tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DTW domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AF01_LEIMA

TriTrypDb:

LmjF.35.1800 , LMJLV39_350024400 , LMJSD75_350023600

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF01

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.730
CLV_C14_Caspase3-7	253	257	PF00656	0.634
CLV_NRD_NRD_1	41	43	PF00675	0.370
CLV_NRD_NRD_1	50	52	PF00675	0.275
CLV_PCSK_KEX2_1	2	4	PF00082	0.533
CLV_PCSK_KEX2_1	41	43	PF00082	0.368
CLV_PCSK_KEX2_1	49	51	PF00082	0.286
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.533
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.347
CLV_PCSK_SKI1_1	50	54	PF00082	0.479
CLV_Separin_Metazoa	325	329	PF03568	0.576
DEG_Nend_UBRbox_1	1	4	PF02207	0.598
DEG_SCF_FBW7_1	243	248	PF00400	0.485
DOC_CYCLIN_RxL_1	18	29	PF00134	0.387
DOC_CYCLIN_RxL_1	46	57	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.256
DOC_MAPK_gen_1	161	170	PF00069	0.256
DOC_PP1_RVXF_1	139	146	PF00149	0.237
DOC_PP1_RVXF_1	22	29	PF00149	0.377
DOC_PP2B_LxvP_1	219	222	PF13499	0.512
DOC_PP2B_LxvP_1	309	312	PF13499	0.417
DOC_PP2B_LxvP_1	71	74	PF13499	0.256
DOC_PP4_FxxP_1	28	31	PF00568	0.304
DOC_USP7_MATH_1	314	318	PF00917	0.594
DOC_WW_Pin1_4	217	222	PF00397	0.566
DOC_WW_Pin1_4	241	246	PF00397	0.622
DOC_WW_Pin1_4	96	101	PF00397	0.237
LIG_14-3-3_CanoR_1	169	178	PF00244	0.264
LIG_14-3-3_CanoR_1	282	288	PF00244	0.450
LIG_APCC_ABBAyCdc20_2	141	147	PF00400	0.237
LIG_BRCT_BRCA1_1	24	28	PF00533	0.289
LIG_FHA_1	117	123	PF00498	0.239
LIG_FHA_1	246	252	PF00498	0.638
LIG_FHA_2	302	308	PF00498	0.419
LIG_LIR_Apic_2	25	31	PF02991	0.285
LIG_LIR_Gen_1	304	314	PF02991	0.402
LIG_LIR_Nem_3	106	110	PF02991	0.237
LIG_LIR_Nem_3	138	143	PF02991	0.295
LIG_LIR_Nem_3	163	168	PF02991	0.252
LIG_LIR_Nem_3	174	180	PF02991	0.222
LIG_LIR_Nem_3	192	198	PF02991	0.237
LIG_LIR_Nem_3	267	273	PF02991	0.275
LIG_LIR_Nem_3	293	299	PF02991	0.389
LIG_LIR_Nem_3	304	309	PF02991	0.355
LIG_LYPXL_yS_3	107	110	PF13949	0.237
LIG_PTB_Apo_2	139	146	PF02174	0.221
LIG_SH2_CRK	140	144	PF00017	0.337
LIG_SH2_CRK	56	60	PF00017	0.237
LIG_SH2_GRB2like	272	275	PF00017	0.284
LIG_SH2_PTP2	276	279	PF00017	0.286
LIG_SH2_PTP2	78	81	PF00017	0.256
LIG_SH2_STAT3	201	204	PF00017	0.292
LIG_SH2_STAT3	272	275	PF00017	0.273
LIG_SH2_STAT3	299	302	PF00017	0.452
LIG_SH2_STAT5	187	190	PF00017	0.237
LIG_SH2_STAT5	196	199	PF00017	0.237
LIG_SH2_STAT5	201	204	PF00017	0.237
LIG_SH2_STAT5	272	275	PF00017	0.273
LIG_SH2_STAT5	276	279	PF00017	0.286
LIG_SH2_STAT5	283	286	PF00017	0.392
LIG_SH2_STAT5	291	294	PF00017	0.412
LIG_SH2_STAT5	299	302	PF00017	0.309
LIG_SH2_STAT5	54	57	PF00017	0.267
LIG_SH2_STAT5	78	81	PF00017	0.259
LIG_SH2_STAT5	8	11	PF00017	0.478
LIG_SH3_3	105	111	PF00018	0.231
