Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CMGC/DYRK protein kinase, putative

Species:

Leishmania major

UniProt:

E9AF07_LEIMA

TriTrypDb:

LmjF.35.1860 , LMJLV39_350025000 , LMJSD75_350024200

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AF07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF07

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018107	peptidyl-threonine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0018210	peptidyl-threonine modification	6	2
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004713	protein tyrosine kinase activity	4	2
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.428
CLV_C14_Caspase3-7	297	301	PF00656	0.172
CLV_C14_Caspase3-7	566	570	PF00656	0.602
CLV_NRD_NRD_1	25	27	PF00675	0.583
CLV_NRD_NRD_1	314	316	PF00675	0.324
CLV_NRD_NRD_1	379	381	PF00675	0.446
CLV_NRD_NRD_1	481	483	PF00675	0.264
CLV_PCSK_KEX2_1	379	381	PF00082	0.446
CLV_PCSK_KEX2_1	481	483	PF00082	0.322
CLV_PCSK_KEX2_1	499	501	PF00082	0.164
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.322
CLV_PCSK_SKI1_1	184	188	PF00082	0.533
CLV_PCSK_SKI1_1	272	276	PF00082	0.264
CLV_PCSK_SKI1_1	408	412	PF00082	0.322
CLV_PCSK_SKI1_1	511	515	PF00082	0.284
DEG_SCF_FBW7_1	146	151	PF00400	0.651
DOC_ANK_TNKS_1	295	302	PF00023	0.172
DOC_CKS1_1	162	167	PF01111	0.623
DOC_CYCLIN_RxL_1	528	536	PF00134	0.298
DOC_MAPK_DCC_7	195	203	PF00069	0.428
DOC_MAPK_gen_1	26	32	PF00069	0.581
DOC_MAPK_gen_1	264	273	PF00069	0.322
DOC_MAPK_gen_1	315	322	PF00069	0.326
DOC_MAPK_gen_1	417	426	PF00069	0.264
DOC_MAPK_gen_1	508	516	PF00069	0.284
DOC_MAPK_HePTP_8	261	273	PF00069	0.322
DOC_MAPK_HePTP_8	414	426	PF00069	0.264
DOC_MAPK_MEF2A_6	195	203	PF00069	0.428
DOC_MAPK_MEF2A_6	264	273	PF00069	0.264
DOC_MAPK_MEF2A_6	417	426	PF00069	0.264
DOC_PP1_RVXF_1	394	401	PF00149	0.264
DOC_PP2B_LxvP_1	426	429	PF13499	0.264
DOC_PP4_MxPP_1	83	86	PF00568	0.537
DOC_USP7_MATH_1	454	458	PF00917	0.244
DOC_USP7_MATH_1	5	9	PF00917	0.581
DOC_USP7_MATH_1	52	56	PF00917	0.603
DOC_USP7_MATH_1	67	71	PF00917	0.668
DOC_WW_Pin1_4	144	149	PF00397	0.645
DOC_WW_Pin1_4	161	166	PF00397	0.483
DOC_WW_Pin1_4	174	179	PF00397	0.479
DOC_WW_Pin1_4	539	544	PF00397	0.311
LIG_14-3-3_CanoR_1	107	114	PF00244	0.587
LIG_14-3-3_CanoR_1	184	190	PF00244	0.385
LIG_14-3-3_CanoR_1	339	347	PF00244	0.284
LIG_14-3-3_CanoR_1	408	414	PF00244	0.322
LIG_Actin_WH2_2	383	398	PF00022	0.172
LIG_BRCT_BRCA1_1	181	185	PF00533	0.517
LIG_BRCT_BRCA1_1	199	203	PF00533	0.423
LIG_BRCT_BRCA1_1	310	314	PF00533	0.322
LIG_BRCT_BRCA1_1	341	345	PF00533	0.322
