Mismatch repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mismatch repair protein PMS1, putative

Species:

Leishmania major

UniProt:

E9AEY8_LEIMA

TriTrypDb:

LmjF.35.1660 , LMJLV39_350023000 , LMJSD75_350022200

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0032300	mismatch repair complex	2	8
GO:0032389	MutLalpha complex	3	2
GO:0032991	protein-containing complex	1	8
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9AEY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006298	mismatch repair	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003690	double-stranded DNA binding	5	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008094	ATP-dependent activity, acting on DNA	2	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0016887	ATP hydrolysis activity	7	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0030983	mismatched DNA binding	6	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140299	small molecule sensor activity	1	8
GO:0140612	DNA damage sensor activity	2	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:0140664	ATP-dependent DNA damage sensor activity	3	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.559
CLV_C14_Caspase3-7	480	484	PF00656	0.698
CLV_C14_Caspase3-7	489	493	PF00656	0.776
CLV_C14_Caspase3-7	511	515	PF00656	0.840
CLV_C14_Caspase3-7	74	78	PF00656	0.592
CLV_NRD_NRD_1	10	12	PF00675	0.516
CLV_NRD_NRD_1	210	212	PF00675	0.544
CLV_NRD_NRD_1	360	362	PF00675	0.376
CLV_NRD_NRD_1	584	586	PF00675	0.654
CLV_NRD_NRD_1	93	95	PF00675	0.679
CLV_PCSK_KEX2_1	345	347	PF00082	0.268
CLV_PCSK_KEX2_1	360	362	PF00082	0.350
CLV_PCSK_KEX2_1	430	432	PF00082	0.662
CLV_PCSK_KEX2_1	584	586	PF00082	0.654
CLV_PCSK_KEX2_1	798	800	PF00082	0.570
CLV_PCSK_KEX2_1	93	95	PF00082	0.683
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.268
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.350
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.714
CLV_PCSK_PC1ET2_1	798	800	PF00082	0.570
CLV_PCSK_SKI1_1	193	197	PF00082	0.502
CLV_PCSK_SKI1_1	259	263	PF00082	0.513
CLV_PCSK_SKI1_1	361	365	PF00082	0.376
CLV_PCSK_SKI1_1	430	434	PF00082	0.704
CLV_PCSK_SKI1_1	719	723	PF00082	0.338
CLV_PCSK_SKI1_1	798	802	PF00082	0.504
CLV_Separin_Metazoa	600	604	PF03568	0.505
DEG_APCC_DBOX_1	819	827	PF00400	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DEG_SPOP_SBC_1	461	465	PF00917	0.807
DOC_CDC14_PxL_1	311	319	PF14671	0.430
DOC_CKS1_1	238	243	PF01111	0.619
DOC_CKS1_1	791	796	PF01111	0.501
DOC_CYCLIN_RxL_1	359	369	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	699	705	PF00134	0.376
DOC_MAPK_gen_1	783	791	PF00069	0.376
DOC_MAPK_gen_1	798	804	PF00069	0.438
DOC_MAPK_MEF2A_6	37	45	PF00069	0.501
