LeishMANIAdb
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Tudor domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tudor domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AF04_LEIMA
TriTrypDb:
LmjF.35.1830 , LMJLV39_350024700 , LMJSD75_350023900
Length:
739

Annotations

LeishMANIAdb annotations

Almost certainly non-TM

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF04
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF04

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.378
CLV_NRD_NRD_1 210 212 PF00675 0.398
CLV_NRD_NRD_1 320 322 PF00675 0.376
CLV_NRD_NRD_1 488 490 PF00675 0.352
CLV_NRD_NRD_1 502 504 PF00675 0.334
CLV_NRD_NRD_1 647 649 PF00675 0.339
CLV_PCSK_KEX2_1 102 104 PF00082 0.378
CLV_PCSK_KEX2_1 488 490 PF00082 0.357
CLV_PCSK_KEX2_1 502 504 PF00082 0.336
CLV_PCSK_KEX2_1 647 649 PF00082 0.339
CLV_PCSK_SKI1_1 250 254 PF00082 0.308
CLV_PCSK_SKI1_1 336 340 PF00082 0.433
CLV_PCSK_SKI1_1 440 444 PF00082 0.305
CLV_PCSK_SKI1_1 649 653 PF00082 0.516
CLV_PCSK_SKI1_1 67 71 PF00082 0.525
CLV_PCSK_SKI1_1 708 712 PF00082 0.352
DOC_CKS1_1 661 666 PF01111 0.475
DOC_CYCLIN_RxL_1 284 295 PF00134 0.361
DOC_CYCLIN_RxL_1 424 432 PF00134 0.343
DOC_CYCLIN_yCln2_LP_2 625 631 PF00134 0.290
DOC_MAPK_gen_1 100 110 PF00069 0.367
DOC_MAPK_gen_1 437 444 PF00069 0.326
DOC_MAPK_RevD_3 526 540 PF00069 0.408
DOC_PP1_RVXF_1 285 292 PF00149 0.356
DOC_PP1_RVXF_1 438 445 PF00149 0.287
DOC_PP1_SILK_1 332 337 PF00149 0.393
DOC_PP4_FxxP_1 421 424 PF00568 0.309
DOC_PP4_FxxP_1 661 664 PF00568 0.467
DOC_USP7_MATH_1 135 139 PF00917 0.399
DOC_USP7_MATH_1 2 6 PF00917 0.554
DOC_USP7_MATH_1 234 238 PF00917 0.494
DOC_USP7_MATH_1 280 284 PF00917 0.577
DOC_USP7_MATH_1 337 341 PF00917 0.424
DOC_USP7_UBL2_3 339 343 PF12436 0.486
DOC_WW_Pin1_4 111 116 PF00397 0.320
DOC_WW_Pin1_4 420 425 PF00397 0.296
DOC_WW_Pin1_4 660 665 PF00397 0.429
LIG_14-3-3_CanoR_1 143 151 PF00244 0.390
LIG_14-3-3_CanoR_1 232 242 PF00244 0.435
LIG_14-3-3_CanoR_1 321 325 PF00244 0.395
LIG_14-3-3_CanoR_1 327 335 PF00244 0.396
LIG_14-3-3_CanoR_1 336 342 PF00244 0.411
LIG_14-3-3_CanoR_1 391 395 PF00244 0.462
LIG_14-3-3_CanoR_1 569 575 PF00244 0.340
LIG_14-3-3_CanoR_1 619 627 PF00244 0.309
LIG_14-3-3_CanoR_1 648 654 PF00244 0.460
LIG_14-3-3_CanoR_1 80 88 PF00244 0.433
LIG_Actin_WH2_2 195 213 PF00022 0.425
LIG_Actin_WH2_2 66 82 PF00022 0.356
LIG_APCC_ABBA_1 220 225 PF00400 0.348
LIG_BRCT_BRCA1_1 671 675 PF00533 0.454
LIG_BRCT_BRCA1_1 73 77 PF00533 0.336
LIG_Clathr_ClatBox_1 133 137 PF01394 0.310
LIG_deltaCOP1_diTrp_1 688 695 PF00928 0.301
LIG_EH_1 30 34 PF12763 0.458
LIG_eIF4E_1 611 617 PF01652 0.347
LIG_FHA_1 143 149 PF00498 0.462
LIG_FHA_1 329 335 PF00498 0.481
LIG_FHA_1 372 378 PF00498 0.527
LIG_FHA_1 466 472 PF00498 0.326
LIG_FHA_1 54 60 PF00498 0.497
LIG_FHA_1 548 554 PF00498 0.397
LIG_FHA_1 630 636 PF00498 0.345
LIG_FHA_1 68 74 PF00498 0.502
LIG_FHA_2 321 327 PF00498 0.471
LIG_FHA_2 593 599 PF00498 0.428
