Putative 60S ribosomal protein L5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L5, putative

Species:

Leishmania major

UniProt:

E9AF10_LEIMA

TriTrypDb:

LmjF.35.1880 , LMJLV39_350025400 , LMJSD75_350024600

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0005737	cytoplasm	2	12
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0044391	ribosomal subunit	3	3
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	9
GO:0005840	ribosome	5	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

E9AF10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF10

PDB structure(s): 6az3_O

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	3
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	3
GO:0019538	protein metabolic process	3	12
GO:0022607	cellular component assembly	4	3
GO:0022618	ribonucleoprotein complex assembly	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0043933	protein-containing complex organization	4	3
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0065003	protein-containing complex assembly	5	3
GO:0071704	organic substance metabolic process	2	12
GO:0071826	ribonucleoprotein complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0008097	5S rRNA binding	6	12
GO:0019843	rRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.549
CLV_NRD_NRD_1	130	132	PF00675	0.259
CLV_NRD_NRD_1	46	48	PF00675	0.291
CLV_NRD_NRD_1	56	58	PF00675	0.291
CLV_PCSK_FUR_1	44	48	PF00082	0.291
CLV_PCSK_KEX2_1	130	132	PF00082	0.259
CLV_PCSK_KEX2_1	311	313	PF00082	0.333
CLV_PCSK_KEX2_1	37	39	PF00082	0.291
CLV_PCSK_KEX2_1	44	46	PF00082	0.291
CLV_PCSK_KEX2_1	56	58	PF00082	0.291
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.333
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.291
CLV_PCSK_SKI1_1	172	176	PF00082	0.259
CLV_PCSK_SKI1_1	238	242	PF00082	0.506
CLV_PCSK_SKI1_1	28	32	PF00082	0.452
CLV_PCSK_SKI1_1	289	293	PF00082	0.297
DEG_APCC_DBOX_1	129	137	PF00400	0.459
DEG_Nend_UBRbox_4	1	3	PF02207	0.361
DEG_SPOP_SBC_1	180	184	PF00917	0.459
DOC_MAPK_gen_1	130	138	PF00069	0.459
DOC_MAPK_gen_1	71	78	PF00069	0.475
DOC_MAPK_MEF2A_6	172	179	PF00069	0.459
DOC_MAPK_MEF2A_6	71	78	PF00069	0.460
DOC_PP1_RVXF_1	249	256	PF00149	0.581
DOC_PP2B_LxvP_1	22	25	PF13499	0.375
DOC_PP4_FxxP_1	67	70	PF00568	0.473
DOC_SPAK_OSR1_1	38	42	PF12202	0.491
DOC_USP7_MATH_1	148	152	PF00917	0.514
DOC_USP7_MATH_1	281	285	PF00917	0.550
DOC_USP7_MATH_1	297	301	PF00917	0.528
DOC_USP7_UBL2_3	285	289	PF12436	0.473
DOC_USP7_UBL2_3	33	37	PF12436	0.440
DOC_WW_Pin1_4	66	71	PF00397	0.473
LIG_14-3-3_CanoR_1	130	134	PF00244	0.514
LIG_14-3-3_CanoR_1	181	189	PF00244	0.457
LIG_eIF4E_1	122	128	PF01652	0.459
LIG_FHA_1	122	128	PF00498	0.459
LIG_FHA_1	301	307	PF00498	0.535
LIG_FHA_2	155	161	PF00498	0.459
LIG_FHA_2	77	83	PF00498	0.473
LIG_LIR_Apic_2	65	70	PF02991	0.473
LIG_LIR_Gen_1	23	34	PF02991	0.371
LIG_LIR_Nem_3	149	155	PF02991	0.465
LIG_LIR_Nem_3	23	29	PF02991	0.400
LIG_LIR_Nem_3	69	75	PF02991	0.473
LIG_PTB_Apo_2	29	36	PF02174	0.440
LIG_PTB_Phospho_1	29	35	PF10480	0.440
LIG_SH2_CRK	152	156	PF00017	0.459
LIG_SH2_CRK	72	76	PF00017	0.473
LIG_SH2_NCK_1	118	122	PF00017	0.459
LIG_SH2_STAP1	102	106	PF00017	0.459
