Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF08_LEIMA

TriTrypDb:

LmjF.35.1870 , LMJLV39_350025100 , LMJSD75_350024300

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.598
CLV_C14_Caspase3-7	61	65	PF00656	0.502
CLV_NRD_NRD_1	294	296	PF00675	0.506
CLV_NRD_NRD_1	562	564	PF00675	0.636
CLV_NRD_NRD_1	567	569	PF00675	0.621
CLV_NRD_NRD_1	639	641	PF00675	0.620
CLV_NRD_NRD_1	683	685	PF00675	0.441
CLV_NRD_NRD_1	703	705	PF00675	0.345
CLV_NRD_NRD_1	729	731	PF00675	0.472
CLV_PCSK_FUR_1	560	564	PF00082	0.653
CLV_PCSK_KEX2_1	294	296	PF00082	0.506
CLV_PCSK_KEX2_1	33	35	PF00082	0.581
CLV_PCSK_KEX2_1	562	564	PF00082	0.631
CLV_PCSK_KEX2_1	567	569	PF00082	0.626
CLV_PCSK_KEX2_1	639	641	PF00082	0.620
CLV_PCSK_KEX2_1	683	685	PF00082	0.499
CLV_PCSK_KEX2_1	729	731	PF00082	0.472
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.581
CLV_PCSK_PC7_1	563	569	PF00082	0.643
CLV_PCSK_SKI1_1	266	270	PF00082	0.557
CLV_PCSK_SKI1_1	347	351	PF00082	0.627
CLV_PCSK_SKI1_1	456	460	PF00082	0.522
CLV_PCSK_SKI1_1	517	521	PF00082	0.413
CLV_PCSK_SKI1_1	609	613	PF00082	0.622
CLV_PCSK_SKI1_1	620	624	PF00082	0.601
CLV_PCSK_SKI1_1	91	95	PF00082	0.657
DEG_APCC_DBOX_1	516	524	PF00400	0.438
DEG_APCC_DBOX_1	552	560	PF00400	0.534
DEG_Nend_Nbox_1	1	3	PF02207	0.518
DEG_SPOP_SBC_1	348	352	PF00917	0.535
DEG_SPOP_SBC_1	72	76	PF00917	0.634
DOC_ANK_TNKS_1	414	421	PF00023	0.579
DOC_CDC14_PxL_1	52	60	PF14671	0.600
DOC_CKS1_1	159	164	PF01111	0.636
DOC_CKS1_1	281	286	PF01111	0.633
DOC_CYCLIN_RxL_1	715	725	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.650
DOC_MAPK_gen_1	514	523	PF00069	0.555
DOC_MAPK_gen_1	704	712	PF00069	0.431
DOC_MAPK_HePTP_8	511	523	PF00069	0.548
DOC_MAPK_JIP1_4	96	102	PF00069	0.608
DOC_MAPK_MEF2A_6	514	523	PF00069	0.555
DOC_MAPK_MEF2A_6	716	724	PF00069	0.481
DOC_PP1_RVXF_1	520	526	PF00149	0.446
DOC_PP2B_LxvP_1	98	101	PF13499	0.675
DOC_SPAK_OSR1_1	492	496	PF12202	0.402
DOC_USP7_MATH_1	237	241	PF00917	0.648
DOC_USP7_MATH_1	301	305	PF00917	0.494
DOC_USP7_MATH_1	348	352	PF00917	0.665
DOC_USP7_MATH_1	353	357	PF00917	0.609
DOC_USP7_MATH_1	425	429	PF00917	0.636
DOC_USP7_MATH_1	47	51	PF00917	0.738
DOC_USP7_MATH_1	549	553	PF00917	0.582
DOC_USP7_MATH_1	593	597	PF00917	0.637
DOC_USP7_MATH_1	631	635	PF00917	0.642
DOC_USP7_MATH_1	641	645	PF00917	0.467
DOC_USP7_MATH_1	653	657	PF00917	0.538
