LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
E9AF14_LEIMA
TriTrypDb:
LmjF.35.1930 * , LMJLV39_350025700 * , LMJSD75_350025000 *
Length:
339

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9AF14
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.603
CLV_C14_Caspase3-7 74 78 PF00656 0.673
CLV_NRD_NRD_1 107 109 PF00675 0.420
CLV_NRD_NRD_1 261 263 PF00675 0.418
CLV_NRD_NRD_1 330 332 PF00675 0.607
CLV_NRD_NRD_1 46 48 PF00675 0.484
CLV_PCSK_KEX2_1 107 109 PF00082 0.457
CLV_PCSK_KEX2_1 261 263 PF00082 0.417
CLV_PCSK_KEX2_1 46 48 PF00082 0.436
CLV_PCSK_PC7_1 42 48 PF00082 0.400
CLV_PCSK_SKI1_1 107 111 PF00082 0.469
CLV_PCSK_SKI1_1 316 320 PF00082 0.624
CLV_PCSK_SKI1_1 95 99 PF00082 0.471
DEG_MDM2_SWIB_1 275 283 PF02201 0.214
DEG_Nend_UBRbox_1 1 4 PF02207 0.621
DEG_SPOP_SBC_1 214 218 PF00917 0.610
DOC_CKS1_1 186 191 PF01111 0.634
DOC_PP2B_LxvP_1 149 152 PF13499 0.663
DOC_USP7_MATH_1 143 147 PF00917 0.666
DOC_USP7_MATH_1 209 213 PF00917 0.712
DOC_USP7_MATH_1 214 218 PF00917 0.568
DOC_USP7_MATH_1 234 238 PF00917 0.578
DOC_USP7_MATH_1 64 68 PF00917 0.677
DOC_USP7_MATH_2 143 149 PF00917 0.625
DOC_WW_Pin1_4 185 190 PF00397 0.629
DOC_WW_Pin1_4 236 241 PF00397 0.658
DOC_WW_Pin1_4 58 63 PF00397 0.822
DOC_WW_Pin1_4 65 70 PF00397 0.754
LIG_14-3-3_CanoR_1 10 18 PF00244 0.614
LIG_14-3-3_CanoR_1 107 116 PF00244 0.570
LIG_14-3-3_CanoR_1 95 103 PF00244 0.619
LIG_Actin_WH2_2 26 44 PF00022 0.591
LIG_BIR_III_4 84 88 PF00653 0.610
LIG_deltaCOP1_diTrp_1 111 122 PF00928 0.599
LIG_FHA_1 11 17 PF00498 0.692
LIG_FHA_1 181 187 PF00498 0.627
LIG_FHA_1 96 102 PF00498 0.591
LIG_LIR_Gen_1 163 174 PF02991 0.591
LIG_LIR_Gen_1 188 194 PF02991 0.636
LIG_LIR_Gen_1 241 252 PF02991 0.597
LIG_LIR_Gen_1 35 45 PF02991 0.597
LIG_LIR_Nem_3 163 169 PF02991 0.594
LIG_LIR_Nem_3 188 193 PF02991 0.633
LIG_LIR_Nem_3 35 41 PF02991 0.593
LIG_LIR_Nem_3 91 96 PF02991 0.669
LIG_NRBOX 325 331 PF00104 0.410
LIG_PDZ_Class_1 334 339 PF00595 0.442
LIG_Pex14_1 122 126 PF04695 0.592
LIG_Pex14_1 272 276 PF04695 0.310
LIG_Pex14_2 275 279 PF04695 0.214
LIG_PTB_Apo_2 184 191 PF02174 0.604
LIG_SH2_CRK 170 174 PF00017 0.585
LIG_SH2_CRK 38 42 PF00017 0.595
LIG_SH2_SRC 200 203 PF00017 0.605
LIG_SH2_STAP1 170 174 PF00017 0.585
LIG_SH2_STAP1 307 311 PF00017 0.423
LIG_SH2_STAT5 38 41 PF00017 0.599
LIG_SH2_STAT5 93 96 PF00017 0.601
LIG_SH3_3 183 189 PF00018 0.626
LIG_SUMO_SIM_par_1 248 253 PF11976 0.604
LIG_TYR_ITIM 305 310 PF00017 0.381
MOD_CDC14_SPxK_1 239 242 PF00782 0.663
MOD_CDK_SPxK_1 236 242 PF00069 0.660
MOD_CK1_1 286 292 PF00069 0.310
MOD_CK2_1 215 221 PF00069 0.709
MOD_CK2_1 253 259 PF00069 0.618
MOD_CK2_1 64 70 PF00069 0.758
MOD_CMANNOS 155 158 PF00535 0.387
MOD_Cter_Amidation 259 262 PF01082 0.402
MOD_GlcNHglycan 144 148 PF01048 0.472
MOD_GlcNHglycan 289 292 PF01048 0.302
MOD_GlcNHglycan 84 88 PF01048 0.437
MOD_GSK3_1 209 216 PF00069 0.612
MOD_GSK3_1 234 241 PF00069 0.658
MOD_GSK3_1 283 290 PF00069 0.283
MOD_GSK3_1 32 39 PF00069 0.581
MOD_GSK3_1 64 71 PF00069 0.749
MOD_NEK2_1 265 270 PF00069 0.612
MOD_NEK2_1 277 282 PF00069 0.355
MOD_NEK2_1 287 292 PF00069 0.459
MOD_NEK2_1 306 311 PF00069 0.363
MOD_NEK2_1 318 323 PF00069 0.397
MOD_NEK2_1 40 45 PF00069 0.602
MOD_PIKK_1 131 137 PF00454 0.628
MOD_PIKK_1 215 221 PF00454 0.638
MOD_PIKK_1 318 324 PF00454 0.399
MOD_PKA_1 107 113 PF00069 0.625
MOD_PKA_2 107 113 PF00069 0.625
MOD_PKA_2 260 266 PF00069 0.611
MOD_Plk_1 252 258 PF00069 0.646
MOD_Plk_1 36 42 PF00069 0.583
MOD_Plk_2-3 159 165 PF00069 0.565
MOD_Plk_2-3 253 259 PF00069 0.615
MOD_Plk_4 306 312 PF00069 0.370
MOD_Plk_4 325 331 PF00069 0.536
MOD_Plk_4 36 42 PF00069 0.593
MOD_ProDKin_1 185 191 PF00069 0.628
MOD_ProDKin_1 236 242 PF00069 0.658
MOD_ProDKin_1 58 64 PF00069 0.820
MOD_ProDKin_1 65 71 PF00069 0.754
TRG_DiLeu_BaEn_1 36 41 PF01217 0.589
TRG_DiLeu_BaEn_4 111 117 PF01217 0.621
TRG_ENDOCYTIC_2 170 173 PF00928 0.588
TRG_ENDOCYTIC_2 307 310 PF00928 0.382
TRG_ENDOCYTIC_2 38 41 PF00928 0.599
TRG_ER_diArg_1 101 104 PF00400 0.647
TRG_ER_diArg_1 107 109 PF00400 0.602
TRG_ER_diArg_1 261 264 PF00400 0.628
TRG_ER_diArg_1 45 47 PF00400 0.678
TRG_NES_CRM1_1 22 36 PF08389 0.598
TRG_Pf-PMV_PEXEL_1 95 99 PF00026 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9K1 Leptomonas seymouri 39% 100%
A0A3Q8IG78 Leishmania donovani 90% 100%
A4HML3 Leishmania braziliensis 70% 100%
A4IB90 Leishmania infantum 89% 100%
E9B670 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS