Calmodulin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEY5_LEIMA

TriTrypDb:

LmjF.35.1630 , LMJLV39_350022700 , LMJSD75_350021900

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.595
CLV_NRD_NRD_1	239	241	PF00675	0.717
CLV_NRD_NRD_1	245	247	PF00675	0.632
CLV_NRD_NRD_1	263	265	PF00675	0.656
CLV_NRD_NRD_1	336	338	PF00675	0.703
CLV_NRD_NRD_1	446	448	PF00675	0.682
CLV_PCSK_KEX2_1	238	240	PF00082	0.747
CLV_PCSK_KEX2_1	244	246	PF00082	0.670
CLV_PCSK_KEX2_1	263	265	PF00082	0.656
CLV_PCSK_KEX2_1	335	337	PF00082	0.758
CLV_PCSK_PC7_1	240	246	PF00082	0.751
CLV_PCSK_SKI1_1	239	243	PF00082	0.725
CLV_PCSK_SKI1_1	422	426	PF00082	0.678
DEG_APCC_DBOX_1	110	118	PF00400	0.475
DOC_CKS1_1	50	55	PF01111	0.610
DOC_MAPK_MEF2A_6	111	118	PF00069	0.402
DOC_MAPK_MEF2A_6	31	39	PF00069	0.587
DOC_MAPK_MEF2A_6	312	321	PF00069	0.600
DOC_MAPK_NFAT4_5	111	119	PF00069	0.402
DOC_MAPK_RevD_3	323	338	PF00069	0.684
DOC_USP7_MATH_1	103	107	PF00917	0.389
DOC_USP7_MATH_1	139	143	PF00917	0.573
DOC_USP7_MATH_1	164	168	PF00917	0.663
DOC_USP7_MATH_1	193	197	PF00917	0.681
DOC_USP7_MATH_1	199	203	PF00917	0.646
DOC_USP7_MATH_1	275	279	PF00917	0.706
DOC_USP7_MATH_1	340	344	PF00917	0.717
DOC_USP7_MATH_1	345	349	PF00917	0.702
DOC_USP7_MATH_1	377	381	PF00917	0.728
DOC_USP7_MATH_1	385	389	PF00917	0.597
DOC_USP7_MATH_1	89	93	PF00917	0.620
DOC_USP7_UBL2_3	232	236	PF12436	0.738
DOC_WW_Pin1_4	213	218	PF00397	0.765
DOC_WW_Pin1_4	249	254	PF00397	0.773
DOC_WW_Pin1_4	323	328	PF00397	0.647
DOC_WW_Pin1_4	351	356	PF00397	0.634
DOC_WW_Pin1_4	427	432	PF00397	0.706
DOC_WW_Pin1_4	49	54	PF00397	0.604
LIG_14-3-3_CanoR_1	146	154	PF00244	0.500
LIG_14-3-3_CanoR_1	312	321	PF00244	0.641
LIG_14-3-3_CanoR_1	341	350	PF00244	0.726
LIG_14-3-3_CanoR_1	420	425	PF00244	0.625
LIG_14-3-3_CanoR_1	8	13	PF00244	0.568
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BIR_III_4	392	396	PF00653	0.734
LIG_BIR_III_4	418	422	PF00653	0.701
LIG_deltaCOP1_diTrp_1	159	165	PF00928	0.423
LIG_eIF4E_1	34	40	PF01652	0.360
LIG_FHA_1	205	211	PF00498	0.725
LIG_FHA_1	316	322	PF00498	0.692
LIG_FHA_1	329	335	PF00498	0.721
LIG_FHA_1	58	64	PF00498	0.553
LIG_FHA_2	122	128	PF00498	0.644
LIG_FHA_2	189	195	PF00498	0.689
LIG_FHA_2	256	262	PF00498	0.756
LIG_LIR_Gen_1	11	21	PF02991	0.494
LIG_LIR_Gen_1	113	123	PF02991	0.498
LIG_LIR_Gen_1	159	166	PF02991	0.514
LIG_LIR_Gen_1	435	445	PF02991	0.731
LIG_LIR_Nem_3	11	16	PF02991	0.484
LIG_LIR_Nem_3	113	118	PF02991	0.469
LIG_LIR_Nem_3	159	165	PF02991	0.510
LIG_LIR_Nem_3	32	37	PF02991	0.544
LIG_LIR_Nem_3	435	441	PF02991	0.734
LIG_LIR_Nem_3	72	76	PF02991	0.403
LIG_PDZ_Class_2	453	458	PF00595	0.607
LIG_SH2_NCK_1	247	251	PF00017	0.691
LIG_SH2_PTP2	34	37	PF00017	0.554
LIG_SH2_SRC	34	37	PF00017	0.452
LIG_SH2_STAT5	288	291	PF00017	0.593
LIG_SH2_STAT5	34	37	PF00017	0.452
LIG_SH3_1	247	253	PF00018	0.801