DOC_USP7_UBL2_3	701	705	PF12436	0.460
DOC_WW_Pin1_4	158	163	PF00397	0.669
DOC_WW_Pin1_4	170	175	PF00397	0.597
DOC_WW_Pin1_4	191	196	PF00397	0.643
DOC_WW_Pin1_4	241	246	PF00397	0.676
DOC_WW_Pin1_4	280	285	PF00397	0.730
DOC_WW_Pin1_4	523	528	PF00397	0.570
DOC_WW_Pin1_4	545	550	PF00397	0.529
LIG_14-3-3_CanoR_1	266	273	PF00244	0.553
LIG_14-3-3_CanoR_1	300	310	PF00244	0.539
LIG_14-3-3_CanoR_1	347	355	PF00244	0.529
LIG_14-3-3_CanoR_1	567	575	PF00244	0.586
LIG_14-3-3_CanoR_1	630	636	PF00244	0.560
LIG_14-3-3_CanoR_1	640	646	PF00244	0.545
LIG_14-3-3_CanoR_1	683	692	PF00244	0.526
LIG_14-3-3_CanoR_1	73	80	PF00244	0.597
LIG_Actin_WH2_2	305	321	PF00022	0.445
LIG_Actin_WH2_2	394	412	PF00022	0.492
LIG_APCC_ABBA_1	493	498	PF00400	0.382
LIG_APCC_ABBAyCdc20_2	492	498	PF00400	0.390
LIG_BIR_III_4	220	224	PF00653	0.586
LIG_CaM_IQ_9	722	737	PF13499	0.457
LIG_CSL_BTD_1	524	527	PF09270	0.455
LIG_CtBP_PxDLS_1	626	630	PF00389	0.545
LIG_EH1_1	15	23	PF00400	0.497
LIG_eIF4E_1	403	409	PF01652	0.552
LIG_eIF4E_1	515	521	PF01652	0.391
LIG_FHA_1	214	220	PF00498	0.606
LIG_FHA_1	242	248	PF00498	0.728
LIG_FHA_1	291	297	PF00498	0.553
LIG_FHA_1	33	39	PF00498	0.630
LIG_FHA_1	350	356	PF00498	0.546
LIG_FHA_1	388	394	PF00498	0.411
LIG_FHA_1	707	713	PF00498	0.491
LIG_FHA_2	435	441	PF00498	0.687
LIG_FHA_2	455	461	PF00498	0.516
LIG_FHA_2	482	488	PF00498	0.501
LIG_FHA_2	556	562	PF00498	0.536
LIG_FHA_2	674	680	PF00498	0.435
LIG_FHA_2	683	689	PF00498	0.454
LIG_FHA_2	692	698	PF00498	0.469
LIG_FHA_2	723	729	PF00498	0.451
LIG_Integrin_RGD_1	189	191	PF01839	0.552
LIG_LIR_Apic_2	158	162	PF02991	0.604
LIG_LIR_Gen_1	136	145	PF02991	0.462
LIG_LIR_Gen_1	308	318	PF02991	0.359
LIG_LIR_Nem_3	136	141	PF02991	0.458
LIG_LIR_Nem_3	308	313	PF02991	0.366
LIG_LIR_Nem_3	460	465	PF02991	0.488
LIG_Pex14_2	12	16	PF04695	0.442
LIG_RPA_C_Fungi	68	80	PF08784	0.534
LIG_SH2_CRK	462	466	PF00017	0.349
LIG_SH2_PTP2	138	141	PF00017	0.494
LIG_SH2_STAP1	515	519	PF00017	0.501
LIG_SH2_STAT3	515	518	PF00017	0.508
LIG_SH2_STAT5	138	141	PF00017	0.440
LIG_SH2_STAT5	536	539	PF00017	0.671
LIG_SH2_STAT5	674	677	PF00017	0.429
LIG_SH3_3	249	255	PF00018	0.659
LIG_SH3_3	278	284	PF00018	0.715
LIG_SH3_3	485	491	PF00018	0.529
LIG_SH3_3	50	56	PF00018	0.755
LIG_SH3_3	596	602	PF00018	0.599
LIG_Sin3_3	310	317	PF02671	0.351
LIG_SUMO_SIM_anti_2	709	714	PF11976	0.494
