Putative 60S ribosomal protein L5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L5, putative

Species:

Leishmania major

UniProt:

E9AF10_LEIMA

TriTrypDb:

LmjF.35.1880 , LMJLV39_350025400 , LMJSD75_350024600

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0005730	nucleolus	5	3
GO:0005737	cytoplasm	2	12
GO:0005840	ribosome	5	9
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	9
GO:0043228	non-membrane-bounded organelle	3	12

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Expansion

Sequence features

E9AF10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF10

PDB structure(s): 6az3_O

Function

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Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	3
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	3
GO:0019538	protein metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0008097	5S rRNA binding	6	12
GO:0019843	rRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.549
CLV_NRD_NRD_1	130	132	PF00675	0.259
CLV_NRD_NRD_1	46	48	PF00675	0.291
CLV_NRD_NRD_1	56	58	PF00675	0.291
CLV_PCSK_FUR_1	44	48	PF00082	0.291
CLV_PCSK_KEX2_1	130	132	PF00082	0.259
CLV_PCSK_KEX2_1	311	313	PF00082	0.333
CLV_PCSK_KEX2_1	37	39	PF00082	0.291
CLV_PCSK_KEX2_1	44	46	PF00082	0.291
CLV_PCSK_KEX2_1	56	58	PF00082	0.291

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P958	Leptomonas seymouri	91%	100%
A0A0S4JJ00	Bodo saltans	80%	100%
A0A1X0P669	Trypanosomatidae	84%	100%
A0A3Q8IJC5	Leishmania donovani	99%	100%
A2WXX3	Oryza sativa subsp. indica	51%	100%
A4HMK9	Leishmania braziliensis	95%	100%
A4IB88	Leishmania infantum	99%	100%
C9ZZL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9AF09	Leishmania major	100%	100%
E9B665	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%

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