LIG_BRCT_BRCA1_2	310	316	PF00533	0.298
LIG_CtBP_PxDLS_1	180	184	PF00389	0.528
LIG_deltaCOP1_diTrp_1	435	439	PF00928	0.322
LIG_deltaCOP1_diTrp_1	548	555	PF00928	0.322
LIG_FHA_1	145	151	PF00498	0.751
LIG_FHA_1	162	168	PF00498	0.491
LIG_FHA_1	251	257	PF00498	0.293
LIG_FHA_1	288	294	PF00498	0.322
LIG_FHA_1	301	307	PF00498	0.322
LIG_FHA_1	353	359	PF00498	0.291
LIG_FHA_1	429	435	PF00498	0.266
LIG_FHA_1	55	61	PF00498	0.637
LIG_FHA_1	562	568	PF00498	0.589
LIG_FHA_2	115	121	PF00498	0.584
LIG_FHA_2	185	191	PF00498	0.506
LIG_FHA_2	430	436	PF00498	0.322
LIG_HCF-1_HBM_1	262	265	PF13415	0.214
LIG_LIR_Apic_2	416	422	PF02991	0.264
LIG_LIR_Apic_2	78	84	PF02991	0.624
LIG_LIR_Gen_1	262	273	PF02991	0.214
LIG_LIR_Gen_1	327	338	PF02991	0.361
LIG_LIR_Gen_1	522	533	PF02991	0.303
LIG_LIR_Nem_3	103	109	PF02991	0.611
LIG_LIR_Nem_3	117	121	PF02991	0.628
LIG_LIR_Nem_3	253	257	PF02991	0.264
LIG_LIR_Nem_3	262	268	PF02991	0.264
LIG_LIR_Nem_3	327	333	PF02991	0.369
LIG_LIR_Nem_3	438	442	PF02991	0.322
LIG_LIR_Nem_3	467	472	PF02991	0.270
LIG_LIR_Nem_3	522	528	PF02991	0.303
LIG_LIR_Nem_3	548	554	PF02991	0.322
LIG_MAD2	364	372	PF02301	0.308
LIG_MLH1_MIPbox_1	199	203	PF16413	0.423
LIG_MYND_1	148	152	PF01753	0.604
LIG_SH2_CRK	106	110	PF00017	0.603
LIG_SH2_CRK	231	235	PF00017	0.327
LIG_SH2_CRK	265	269	PF00017	0.214
LIG_SH2_CRK	330	334	PF00017	0.322
LIG_SH2_CRK	81	85	PF00017	0.573
LIG_SH2_NCK_1	330	334	PF00017	0.322
LIG_SH2_NCK_1	81	85	PF00017	0.589
LIG_SH2_PTP2	318	321	PF00017	0.326
LIG_SH2_SRC	197	200	PF00017	0.485
LIG_SH2_SRC	330	333	PF00017	0.326
LIG_SH2_STAP1	280	284	PF00017	0.322
LIG_SH2_STAP1	430	434	PF00017	0.264
LIG_SH2_STAT3	280	283	PF00017	0.322
LIG_SH2_STAT5	197	200	PF00017	0.545
LIG_SH2_STAT5	202	205	PF00017	0.345
LIG_SH2_STAT5	280	283	PF00017	0.322
LIG_SH2_STAT5	318	321	PF00017	0.325
LIG_SH2_STAT5	413	416	PF00017	0.267
LIG_SH2_STAT5	430	433	PF00017	0.297
LIG_SH2_STAT5	468	471	PF00017	0.264
LIG_SH2_STAT5	475	478	PF00017	0.264
LIG_SH3_1	499	505	PF00018	0.327
LIG_SH3_1	81	87	PF00018	0.615
LIG_SH3_3	159	165	PF00018	0.632
LIG_SH3_3	175	181	PF00018	0.568
LIG_SH3_3	448	454	PF00018	0.264
LIG_SH3_3	499	505	PF00018	0.290
LIG_SH3_3	61	67	PF00018	0.641
LIG_SH3_3	81	87	PF00018	0.433
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.336
LIG_TRAF2_1	188	191	PF00917	0.381
LIG_TRAF2_1	284	287	PF00917	0.322
LIG_TRAF2_1	403	406	PF00917	0.322
LIG_TRFH_1	322	326	PF08558	0.322
LIG_WRC_WIRS_1	436	441	PF05994	0.322
MOD_CK1_1	151	157	PF00069	0.662
MOD_CK1_1	388	394	PF00069	0.355
MOD_CK1_1	560	566	PF00069	0.575
MOD_CK2_1	114	120	PF00069	0.582