LIG_SUMO_SIM_par_1	237	242	PF11976	0.532
LIG_SUMO_SIM_par_1	707	714	PF11976	0.513
LIG_TRAF2_1	166	169	PF00917	0.528
LIG_WRC_WIRS_1	306	311	PF05994	0.361
MOD_CDC14_SPxK_1	194	197	PF00782	0.627
MOD_CDK_SPxK_1	158	164	PF00069	0.636
MOD_CDK_SPxK_1	191	197	PF00069	0.630
MOD_CDK_SPxxK_3	163	170	PF00069	0.647
MOD_CK1_1	108	114	PF00069	0.495
MOD_CK1_1	308	314	PF00069	0.439
MOD_CK1_1	32	38	PF00069	0.663
MOD_CK1_1	379	385	PF00069	0.548
MOD_CK1_1	404	410	PF00069	0.490
MOD_CK1_1	448	454	PF00069	0.653
MOD_CK1_1	528	534	PF00069	0.519
MOD_CK1_1	548	554	PF00069	0.465
MOD_CK1_1	576	582	PF00069	0.625
MOD_CK1_1	634	640	PF00069	0.558
MOD_CK1_1	644	650	PF00069	0.523
MOD_CK1_1	656	662	PF00069	0.492
MOD_CK2_1	163	169	PF00069	0.552
MOD_CK2_1	203	209	PF00069	0.665
MOD_CK2_1	555	561	PF00069	0.542
MOD_CK2_1	673	679	PF00069	0.434
MOD_CK2_1	682	688	PF00069	0.455
MOD_CK2_1	691	697	PF00069	0.464
MOD_CK2_1	722	728	PF00069	0.446
MOD_Cter_Amidation	141	144	PF01082	0.502
MOD_DYRK1A_RPxSP_1	280	284	PF00069	0.643
MOD_GlcNHglycan	205	208	PF01048	0.713
MOD_GlcNHglycan	209	212	PF01048	0.664
MOD_GlcNHglycan	262	265	PF01048	0.539
MOD_GlcNHglycan	284	287	PF01048	0.663
MOD_GlcNHglycan	323	326	PF01048	0.451
MOD_GlcNHglycan	355	358	PF01048	0.609
MOD_GlcNHglycan	360	363	PF01048	0.584
MOD_GlcNHglycan	416	419	PF01048	0.632
MOD_GlcNHglycan	423	426	PF01048	0.744
MOD_GlcNHglycan	449	453	PF01048	0.615
MOD_GlcNHglycan	48	52	PF01048	0.585
MOD_GlcNHglycan	502	505	PF01048	0.349
MOD_GlcNHglycan	530	533	PF01048	0.534
MOD_GlcNHglycan	545	548	PF01048	0.538
MOD_GlcNHglycan	585	588	PF01048	0.660
MOD_GlcNHglycan	595	598	PF01048	0.501
MOD_GlcNHglycan	646	649	PF01048	0.513
MOD_GlcNHglycan	655	658	PF01048	0.524
MOD_GlcNHglycan	81	84	PF01048	0.739
MOD_GSK3_1	203	210	PF00069	0.682
MOD_GSK3_1	237	244	PF00069	0.703
MOD_GSK3_1	25	32	PF00069	0.581
MOD_GSK3_1	256	263	PF00069	0.555
MOD_GSK3_1	276	283	PF00069	0.629
MOD_GSK3_1	301	308	PF00069	0.458
MOD_GSK3_1	338	345	PF00069	0.548
MOD_GSK3_1	349	356	PF00069	0.549
MOD_GSK3_1	379	386	PF00069	0.470
MOD_GSK3_1	387	394	PF00069	0.406
MOD_GSK3_1	421	428	PF00069	0.605
MOD_GSK3_1	441	448	PF00069	0.486
MOD_GSK3_1	545	552	PF00069	0.558
MOD_GSK3_1	576	583	PF00069	0.610
MOD_GSK3_1	605	612	PF00069	0.592
MOD_GSK3_1	630	637	PF00069	0.573
MOD_GSK3_1	673	680	PF00069	0.446
MOD_GSK3_1	682	689	PF00069	0.507