LIG_SH2_STAP1	118	122	PF00017	0.459
LIG_SH2_STAT3	236	239	PF00017	0.419
LIG_SH2_STAT5	236	239	PF00017	0.419
LIG_SH2_STAT5	35	38	PF00017	0.480
LIG_SH3_2	203	208	PF14604	0.566
LIG_SH3_3	200	206	PF00018	0.473
LIG_UBA3_1	83	91	PF00899	0.450
MOD_CDK_SPK_2	66	71	PF00069	0.325
MOD_CDK_SPxxK_3	66	73	PF00069	0.325
MOD_CK1_1	300	306	PF00069	0.434
MOD_CK2_1	304	310	PF00069	0.347
MOD_GlcNHglycan	152	155	PF01048	0.427
MOD_GlcNHglycan	306	309	PF01048	0.450
MOD_GSK3_1	14	21	PF00069	0.380
MOD_GSK3_1	150	157	PF00069	0.356
MOD_GSK3_1	300	307	PF00069	0.306
MOD_GSK3_1	62	69	PF00069	0.325
MOD_NEK2_1	179	184	PF00069	0.303
MOD_PKA_1	13	19	PF00069	0.386
MOD_PKA_1	304	310	PF00069	0.423
MOD_PKA_2	129	135	PF00069	0.382
MOD_PKA_2	180	186	PF00069	0.303
MOD_PKA_2	76	82	PF00069	0.325
MOD_Plk_1	214	220	PF00069	0.574
MOD_Plk_2-3	215	221	PF00069	0.529
MOD_ProDKin_1	66	72	PF00069	0.325
MOD_SUMO_for_1	240	243	PF00179	0.511
MOD_SUMO_for_1	291	294	PF00179	0.336
MOD_SUMO_rev_2	215	223	PF00179	0.567
MOD_SUMO_rev_2	243	253	PF00179	0.495
TRG_ENDOCYTIC_2	152	155	PF00928	0.306
TRG_ENDOCYTIC_2	72	75	PF00928	0.325
TRG_ER_diArg_1	43	46	PF00400	0.350
TRG_NLS_Bipartite_1	273	293	PF00514	0.325
TRG_NLS_MonoExtC_3	288	293	PF00514	0.339
TRG_NLS_MonoExtN_4	288	293	PF00514	0.343
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P958	Leptomonas seymouri	91%	100%
A0A0S4JJ00	Bodo saltans	80%	100%
A0A1X0P669	Trypanosomatidae	84%	100%
A0A3Q8IJC5	Leishmania donovani	99%	100%
A2WXX3	Oryza sativa subsp. indica	51%	100%
A4HMK9	Leishmania braziliensis	95%	100%
A4IB88	Leishmania infantum	99%	100%
C9ZZL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9AF09	Leishmania major	100%	100%
E9B665	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O22608	Dunaliella salina	49%	100%
O44248	Anopheles gambiae	55%	100%
O59953	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	53%	100%
O65353	Helianthus annuus	51%	100%
O74306	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
O76190	Bombyx mori	52%	100%
P09895	Rattus norvegicus	56%	100%
P15125	Xenopus laevis	55%	100%
P15126	Xenopus laevis	55%	100%
P22451	Gallus gallus	57%	100%
P26321	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	100%
P46777	Homo sapiens	57%	100%
P47962	Mus musculus	56%	100%
P49227	Arabidopsis thaliana	54%	100%
P49405	Caenorhabditis elegans	56%	100%
P52822	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
Q0JGY1	Oryza sativa subsp. japonica	51%	100%
Q1HQU2	Aedes aegypti	55%	100%
Q231U7	Tetrahymena thermophila (strain SB210)	50%	100%
Q26481	Styela clava	52%	100%
Q4KTI3	Suberites domuncula	54%	100%
Q4N655	Theileria parva	53%	100%
Q4R5M0	Macaca fascicularis	56%	100%
Q4UDE7	Theileria annulata	52%	100%
Q54XX3	Dictyostelium discoideum	55%	100%
Q56FG6	Lysiphlebus testaceipes	51%	100%
Q58DW5	Bos taurus	57%	100%
Q5AGZ7	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	100%
Q5EY89	Eimeria tenella	53%	100%
Q5XUC7	Toxoptera citricida	50%	100%
Q627R7	Caenorhabditis briggsae	56%	100%
Q6JWW5	Oikopleura dioica	52%	100%
Q6UNT2	Cucumis sativus	52%	100%
Q8L4L4	Oryza sativa subsp. japonica	52%	100%
Q8LBI1	Arabidopsis thaliana	54%	100%
Q9W5R8	Drosophila melanogaster	53%	100%
V5BHY0	Trypanosoma cruzi	77%	100%