MOD_CK2_1	184	190	PF00069	0.443
MOD_CK2_1	383	389	PF00069	0.337
MOD_CK2_1	399	405	PF00069	0.264
MOD_CK2_1	454	460	PF00069	0.244
MOD_GlcNHglycan	102	105	PF01048	0.728
MOD_GlcNHglycan	109	112	PF01048	0.636
MOD_GlcNHglycan	126	129	PF01048	0.530
MOD_GlcNHglycan	401	404	PF01048	0.308
MOD_GlcNHglycan	5	8	PF01048	0.566
MOD_GlcNHglycan	50	53	PF01048	0.639
MOD_GlcNHglycan	559	562	PF01048	0.449
MOD_GlcNHglycan	69	72	PF01048	0.526
MOD_GSK3_1	124	131	PF00069	0.556
MOD_GSK3_1	142	149	PF00069	0.669
MOD_GSK3_1	17	24	PF00069	0.547
MOD_GSK3_1	381	388	PF00069	0.355
MOD_GSK3_1	409	416	PF00069	0.264
MOD_GSK3_1	48	55	PF00069	0.602
MOD_GSK3_1	556	563	PF00069	0.507
MOD_GSK3_1	565	572	PF00069	0.521
MOD_GSK3_1	62	69	PF00069	0.793
MOD_GSK3_1	75	82	PF00069	0.570
MOD_N-GLC_1	121	126	PF02516	0.578
MOD_N-GLC_1	17	22	PF02516	0.574
MOD_N-GLC_1	278	283	PF02516	0.322
MOD_N-GLC_1	36	41	PF02516	0.598
MOD_N-GLC_1	494	499	PF02516	0.209
MOD_N-GLC_2	158	160	PF02516	0.649
MOD_NEK2_1	308	313	PF00069	0.329
MOD_NEK2_1	567	572	PF00069	0.603
MOD_PIKK_1	54	60	PF00454	0.603
MOD_PKA_2	114	120	PF00069	0.582
MOD_PKA_2	215	221	PF00069	0.460
MOD_PKA_2	477	483	PF00069	0.183
MOD_PKA_2	555	561	PF00069	0.476
MOD_Plk_1	36	42	PF00069	0.597
MOD_Plk_1	391	397	PF00069	0.370
MOD_Plk_1	45	51	PF00069	0.540
MOD_Plk_2-3	287	293	PF00069	0.326
MOD_Plk_4	197	203	PF00069	0.426
MOD_Plk_4	36	42	PF00069	0.513
MOD_Plk_4	471	477	PF00069	0.304
MOD_ProDKin_1	144	150	PF00069	0.646
MOD_ProDKin_1	161	167	PF00069	0.483
MOD_ProDKin_1	174	180	PF00069	0.476
MOD_ProDKin_1	539	545	PF00069	0.311
MOD_SUMO_for_1	370	373	PF00179	0.264
MOD_SUMO_rev_2	131	140	PF00179	0.584
MOD_SUMO_rev_2	286	291	PF00179	0.299
TRG_DiLeu_BaEn_4	286	292	PF01217	0.322
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.326
TRG_ENDOCYTIC_2	106	109	PF00928	0.617
TRG_ENDOCYTIC_2	118	121	PF00928	0.654
TRG_ENDOCYTIC_2	231	234	PF00928	0.321
TRG_ENDOCYTIC_2	243	246	PF00928	0.264
TRG_ENDOCYTIC_2	265	268	PF00928	0.214
TRG_ENDOCYTIC_2	318	321	PF00928	0.303
TRG_ENDOCYTIC_2	330	333	PF00928	0.363
TRG_ENDOCYTIC_2	450	453	PF00928	0.264
TRG_ER_diArg_1	538	541	PF00400	0.326
TRG_NLS_Bipartite_1	481	502	PF00514	0.322
TRG_NLS_MonoExtC_3	497	502	PF00514	0.322
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D6	Leptomonas seymouri	72%	80%
A0A0S4IL53	Bodo saltans	25%	85%
A0A0S4IUF2	Bodo saltans	41%	100%
A0A0S4JTP3	Bodo saltans	31%	71%
A0A3Q8IB74	Leishmania donovani	28%	100%
A0A3Q8IH39	Leishmania donovani	26%	100%
A0A3Q8ITZ9	Leishmania donovani	29%	100%
A0A3Q8IVR8	Leishmania donovani	34%	100%
A0A3S5H6C8	Leishmania donovani	28%	100%
