Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEY1_LEIMA

TriTrypDb:

LmjF.35.1590 , LMJLV39_350022300 , LMJSD75_350021500

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AEY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.529
CLV_C14_Caspase3-7	247	251	PF00656	0.418
CLV_NRD_NRD_1	123	125	PF00675	0.720
CLV_NRD_NRD_1	330	332	PF00675	0.569
CLV_NRD_NRD_1	431	433	PF00675	0.712
CLV_PCSK_KEX2_1	110	112	PF00082	0.713
CLV_PCSK_KEX2_1	122	124	PF00082	0.656
CLV_PCSK_KEX2_1	143	145	PF00082	0.650
CLV_PCSK_KEX2_1	330	332	PF00082	0.666
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.713
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.703
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.666
CLV_PCSK_SKI1_1	10	14	PF00082	0.495
CLV_PCSK_SKI1_1	408	412	PF00082	0.537
CLV_PCSK_SKI1_1	513	517	PF00082	0.590
CLV_PCSK_SKI1_1	557	561	PF00082	0.579
CLV_PCSK_SKI1_1	59	63	PF00082	0.703
DEG_APCC_DBOX_1	496	504	PF00400	0.425
DEG_APCC_DBOX_1	9	17	PF00400	0.684
DEG_COP1_1	247	257	PF00400	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.717
DOC_CYCLIN_RxL_1	510	521	PF00134	0.402
DOC_CYCLIN_yClb3_PxF_3	255	263	PF00134	0.341
DOC_MAPK_DCC_7	10	18	PF00069	0.709
DOC_MAPK_gen_1	143	151	PF00069	0.498
DOC_MAPK_gen_1	155	164	PF00069	0.523
DOC_MAPK_gen_1	4	13	PF00069	0.670
DOC_MAPK_gen_1	407	415	PF00069	0.368
DOC_MAPK_MEF2A_6	131	139	PF00069	0.455
DOC_MAPK_MEF2A_6	144	153	PF00069	0.488
DOC_MAPK_MEF2A_6	158	166	PF00069	0.425
DOC_MAPK_MEF2A_6	407	415	PF00069	0.380
DOC_PP2B_LxvP_1	252	255	PF13499	0.366
DOC_PP2B_LxvP_1	515	518	PF13499	0.415
DOC_SPAK_OSR1_1	347	351	PF12202	0.467
DOC_USP7_MATH_1	381	385	PF00917	0.337
DOC_USP7_MATH_1	388	392	PF00917	0.351
DOC_USP7_MATH_1	5	9	PF00917	0.775
DOC_WW_Pin1_4	182	187	PF00397	0.516
DOC_WW_Pin1_4	278	283	PF00397	0.452
DOC_WW_Pin1_4	340	345	PF00397	0.311
DOC_WW_Pin1_4	386	391	PF00397	0.423
DOC_WW_Pin1_4	461	466	PF00397	0.345
DOC_WW_Pin1_4	526	531	PF00397	0.417
LIG_14-3-3_CanoR_1	173	178	PF00244	0.488
LIG_14-3-3_CanoR_1	284	292	PF00244	0.435
LIG_14-3-3_CanoR_1	38	44	PF00244	0.490
LIG_14-3-3_CanoR_1	497	501	PF00244	0.448
LIG_14-3-3_CanoR_1	543	551	PF00244	0.390
LIG_14-3-3_CanoR_1	557	565	PF00244	0.333
LIG_14-3-3_CanoR_1	6	13	PF00244	0.712
LIG_14-3-3_CanoR_1	63	73	PF00244	0.460
LIG_Actin_WH2_2	44	61	PF00022	0.513
LIG_BRCT_BRCA1_1	225	229	PF00533	0.492
LIG_Clathr_ClatBox_1	134	138	PF01394	0.547
LIG_Clathr_ClatBox_1	535	539	PF01394	0.390
LIG_deltaCOP1_diTrp_1	573	578	PF00928	0.369
LIG_EH_1	549	553	PF12763	0.314
