LINES_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP82

Species:

Leishmania major

UniProt:

E9AEY2_LEIMA

TriTrypDb:

LmjF.35.1600 , LMJLV39_350022400 , LMJSD75_350021600

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0031080	nuclear pore outer ring	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9AEY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.595
CLV_C14_Caspase3-7	173	177	PF00656	0.393
CLV_C14_Caspase3-7	225	229	PF00656	0.446
CLV_C14_Caspase3-7	242	246	PF00656	0.588
CLV_C14_Caspase3-7	326	330	PF00656	0.514
CLV_C14_Caspase3-7	549	553	PF00656	0.351
CLV_C14_Caspase3-7	642	646	PF00656	0.409
CLV_C14_Caspase3-7	81	85	PF00656	0.524
CLV_C14_Caspase3-7	9	13	PF00656	0.451
CLV_NRD_NRD_1	183	185	PF00675	0.490
CLV_NRD_NRD_1	413	415	PF00675	0.388
CLV_NRD_NRD_1	588	590	PF00675	0.482
CLV_PCSK_KEX2_1	183	185	PF00082	0.490
CLV_PCSK_KEX2_1	202	204	PF00082	0.488
CLV_PCSK_KEX2_1	281	283	PF00082	0.520
CLV_PCSK_KEX2_1	413	415	PF00082	0.388
CLV_PCSK_KEX2_1	588	590	PF00082	0.482
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.433
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.520
CLV_PCSK_SKI1_1	202	206	PF00082	0.377
CLV_PCSK_SKI1_1	23	27	PF00082	0.481
CLV_PCSK_SKI1_1	278	282	PF00082	0.436
CLV_PCSK_SKI1_1	292	296	PF00082	0.248
CLV_PCSK_SKI1_1	414	418	PF00082	0.399
CLV_PCSK_SKI1_1	504	508	PF00082	0.465
CLV_PCSK_SKI1_1	589	593	PF00082	0.513
DEG_APCC_DBOX_1	413	421	PF00400	0.356
DEG_Nend_UBRbox_3	1	3	PF02207	0.692
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.376
DOC_MAPK_gen_1	202	209	PF00069	0.440
DOC_MAPK_MEF2A_6	202	209	PF00069	0.440
DOC_PP2B_LxvP_1	427	430	PF13499	0.396
DOC_PP4_FxxP_1	209	212	PF00568	0.461
DOC_USP7_MATH_1	170	174	PF00917	0.394
DOC_USP7_MATH_1	369	373	PF00917	0.679
DOC_USP7_MATH_1	495	499	PF00917	0.298
DOC_USP7_MATH_1	604	608	PF00917	0.342
DOC_USP7_MATH_1	644	648	PF00917	0.432
DOC_USP7_MATH_1	661	665	PF00917	0.466
DOC_USP7_MATH_1	686	690	PF00917	0.422
DOC_USP7_MATH_1	732	736	PF00917	0.576
DOC_USP7_MATH_1	761	765	PF00917	0.548
DOC_WW_Pin1_4	471	476	PF00397	0.318
LIG_14-3-3_CanoR_1	203	208	PF00244	0.462
LIG_14-3-3_CanoR_1	230	234	PF00244	0.438
LIG_14-3-3_CanoR_1	292	301	PF00244	0.384
LIG_14-3-3_CanoR_1	313	318	PF00244	0.525
LIG_14-3-3_CanoR_1	638	648	PF00244	0.467
LIG_14-3-3_CanoR_1	663	671	PF00244	0.603
LIG_Actin_WH2_2	86	101	PF00022	0.337
LIG_BRCT_BRCA1_1	21	25	PF00533	0.411
LIG_BRCT_BRCA1_1	665	669	PF00533	0.480
LIG_BRCT_BRCA1_1	699	703	PF00533	0.472
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.406
LIG_FHA_1	189	195	PF00498	0.544
LIG_FHA_1	293	299	PF00498	0.432
LIG_FHA_1	392	398	PF00498	0.638
LIG_FHA_1	419	425	PF00498	0.418
LIG_FHA_1	461	467	PF00498	0.420