DOC_MAPK_MEF2A_6	566	574	PF00069	0.675
DOC_PP1_RVXF_1	273	279	PF00149	0.376
DOC_PP2B_LxvP_1	501	504	PF13499	0.841
DOC_PP2B_LxvP_1	699	702	PF13499	0.430
DOC_USP7_MATH_1	140	144	PF00917	0.458
DOC_USP7_MATH_1	145	149	PF00917	0.460
DOC_USP7_MATH_1	257	261	PF00917	0.503
DOC_USP7_MATH_1	330	334	PF00917	0.413
DOC_USP7_MATH_1	461	465	PF00917	0.799
DOC_USP7_MATH_1	539	543	PF00917	0.752
DOC_USP7_MATH_1	784	788	PF00917	0.376
DOC_USP7_UBL2_3	208	212	PF12436	0.625
DOC_USP7_UBL2_3	645	649	PF12436	0.471
DOC_WW_Pin1_4	237	242	PF00397	0.615
DOC_WW_Pin1_4	354	359	PF00397	0.462
DOC_WW_Pin1_4	414	419	PF00397	0.606
DOC_WW_Pin1_4	455	460	PF00397	0.793
DOC_WW_Pin1_4	496	501	PF00397	0.837
DOC_WW_Pin1_4	503	508	PF00397	0.831
DOC_WW_Pin1_4	692	697	PF00397	0.390
DOC_WW_Pin1_4	78	83	PF00397	0.583
DOC_WW_Pin1_4	790	795	PF00397	0.501
LIG_14-3-3_CanoR_1	165	169	PF00244	0.493
LIG_14-3-3_CanoR_1	259	268	PF00244	0.521
LIG_14-3-3_CanoR_1	275	281	PF00244	0.430
LIG_14-3-3_CanoR_1	297	305	PF00244	0.321
LIG_14-3-3_CanoR_1	346	351	PF00244	0.398
LIG_14-3-3_CanoR_1	407	414	PF00244	0.557
LIG_14-3-3_CanoR_1	416	424	PF00244	0.648
LIG_14-3-3_CanoR_1	806	814	PF00244	0.498
LIG_BRCT_BRCA1_1	132	136	PF00533	0.591
LIG_BRCT_BRCA1_1	278	282	PF00533	0.462
LIG_eIF4E_1	683	689	PF01652	0.501
LIG_FHA_1	157	163	PF00498	0.504
LIG_FHA_1	172	178	PF00498	0.465
LIG_FHA_1	21	27	PF00498	0.420
LIG_FHA_1	256	262	PF00498	0.573
LIG_FHA_1	284	290	PF00498	0.381
LIG_FHA_1	38	44	PF00498	0.265
LIG_FHA_1	497	503	PF00498	0.757
LIG_FHA_1	541	547	PF00498	0.692
LIG_FHA_1	734	740	PF00498	0.355
LIG_FHA_1	768	774	PF00498	0.430
LIG_FHA_1	79	85	PF00498	0.557
LIG_FHA_1	820	826	PF00498	0.503
LIG_FHA_2	1	7	PF00498	0.525
LIG_FHA_2	102	108	PF00498	0.705
LIG_FHA_2	112	118	PF00498	0.527
LIG_FHA_2	487	493	PF00498	0.846
LIG_FHA_2	592	598	PF00498	0.611
LIG_FHA_2	633	639	PF00498	0.519
LIG_LIR_Apic_2	811	817	PF02991	0.519
LIG_LIR_Nem_3	262	268	PF02991	0.420
LIG_LIR_Nem_3	279	285	PF02991	0.265
LIG_LIR_Nem_3	594	598	PF02991	0.550
LIG_LYPXL_yS_3	595	598	PF13949	0.634
LIG_MYND_1	500	504	PF01753	0.836
LIG_Pex14_1	278	282	PF04695	0.376
LIG_Pex14_2	657	661	PF04695	0.376
LIG_SH2_CRK	265	269	PF00017	0.430
LIG_SH2_CRK	741	745	PF00017	0.455
LIG_SH2_CRK	748	752	PF00017	0.390
LIG_SH2_CRK	766	770	PF00017	0.242
LIG_SH2_GRB2like	477	480	PF00017	0.556
LIG_SH2_NCK_1	748	752	PF00017	0.376
LIG_SH2_STAP1	352	356	PF00017	0.376
LIG_SH2_STAP1	477	481	PF00017	0.675
LIG_SH2_STAP1	685	689	PF00017	0.376
LIG_SH2_STAT5	206	209	PF00017	0.605
LIG_SH2_STAT5	337	340	PF00017	0.268
LIG_SH2_STAT5	438	441	PF00017	0.762
LIG_SH2_STAT5	557	560	PF00017	0.779
LIG_SH2_STAT5	642	645	PF00017	0.484
LIG_SH3_1	741	747	PF00018	0.501
