	PF00069	0.439
MOD_ProDKin_1	245	251	PF00069	0.679
MOD_ProDKin_1	26	32	PF00069	0.491
MOD_ProDKin_1	271	277	PF00069	0.770
MOD_ProDKin_1	364	370	PF00069	0.526
MOD_ProDKin_1	6	12	PF00069	0.632
MOD_SUMO_for_1	257	260	PF00179	0.657
TRG_DiLeu_BaEn_1	443	448	PF01217	0.620
TRG_DiLeu_BaEn_4	239	245	PF01217	0.639
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.655
TRG_ENDOCYTIC_2	247	250	PF00928	0.644
TRG_ENDOCYTIC_2	321	324	PF00928	0.472
TRG_ENDOCYTIC_2	79	82	PF00928	0.572
TRG_ER_diArg_1	108	111	PF00400	0.797

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ4	Leptomonas seymouri	48%	97%
A0A3S5H7Z2	Leishmania donovani	93%	100%
A4HML4	Leishmania braziliensis	77%	100%
A4IB91	Leishmania infantum	93%	100%
E9B671	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%