LIG_FHA_1	50	56	PF00498	0.641
LIG_FHA_1	578	584	PF00498	0.432
LIG_FHA_1	708	714	PF00498	0.414
LIG_FHA_2	206	212	PF00498	0.551
LIG_FHA_2	254	260	PF00498	0.593
LIG_FHA_2	291	297	PF00498	0.475
LIG_FHA_2	640	646	PF00498	0.490
LIG_FHA_2	702	708	PF00498	0.469
LIG_LIR_Apic_2	206	212	PF02991	0.464
LIG_LIR_Gen_1	451	461	PF02991	0.422
LIG_LIR_Gen_1	69	79	PF02991	0.374
LIG_LIR_Gen_1	700	707	PF02991	0.418
LIG_LIR_Nem_3	22	28	PF02991	0.349
LIG_LIR_Nem_3	306	311	PF02991	0.450
LIG_LIR_Nem_3	316	321	PF02991	0.467
LIG_LIR_Nem_3	451	456	PF02991	0.418
LIG_LIR_Nem_3	497	503	PF02991	0.353
LIG_LIR_Nem_3	69	74	PF02991	0.372
LIG_LIR_Nem_3	700	706	PF02991	0.417
LIG_LIR_Nem_3	88	94	PF02991	0.346
LIG_NRBOX	269	275	PF00104	0.331
LIG_PCNA_yPIPBox_3	569	583	PF02747	0.314
LIG_PDZ_Class_1	774	779	PF00595	0.513
LIG_Pex14_1	118	122	PF04695	0.425
LIG_Pex14_1	71	75	PF04695	0.413
LIG_Pex14_2	507	511	PF04695	0.475
LIG_RPA_C_Fungi	760	772	PF08784	0.485
LIG_SH2_CRK	308	312	PF00017	0.381
LIG_SH2_CRK	453	457	PF00017	0.350
LIG_SH2_CRK	473	477	PF00017	0.186
LIG_SH2_CRK	500	504	PF00017	0.369
LIG_SH2_NCK_1	746	750	PF00017	0.451
LIG_SH2_STAP1	315	319	PF00017	0.358
LIG_SH2_STAP1	33	37	PF00017	0.514
LIG_SH2_STAP1	335	339	PF00017	0.515
LIG_SH2_STAP1	453	457	PF00017	0.435
LIG_SH2_STAP1	546	550	PF00017	0.407
LIG_SH2_STAT5	181	184	PF00017	0.380
LIG_SH2_STAT5	321	324	PF00017	0.507
LIG_SH2_STAT5	627	630	PF00017	0.465
LIG_SH3_4	23	30	PF00018	0.382
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.426
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.319
LIG_SUMO_SIM_par_1	203	208	PF11976	0.446
LIG_SUMO_SIM_par_1	271	277	PF11976	0.336
LIG_SUMO_SIM_par_1	392	398	PF11976	0.636
LIG_SUMO_SIM_par_1	739	745	PF11976	0.488
LIG_TRAF2_1	376	379	PF00917	0.751
LIG_UBA3_1	272	281	PF00899	0.466
MOD_CK1_1	229	235	PF00069	0.561
MOD_CK1_1	237	243	PF00069	0.474
MOD_CK1_1	248	254	PF00069	0.710
MOD_CK1_1	290	296	PF00069	0.468
MOD_CK1_1	373	379	PF00069	0.632
MOD_CK1_1	408	414	PF00069	0.527
MOD_CK1_1	512	518	PF00069	0.488
MOD_CK1_1	662	668	PF00069	0.550
MOD_CK1_1	69	75	PF00069	0.388
MOD_CK1_1	728	734	PF00069	0.537
MOD_CK2_1	373	379	PF00069	0.551
MOD_CK2_1	537	543	PF00069	0.483
MOD_CK2_1	686	692	PF00069	0.555
MOD_CK2_1	701	707	PF00069	0.355
MOD_CMANNOS	118	121	PF00535	0.370
MOD_GlcNHglycan	111	114	PF01048	0.354
MOD_GlcNHglycan	186	189	PF01048	0.446
MOD_GlcNHglycan	241	244	PF01048	0.702
MOD_GlcNHglycan	247	250	PF01048	0.725
MOD_GlcNHglycan	435	438	PF01048	0.615
MOD_GlcNHglycan	511	514	PF01048	0.353
MOD_GlcNHglycan	563	566	PF01048	0.447
MOD_GlcNHglycan	606	609	PF01048	0.525
MOD_GlcNHglycan	634	637	PF01048	0.386
MOD_GlcNHglycan	665	668	PF01048	0.562
MOD_GlcNHglycan	68	71	PF01048	0.470
