Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEZ9_LEIMA

TriTrypDb:

LmjF.35.1770 , LMJLV39_350024200 , LMJSD75_350023400

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	204	210	PF00089	0.536
CLV_NRD_NRD_1	127	129	PF00675	0.594
CLV_NRD_NRD_1	181	183	PF00675	0.546
CLV_PCSK_KEX2_1	129	131	PF00082	0.632
CLV_PCSK_KEX2_1	181	183	PF00082	0.546
CLV_PCSK_KEX2_1	206	208	PF00082	0.531
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.632
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.615
CLV_PCSK_SKI1_1	203	207	PF00082	0.551
CLV_Separin_Metazoa	155	159	PF03568	0.623
DOC_MAPK_MEF2A_6	189	198	PF00069	0.365
DOC_USP7_MATH_1	33	37	PF00917	0.616
DOC_USP7_MATH_1	58	62	PF00917	0.490
DOC_WW_Pin1_4	34	39	PF00397	0.606
DOC_WW_Pin1_4	41	46	PF00397	0.534
LIG_14-3-3_CanoR_1	128	135	PF00244	0.713
LIG_14-3-3_CanoR_1	18	24	PF00244	0.602
LIG_14-3-3_CanoR_1	3	9	PF00244	0.649
LIG_BIR_III_4	82	86	PF00653	0.502
LIG_FHA_1	191	197	PF00498	0.480
LIG_FHA_1	67	73	PF00498	0.460
LIG_FHA_1	84	90	PF00498	0.481
LIG_FHA_2	21	27	PF00498	0.615
LIG_LIR_Nem_3	36	42	PF02991	0.589
LIG_LIR_Nem_3	6	12	PF02991	0.504
LIG_NRBOX	200	206	PF00104	0.545
LIG_PCNA_PIPBox_1	115	124	PF02747	0.602
LIG_PCNA_yPIPBox_3	110	122	PF02747	0.601
LIG_PCNA_yPIPBox_3	169	178	PF02747	0.507
LIG_Pex14_2	49	53	PF04695	0.616
LIG_SH2_NCK_1	19	23	PF00017	0.630
LIG_SH2_STAP1	152	156	PF00017	0.503
LIG_SH2_STAT5	121	124	PF00017	0.575
LIG_SH2_STAT5	138	141	PF00017	0.602
LIG_SH2_STAT5	75	78	PF00017	0.436
LIG_SH2_STAT5	87	90	PF00017	0.511
LIG_SH3_3	39	45	PF00018	0.580
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.621
LIG_SUMO_SIM_par_1	192	197	PF11976	0.363
MOD_CDK_SPxK_1	34	40	PF00069	0.605
MOD_CDK_SPxxK_3	41	48	PF00069	0.553
MOD_CK1_1	20	26	PF00069	0.647
MOD_CK2_1	20	26	PF00069	0.615
MOD_GlcNHglycan	130	133	PF01048	0.631
MOD_GlcNHglycan	72	75	PF01048	0.391
MOD_GSK3_1	120	127	PF00069	0.600
MOD_GSK3_1	66	73	PF00069	0.469
MOD_N-GLC_1	190	195	PF02516	0.515
MOD_NEK2_1	2	7	PF00069	0.650
MOD_PIKK_1	98	104	PF00454	0.593
MOD_PKA_1	128	134	PF00069	0.648
MOD_PKA_2	17	23	PF00069	0.617
MOD_PKA_2	2	8	PF00069	0.585
MOD_Plk_1	190	196	PF00069	0.494
MOD_Plk_4	190	196	PF00069	0.484
MOD_Plk_4	58	64	PF00069	0.474
MOD_Plk_4	83	89	PF00069	0.485
MOD_ProDKin_1	34	40	PF00069	0.605
MOD_ProDKin_1	41	47	PF00069	0.530
MOD_SUMO_for_1	133	136	PF00179	0.690
MOD_SUMO_rev_2	123	127	PF00179	0.582
MOD_SUMO_rev_2	78	86	PF00179	0.473
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.583
TRG_ER_diArg_1	180	182	PF00400	0.545
TRG_NLS_MonoExtN_4	126	132	PF00514	0.613
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T0	Leptomonas seymouri	80%	100%
A0A0S4KLR7	Bodo saltans	58%	100%
A0A1X0P7A8	Trypanosomatidae	62%	100%
A0A3Q8IG68	Leishmania donovani	97%	100%
A4HMJ9	Leishmania braziliensis	87%	100%
A4IB78	Leishmania infantum	97%	100%
C9ZZK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B655	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%