LIG_FHA_1	113	119	PF00498	0.450
LIG_FHA_1	235	241	PF00498	0.458
LIG_FHA_1	275	281	PF00498	0.510
LIG_FHA_1	317	323	PF00498	0.480
LIG_FHA_1	531	537	PF00498	0.381
LIG_FHA_1	543	549	PF00498	0.297
LIG_FHA_1	67	73	PF00498	0.499
LIG_FHA_2	155	161	PF00498	0.463
LIG_FHA_2	190	196	PF00498	0.497
LIG_FHA_2	202	208	PF00498	0.519
LIG_FHA_2	242	248	PF00498	0.425
LIG_FHA_2	251	257	PF00498	0.475
LIG_FHA_2	285	291	PF00498	0.410
LIG_FHA_2	354	360	PF00498	0.382
LIG_FHA_2	519	525	PF00498	0.467
LIG_HCF-1_HBM_1	486	489	PF13415	0.419
LIG_LIR_Gen_1	286	297	PF02991	0.396
LIG_LIR_Gen_1	486	493	PF02991	0.302
LIG_LIR_Gen_1	529	540	PF02991	0.392
LIG_LIR_Nem_3	101	107	PF02991	0.452
LIG_LIR_Nem_3	226	232	PF02991	0.413
LIG_LIR_Nem_3	286	292	PF02991	0.372
LIG_LIR_Nem_3	311	316	PF02991	0.338
LIG_LIR_Nem_3	394	400	PF02991	0.424
LIG_LIR_Nem_3	529	535	PF02991	0.402
LIG_LYPXL_yS_3	445	448	PF13949	0.460
LIG_MYND_1	514	518	PF01753	0.446
LIG_NRBOX	499	505	PF00104	0.457
LIG_PCNA_yPIPBox_3	77	87	PF02747	0.522
LIG_Pex14_1	357	361	PF04695	0.457
LIG_Pex14_2	177	181	PF04695	0.448
LIG_Pex14_2	24	28	PF04695	0.368
LIG_Pex14_2	309	313	PF04695	0.356
LIG_PTB_Apo_2	301	308	PF02174	0.404
LIG_REV1ctd_RIR_1	258	267	PF16727	0.459
LIG_SH2_CRK	438	442	PF00017	0.373
LIG_SH2_GRB2like	178	181	PF00017	0.443
LIG_SH2_GRB2like	520	523	PF00017	0.444
LIG_SH2_NCK_1	520	524	PF00017	0.449
LIG_SH2_STAT5	178	181	PF00017	0.489
LIG_SH2_STAT5	315	318	PF00017	0.411
LIG_SH2_STAT5	336	339	PF00017	0.424
LIG_SH2_STAT5	440	443	PF00017	0.335
LIG_SH2_STAT5	483	486	PF00017	0.325
LIG_SH2_STAT5	489	492	PF00017	0.311
LIG_SH2_STAT5	520	523	PF00017	0.468
LIG_SH2_STAT5	558	561	PF00017	0.309
LIG_SH3_2	279	284	PF14604	0.350
LIG_SH3_3	122	128	PF00018	0.388
LIG_SH3_3	237	243	PF00018	0.440
LIG_SH3_3	252	258	PF00018	0.480
LIG_SH3_3	276	282	PF00018	0.394
LIG_SH3_3	338	344	PF00018	0.329
LIG_SUMO_SIM_par_1	46	53	PF11976	0.404
LIG_SUMO_SIM_par_1	501	508	PF11976	0.432
LIG_SUMO_SIM_par_1	533	539	PF11976	0.318
LIG_TYR_ITIM	436	441	PF00017	0.399
LIG_WRC_WIRS_1	174	179	PF05994	0.444
MOD_CDC14_SPxK_1	281	284	PF00782	0.304
MOD_CDK_SPxK_1	278	284	PF00069	0.333
MOD_CDK_SPxxK_3	340	347	PF00069	0.419
MOD_CDK_SPxxK_3	386	393	PF00069	0.364
MOD_CK1_1	176	182	PF00069	0.451
MOD_CK1_1	502	508	PF00069	0.457
MOD_CK2_1	154	160	PF00069	0.465
MOD_CK2_1	189	195	PF00069	0.518
MOD_CK2_1	201	207	PF00069	0.403
MOD_CK2_1	241	247	PF00069	0.403
MOD_CK2_1	250	256	PF00069	0.455
MOD_CK2_1	284	290	PF00069	0.391
MOD_CK2_1	353	359	PF00069	0.433
MOD_CK2_1	388	394	PF00069	0.344
MOD_CK2_1	488	494	PF00069	0.386