MOD_GlcNHglycan	730	733	PF01048	0.606
MOD_GlcNHglycan	94	97	PF01048	0.430
MOD_GSK3_1	184	191	PF00069	0.498
MOD_GSK3_1	2	9	PF00069	0.593
MOD_GSK3_1	369	376	PF00069	0.593
MOD_GSK3_1	389	396	PF00069	0.606
MOD_GSK3_1	405	412	PF00069	0.620
MOD_GSK3_1	495	502	PF00069	0.396
MOD_GSK3_1	507	514	PF00069	0.364
MOD_GSK3_1	557	564	PF00069	0.474
MOD_GSK3_1	655	662	PF00069	0.666
MOD_GSK3_1	675	682	PF00069	0.429
MOD_GSK3_1	697	704	PF00069	0.480
MOD_GSK3_1	708	715	PF00069	0.480
MOD_GSK3_1	722	729	PF00069	0.581
MOD_N-GLC_1	109	114	PF02516	0.412
MOD_N-GLC_1	245	250	PF02516	0.640
MOD_NEK2_1	151	156	PF00069	0.433
MOD_NEK2_1	205	210	PF00069	0.453
MOD_NEK2_1	226	231	PF00069	0.520
MOD_NEK2_1	234	239	PF00069	0.571
MOD_NEK2_1	506	511	PF00069	0.351
MOD_NEK2_1	61	66	PF00069	0.581
MOD_NEK2_1	712	717	PF00069	0.500
MOD_NEK2_1	74	79	PF00069	0.292
MOD_NEK2_2	495	500	PF00069	0.361
MOD_NEK2_2	644	649	PF00069	0.315
MOD_PIKK_1	237	243	PF00454	0.527
MOD_PIKK_1	557	563	PF00454	0.347
MOD_PIKK_1	574	580	PF00454	0.433
MOD_PK_1	537	543	PF00069	0.271
MOD_PKA_2	229	235	PF00069	0.446
MOD_PKA_2	237	243	PF00069	0.563
MOD_PKA_2	662	668	PF00069	0.531
MOD_Plk_1	495	501	PF00069	0.420
MOD_Plk_1	61	67	PF00069	0.625
MOD_Plk_1	644	650	PF00069	0.469
MOD_Plk_2-3	117	123	PF00069	0.378
MOD_Plk_2-3	393	399	PF00069	0.569
MOD_Plk_4	117	123	PF00069	0.472
MOD_Plk_4	151	157	PF00069	0.475
MOD_Plk_4	170	176	PF00069	0.354
MOD_Plk_4	229	235	PF00069	0.428
MOD_Plk_4	253	259	PF00069	0.607
MOD_Plk_4	313	319	PF00069	0.514
MOD_Plk_4	44	50	PF00069	0.651
MOD_Plk_4	495	501	PF00069	0.378
MOD_Plk_4	698	704	PF00069	0.338
MOD_Plk_4	708	714	PF00069	0.354
MOD_ProDKin_1	471	477	PF00069	0.318
MOD_SUMO_for_1	523	526	PF00179	0.465
TRG_DiLeu_BaEn_1	89	94	PF01217	0.375
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.417
TRG_DiLeu_BaLyEn_6	737	742	PF01217	0.407
TRG_ENDOCYTIC_2	308	311	PF00928	0.359
TRG_ENDOCYTIC_2	315	318	PF00928	0.371
TRG_ENDOCYTIC_2	335	338	PF00928	0.330
TRG_ENDOCYTIC_2	453	456	PF00928	0.426
TRG_ENDOCYTIC_2	473	476	PF00928	0.187
TRG_ENDOCYTIC_2	500	503	PF00928	0.348
TRG_ER_diArg_1	182	184	PF00400	0.390
TRG_ER_diArg_1	413	415	PF00400	0.393
TRG_ER_diArg_1	587	589	PF00400	0.462
TRG_NES_CRM1_1	89	102	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	765	769	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P593	Leptomonas seymouri	52%	98%
A0A0S4J4X2	Bodo saltans	26%	100%
A0A3S7X934	Leishmania donovani	94%	100%
A0A422NQA4	Trypanosoma rangeli	31%	100%
A4HMI1	Leishmania braziliensis	79%	100%
A4IB61	Leishmania infantum	94%	100%
C9ZZH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B638	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B3W9	Trypanosoma cruzi	29%	100%