Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEY3_LEIMA

TriTrypDb:

LmjF.35.1610 , LMJLV39_350022500 , LMJSD75_350021700

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

E9AEY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY3

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	906	910	PF00656	0.755
CLV_C14_Caspase3-7	936	940	PF00656	0.701
CLV_MEL_PAP_1	895	901	PF00089	0.412
CLV_NRD_NRD_1	269	271	PF00675	0.767
CLV_NRD_NRD_1	339	341	PF00675	0.737
CLV_NRD_NRD_1	489	491	PF00675	0.527
CLV_NRD_NRD_1	504	506	PF00675	0.495
CLV_NRD_NRD_1	825	827	PF00675	0.407
CLV_NRD_NRD_1	91	93	PF00675	0.460
CLV_PCSK_KEX2_1	269	271	PF00082	0.767

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N6	Leptomonas seymouri	38%	98%
A0A1X0P5S8	Trypanosomatidae	22%	100%
A0A3S5H7Z0	Leishmania donovani	90%	100%
A4HMI2	Leishmania braziliensis	69%	100%
A4IB62	Leishmania infantum	90%	100%
E9B639	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%

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