Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEZ0_LEIMA

TriTrypDb:

LmjF.35.1680 , LMJLV39_350023200 , LMJSD75_350022400

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AEZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.547
CLV_NRD_NRD_1	227	229	PF00675	0.571
CLV_NRD_NRD_1	259	261	PF00675	0.617
CLV_NRD_NRD_1	89	91	PF00675	0.338
CLV_PCSK_FUR_1	225	229	PF00082	0.511
CLV_PCSK_KEX2_1	173	175	PF00082	0.545
CLV_PCSK_KEX2_1	227	229	PF00082	0.571
CLV_PCSK_KEX2_1	259	261	PF00082	0.617
CLV_PCSK_KEX2_1	87	89	PF00082	0.368
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.390
CLV_PCSK_SKI1_1	14	18	PF00082	0.292
CLV_PCSK_SKI1_1	148	152	PF00082	0.391
DEG_SCF_FBW7_1	185	192	PF00400	0.614
DOC_CKS1_1	218	223	PF01111	0.759
DOC_CKS1_1	39	44	PF01111	0.500
DOC_MAPK_gen_1	87	96	PF00069	0.508
DOC_MAPK_MEF2A_6	140	149	PF00069	0.489
DOC_MAPK_MEF2A_6	89	98	PF00069	0.531
DOC_PP1_RVXF_1	109	115	PF00149	0.379
DOC_PP1_RVXF_1	138	144	PF00149	0.444
DOC_PP4_FxxP_1	79	82	PF00568	0.585
DOC_WW_Pin1_4	185	190	PF00397	0.751
DOC_WW_Pin1_4	217	222	PF00397	0.717
DOC_WW_Pin1_4	232	237	PF00397	0.693
DOC_WW_Pin1_4	238	243	PF00397	0.704
DOC_WW_Pin1_4	258	263	PF00397	0.719
DOC_WW_Pin1_4	265	270	PF00397	0.741
DOC_WW_Pin1_4	38	43	PF00397	0.494
LIG_14-3-3_CanoR_1	14	19	PF00244	0.500
LIG_14-3-3_CanoR_1	211	218	PF00244	0.786
LIG_EH1_1	143	151	PF00400	0.475
LIG_FHA_1	108	114	PF00498	0.403
LIG_FHA_1	136	142	PF00498	0.474
LIG_FHA_1	18	24	PF00498	0.364
LIG_FHA_1	180	186	PF00498	0.627
LIG_FHA_1	195	201	PF00498	0.715
LIG_FHA_2	190	196	PF00498	0.743
LIG_FHA_2	221	227	PF00498	0.745
LIG_GBD_Chelix_1	59	67	PF00786	0.283
LIG_LIR_Apic_2	215	221	PF02991	0.749
LIG_LIR_Apic_2	237	242	PF02991	0.723
LIG_LIR_Gen_1	133	144	PF02991	0.349
LIG_LIR_Gen_1	28	36	PF02991	0.420
LIG_LIR_Nem_3	133	139	PF02991	0.349
LIG_LIR_Nem_3	28	33	PF02991	0.434
LIG_MAD2	111	119	PF02301	0.462
LIG_PDZ_Class_2	273	278	PF00595	0.749
LIG_Pex14_1	114	118	PF04695	0.360
LIG_Pex14_1	75	79	PF04695	0.544
LIG_Pex14_2	21	25	PF04695	0.369
LIG_SH2_CRK	136	140	PF00017	0.369
LIG_SH2_NCK_1	218	222	PF00017	0.697
LIG_SH2_STAT5	127	130	PF00017	0.444
LIG_SH2_STAT5	181	184	PF00017	0.729
LIG_SH2_STAT5	54	57	PF00017	0.485
LIG_SH2_STAT5	65	68	PF00017	0.344
LIG_SH3_3	113	119	PF00018	0.385
LIG_SH3_3	263	269	PF00018	0.771
LIG_SH3_3	36	42	PF00018	0.478
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.447
