Dynein-associated roadblock protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein-associated roadblock protein-like protein

Species:

Leishmania major

UniProt:

E9AEZ6_LEIMA

TriTrypDb:

LmjF.35.1750 , LMJLV39_350023800 , LMJSD75_350023000

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0005815	microtubule organizing center	2	2
GO:0005868	cytoplasmic dynein complex	4	5
GO:0005875	microtubule associated complex	2	5
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	5
GO:1902494	catalytic complex	2	5
GO:0005874	microtubule	6	3
GO:0099080	supramolecular complex	2	3
GO:0099081	supramolecular polymer	3	3
GO:0099512	supramolecular fiber	4	3
GO:0099513	polymeric cytoskeletal fiber	5	3

Expansion

Sequence features

E9AEZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEZ6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	5
GO:0007018	microtubule-based movement	3	5
GO:0009987	cellular process	1	5

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0045505	dynein intermediate chain binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.421
DOC_CYCLIN_yClb1_LxF_4	86	92	PF00134	0.320
DOC_MAPK_gen_1	95	103	PF00069	0.320
DOC_MAPK_MEF2A_6	107	114	PF00069	0.320
DOC_USP7_MATH_1	51	55	PF00917	0.320
DOC_WW_Pin1_4	47	52	PF00397	0.334
LIG_14-3-3_CanoR_1	13	17	PF00244	0.516
LIG_14-3-3_CanoR_1	20	30	PF00244	0.476
LIG_14-3-3_CanoR_1	32	39	PF00244	0.238
LIG_FHA_1	38	44	PF00498	0.340
LIG_FHA_1	84	90	PF00498	0.320
LIG_FHA_2	53	59	PF00498	0.299
LIG_LIR_Gen_1	106	117	PF02991	0.320
LIG_LIR_Gen_1	28	37	PF02991	0.324
LIG_LIR_Nem_3	106	112	PF02991	0.320
LIG_LIR_Nem_3	28	33	PF02991	0.324
LIG_LIR_Nem_3	88	94	PF02991	0.320
LIG_SH2_STAP1	65	69	PF00017	0.320
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.320
LIG_SUMO_SIM_anti_2	40	48	PF11976	0.355
LIG_SUMO_SIM_par_1	40	48	PF11976	0.321
LIG_UBA3_1	68	75	PF00899	0.320
MOD_CDK_SPxK_1	47	53	PF00069	0.374
MOD_CK1_1	15	21	PF00069	0.555
MOD_CK1_1	47	53	PF00069	0.445
MOD_CK2_1	51	57	PF00069	0.320
MOD_GSK3_1	47	54	PF00069	0.298
MOD_GSK3_1	7	14	PF00069	0.536
MOD_N-GLC_1	37	42	PF02516	0.355
MOD_NEK2_1	16	21	PF00069	0.644
MOD_NEK2_1	68	73	PF00069	0.344
MOD_PIKK_1	31	37	PF00454	0.320
MOD_PKA_2	31	37	PF00069	0.291
MOD_PKA_2	52	58	PF00069	0.320
MOD_PKA_2	7	13	PF00069	0.537
MOD_Plk_1	56	62	PF00069	0.374
MOD_ProDKin_1	47	53	PF00069	0.334
TRG_ENDOCYTIC_2	65	68	PF00928	0.320
TRG_ER_diArg_1	92	95	PF00400	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V1	Leptomonas seymouri	40%	100%
A0A0N1HUN3	Leptomonas seymouri	94%	100%
A0A0S4KIT1	Bodo saltans	85%	100%
A0A1X0P773	Trypanosomatidae	48%	100%
A0A3Q8IJB4	Leishmania donovani	97%	100%
A0A3Q8IJQ7	Leishmania donovani	36%	100%
A0A422P0L4	Trypanosoma rangeli	47%	100%
A4H9K8	Leishmania braziliensis	34%	100%
A4HMJ5	Leishmania braziliensis	95%	100%
A4HXX4	Leishmania infantum	36%	100%
A4IB75	Leishmania infantum	97%	100%
C9ZMI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZWI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZZS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ARN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B652	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	79%
P62627	Mus musculus	58%	100%
P62628	Rattus norvegicus	58%	100%
Q32P85	Bos taurus	56%	100%
Q3T140	Bos taurus	58%	100%
Q4QDU1	Leishmania major	36%	100%
Q8TF09	Homo sapiens	56%	100%
Q9DAJ5	Mus musculus	56%	100%
Q9NP97	Homo sapiens	60%	100%
V5BM74	Trypanosoma cruzi	48%	100%