LIG_SH3_3	118	124	PF00018	0.217
LIG_SH3_3	218	224	PF00018	0.508
LIG_SH3_3	307	313	PF00018	0.389
LIG_SH3_3	320	326	PF00018	0.555
LIG_SH3_3	77	83	PF00018	0.348
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.351
LIG_WW_3	325	329	PF00397	0.576
MOD_CDK_SPK_2	241	246	PF00069	0.578
MOD_CK1_1	125	131	PF00069	0.205
MOD_CK1_1	172	178	PF00069	0.280
MOD_CK1_1	215	221	PF00069	0.586
MOD_CK1_1	230	236	PF00069	0.726
MOD_CK1_1	238	244	PF00069	0.678
MOD_CK1_1	317	323	PF00069	0.696
MOD_CK1_1	96	102	PF00069	0.236
MOD_CK2_1	302	308	PF00069	0.434
MOD_CK2_1	8	14	PF00069	0.552
MOD_GlcNHglycan	215	218	PF01048	0.555
MOD_GlcNHglycan	237	240	PF01048	0.731
MOD_GlcNHglycan	253	256	PF01048	0.582
MOD_GlcNHglycan	284	287	PF01048	0.528
MOD_GlcNHglycan	296	299	PF01048	0.491
MOD_GSK3_1	146	153	PF00069	0.237
MOD_GSK3_1	183	190	PF00069	0.241
MOD_GSK3_1	213	220	PF00069	0.528
MOD_GSK3_1	22	29	PF00069	0.286
MOD_GSK3_1	230	237	PF00069	0.777
MOD_GSK3_1	241	248	PF00069	0.516
MOD_GSK3_1	251	258	PF00069	0.463
MOD_GSK3_1	317	324	PF00069	0.667
MOD_GSK3_1	89	96	PF00069	0.262
MOD_LATS_1	167	173	PF00433	0.316
MOD_N-GLC_1	302	307	PF02516	0.424
MOD_N-GLC_1	317	322	PF02516	0.473
MOD_NEK2_1	145	150	PF00069	0.256
MOD_NEK2_1	212	217	PF00069	0.370
MOD_NEK2_1	22	27	PF00069	0.301
MOD_NEK2_1	93	98	PF00069	0.237
MOD_NEK2_2	58	63	PF00069	0.258
MOD_PIKK_1	169	175	PF00454	0.280
MOD_PIKK_1	200	206	PF00454	0.292
MOD_PKA_2	160	166	PF00069	0.292
MOD_PKA_2	281	287	PF00069	0.426
MOD_Plk_1	116	122	PF00069	0.280
MOD_Plk_1	125	131	PF00069	0.280
MOD_Plk_1	146	152	PF00069	0.256
MOD_Plk_1	255	261	PF00069	0.372
MOD_Plk_1	302	308	PF00069	0.588
MOD_Plk_4	116	122	PF00069	0.237
MOD_Plk_4	172	178	PF00069	0.260
MOD_Plk_4	183	189	PF00069	0.318
MOD_ProDKin_1	217	223	PF00069	0.569
MOD_ProDKin_1	241	247	PF00069	0.619
MOD_ProDKin_1	96	102	PF00069	0.237
MOD_SUMO_rev_2	229	236	PF00179	0.579
TRG_DiLeu_BaEn_1	264	269	PF01217	0.304
TRG_ENDOCYTIC_2	107	110	PF00928	0.237
TRG_ENDOCYTIC_2	140	143	PF00928	0.370
TRG_ENDOCYTIC_2	195	198	PF00928	0.237
TRG_ENDOCYTIC_2	276	279	PF00928	0.290
TRG_ENDOCYTIC_2	56	59	PF00928	0.237
TRG_ENDOCYTIC_2	78	81	PF00928	0.256
TRG_ER_diArg_1	33	36	PF00400	0.374
TRG_ER_diArg_1	50	52	PF00400	0.224
TRG_NLS_MonoCore_2	1	6	PF00514	0.654
TRG_NLS_MonoExtN_4	46	53	PF00514	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD7	Leptomonas seymouri	78%	100%
A0A0S4IR26	Bodo saltans	50%	100%
A0A1X0P5T8	Trypanosomatidae	63%	100%
A0A3S7X980	Leishmania donovani	94%	100%
A4HMK1	Leishmania braziliensis	86%	100%
A4IB80	Leishmania infantum	94%	100%
C9ZZK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B657	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q9D8U7	Mus musculus	33%	100%
V5B8W4	Trypanosoma cruzi	62%	100%