MOD_CK2_1	495	501	PF00069	0.347
MOD_CK2_1	518	524	PF00069	0.444
MOD_GlcNHglycan	232	235	PF01048	0.692
MOD_GSK3_1	176	183	PF00069	0.446
MOD_GSK3_1	230	237	PF00069	0.451
MOD_GSK3_1	274	281	PF00069	0.433
MOD_GSK3_1	495	502	PF00069	0.430
MOD_GSK3_1	526	533	PF00069	0.458
MOD_GSK3_1	553	560	PF00069	0.306
MOD_N-GLC_1	112	117	PF02516	0.711
MOD_N-GLC_1	201	206	PF02516	0.673
MOD_N-GLC_1	234	239	PF02516	0.669
MOD_N-GLC_1	261	266	PF02516	0.686
MOD_N-GLC_1	305	310	PF02516	0.544
MOD_N-GLC_1	446	451	PF02516	0.635
MOD_N-GLC_2	180	182	PF02516	0.644
MOD_NEK2_1	261	266	PF00069	0.411
MOD_NEK2_1	283	288	PF00069	0.418
MOD_NEK2_1	316	321	PF00069	0.416
MOD_NEK2_1	415	420	PF00069	0.342
MOD_NEK2_1	552	557	PF00069	0.331
MOD_PIKK_1	507	513	PF00454	0.464
MOD_PIKK_1	66	72	PF00454	0.516
MOD_PKA_2	283	289	PF00069	0.415
MOD_PKA_2	290	296	PF00069	0.255
MOD_PKA_2	37	43	PF00069	0.512
MOD_PKA_2	496	502	PF00069	0.448
MOD_PKA_2	5	11	PF00069	0.720
MOD_PKA_2	542	548	PF00069	0.358
MOD_Plk_1	261	267	PF00069	0.485
MOD_Plk_1	305	311	PF00069	0.342
MOD_Plk_1	507	513	PF00069	0.483
MOD_Plk_2-3	250	256	PF00069	0.507
MOD_Plk_2-3	50	56	PF00069	0.394
MOD_Plk_2-3	96	102	PF00069	0.496
MOD_Plk_4	130	136	PF00069	0.488
MOD_Plk_4	499	505	PF00069	0.450
MOD_ProDKin_1	182	188	PF00069	0.514
MOD_ProDKin_1	278	284	PF00069	0.443
MOD_ProDKin_1	340	346	PF00069	0.312
MOD_ProDKin_1	386	392	PF00069	0.420
MOD_ProDKin_1	461	467	PF00069	0.341
MOD_ProDKin_1	526	532	PF00069	0.413
MOD_SUMO_for_1	109	112	PF00179	0.513
MOD_SUMO_rev_2	311	316	PF00179	0.385
MOD_SUMO_rev_2	55	61	PF00179	0.509
MOD_SUMO_rev_2	94	99	PF00179	0.400
TRG_DiLeu_BaEn_1	130	135	PF01217	0.539
TRG_DiLeu_BaEn_1	68	73	PF01217	0.519
TRG_DiLeu_BaEn_4	247	253	PF01217	0.487
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.366
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.278
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.455
TRG_ENDOCYTIC_2	104	107	PF00928	0.504
TRG_ENDOCYTIC_2	438	441	PF00928	0.364
TRG_ENDOCYTIC_2	445	448	PF00928	0.409
TRG_ENDOCYTIC_2	489	492	PF00928	0.316
TRG_ER_diArg_1	121	124	PF00400	0.495
TRG_NES_CRM1_1	140	154	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ6	Leptomonas seymouri	42%	100%
A0A0S4J8J1	Bodo saltans	25%	100%
A0A1X0P5Y1	Trypanosomatidae	29%	100%
A0A3R7KJC8	Trypanosoma rangeli	28%	100%
A0A3S7X958	Leishmania donovani	90%	100%
A4HMI0	Leishmania braziliensis	69%	100%
A4IB60	Leishmania infantum	90%	100%
E9B637	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BJE1	Trypanosoma cruzi	29%	100%