Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF05_LEIMA

TriTrypDb:

LmjF.35.1840 , LMJLV39_350024800 , LMJSD75_350024000

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AF05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.684
DEG_Nend_UBRbox_1	1	4	PF02207	0.671
DOC_CKS1_1	47	52	PF01111	0.391
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.644
DOC_USP7_MATH_1	140	144	PF00917	0.753
DOC_WW_Pin1_4	132	137	PF00397	0.722
DOC_WW_Pin1_4	145	150	PF00397	0.633
DOC_WW_Pin1_4	46	51	PF00397	0.387
LIG_FHA_1	118	124	PF00498	0.620
LIG_FHA_1	40	46	PF00498	0.325
LIG_FHA_1	47	53	PF00498	0.391
LIG_LIR_Gen_1	139	149	PF02991	0.718
LIG_LIR_Gen_1	42	52	PF02991	0.357
LIG_LIR_Nem_3	139	144	PF02991	0.767
LIG_LIR_Nem_3	38	43	PF02991	0.417
LIG_Pex14_1	40	44	PF04695	0.398
LIG_SH2_CRK	141	145	PF00017	0.752
LIG_SH2_NCK_1	141	145	PF00017	0.715
LIG_SH2_PTP2	44	47	PF00017	0.438
LIG_SH2_STAT5	34	37	PF00017	0.554
LIG_SH2_STAT5	44	47	PF00017	0.438
LIG_SH2_STAT5	61	64	PF00017	0.417
LIG_SH3_3	25	31	PF00018	0.357
LIG_SH3_3	44	50	PF00018	0.391
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.361
LIG_TYR_ITSM	40	47	PF00017	0.360
MOD_CDC14_SPxK_1	135	138	PF00782	0.709
MOD_CDK_SPxK_1	132	138	PF00069	0.705
MOD_CDK_SPxxK_3	145	152	PF00069	0.740
MOD_CK1_1	142	148	PF00069	0.703
MOD_CK1_1	18	24	PF00069	0.422
MOD_CK1_1	73	79	PF00069	0.684
MOD_CK2_1	73	79	PF00069	0.684
MOD_GlcNHglycan	6	9	PF01048	0.529
MOD_GSK3_1	128	135	PF00069	0.662
MOD_GSK3_1	35	42	PF00069	0.467
MOD_GSK3_1	69	76	PF00069	0.674
MOD_GSK3_1	86	93	PF00069	0.743
MOD_NEK2_1	23	28	PF00069	0.464
MOD_NEK2_1	39	44	PF00069	0.439
MOD_Plk_1	90	96	PF00069	0.677
MOD_Plk_4	118	124	PF00069	0.673
MOD_Plk_4	35	41	PF00069	0.506
MOD_Plk_4	70	76	PF00069	0.686
MOD_Plk_4	90	96	PF00069	0.673
MOD_ProDKin_1	132	138	PF00069	0.722
MOD_ProDKin_1	145	151	PF00069	0.634
MOD_ProDKin_1	46	52	PF00069	0.387
MOD_SUMO_for_1	109	112	PF00179	0.666
TRG_ENDOCYTIC_2	141	144	PF00928	0.773
TRG_ENDOCYTIC_2	44	47	PF00928	0.438
TRG_ENDOCYTIC_2	61	64	PF00928	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJI6	Leptomonas seymouri	59%	100%
A0A1X0P639	Trypanosomatidae	35%	100%
A0A3Q8IM56	Leishmania donovani	93%	100%
A4HMK5	Leishmania braziliensis	66%	100%
A4IB84	Leishmania infantum	93%	100%
E9B661	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BHZ7	Trypanosoma cruzi	38%	100%