LIG_SH3_3	223	229	PF00018	0.499
LIG_SH3_3	309	315	PF00018	0.376
LIG_SH3_3	501	507	PF00018	0.601
LIG_SH3_3	599	605	PF00018	0.729
LIG_SH3_3	741	747	PF00018	0.376
LIG_Sin3_3	611	618	PF02671	0.532
LIG_SUMO_SIM_par_1	243	250	PF11976	0.494
LIG_SUMO_SIM_par_1	496	506	PF11976	0.751
LIG_SUMO_SIM_par_1	828	833	PF11976	0.457
LIG_TRAF2_1	366	369	PF00917	0.348
LIG_TRAF2_1	379	382	PF00917	0.404
LIG_TRAF2_1	386	389	PF00917	0.476
LIG_TYR_ITIM	746	751	PF00017	0.376
LIG_TYR_ITIM	764	769	PF00017	0.376
LIG_WRC_WIRS_1	282	287	PF05994	0.424
LIG_WRC_WIRS_1	472	477	PF05994	0.679
MOD_CDK_SPxK_1	354	360	PF00069	0.462
MOD_CDK_SPxxK_3	354	361	PF00069	0.462
MOD_CK1_1	130	136	PF00069	0.676
MOD_CK1_1	148	154	PF00069	0.339
MOD_CK1_1	156	162	PF00069	0.510
MOD_CK1_1	172	178	PF00069	0.496
MOD_CK1_1	215	221	PF00069	0.474
MOD_CK1_1	281	287	PF00069	0.501
MOD_CK1_1	290	296	PF00069	0.353
MOD_CK1_1	420	426	PF00069	0.641
MOD_CK1_1	452	458	PF00069	0.826
MOD_CK1_1	505	511	PF00069	0.740
MOD_CK1_1	520	526	PF00069	0.634
MOD_CK1_1	617	623	PF00069	0.679
MOD_CK1_1	627	633	PF00069	0.640
MOD_CK1_1	730	736	PF00069	0.434
MOD_CK1_1	779	785	PF00069	0.376
MOD_CK1_1	86	92	PF00069	0.573
MOD_CK2_1	112	118	PF00069	0.774
MOD_CK2_1	172	178	PF00069	0.622
MOD_CK2_1	257	263	PF00069	0.510
MOD_CK2_1	523	529	PF00069	0.767
MOD_CK2_1	644	650	PF00069	0.505
MOD_CK2_1	705	711	PF00069	0.501
MOD_GlcNHglycan	117	121	PF01048	0.758
MOD_GlcNHglycan	155	158	PF01048	0.621
MOD_GlcNHglycan	242	245	PF01048	0.504
MOD_GlcNHglycan	253	256	PF01048	0.477
MOD_GlcNHglycan	292	295	PF01048	0.455
MOD_GlcNHglycan	384	387	PF01048	0.625
MOD_GlcNHglycan	419	422	PF01048	0.611
MOD_GlcNHglycan	451	454	PF01048	0.741
MOD_GlcNHglycan	510	513	PF01048	0.745
MOD_GlcNHglycan	525	528	PF01048	0.685
MOD_GlcNHglycan	606	609	PF01048	0.762
MOD_GlcNHglycan	616	619	PF01048	0.698
MOD_GlcNHglycan	707	710	PF01048	0.424
MOD_GlcNHglycan	751	754	PF01048	0.509
MOD_GlcNHglycan	8	11	PF01048	0.500
MOD_GSK3_1	112	119	PF00069	0.799
MOD_GSK3_1	126	133	PF00069	0.546
MOD_GSK3_1	156	163	PF00069	0.504
MOD_GSK3_1	164	171	PF00069	0.504
MOD_GSK3_1	17	24	PF00069	0.489
MOD_GSK3_1	212	219	PF00069	0.529
MOD_GSK3_1	240	247	PF00069	0.506
MOD_GSK3_1	251	258	PF00069	0.472
MOD_GSK3_1	283	290	PF00069	0.353
MOD_GSK3_1	457	464	PF00069	0.615
MOD_GSK3_1	502	509	PF00069	0.764
MOD_GSK3_1	517	524	PF00069	0.610
MOD_GSK3_1	701	708	PF00069	0.462
MOD_GSK3_1	78	85	PF00069	0.546
MOD_N-GLC_1	330	335	PF02516	0.430
MOD_N-GLC_1	346	351	PF02516	0.430
MOD_N-GLC_1	354	359	PF02516	0.462
MOD_NEK2_1	268	273	PF00069	0.430
MOD_NEK2_1	434	439	PF00069	0.634
MOD_NEK2_1	616	621	PF00069	0.663
MOD_NEK2_1	67	72	PF00069	0.585
MOD_NEK2_1	727	732	PF00069	0.387