LIG_TYR_ITIM	134	139	PF00017	0.408
LIG_UBA3_1	145	151	PF00899	0.592
LIG_WRC_WIRS_1	18	23	PF05994	0.444
LIG_WRC_WIRS_1	32	37	PF05994	0.444
MOD_CDC14_SPxK_1	235	238	PF00782	0.709
MOD_CDK_SPK_2	265	270	PF00069	0.751
MOD_CDK_SPxK_1	232	238	PF00069	0.798
MOD_CK1_1	135	141	PF00069	0.369
MOD_CK1_1	234	240	PF00069	0.756
MOD_CK1_1	241	247	PF00069	0.746
MOD_CK1_1	261	267	PF00069	0.577
MOD_CK1_1	268	274	PF00069	0.696
MOD_CK1_1	28	34	PF00069	0.480
MOD_CK1_1	44	50	PF00069	0.275
MOD_GlcNHglycan	212	215	PF01048	0.581
MOD_GlcNHglycan	270	273	PF01048	0.581
MOD_GSK3_1	10	17	PF00069	0.555
MOD_GSK3_1	130	137	PF00069	0.413
MOD_GSK3_1	152	159	PF00069	0.684
MOD_GSK3_1	185	192	PF00069	0.705
MOD_GSK3_1	234	241	PF00069	0.768
MOD_GSK3_1	247	254	PF00069	0.727
MOD_GSK3_1	261	268	PF00069	0.815
MOD_GSK3_1	34	41	PF00069	0.578
MOD_N-GLC_1	162	167	PF02516	0.494
MOD_NEK2_1	134	139	PF00069	0.364
MOD_NEK2_1	152	157	PF00069	0.591
MOD_NEK2_1	247	252	PF00069	0.729
MOD_NEK2_1	25	30	PF00069	0.373
MOD_NEK2_1	46	51	PF00069	0.393
MOD_NEK2_1	55	60	PF00069	0.349
MOD_NEK2_1	67	72	PF00069	0.316
MOD_NEK2_1	9	14	PF00069	0.587
MOD_NEK2_2	194	199	PF00069	0.721
MOD_PIKK_1	163	169	PF00454	0.699
MOD_PIKK_1	247	253	PF00454	0.749
MOD_PIKK_1	41	47	PF00454	0.392
MOD_PKA_2	210	216	PF00069	0.793
MOD_PKA_2	251	257	PF00069	0.796
MOD_Plk_1	194	200	PF00069	0.611
MOD_Plk_1	245	251	PF00069	0.754
MOD_Plk_4	14	20	PF00069	0.499
MOD_Plk_4	194	200	PF00069	0.748
MOD_Plk_4	25	31	PF00069	0.329
MOD_Plk_4	34	40	PF00069	0.558
MOD_Plk_4	55	61	PF00069	0.375
MOD_Plk_4	67	73	PF00069	0.329
MOD_ProDKin_1	185	191	PF00069	0.750
MOD_ProDKin_1	217	223	PF00069	0.717
MOD_ProDKin_1	232	238	PF00069	0.681
MOD_ProDKin_1	258	264	PF00069	0.760
MOD_ProDKin_1	265	271	PF00069	0.739
MOD_ProDKin_1	38	44	PF00069	0.490
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.606
TRG_ENDOCYTIC_2	136	139	PF00928	0.369
TRG_ENDOCYTIC_2	54	57	PF00928	0.358
TRG_ER_diArg_1	172	174	PF00400	0.720
TRG_ER_diArg_1	258	260	PF00400	0.711
TRG_ER_diArg_1	88	90	PF00400	0.553
TRG_NLS_MonoCore_2	86	91	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T3	Leptomonas seymouri	47%	95%
A0A0S4IQJ0	Bodo saltans	23%	76%
A0A3Q8IV65	Leishmania donovani	90%	100%
A0A3R7M240	Trypanosoma rangeli	42%	100%
A4HMI9	Leishmania braziliensis	64%	97%
A4IB69	Leishmania infantum	90%	100%
E9B646	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5B3X7	Trypanosoma cruzi	40%	100%