Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEZ7_LEIMA

TriTrypDb:

LmjF.35.1755 , LMJLV39_350024000 , LMJSD75_350023200

Length:

140

Annotations

LeishMANIAdb annotations

No signal peptide, but transit signal possible. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AEZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	92	96	PF00082	0.616
DEG_APCC_DBOX_1	16	24	PF00400	0.549
DEG_APCC_DBOX_1	4	12	PF00400	0.650
DEG_Nend_Nbox_1	1	3	PF02207	0.687
DEG_ODPH_VHL_1	8	20	PF01847	0.607
DOC_CDC14_PxL_1	6	14	PF14671	0.681
DOC_CKS1_1	108	113	PF01111	0.548
DOC_PP2B_PxIxI_1	49	55	PF00149	0.442
DOC_PP4_FxxP_1	117	120	PF00568	0.521
DOC_USP7_MATH_1	33	37	PF00917	0.616
DOC_WW_Pin1_4	107	112	PF00397	0.442
DOC_WW_Pin1_4	118	123	PF00397	0.405
DOC_WW_Pin1_4	92	97	PF00397	0.411
LIG_14-3-3_CanoR_1	102	107	PF00244	0.519
LIG_14-3-3_CanoR_1	3	9	PF00244	0.710
LIG_BRCT_BRCA1_1	52	56	PF00533	0.449
LIG_deltaCOP1_diTrp_1	124	128	PF00928	0.409
LIG_deltaCOP1_diTrp_1	38	44	PF00928	0.598
LIG_DLG_GKlike_1	102	110	PF00625	0.540
LIG_FHA_1	62	68	PF00498	0.392
LIG_FHA_1	79	85	PF00498	0.323
LIG_FHA_2	114	120	PF00498	0.435
LIG_LIR_Apic_2	116	120	PF02991	0.433
LIG_LIR_Gen_1	53	63	PF02991	0.398
LIG_LIR_Gen_1	85	94	PF02991	0.421
LIG_LIR_Nem_3	124	128	PF02991	0.404
LIG_LIR_Nem_3	25	30	PF02991	0.618
LIG_LIR_Nem_3	38	43	PF02991	0.588
LIG_LIR_Nem_3	53	59	PF02991	0.328
LIG_LIR_Nem_3	70	74	PF02991	0.273
LIG_LIR_Nem_3	85	89	PF02991	0.397
LIG_LYPXL_S_1	48	52	PF13949	0.358
LIG_LYPXL_yS_3	49	52	PF13949	0.476
LIG_Pex14_1	40	44	PF04695	0.597
LIG_SH2_CRK	27	31	PF00017	0.630
LIG_SH2_SRC	86	89	PF00017	0.408
LIG_SH2_STAT3	134	137	PF00017	0.453
LIG_SH2_STAT5	134	137	PF00017	0.453
LIG_SH3_3	108	114	PF00018	0.444
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.359
LIG_SUMO_SIM_par_1	50	55	PF11976	0.448
LIG_SUMO_SIM_par_1	64	70	PF11976	0.372
LIG_TYR_ITIM	84	89	PF00017	0.406
LIG_TYR_ITSM	23	30	PF00017	0.625
LIG_WRC_WIRS_1	103	108	PF05994	0.541
MOD_CK1_1	107	113	PF00069	0.546
MOD_CK1_1	13	19	PF00069	0.569
MOD_GSK3_1	22	29	PF00069	0.664
MOD_GSK3_1	50	57	PF00069	0.309
MOD_GSK3_1	78	85	PF00069	0.438
MOD_NEK2_1	1	6	PF00069	0.666
MOD_PKA_2	4	10	PF00069	0.675
MOD_PKB_1	102	110	PF00069	0.540
MOD_Plk_2-3	82	88	PF00069	0.425
MOD_Plk_4	61	67	PF00069	0.442
MOD_ProDKin_1	107	113	PF00069	0.441
MOD_ProDKin_1	118	124	PF00069	0.404
MOD_ProDKin_1	92	98	PF00069	0.410
MOD_SUMO_for_1	23	26	PF00179	0.616
MOD_SUMO_rev_2	124	132	PF00179	0.407
TRG_DiLeu_BaEn_2	37	43	PF01217	0.600
TRG_ENDOCYTIC_2	27	30	PF00928	0.634
TRG_ENDOCYTIC_2	49	52	PF00928	0.476
TRG_ENDOCYTIC_2	74	77	PF00928	0.377
TRG_ENDOCYTIC_2	86	89	PF00928	0.398
TRG_ER_diArg_1	2	5	PF00400	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D9	Leptomonas seymouri	78%	100%
A0A0S4KFM7	Bodo saltans	72%	99%
A0A1X0P629	Trypanosomatidae	72%	100%
A0A3R7M0Z8	Trypanosoma rangeli	68%	100%
A0A3S7X9C1	Leishmania donovani	98%	100%
A4HMJ7	Leishmania braziliensis	91%	100%
A4IB76	Leishmania infantum	98%	100%
C9ZZK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9B653	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5D9I0	Trypanosoma cruzi	69%	100%