MOD_NEK2_1	739	744	PF00069	0.319
MOD_NEK2_1	83	88	PF00069	0.402
MOD_NEK2_2	160	165	PF00069	0.611
MOD_NEK2_2	217	222	PF00069	0.478
MOD_NEK2_2	586	591	PF00069	0.703
MOD_PIKK_1	112	118	PF00454	0.787
MOD_PIKK_1	330	336	PF00454	0.420
MOD_PIKK_1	422	428	PF00454	0.695
MOD_PIKK_1	579	585	PF00454	0.765
MOD_PIKK_1	617	623	PF00454	0.747
MOD_PIKK_1	805	811	PF00454	0.495
MOD_PK_1	566	572	PF00069	0.675
MOD_PKA_2	112	118	PF00069	0.592
MOD_PKA_2	164	170	PF00069	0.486
MOD_PKA_2	296	302	PF00069	0.376
MOD_PKA_2	406	412	PF00069	0.531
MOD_PKA_2	624	630	PF00069	0.757
MOD_PKA_2	730	736	PF00069	0.501
MOD_PKA_2	785	791	PF00069	0.376
MOD_PKA_2	805	811	PF00069	0.242
MOD_PKA_2	819	825	PF00069	0.383
MOD_PKA_2	86	92	PF00069	0.573
MOD_Plk_1	148	154	PF00069	0.438
MOD_Plk_1	20	26	PF00069	0.430
MOD_Plk_1	346	352	PF00069	0.421
MOD_Plk_1	409	415	PF00069	0.464
MOD_Plk_1	434	440	PF00069	0.556
MOD_Plk_1	572	578	PF00069	0.721
MOD_Plk_4	21	27	PF00069	0.376
MOD_Plk_4	244	250	PF00069	0.465
MOD_Plk_4	462	468	PF00069	0.707
MOD_Plk_4	471	477	PF00069	0.627
MOD_Plk_4	785	791	PF00069	0.376
MOD_ProDKin_1	237	243	PF00069	0.612
MOD_ProDKin_1	354	360	PF00069	0.462
MOD_ProDKin_1	414	420	PF00069	0.607
MOD_ProDKin_1	455	461	PF00069	0.794
MOD_ProDKin_1	496	502	PF00069	0.838
MOD_ProDKin_1	503	509	PF00069	0.690
MOD_ProDKin_1	692	698	PF00069	0.390
MOD_ProDKin_1	78	84	PF00069	0.575
MOD_ProDKin_1	790	796	PF00069	0.501
MOD_SUMO_for_1	105	108	PF00179	0.838
MOD_SUMO_for_1	432	435	PF00179	0.692
MOD_SUMO_rev_2	30	39	PF00179	0.497
MOD_SUMO_rev_2	514	523	PF00179	0.748
MOD_SUMO_rev_2	711	721	PF00179	0.430
MOD_SUMO_rev_2	730	739	PF00179	0.430
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.448
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.501
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.513
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.499
TRG_DiLeu_LyEn_5	497	502	PF01217	0.760
TRG_ENDOCYTIC_2	265	268	PF00928	0.430
TRG_ENDOCYTIC_2	337	340	PF00928	0.268
TRG_ENDOCYTIC_2	595	598	PF00928	0.634
TRG_ENDOCYTIC_2	685	688	PF00928	0.376
TRG_ENDOCYTIC_2	748	751	PF00928	0.376
TRG_ENDOCYTIC_2	766	769	PF00928	0.376
TRG_ER_diArg_1	180	183	PF00400	0.604
TRG_ER_diArg_1	201	204	PF00400	0.527
TRG_NLS_Bipartite_1	345	364	PF00514	0.268
TRG_NLS_MonoExtC_3	429	435	PF00514	0.711
TRG_NLS_MonoExtN_4	358	364	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	629	634	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H3	Leptomonas seymouri	62%	100%
A0A3Q8IM41	Leishmania donovani	94%	100%
A4HMI7	Leishmania braziliensis	82%	100%
A4IB67	Leishmania infantum	93%	100%
C9ZZH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B644	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%