LIG_FHA_2 635 641 PF00498 0.332
LIG_FHA_2 697 703 PF00498 0.369
LIG_IBAR_NPY_1 602 604 PF08397 0.376
LIG_LIR_Apic_2 418 424 PF02991 0.305
LIG_LIR_Gen_1 122 130 PF02991 0.453
LIG_LIR_Gen_1 228 235 PF02991 0.508
LIG_LIR_Gen_1 398 407 PF02991 0.361
LIG_LIR_Gen_1 482 490 PF02991 0.355
LIG_LIR_Nem_3 122 126 PF02991 0.475
LIG_LIR_Nem_3 214 219 PF02991 0.406
LIG_LIR_Nem_3 228 233 PF02991 0.464
LIG_LIR_Nem_3 251 256 PF02991 0.305
LIG_LIR_Nem_3 305 309 PF02991 0.439
LIG_LIR_Nem_3 374 379 PF02991 0.543
LIG_LIR_Nem_3 398 402 PF02991 0.289
LIG_LIR_Nem_3 448 454 PF02991 0.430
LIG_LIR_Nem_3 482 487 PF02991 0.372
LIG_LIR_Nem_3 510 515 PF02991 0.288
LIG_LIR_Nem_3 584 588 PF02991 0.334
LIG_LIR_Nem_3 626 630 PF02991 0.354
LIG_LIR_Nem_3 705 710 PF02991 0.324
LIG_NRBOX 527 533 PF00104 0.339
LIG_Pex14_2 249 253 PF04695 0.442
LIG_Pex14_2 417 421 PF04695 0.427
LIG_Pex14_2 623 627 PF04695 0.299
LIG_PTB_Apo_2 141 148 PF02174 0.460
LIG_PTB_Apo_2 505 512 PF02174 0.318
LIG_PTB_Phospho_1 141 147 PF10480 0.434
LIG_REV1ctd_RIR_1 441 450 PF16727 0.333
LIG_REV1ctd_RIR_1 708 715 PF16727 0.375
LIG_SH2_CRK 230 234 PF00017 0.440
LIG_SH2_CRK 399 403 PF00017 0.287
LIG_SH2_CRK 484 488 PF00017 0.379
LIG_SH2_GRB2like 506 509 PF00017 0.327
LIG_SH2_NCK_1 230 234 PF00017 0.440
LIG_SH2_NCK_1 45 49 PF00017 0.503
LIG_SH2_PTP2 123 126 PF00017 0.463
LIG_SH2_PTP2 376 379 PF00017 0.534
LIG_SH2_SRC 185 188 PF00017 0.445
LIG_SH2_SRC 484 487 PF00017 0.459
LIG_SH2_SRC 506 509 PF00017 0.377
LIG_SH2_SRC 604 607 PF00017 0.328
LIG_SH2_STAP1 230 234 PF00017 0.428
LIG_SH2_STAP1 245 249 PF00017 0.255
LIG_SH2_STAT3 312 315 PF00017 0.482
LIG_SH2_STAT3 392 395 PF00017 0.398
LIG_SH2_STAT5 123 126 PF00017 0.333
LIG_SH2_STAT5 147 150 PF00017 0.425
LIG_SH2_STAT5 185 188 PF00017 0.445
LIG_SH2_STAT5 22 25 PF00017 0.547
LIG_SH2_STAT5 230 233 PF00017 0.453
LIG_SH2_STAT5 307 310 PF00017 0.439
LIG_SH2_STAT5 351 354 PF00017 0.370
LIG_SH2_STAT5 376 379 PF00017 0.406
LIG_SH2_STAT5 392 395 PF00017 0.307
LIG_SH2_STAT5 420 423 PF00017 0.302
LIG_SH2_STAT5 486 489 PF00017 0.371
LIG_SH2_STAT5 506 509 PF00017 0.185
LIG_SH2_STAT5 604 607 PF00017 0.328
LIG_SH2_STAT5 734 737 PF00017 0.362
LIG_SH3_2 716 721 PF14604 0.391
LIG_SH3_3 184 190 PF00018 0.371
LIG_SH3_3 365 371 PF00018 0.464
LIG_SH3_3 651 657 PF00018 0.446
LIG_SH3_3 713 719 PF00018 0.359
LIG_SUMO_SIM_anti_2 114 120 PF11976 0.363
LIG_SUMO_SIM_par_1 109 114 PF11976 0.303
LIG_SUMO_SIM_par_1 117 122 PF11976 0.295
LIG_SUMO_SIM_par_1 549 557 PF11976 0.378
LIG_TRAF2_1 642 645 PF00917 0.330
LIG_TYR_ITIM 121 126 PF00017 0.465
LIG_TYR_ITIM 183 188 PF00017 0.437
LIG_TYR_ITSM 372 379 PF00017 0.437
LIG_UBA3_1 531 540 PF00899 0.406
LIG_WRC_WIRS_1 451 456 PF05994 0.387
LIG_WRC_WIRS_1 466 471 PF05994 0.259
MOD_CDK_SPxxK_3 420 427 PF00069 0.297
MOD_CK1_1 267 273 PF00069 0.399
MOD_CK1_1 329 335 PF00069 0.490
MOD_CK1_1 453 459 PF00069 0.399
MOD_CK1_1 81 87 PF00069 0.308
MOD_CK2_1 280 286 PF00069 0.579