MOD_GSK3_1	718	725	PF00069	0.487
MOD_GSK3_1	79	86	PF00069	0.628
MOD_LATS_1	77	83	PF00433	0.550
MOD_N-GLC_1	145	150	PF02516	0.480
MOD_NEK2_1	318	323	PF00069	0.448
MOD_NEK2_1	486	491	PF00069	0.487
MOD_NEK2_1	543	548	PF00069	0.570
MOD_NEK2_1	607	612	PF00069	0.659
MOD_NEK2_1	629	634	PF00069	0.551
MOD_NEK2_1	722	727	PF00069	0.436
MOD_NEK2_2	491	496	PF00069	0.401
MOD_PIKK_1	184	190	PF00454	0.657
MOD_PIKK_1	370	376	PF00454	0.469
MOD_PIKK_1	722	728	PF00454	0.446
MOD_PK_1	34	40	PF00069	0.595
MOD_PKA_1	567	573	PF00069	0.528
MOD_PKA_2	177	183	PF00069	0.649
MOD_PKA_2	318	324	PF00069	0.408
MOD_PKA_2	414	420	PF00069	0.592
MOD_PKA_2	425	431	PF00069	0.624
MOD_PKA_2	491	497	PF00069	0.391
MOD_PKA_2	567	573	PF00069	0.592
MOD_PKA_2	576	582	PF00069	0.519
MOD_PKA_2	629	635	PF00069	0.580
MOD_PKA_2	682	688	PF00069	0.479
MOD_PKA_2	72	78	PF00069	0.583
MOD_PKB_1	443	451	PF00069	0.622
MOD_Plk_1	105	111	PF00069	0.480
MOD_Plk_1	145	151	PF00069	0.488
MOD_Plk_1	404	410	PF00069	0.490
MOD_Plk_1	47	53	PF00069	0.607
MOD_Plk_1	706	712	PF00069	0.515
MOD_Plk_1	718	724	PF00069	0.442
MOD_Plk_4	213	219	PF00069	0.606
MOD_Plk_4	305	311	PF00069	0.411
MOD_Plk_4	388	394	PF00069	0.473
MOD_Plk_4	404	410	PF00069	0.401
MOD_Plk_4	609	615	PF00069	0.580
MOD_Plk_4	641	647	PF00069	0.532
MOD_Plk_4	677	683	PF00069	0.436
MOD_Plk_4	691	697	PF00069	0.464
MOD_ProDKin_1	158	164	PF00069	0.671
MOD_ProDKin_1	170	176	PF00069	0.597
MOD_ProDKin_1	191	197	PF00069	0.643
MOD_ProDKin_1	241	247	PF00069	0.675
MOD_ProDKin_1	280	286	PF00069	0.725
MOD_ProDKin_1	523	529	PF00069	0.576
MOD_ProDKin_1	545	551	PF00069	0.531
TRG_DiLeu_BaEn_1	48	53	PF01217	0.607
TRG_DiLeu_BaEn_1	516	521	PF01217	0.388
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.613
TRG_ENDOCYTIC_2	138	141	PF00928	0.456
TRG_ENDOCYTIC_2	462	465	PF00928	0.389
TRG_ER_diArg_1	294	296	PF00400	0.478
TRG_ER_diArg_1	443	446	PF00400	0.680
TRG_ER_diArg_1	567	569	PF00400	0.539
TRG_ER_diArg_1	639	641	PF00400	0.581
TRG_ER_diArg_1	682	684	PF00400	0.521
TRG_NES_CRM1_1	305	315	PF08389	0.367
TRG_NES_CRM1_1	6	20	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIY4	Leptomonas seymouri	48%	91%
A0A3Q8II80	Leishmania donovani	90%	100%
A4HMK8	Leishmania braziliensis	68%	100%
A4IB87	Leishmania infantum	90%	100%
E9B664	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%