Putative 60S ribosomal protein L5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L5, putative

Species:

Leishmania major

UniProt:

E9AF09_LEIMA

TriTrypDb:

LmjF.35.1880 , LMJLV39_350025200 , LMJSD75_350024600

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0005737	cytoplasm	2	12
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0044391	ribosomal subunit	3	3
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	9
GO:0005840	ribosome	5	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

E9AF09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF09

PDB structure(s): 6az3_O

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	3
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	3
GO:0019538	protein metabolic process	3	12
GO:0022607	cellular component assembly	4	3
GO:0022618	ribonucleoprotein complex assembly	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0043933	protein-containing complex organization	4	3
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0065003	protein-containing complex assembly	5	3
GO:0071704	organic substance metabolic process	2	12
GO:0071826	ribonucleoprotein complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0008097	5S rRNA binding	6	12
GO:0019843	rRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.603
CLV_NRD_NRD_1	107	109	PF00675	0.307
CLV_NRD_NRD_1	23	25	PF00675	0.349
CLV_NRD_NRD_1	33	35	PF00675	0.349
CLV_PCSK_FUR_1	21	25	PF00082	0.349
CLV_PCSK_KEX2_1	107	109	PF00082	0.307
CLV_PCSK_KEX2_1	14	16	PF00082	0.349
CLV_PCSK_KEX2_1	21	23	PF00082	0.349
CLV_PCSK_KEX2_1	288	290	PF00082	0.389
CLV_PCSK_KEX2_1	33	35	PF00082	0.349
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.349
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.389
CLV_PCSK_SKI1_1	149	153	PF00082	0.318
CLV_PCSK_SKI1_1	215	219	PF00082	0.569
CLV_PCSK_SKI1_1	266	270	PF00082	0.349
CLV_PCSK_SKI1_1	5	9	PF00082	0.510
DEG_APCC_DBOX_1	106	114	PF00400	0.518
DEG_SPOP_SBC_1	157	161	PF00917	0.518
DOC_MAPK_gen_1	107	115	PF00069	0.518
DOC_MAPK_gen_1	48	55	PF00069	0.534
DOC_MAPK_MEF2A_6	149	156	PF00069	0.518
DOC_MAPK_MEF2A_6	48	55	PF00069	0.515
DOC_PP1_RVXF_1	226	233	PF00149	0.605
DOC_PP4_FxxP_1	44	47	PF00568	0.532
DOC_SPAK_OSR1_1	15	19	PF12202	0.549
DOC_USP7_MATH_1	125	129	PF00917	0.571
DOC_USP7_MATH_1	258	262	PF00917	0.603
DOC_USP7_MATH_1	274	278	PF00917	0.584
DOC_USP7_UBL2_3	10	14	PF12436	0.501
DOC_USP7_UBL2_3	262	266	PF12436	0.532
DOC_WW_Pin1_4	43	48	PF00397	0.532
LIG_14-3-3_CanoR_1	107	111	PF00244	0.565
LIG_14-3-3_CanoR_1	158	166	PF00244	0.512
LIG_eIF4E_1	99	105	PF01652	0.518
LIG_FHA_1	278	284	PF00498	0.591
LIG_FHA_1	99	105	PF00498	0.518
LIG_FHA_2	132	138	PF00498	0.507
LIG_FHA_2	54	60	PF00498	0.532
LIG_LIR_Apic_2	42	47	PF02991	0.532
LIG_LIR_Nem_3	126	132	PF02991	0.523
LIG_LIR_Nem_3	46	52	PF02991	0.532
LIG_PTB_Apo_2	6	13	PF02174	0.500
LIG_PTB_Phospho_1	6	12	PF10480	0.500
LIG_SH2_CRK	129	133	PF00017	0.518
LIG_SH2_CRK	49	53	PF00017	0.532
LIG_SH2_NCK_1	95	99	PF00017	0.518
LIG_SH2_STAP1	79	83	PF00017	0.518
LIG_SH2_STAP1	95	99	PF00017	0.518
LIG_SH2_STAT3	213	216	PF00017	0.481
LIG_SH2_STAT5	12	15	PF00017	0.541
LIG_SH2_STAT5	213	216	PF00017	0.466
LIG_SH3_2	180	185	PF14604	0.624
LIG_SH3_3	177	183	PF00018	0.532
LIG_UBA3_1	60	68	PF00899	0.498
MOD_CDK_SPK_2	43	48	PF00069	0.389
MOD_CDK_SPxxK_3	43	50	PF00069	0.389
MOD_CK1_1	277	283	PF00069	0.481
MOD_CK2_1	281	287	PF00069	0.410
MOD_GlcNHglycan	129	132	PF01048	0.484
