Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AEY6_LEIMA

TriTrypDb:

LmjF.35.1640 , LMJLV39_350022800 , LMJSD75_350022000

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.710
CLV_NRD_NRD_1	228	230	PF00675	0.540
CLV_NRD_NRD_1	253	255	PF00675	0.573
CLV_PCSK_KEX2_1	228	230	PF00082	0.540
CLV_PCSK_KEX2_1	253	255	PF00082	0.563
CLV_PCSK_SKI1_1	244	248	PF00082	0.563
CLV_PCSK_SKI1_1	276	280	PF00082	0.510
CLV_PCSK_SKI1_1	72	76	PF00082	0.533
DEG_Nend_UBRbox_1	1	4	PF02207	0.527
DOC_MIT_MIM_1	347	356	PF04212	0.537
DOC_PP4_FxxP_1	144	147	PF00568	0.572
DOC_PP4_FxxP_1	158	161	PF00568	0.432
DOC_USP7_MATH_1	120	124	PF00917	0.775
DOC_USP7_MATH_1	189	193	PF00917	0.643
DOC_USP7_MATH_1	218	222	PF00917	0.618
DOC_USP7_MATH_1	311	315	PF00917	0.578
DOC_USP7_MATH_1	326	330	PF00917	0.560
DOC_USP7_MATH_1	96	100	PF00917	0.611
DOC_WW_Pin1_4	157	162	PF00397	0.703
DOC_WW_Pin1_4	75	80	PF00397	0.640
LIG_14-3-3_CanoR_1	150	158	PF00244	0.699
LIG_14-3-3_CanoR_1	95	104	PF00244	0.681
LIG_Actin_WH2_2	293	309	PF00022	0.612
LIG_APCC_ABBA_1	265	270	PF00400	0.513
LIG_BRCT_BRCA1_1	154	158	PF00533	0.581
LIG_EH1_1	240	248	PF00400	0.566
LIG_FHA_1	55	61	PF00498	0.608
LIG_LIR_Apic_2	142	147	PF02991	0.576
LIG_LIR_Apic_2	155	161	PF02991	0.567
LIG_LIR_Nem_3	263	268	PF02991	0.530
LIG_LIR_Nem_3	280	285	PF02991	0.564
LIG_MAD2	4	12	PF02301	0.613
LIG_NRBOX	212	218	PF00104	0.575
LIG_PDZ_Class_3	351	356	PF00595	0.596
LIG_Pex14_2	265	269	PF04695	0.627
LIG_SH2_STAT3	283	286	PF00017	0.620
LIG_SH3_3	13	19	PF00018	0.633
LIG_SH3_3	3	9	PF00018	0.614
LIG_SH3_3	337	343	PF00018	0.417
LIG_TRAF2_1	129	132	PF00917	0.744
LIG_WW_1	146	149	PF00397	0.646
MOD_CDK_SPxxK_3	75	82	PF00069	0.597
MOD_CK1_1	152	158	PF00069	0.655
MOD_CK1_1	160	166	PF00069	0.488
MOD_CK1_1	221	227	PF00069	0.538
MOD_CK1_1	28	34	PF00069	0.644
MOD_CK2_1	126	132	PF00069	0.671
MOD_CK2_1	189	195	PF00069	0.718
MOD_GlcNHglycan	120	123	PF01048	0.608
MOD_GlcNHglycan	128	131	PF01048	0.682
MOD_GlcNHglycan	152	155	PF01048	0.565
MOD_GlcNHglycan	191	194	PF01048	0.653
MOD_GlcNHglycan	27	30	PF01048	0.671
MOD_GlcNHglycan	286	289	PF01048	0.669
MOD_GlcNHglycan	98	101	PF01048	0.667
MOD_GSK3_1	149	156	PF00069	0.745
MOD_GSK3_1	25	32	PF00069	0.640
MOD_GSK3_1	284	291	PF00069	0.598
MOD_N-GLC_1	25	30	PF02516	0.566
MOD_PIKK_1	160	166	PF00454	0.576
MOD_PIKK_1	221	227	PF00454	0.518
MOD_PKA_2	149	155	PF00069	0.657
MOD_Plk_1	29	35	PF00069	0.536
MOD_Plk_4	11	17	PF00069	0.598
MOD_Plk_4	327	333	PF00069	0.560
MOD_ProDKin_1	157	163	PF00069	0.698
MOD_ProDKin_1	75	81	PF00069	0.642
TRG_DiLeu_BaEn_1	177	182	PF01217	0.596
TRG_ENDOCYTIC_2	282	285	PF00928	0.548
TRG_ER_diArg_1	1	4	PF00400	0.602
TRG_ER_diArg_1	241	244	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF7	Leptomonas seymouri	36%	100%
A0A3S7X929	Leishmania donovani	90%	100%
A4HMI5	Leishmania braziliensis	72%	100%
A4IB65	Leishmania infantum	90%	100%
E9B642	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%