MOD_CK2_1 308 314 PF00069 0.444
MOD_CK2_1 592 598 PF00069 0.437
MOD_CK2_1 634 640 PF00069 0.338
MOD_CK2_1 696 702 PF00069 0.326
MOD_GlcNHglycan 195 198 PF01048 0.391
MOD_GlcNHglycan 236 239 PF01048 0.445
MOD_GlcNHglycan 281 285 PF01048 0.618
MOD_GlcNHglycan 339 342 PF01048 0.492
MOD_GlcNHglycan 402 405 PF01048 0.287
MOD_GlcNHglycan 532 535 PF01048 0.442
MOD_GlcNHglycan 671 674 PF01048 0.435
MOD_GlcNHglycan 680 683 PF01048 0.386
MOD_GSK3_1 142 149 PF00069 0.569
MOD_GSK3_1 18 25 PF00069 0.471
MOD_GSK3_1 189 196 PF00069 0.366
MOD_GSK3_1 316 323 PF00069 0.433
MOD_GSK3_1 326 333 PF00069 0.429
MOD_GSK3_1 425 432 PF00069 0.323
MOD_GSK3_1 67 74 PF00069 0.512
MOD_GSK3_1 680 687 PF00069 0.386
MOD_N-GLC_1 507 512 PF02516 0.318
MOD_NEK2_1 320 325 PF00069 0.361
MOD_NEK2_1 429 434 PF00069 0.318
MOD_NEK2_1 547 552 PF00069 0.486
MOD_NEK2_1 78 83 PF00069 0.320
MOD_NEK2_2 2 7 PF00069 0.548
MOD_PIKK_1 453 459 PF00454 0.328
MOD_PIKK_1 81 87 PF00454 0.308
MOD_PKA_1 211 217 PF00069 0.499
MOD_PKA_2 142 148 PF00069 0.467
MOD_PKA_2 320 326 PF00069 0.398
MOD_PKA_2 390 396 PF00069 0.465
MOD_PKA_2 40 46 PF00069 0.401
MOD_PKA_2 618 624 PF00069 0.318
MOD_PKA_2 684 690 PF00069 0.426
MOD_PKA_2 79 85 PF00069 0.442
MOD_Plk_1 297 303 PF00069 0.370
MOD_Plk_1 507 513 PF00069 0.315
MOD_Plk_2-3 305 311 PF00069 0.307
MOD_Plk_4 256 262 PF00069 0.444
MOD_Plk_4 330 336 PF00069 0.418
MOD_Plk_4 372 378 PF00069 0.535
MOD_Plk_4 425 431 PF00069 0.322
MOD_Plk_4 450 456 PF00069 0.426
MOD_Plk_4 507 513 PF00069 0.294
MOD_Plk_4 527 533 PF00069 0.184
MOD_ProDKin_1 111 117 PF00069 0.315
MOD_ProDKin_1 420 426 PF00069 0.293
MOD_ProDKin_1 660 666 PF00069 0.430
MOD_SUMO_rev_2 168 178 PF00179 0.397
MOD_SUMO_rev_2 364 374 PF00179 0.382
TRG_DiLeu_BaEn_1 198 203 PF01217 0.343
TRG_DiLeu_BaEn_1 527 532 PF01217 0.334
TRG_DiLeu_BaLyEn_6 147 152 PF01217 0.341
TRG_DiLeu_BaLyEn_6 158 163 PF01217 0.367
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.403
TRG_DiLeu_BaLyEn_6 542 547 PF01217 0.375
TRG_ENDOCYTIC_2 123 126 PF00928 0.470
TRG_ENDOCYTIC_2 185 188 PF00928 0.445
TRG_ENDOCYTIC_2 216 219 PF00928 0.359
TRG_ENDOCYTIC_2 230 233 PF00928 0.436
TRG_ENDOCYTIC_2 376 379 PF00928 0.534
TRG_ENDOCYTIC_2 399 402 PF00928 0.286
TRG_ENDOCYTIC_2 451 454 PF00928 0.435
TRG_ENDOCYTIC_2 484 487 PF00928 0.373
TRG_ENDOCYTIC_2 707 710 PF00928 0.342
TRG_ER_diArg_1 487 489 PF00400 0.326
TRG_ER_diArg_1 646 648 PF00400 0.342
TRG_NES_CRM1_1 294 305 PF08389 0.344

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4C7 Leptomonas seymouri 84% 100%
A0A0S4ILQ1 Bodo saltans 59% 99%
A0A1X0P5V8 Trypanosomatidae 65% 100%
A0A3Q8IHX6 Leishmania donovani 98% 100%
A0A422NNY1 Trypanosoma rangeli 67% 100%
A4HMK4 Leishmania braziliensis 93% 100%
A4IB83 Leishmania infantum 98% 100%
C9ZZK8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9B660 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
V5D9G0 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS