Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEY3_LEIMA

TriTrypDb:

LmjF.35.1610 , LMJLV39_350022500 , LMJSD75_350021700

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AEY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	906	910	PF00656	0.755
CLV_C14_Caspase3-7	936	940	PF00656	0.701
CLV_MEL_PAP_1	895	901	PF00089	0.412
CLV_NRD_NRD_1	269	271	PF00675	0.767
CLV_NRD_NRD_1	339	341	PF00675	0.737
CLV_NRD_NRD_1	489	491	PF00675	0.527
CLV_NRD_NRD_1	504	506	PF00675	0.495
CLV_NRD_NRD_1	825	827	PF00675	0.407
CLV_NRD_NRD_1	91	93	PF00675	0.460
CLV_PCSK_KEX2_1	269	271	PF00082	0.767
CLV_PCSK_KEX2_1	339	341	PF00082	0.737
CLV_PCSK_KEX2_1	489	491	PF00082	0.471
CLV_PCSK_KEX2_1	504	506	PF00082	0.495
CLV_PCSK_KEX2_1	645	647	PF00082	0.473
CLV_PCSK_KEX2_1	825	827	PF00082	0.363
CLV_PCSK_KEX2_1	91	93	PF00082	0.460
CLV_PCSK_KEX2_1	933	935	PF00082	0.409
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.473
CLV_PCSK_PC1ET2_1	933	935	PF00082	0.409
CLV_PCSK_SKI1_1	27	31	PF00082	0.470
CLV_PCSK_SKI1_1	315	319	PF00082	0.569
CLV_PCSK_SKI1_1	490	494	PF00082	0.490
CLV_PCSK_SKI1_1	505	509	PF00082	0.543
CLV_PCSK_SKI1_1	528	532	PF00082	0.526
CLV_PCSK_SKI1_1	628	632	PF00082	0.441
CLV_PCSK_SKI1_1	732	736	PF00082	0.531
CLV_PCSK_SKI1_1	772	776	PF00082	0.462
CLV_PCSK_SKI1_1	802	806	PF00082	0.430
CLV_PCSK_SKI1_1	851	855	PF00082	0.710
CLV_PCSK_SKI1_1	881	885	PF00082	0.372
DEG_APCC_DBOX_1	26	34	PF00400	0.655
DEG_APCC_DBOX_1	504	512	PF00400	0.716
DEG_APCC_DBOX_1	570	578	PF00400	0.407
DEG_APCC_DBOX_1	875	883	PF00400	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.727
DEG_SPOP_SBC_1	341	345	PF00917	0.490
DEG_SPOP_SBC_1	378	382	PF00917	0.473
DOC_CDC14_PxL_1	155	163	PF14671	0.535
DOC_CKS1_1	511	516	PF01111	0.709
DOC_CKS1_1	891	896	PF01111	0.733
DOC_CYCLIN_RxL_1	729	736	PF00134	0.678
DOC_MAPK_gen_1	304	314	PF00069	0.432
DOC_MAPK_gen_1	825	831	PF00069	0.571
DOC_MAPK_gen_1	851	860	PF00069	0.351
DOC_MAPK_gen_1	91	99	PF00069	0.596
DOC_MAPK_gen_1	923	931	PF00069	0.626
DOC_MAPK_MEF2A_6	402	409	PF00069	0.433
DOC_MAPK_MEF2A_6	419	427	PF00069	0.328
DOC_MAPK_MEF2A_6	504	511	PF00069	0.578
DOC_MAPK_MEF2A_6	567	576	PF00069	0.484
DOC_MAPK_MEF2A_6	582	590	PF00069	0.316
DOC_MAPK_MEF2A_6	851	860	PF00069	0.342
DOC_PP2B_LxvP_1	142	145	PF13499	0.547
DOC_PP2B_LxvP_1	153	156	PF13499	0.541
DOC_PP2B_LxvP_1	193	196	PF13499	0.523
DOC_PP4_FxxP_1	816	819	PF00568	0.525
DOC_PP4_MxPP_1	290	293	PF00568	0.444
DOC_PP4_MxPP_1	394	397	PF00568	0.352
DOC_USP7_MATH_1	323	327	PF00917	0.541
DOC_USP7_MATH_1	341	345	PF00917	0.385
DOC_USP7_MATH_1	350	354	PF00917	0.458
DOC_USP7_MATH_1	378	382	PF00917	0.485
DOC_USP7_MATH_1	512	516	PF00917	0.695
DOC_USP7_MATH_1	526	530	PF00917	0.638
DOC_USP7_MATH_1	543	547	PF00917	0.238
DOC_USP7_MATH_1	791	795	PF00917	0.665
DOC_USP7_MATH_1	897	901	PF00917	0.728
DOC_USP7_MATH_1	905	909	PF00917	0.739
DOC_WW_Pin1_4	148	153	PF00397	0.538
DOC_WW_Pin1_4	174	179	PF00397	0.541
DOC_WW_Pin1_4	185	190	PF00397	0.551
DOC_WW_Pin1_4	326	331	PF00397	0.519
DOC_WW_Pin1_4	510	515	PF00397	0.714
DOC_WW_Pin1_4	815	820	PF00397	0.508
DOC_WW_Pin1_4	890	895	PF00397	0.695
LIG_14-3-3_CanoR_1	162	167	PF00244	0.461
LIG_14-3-3_CanoR_1	204	209	PF00244	0.523
LIG_14-3-3_CanoR_1	221	229	PF00244	0.554
LIG_14-3-3_CanoR_1	274	282	PF00244	0.520
LIG_14-3-3_CanoR_1	444	448	PF00244	0.677
LIG_14-3-3_CanoR_1	538	542	PF00244	0.556
LIG_14-3-3_CanoR_1	571	575	PF00244	0.407
LIG_14-3-3_CanoR_1	622	630	PF00244	0.716
LIG_14-3-3_CanoR_1	635	640	PF00244	0.638
LIG_14-3-3_CanoR_1	876	880	PF00244	0.685
LIG_14-3-3_CanoR_1	898	902	PF00244	0.771
LIG_14-3-3_CanoR_1	91	95	PF00244	0.617
LIG_Actin_WH2_2	294	311	PF00022	0.462
LIG_BIR_III_2	149	153	PF00653	0.434
LIG_BRCT_BRCA1_1	100	104	PF00533	0.413
LIG_BRCT_BRCA1_1	25	29	PF00533	0.268
LIG_BRCT_BRCA1_1	42	46	PF00533	0.321
LIG_CSL_BTD_1	745	748	PF09270	0.745
LIG_EH1_1	776	784	PF00400	0.430
LIG_eIF4E_1	10	16	PF01652	0.443
LIG_eIF4E_1	31	37	PF01652	0.537
LIG_EVH1_1	155	159	PF00568	0.438
LIG_EVH1_2	748	752	PF00568	0.673
LIG_FHA_1	179	185	PF00498	0.572
LIG_FHA_1	198	204	PF00498	0.573
LIG_FHA_1	230	236	PF00498	0.464
LIG_FHA_1	240	246	PF00498	0.450
LIG_FHA_1	390	396	PF00498	0.384
LIG_FHA_1	571	577	PF00498	0.305
LIG_FHA_1	585	591	PF00498	0.327
LIG_FHA_1	59	65	PF00498	0.423
LIG_FHA_1	6	12	PF00498	0.535
LIG_FHA_1	705	711	PF00498	0.417
LIG_FHA_1	718	724	PF00498	0.612
LIG_FHA_1	861	867	PF00498	0.430
LIG_FHA_1	885	891	PF00498	0.727
LIG_FHA_2	122	128	PF00498	0.515
LIG_FHA_2	331	337	PF00498	0.591
LIG_FHA_2	361	367	PF00498	0.392
LIG_FHA_2	842	848	PF00498	0.464
LIG_GBD_Chelix_1	858	866	PF00786	0.410
LIG_GBD_Chelix_1	882	890	PF00786	0.492
LIG_Integrin_RGD_1	218	220	PF01839	0.734
LIG_LIR_Apic_2	745	749	PF02991	0.692
LIG_LIR_Apic_2	800	806	PF02991	0.410
LIG_LIR_Apic_2	815	819	PF02991	0.528
LIG_LIR_Gen_1	165	172	PF02991	0.563
LIG_LIR_Gen_1	276	287	PF02991	0.482
LIG_LIR_Gen_1	422	432	PF02991	0.260
LIG_LIR_Gen_1	604	614	PF02991	0.553
LIG_LIR_Gen_1	651	659	PF02991	0.490
LIG_LIR_Gen_1	660	669	PF02991	0.326
LIG_LIR_Gen_1	74	82	PF02991	0.513
LIG_LIR_LC3C_4	436	440	PF02991	0.385
LIG_LIR_LC3C_4	855	858	PF02991	0.398
LIG_LIR_Nem_3	100	105	PF02991	0.430
LIG_LIR_Nem_3	165	170	PF02991	0.498
LIG_LIR_Nem_3	276	282	PF02991	0.467
LIG_LIR_Nem_3	318	324	PF02991	0.410
LIG_LIR_Nem_3	422	427	PF02991	0.260
LIG_LIR_Nem_3	604	609	PF02991	0.669
LIG_LIR_Nem_3	651	655	PF02991	0.512
LIG_LIR_Nem_3	660	664	PF02991	0.338
LIG_LIR_Nem_3	74	78	PF02991	0.513
LIG_LIR_Nem_3	8	13	PF02991	0.520
LIG_LIR_Nem_3	847	853	PF02991	0.445
LIG_LIR_Nem_3	93	99	PF02991	0.480
LIG_LYPXL_yS_3	324	327	PF13949	0.379
LIG_MAD2	136	144	PF02301	0.541
LIG_MYND_1	140	144	PF01753	0.544
LIG_NRBOX	612	618	PF00104	0.619
LIG_NRBOX	865	871	PF00104	0.411
LIG_PCNA_PIPBox_1	626	635	PF02747	0.695
LIG_PCNA_yPIPBox_3	622	633	PF02747	0.723
LIG_PCNA_yPIPBox_3	842	854	PF02747	0.464
LIG_PDZ_Class_3	936	941	PF00595	0.703
LIG_Pex14_1	566	570	PF04695	0.454
LIG_Pex14_2	813	817	PF04695	0.430
LIG_SH2_CRK	167	171	PF00017	0.517
LIG_SH2_CRK	279	283	PF00017	0.526
LIG_SH2_CRK	850	854	PF00017	0.469
LIG_SH2_NCK_1	447	451	PF00017	0.593
LIG_SH2_PTP2	10	13	PF00017	0.268
LIG_SH2_STAP1	105	109	PF00017	0.501
LIG_SH2_STAP1	247	251	PF00017	0.497
LIG_SH2_STAP1	562	566	PF00017	0.484
LIG_SH2_STAP1	650	654	PF00017	0.534
LIG_SH2_STAP1	797	801	PF00017	0.501
LIG_SH2_STAT5	10	13	PF00017	0.268
LIG_SH2_STAT5	247	250	PF00017	0.583
LIG_SH2_STAT5	279	282	PF00017	0.513
LIG_SH2_STAT5	416	419	PF00017	0.461
LIG_SH2_STAT5	467	470	PF00017	0.686
LIG_SH2_STAT5	632	635	PF00017	0.631
LIG_SH2_STAT5	773	776	PF00017	0.333
LIG_SH2_STAT5	803	806	PF00017	0.369
LIG_SH2_STAT5	812	815	PF00017	0.394
LIG_SH2_STAT5	830	833	PF00017	0.468
LIG_SH3_3	109	115	PF00018	0.424
LIG_SH3_3	134	140	PF00018	0.535
LIG_SH3_3	153	159	PF00018	0.572
LIG_SH3_3	186	192	PF00018	0.516
LIG_SH3_3	286	292	PF00018	0.543
LIG_SH3_3	428	434	PF00018	0.501
LIG_SH3_3	816	822	PF00018	0.511
LIG_SH3_3	891	897	PF00018	0.656
LIG_Sin3_3	596	603	PF02671	0.606
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.501
LIG_SUMO_SIM_anti_2	550	556	PF11976	0.418
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.417
LIG_SUMO_SIM_par_1	74	81	PF11976	0.468
LIG_TRAF2_1	914	917	PF00917	0.647
LIG_TYR_ITIM	771	776	PF00017	0.556
LIG_TYR_ITSM	6	13	PF00017	0.546
LIG_WRC_WIRS_1	658	663	PF05994	0.452
LIG_WRC_WIRS_1	718	723	PF05994	0.623
LIG_WRC_WIRS_1	813	818	PF05994	0.268
LIG_WRC_WIRS_1	99	104	PF05994	0.415
LIG_WW_2	156	159	PF00397	0.472
LIG_WW_3	143	147	PF00397	0.547
LIG_WW_3	895	899	PF00397	0.624
MOD_CDK_SPK_2	185	190	PF00069	0.436
MOD_CK1_1	151	157	PF00069	0.553
MOD_CK1_1	182	188	PF00069	0.544
MOD_CK1_1	238	244	PF00069	0.561
MOD_CK1_1	326	332	PF00069	0.538
MOD_CK1_1	343	349	PF00069	0.424
MOD_CK1_1	360	366	PF00069	0.378
MOD_CK1_1	742	748	PF00069	0.739
MOD_CK1_1	90	96	PF00069	0.743
MOD_CK2_1	121	127	PF00069	0.572
MOD_CK2_1	330	336	PF00069	0.537
MOD_CK2_1	360	366	PF00069	0.413
MOD_CK2_1	379	385	PF00069	0.464
MOD_CK2_1	905	911	PF00069	0.666
MOD_CMANNOS	408	411	PF00535	0.703
MOD_Cter_Amidation	267	270	PF01082	0.770
MOD_GlcNHglycan	127	131	PF01048	0.759
MOD_GlcNHglycan	173	177	PF01048	0.734
MOD_GlcNHglycan	184	187	PF01048	0.757
MOD_GlcNHglycan	237	240	PF01048	0.718
MOD_GlcNHglycan	255	258	PF01048	0.734
MOD_GlcNHglycan	345	348	PF01048	0.781
MOD_GlcNHglycan	359	362	PF01048	0.629
MOD_GlcNHglycan	42	45	PF01048	0.584
MOD_GlcNHglycan	435	438	PF01048	0.394
MOD_GlcNHglycan	450	453	PF01048	0.365
MOD_GlcNHglycan	486	489	PF01048	0.457
MOD_GlcNHglycan	515	518	PF01048	0.462
MOD_GlcNHglycan	528	531	PF01048	0.531
MOD_GlcNHglycan	545	548	PF01048	0.214
MOD_GlcNHglycan	69	72	PF01048	0.487
MOD_GlcNHglycan	83	86	PF01048	0.423
MOD_GSK3_1	144	151	PF00069	0.521
MOD_GSK3_1	174	181	PF00069	0.565
MOD_GSK3_1	235	242	PF00069	0.499
MOD_GSK3_1	315	322	PF00069	0.399
MOD_GSK3_1	326	333	PF00069	0.540
MOD_GSK3_1	46	53	PF00069	0.484
MOD_GSK3_1	584	591	PF00069	0.483
MOD_GSK3_1	67	74	PF00069	0.424
MOD_GSK3_1	700	707	PF00069	0.462
MOD_GSK3_1	738	745	PF00069	0.678
MOD_GSK3_1	886	893	PF00069	0.668
MOD_GSK3_1	905	912	PF00069	0.744
MOD_N-GLC_1	121	126	PF02516	0.718
MOD_N-GLC_1	209	214	PF02516	0.804
MOD_N-GLC_1	315	320	PF02516	0.604
MOD_N-GLC_1	67	72	PF02516	0.424
MOD_N-GLC_1	691	696	PF02516	0.551
MOD_NEK2_1	126	131	PF00069	0.575
MOD_NEK2_1	179	184	PF00069	0.569
MOD_NEK2_1	209	214	PF00069	0.440
MOD_NEK2_1	23	28	PF00069	0.409
MOD_NEK2_1	308	313	PF00069	0.337
MOD_NEK2_1	377	382	PF00069	0.432
MOD_NEK2_1	425	430	PF00069	0.497
MOD_NEK2_1	483	488	PF00069	0.722
MOD_NEK2_1	584	589	PF00069	0.390
MOD_NEK2_1	657	662	PF00069	0.401
MOD_NEK2_1	704	709	PF00069	0.383
MOD_NEK2_1	78	83	PF00069	0.515
MOD_NEK2_1	841	846	PF00069	0.588
MOD_NEK2_1	87	92	PF00069	0.715
MOD_NEK2_2	260	265	PF00069	0.530
MOD_NEK2_2	350	355	PF00069	0.496
MOD_NEK2_2	557	562	PF00069	0.514
MOD_NEK2_2	797	802	PF00069	0.376
MOD_NEK2_2	812	817	PF00069	0.376
MOD_PIKK_1	220	226	PF00454	0.601
MOD_PIKK_1	239	245	PF00454	0.353
MOD_PIKK_1	622	628	PF00454	0.725
MOD_PK_1	204	210	PF00069	0.428
MOD_PK_1	927	933	PF00069	0.766
MOD_PKA_1	214	220	PF00069	0.529
MOD_PKA_2	220	226	PF00069	0.594
MOD_PKA_2	273	279	PF00069	0.476
MOD_PKA_2	308	314	PF00069	0.347
MOD_PKA_2	443	449	PF00069	0.673
MOD_PKA_2	537	543	PF00069	0.556
MOD_PKA_2	570	576	PF00069	0.407
MOD_PKA_2	875	881	PF00069	0.728
MOD_PKA_2	897	903	PF00069	0.797
MOD_PKA_2	90	96	PF00069	0.661
MOD_PKB_1	925	933	PF00069	0.765
MOD_Plk_1	121	127	PF00069	0.558
MOD_Plk_1	239	245	PF00069	0.513
MOD_Plk_1	315	321	PF00069	0.431
MOD_Plk_1	5	11	PF00069	0.696
MOD_Plk_1	50	56	PF00069	0.519
MOD_Plk_1	67	73	PF00069	0.237
MOD_Plk_1	691	697	PF00069	0.351
MOD_Plk_1	927	933	PF00069	0.799
MOD_Plk_4	162	168	PF00069	0.459
MOD_Plk_4	204	210	PF00069	0.445
MOD_Plk_4	296	302	PF00069	0.546
MOD_Plk_4	308	314	PF00069	0.342
MOD_Plk_4	379	385	PF00069	0.440
MOD_Plk_4	395	401	PF00069	0.427
MOD_Plk_4	5	11	PF00069	0.668
MOD_Plk_4	537	543	PF00069	0.556
MOD_Plk_4	570	576	PF00069	0.301
MOD_Plk_4	628	634	PF00069	0.711
MOD_Plk_4	635	641	PF00069	0.629
MOD_Plk_4	657	663	PF00069	0.453
MOD_Plk_4	683	689	PF00069	0.525
MOD_Plk_4	700	706	PF00069	0.242
MOD_Plk_4	71	77	PF00069	0.385
MOD_Plk_4	717	723	PF00069	0.593
MOD_Plk_4	742	748	PF00069	0.681
MOD_Plk_4	785	791	PF00069	0.381
MOD_Plk_4	812	818	PF00069	0.301
MOD_Plk_4	836	842	PF00069	0.379
MOD_Plk_4	98	104	PF00069	0.376
MOD_ProDKin_1	148	154	PF00069	0.538
MOD_ProDKin_1	174	180	PF00069	0.542
MOD_ProDKin_1	185	191	PF00069	0.552
MOD_ProDKin_1	326	332	PF00069	0.522
MOD_ProDKin_1	510	516	PF00069	0.708
MOD_ProDKin_1	815	821	PF00069	0.513
MOD_ProDKin_1	890	896	PF00069	0.697
MOD_SUMO_for_1	170	173	PF00179	0.520
MOD_SUMO_rev_2	915	924	PF00179	0.682
TRG_DiLeu_BaEn_1	127	132	PF01217	0.515
TRG_DiLeu_BaEn_2	716	722	PF01217	0.699
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.640
TRG_ENDOCYTIC_2	10	13	PF00928	0.425
TRG_ENDOCYTIC_2	167	170	PF00928	0.521
TRG_ENDOCYTIC_2	279	282	PF00928	0.523
TRG_ENDOCYTIC_2	324	327	PF00928	0.496
TRG_ENDOCYTIC_2	773	776	PF00928	0.430
TRG_ENDOCYTIC_2	850	853	PF00928	0.469
TRG_ER_diArg_1	306	309	PF00400	0.428
TRG_ER_diArg_1	824	826	PF00400	0.722
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	851	855	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N6	Leptomonas seymouri	38%	98%
A0A1X0P5S8	Trypanosomatidae	22%	100%
A0A3S5H7Z0	Leishmania donovani	90%	100%
A4HMI2	Leishmania braziliensis	69%	100%
A4IB62	Leishmania infantum	90%	100%
E9B639	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%