rRNA processing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic rRNA processing protein EBP2, putative

Species:

Leishmania major

UniProt:

E9AF03_LEIMA

TriTrypDb:

LmjF.35.1820 , LMJLV39_350024600 , LMJSD75_350023800

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0034399	nuclear periphery	2	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9AF03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF03

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0042273	ribosomal large subunit biogenesis	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044085	cellular component biogenesis	3	11
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0042254	ribosome biogenesis	5	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.718
CLV_C14_Caspase3-7	71	75	PF00656	0.532
CLV_NRD_NRD_1	17	19	PF00675	0.504
CLV_NRD_NRD_1	184	186	PF00675	0.292
CLV_NRD_NRD_1	219	221	PF00675	0.311
CLV_NRD_NRD_1	223	225	PF00675	0.286
CLV_NRD_NRD_1	8	10	PF00675	0.508
CLV_PCSK_FUR_1	207	211	PF00082	0.338
CLV_PCSK_FUR_1	220	224	PF00082	0.320
CLV_PCSK_KEX2_1	10	12	PF00082	0.503
CLV_PCSK_KEX2_1	120	122	PF00082	0.292
CLV_PCSK_KEX2_1	148	150	PF00082	0.301
CLV_PCSK_KEX2_1	16	18	PF00082	0.506
CLV_PCSK_KEX2_1	184	186	PF00082	0.291
CLV_PCSK_KEX2_1	209	211	PF00082	0.285
CLV_PCSK_KEX2_1	222	224	PF00082	0.306
CLV_PCSK_KEX2_1	244	246	PF00082	0.408
CLV_PCSK_KEX2_1	263	265	PF00082	0.317
CLV_PCSK_KEX2_1	270	272	PF00082	0.629
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.503
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.292
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.320
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.285
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.301
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.445
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.322
CLV_PCSK_PC7_1	205	211	PF00082	0.301
CLV_PCSK_SKI1_1	100	104	PF00082	0.290
CLV_PCSK_SKI1_1	12	16	PF00082	0.540
CLV_PCSK_SKI1_1	185	189	PF00082	0.300
CLV_PCSK_SKI1_1	241	245	PF00082	0.412
CLV_Separin_Metazoa	200	204	PF03568	0.301
DEG_SPOP_SBC_1	102	106	PF00917	0.320
DOC_CKS1_1	249	254	PF01111	0.412
DOC_CYCLIN_RxL_1	9	19	PF00134	0.571
DOC_PP1_RVXF_1	86	92	PF00149	0.412
DOC_PP4_FxxP_1	91	94	PF00568	0.301
DOC_USP7_MATH_1	102	106	PF00917	0.303
DOC_USP7_MATH_1	243	247	PF00917	0.362
DOC_USP7_MATH_1	65	69	PF00917	0.749
DOC_USP7_UBL2_3	188	192	PF12436	0.301
DOC_USP7_UBL2_3	263	267	PF12436	0.373
DOC_WW_Pin1_4	248	253	PF00397	0.373
DOC_WW_Pin1_4	29	34	PF00397	0.755
LIG_14-3-3_CanoR_1	100	110	PF00244	0.315
LIG_14-3-3_CanoR_1	135	140	PF00244	0.344
LIG_14-3-3_CanoR_1	184	188	PF00244	0.393
LIG_FHA_1	104	110	PF00498	0.301
LIG_FHA_1	132	138	PF00498	0.398
LIG_FHA_1	249	255	PF00498	0.347
LIG_FHA_2	85	91	PF00498	0.388
LIG_LIR_Apic_2	90	94	PF02991	0.322
LIG_LIR_Gen_1	151	162	PF02991	0.288
LIG_NRP_CendR_1	270	273	PF00754	0.660
LIG_PCNA_yPIPBox_3	220	233	PF02747	0.445
LIG_SH2_NCK_1	4	8	PF00017	0.528
LIG_SH2_SRC	4	7	PF00017	0.601
LIG_SH2_SRC	47	50	PF00017	0.745
LIG_SH2_STAP1	154	158	PF00017	0.301
LIG_SH2_STAP1	4	8	PF00017	0.460
LIG_SH2_STAT5	47	50	PF00017	0.745
LIG_SH3_3	59	65	PF00018	0.643
LIG_SUMO_SIM_par_1	129	134	PF11976	0.353
LIG_TRAF2_1	50	53	PF00917	0.744
MOD_CDK_SPK_2	248	253	PF00069	0.373
MOD_CDK_SPxxK_3	248	255	PF00069	0.373
MOD_CK1_1	105	111	PF00069	0.323
MOD_CK2_1	135	141	PF00069	0.308
MOD_CK2_1	183	189	PF00069	0.386
MOD_CK2_1	29	35	PF00069	0.722
MOD_CK2_1	47	53	PF00069	0.706
MOD_CK2_1	65	71	PF00069	0.721
MOD_CK2_1	84	90	PF00069	0.364
MOD_GSK3_1	101	108	PF00069	0.316
MOD_GSK3_1	131	138	PF00069	0.398
MOD_N-GLC_1	225	230	PF02516	0.445
MOD_NEK2_1	101	106	PF00069	0.301
MOD_NEK2_1	131	136	PF00069	0.353
MOD_NEK2_1	171	176	PF00069	0.328
MOD_NEK2_1	212	217	PF00069	0.412
MOD_PKA_2	183	189	PF00069	0.404
MOD_Plk_4	126	132	PF00069	0.321
MOD_ProDKin_1	248	254	PF00069	0.373
MOD_ProDKin_1	29	35	PF00069	0.754
MOD_SUMO_for_1	119	122	PF00179	0.301
MOD_SUMO_rev_2	236	246	PF00179	0.440
TRG_ENDOCYTIC_2	154	157	PF00928	0.285
TRG_ER_diArg_1	15	18	PF00400	0.603
TRG_ER_diArg_1	202	205	PF00400	0.301
TRG_ER_diArg_1	252	255	PF00400	0.361
TRG_ER_diArg_1	270	273	PF00400	0.617
TRG_NLS_Bipartite_1	209	226	PF00514	0.301
TRG_NLS_MonoCore_2	219	224	PF00514	0.303
TRG_NLS_MonoCore_2	8	13	PF00514	0.488
TRG_NLS_MonoExtC_3	219	224	PF00514	0.324
TRG_NLS_MonoExtN_4	220	226	PF00514	0.301
TRG_NLS_MonoExtN_4	241	248	PF00514	0.445
TRG_NLS_MonoExtN_4	9	14	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I326	Leptomonas seymouri	74%	100%
A0A0S4IQU9	Bodo saltans	58%	100%
A0A1X0P5U9	Trypanosomatidae	73%	100%
A0A3Q8IPE1	Leishmania donovani	95%	100%
A0A3R7KIH6	Trypanosoma rangeli	68%	100%
A4HMK3	Leishmania braziliensis	86%	100%
A4IB82	Leishmania infantum	95%	100%
C9ZZK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B659	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	82%