A0A3S5H789	Leishmania donovani	26%	100%
A0A3S5H7N7	Leishmania donovani	27%	100%
A0A3S7WQK7	Leishmania donovani	28%	100%
A0A3S7WR45	Leishmania donovani	26%	100%
A0A3S7WRG1	Leishmania donovani	26%	100%
A0A3S7WY10	Leishmania donovani	25%	100%
A0A3S7X9D1	Leishmania donovani	95%	100%
A0A3S7XA45	Leishmania donovani	31%	100%
A0A422NSR4	Trypanosoma rangeli	25%	66%
A0A451EJH2	Leishmania donovani	27%	100%
A4H5L7	Leishmania braziliensis	27%	100%
A4H601	Leishmania braziliensis	26%	100%
A4H641	Leishmania braziliensis	26%	100%
A4H7F4	Leishmania braziliensis	25%	97%
A4H9X5	Leishmania braziliensis	29%	100%
A4HC27	Leishmania braziliensis	30%	100%
A4HIM5	Leishmania braziliensis	27%	100%
A4HMK7	Leishmania braziliensis	82%	100%
A4HNG3	Leishmania braziliensis	30%	100%
A4HNT2	Leishmania braziliensis	34%	100%
A4HRN3	Leishmania infantum	27%	100%
A4HTV4	Leishmania infantum	28%	100%
A4HTV5	Leishmania infantum	28%	100%
A4HUC8	Leishmania infantum	26%	100%
A4HUG1	Leishmania infantum	26%	100%
A4HUS3	Leishmania infantum	26%	100%
A4HYX6	Leishmania infantum	26%	100%
A4I5X0	Leishmania infantum	27%	100%
A4IB86	Leishmania infantum	94%	100%
A4IC54	Leishmania infantum	31%	100%
A4ICR2	Leishmania infantum	34%	100%
A8WJR8	Caenorhabditis briggsae	40%	71%
D0A4N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ACB1	Leishmania major	27%	100%
E9AFX4	Leishmania major	30%	100%
E9AGS0	Leishmania infantum	28%	100%
E9AJJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AN28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ANF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ASJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B164	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O43781	Homo sapiens	38%	98%
P83102	Drosophila melanogaster	38%	69%
Q09815	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	69%
Q45FA5	Physarum polycephalum	27%	100%
Q4Q204	Leishmania major	34%	100%
Q4Q449	Leishmania major	29%	100%
Q4Q701	Leishmania major	28%	100%
Q4QC19	Leishmania major	31%	100%
Q4QDK3	Leishmania major	28%	100%
Q4QFG6	Leishmania major	36%	100%
Q4QH69	Leishmania major	26%	100%
Q4QHG6	Leishmania major	26%	100%
Q4QHJ8	Leishmania major	26%	100%
Q4QHY3	Leishmania major	28%	100%
Q4QHY4	Leishmania major	28%	100%
Q4R6S5	Macaca fascicularis	38%	100%
Q4V8A3	Rattus norvegicus	38%	98%
Q5U4C9	Mus musculus	41%	96%
Q5ZIU3	Gallus gallus	40%	100%
Q922Y0	Mus musculus	38%	98%
Q92630	Homo sapiens	40%	96%
Q9V3D5	Drosophila melanogaster	39%	80%
Q9XTF3	Caenorhabditis elegans	40%	70%
V5AZ01	Trypanosoma cruzi	27%	74%
V5DIC3	Trypanosoma cruzi	32%	95%