MOD_GlcNHglycan	283	286	PF01048	0.498
MOD_GSK3_1	127	134	PF00069	0.418
MOD_GSK3_1	277	284	PF00069	0.369
MOD_GSK3_1	39	46	PF00069	0.389
MOD_NEK2_1	156	161	PF00069	0.361
MOD_PKA_1	281	287	PF00069	0.481
MOD_PKA_2	106	112	PF00069	0.435
MOD_PKA_2	157	163	PF00069	0.356
MOD_PKA_2	53	59	PF00069	0.389
MOD_Plk_1	191	197	PF00069	0.628
MOD_Plk_2-3	192	198	PF00069	0.573
MOD_ProDKin_1	43	49	PF00069	0.389
MOD_SUMO_for_1	217	220	PF00179	0.572
MOD_SUMO_for_1	268	271	PF00179	0.399
MOD_SUMO_rev_2	192	200	PF00179	0.620
MOD_SUMO_rev_2	220	230	PF00179	0.560
TRG_ENDOCYTIC_2	129	132	PF00928	0.364
TRG_ENDOCYTIC_2	49	52	PF00928	0.389
TRG_ER_diArg_1	20	23	PF00400	0.413
TRG_NLS_Bipartite_1	250	270	PF00514	0.389
TRG_NLS_MonoExtC_3	265	270	PF00514	0.382
TRG_NLS_MonoExtN_4	265	270	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P958	Leptomonas seymouri	91%	100%
A0A0S4JJ00	Bodo saltans	80%	100%
A0A1X0P669	Trypanosomatidae	84%	99%
A0A3Q8IJC5	Leishmania donovani	99%	100%
A1RVN4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	35%	100%
A2BMD8	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	36%	100%
A2WXX3	Oryza sativa subsp. indica	52%	100%
A3MSJ3	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	36%	100%
A4HMK9	Leishmania braziliensis	95%	100%
A4IB88	Leishmania infantum	99%	100%
A4WMD6	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	36%	100%
A8AC01	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	31%	100%
A8M9I3	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	37%	100%
B1Y8V2	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	36%	100%
C9ZZL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	99%
E9AF10	Leishmania major	100%	93%
E9B665	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O22608	Dunaliella salina	49%	100%
O44248	Anopheles gambiae	55%	94%
O59953	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	53%	100%
O65353	Helianthus annuus	51%	100%
O74306	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
O76190	Bombyx mori	52%	100%
P09895	Rattus norvegicus	56%	100%
P15125	Xenopus laevis	55%	100%
P15126	Xenopus laevis	55%	100%
P22451	Gallus gallus	57%	100%
P26321	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	100%
P46777	Homo sapiens	57%	100%
P47962	Mus musculus	56%	100%
P49227	Arabidopsis thaliana	54%	100%
P49405	Caenorhabditis elegans	56%	100%
P52822	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
Q0JGY1	Oryza sativa subsp. japonica	52%	100%
Q18GG8	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	32%	100%
Q1HQU2	Aedes aegypti	55%	100%
Q231U7	Tetrahymena thermophila (strain SB210)	50%	100%
Q26481	Styela clava	52%	100%
Q4KTI3	Suberites domuncula	54%	100%
Q4N655	Theileria parva	53%	100%
Q4R5M0	Macaca fascicularis	56%	100%
Q4UDE7	Theileria annulata	52%	100%
Q54XX3	Dictyostelium discoideum	55%	100%
Q56FG6	Lysiphlebus testaceipes	51%	100%
Q58DW5	Bos taurus	57%	100%
Q5AGZ7	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	100%
Q5EY89	Eimeria tenella	53%	98%
Q5XUC7	Toxoptera citricida	50%	100%
Q627R7	Caenorhabditis briggsae	56%	100%
Q6JWW5	Oikopleura dioica	52%	100%
Q6UNT2	Cucumis sativus	52%	100%
Q8L4L4	Oryza sativa subsp. japonica	52%	100%
Q8LBI1	Arabidopsis thaliana	54%	100%
Q8ZVV7	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	39%	100%
Q9W5R8	Drosophila melanogaster	53%	100%
Q9YF94	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	100%
V5BHY0	Trypanosoma cruzi	77%	100%