LIG_SH3_2	355	360	PF14604	0.555
LIG_SH3_3	222	228	PF00018	0.625
LIG_SH3_3	247	253	PF00018	0.801
LIG_SH3_3	30	36	PF00018	0.581
LIG_SH3_3	324	330	PF00018	0.689
LIG_SH3_3	352	358	PF00018	0.638
LIG_SUMO_SIM_anti_2	318	323	PF11976	0.570
LIG_TRAF2_2	225	230	PF00917	0.746
LIG_UBA3_1	440	448	PF00899	0.682
LIG_WW_3	357	361	PF00397	0.711
MOD_CAAXbox	455	458	PF01239	0.603
MOD_CDK_SPK_2	351	356	PF00069	0.569
MOD_CK1_1	167	173	PF00069	0.582
MOD_CK1_1	284	290	PF00069	0.556
MOD_CK1_1	343	349	PF00069	0.670
MOD_CK2_1	107	113	PF00069	0.461
MOD_CK2_1	123	129	PF00069	0.595
MOD_CK2_1	145	151	PF00069	0.495
MOD_CK2_1	160	166	PF00069	0.425
MOD_CK2_1	188	194	PF00069	0.686
MOD_CK2_1	255	261	PF00069	0.754
MOD_CK2_1	288	294	PF00069	0.707
MOD_CK2_1	429	435	PF00069	0.712
MOD_Cter_Amidation	261	264	PF01082	0.585
MOD_GlcNHglycan	102	106	PF01048	0.573
MOD_GlcNHglycan	119	122	PF01048	0.426
MOD_GlcNHglycan	141	144	PF01048	0.555
MOD_GlcNHglycan	162	165	PF01048	0.466
MOD_GlcNHglycan	220	223	PF01048	0.785
MOD_GlcNHglycan	290	293	PF01048	0.560
MOD_GlcNHglycan	343	346	PF01048	0.673
MOD_GlcNHglycan	363	366	PF01048	0.677
MOD_GlcNHglycan	389	392	PF01048	0.771
MOD_GlcNHglycan	431	434	PF01048	0.587
MOD_GlcNHglycan	449	452	PF01048	0.458
MOD_GSK3_1	117	124	PF00069	0.336
MOD_GSK3_1	137	144	PF00069	0.396
MOD_GSK3_1	160	167	PF00069	0.560
MOD_GSK3_1	199	206	PF00069	0.712
MOD_GSK3_1	275	282	PF00069	0.722
MOD_GSK3_1	284	291	PF00069	0.601
MOD_GSK3_1	306	313	PF00069	0.647
MOD_GSK3_1	341	348	PF00069	0.722
MOD_GSK3_1	410	417	PF00069	0.735
MOD_GSK3_1	443	450	PF00069	0.652
MOD_GSK3_1	97	104	PF00069	0.612
MOD_N-GLC_1	341	346	PF02516	0.732
MOD_NEK2_1	116	121	PF00069	0.516
MOD_NEK2_1	310	315	PF00069	0.652
MOD_NEK2_1	440	445	PF00069	0.749
MOD_NEK2_1	59	64	PF00069	0.514
MOD_NEK2_2	292	297	PF00069	0.570
MOD_PIKK_1	281	287	PF00454	0.557
MOD_PIKK_1	310	316	PF00454	0.805
MOD_PK_1	420	426	PF00069	0.623
MOD_PK_1	8	14	PF00069	0.462
MOD_PKA_1	447	453	PF00069	0.571
MOD_PKA_2	145	151	PF00069	0.485
MOD_PKA_2	167	173	PF00069	0.594
MOD_PKA_2	340	346	PF00069	0.615
MOD_PKA_2	446	452	PF00069	0.582
MOD_Plk_1	183	189	PF00069	0.550
MOD_Plk_4	292	298	PF00069	0.604
MOD_Plk_4	8	14	PF00069	0.462
MOD_ProDKin_1	213	219	PF00069	0.763
MOD_ProDKin_1	249	255	PF00069	0.776
MOD_ProDKin_1	323	329	PF00069	0.646
MOD_ProDKin_1	351	357	PF00069	0.634
MOD_ProDKin_1	427	433	PF00069	0.707
MOD_ProDKin_1	49	55	PF00069	0.601
TRG_ENDOCYTIC_2	34	37	PF00928	0.554
TRG_ER_diArg_1	237	240	PF00400	0.660
TRG_ER_diArg_1	244	246	PF00400	0.630
TRG_ER_diArg_1	263	265	PF00400	0.574
TRG_ER_diArg_1	334	337	PF00400	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P595	Leptomonas seymouri	39%	91%
A0A3S7X927	Leishmania donovani	81%	96%
A4HMI4	Leishmania braziliensis	49%	100%
A4IB64	Leishmania infantum	81%	96%
E9B641	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%