Putative metacaspase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metacaspase

Species:

Leishmania major

UniProt:

E9AEY0_LEIMA

TriTrypDb:

LmjF.35.1580 , LMJLV39_350022200 , LMJSD75_350021400

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	4
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AEY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEY0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006979	response to oxidative stress	3	2
GO:0008152	metabolic process	1	2
GO:0016485	protein processing	5	2
GO:0016540	protein autoprocessing	6	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0050896	response to stimulus	1	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004175	endopeptidase activity	4	2
GO:0004197	cysteine-type endopeptidase activity	5	2
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	4
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	215	221	PF00089	0.346
CLV_NRD_NRD_1	232	234	PF00675	0.334
CLV_NRD_NRD_1	293	295	PF00675	0.354
CLV_NRD_NRD_1	39	41	PF00675	0.508
CLV_PCSK_FUR_1	29	33	PF00082	0.426
CLV_PCSK_KEX2_1	232	234	PF00082	0.332
CLV_PCSK_KEX2_1	31	33	PF00082	0.413
CLV_PCSK_KEX2_1	39	41	PF00082	0.439
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.452
CLV_PCSK_SKI1_1	125	129	PF00082	0.366
CLV_PCSK_SKI1_1	63	67	PF00082	0.269
CLV_PCSK_SKI1_1	75	79	PF00082	0.269
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.399
DOC_MAPK_gen_1	294	301	PF00069	0.436
DOC_MAPK_gen_1	61	69	PF00069	0.323
DOC_MAPK_MEF2A_6	61	69	PF00069	0.323
DOC_PP2B_LxvP_1	185	188	PF13499	0.421
DOC_PP2B_LxvP_1	208	211	PF13499	0.304
DOC_PP2B_LxvP_1	401	404	PF13499	0.659
DOC_USP7_MATH_1	12	16	PF00917	0.598
DOC_USP7_MATH_1	188	192	PF00917	0.307
DOC_WW_Pin1_4	368	373	PF00397	0.631
DOC_WW_Pin1_4	427	432	PF00397	0.711
LIG_14-3-3_CanoR_1	339	344	PF00244	0.487
LIG_14-3-3_CanoR_1	40	46	PF00244	0.517
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_Clathr_ClatBox_1	165	169	PF01394	0.356
LIG_Clathr_ClatBox_1	24	28	PF01394	0.417
LIG_eIF4E_1	313	319	PF01652	0.437
LIG_EVH1_1	401	405	PF00568	0.720
LIG_FHA_1	129	135	PF00498	0.421
LIG_FHA_1	269	275	PF00498	0.296
LIG_FHA_1	387	393	PF00498	0.738
LIG_FHA_2	250	256	PF00498	0.294
LIG_FHA_2	287	293	PF00498	0.388
LIG_LIR_Apic_2	213	217	PF02991	0.421
LIG_LIR_Gen_1	179	190	PF02991	0.344
LIG_LIR_Gen_1	209	219	PF02991	0.296
LIG_LIR_Gen_1	271	280	PF02991	0.312
LIG_LIR_Gen_1	281	287	PF02991	0.288
LIG_LIR_Nem_3	108	114	PF02991	0.344
LIG_LIR_Nem_3	138	144	PF02991	0.269
LIG_LIR_Nem_3	179	185	PF02991	0.318
LIG_LIR_Nem_3	209	215	PF02991	0.270
LIG_LIR_Nem_3	271	275	PF02991	0.294
LIG_LIR_Nem_3	281	285	PF02991	0.257
LIG_LIR_Nem_3	311	316	PF02991	0.400
LIG_LIR_Nem_3	317	322	PF02991	0.341
LIG_LIR_Nem_3	428	432	PF02991	0.731
LIG_NRBOX	282	288	PF00104	0.402
LIG_Pex14_1	374	378	PF04695	0.714
LIG_SH2_CRK	409	413	PF00017	0.741
LIG_SH2_CRK	51	55	PF00017	0.447
LIG_SH2_GRB2like	282	285	PF00017	0.421
LIG_SH2_NCK_1	409	413	PF00017	0.606
LIG_SH2_PTP2	214	217	PF00017	0.421
LIG_SH2_SRC	282	285	PF00017	0.356
LIG_SH2_SRC	400	403	PF00017	0.626
LIG_SH2_SRC	409	412	PF00017	0.605
LIG_SH2_STAP1	161	165	PF00017	0.322
LIG_SH2_STAT3	227	230	PF00017	0.417
LIG_SH2_STAT3	378	381	PF00017	0.712
LIG_SH2_STAT5	214	217	PF00017	0.348
LIG_SH2_STAT5	282	285	PF00017	0.344
LIG_SH2_STAT5	400	403	PF00017	0.626
LIG_SH2_STAT5	427	430	PF00017	0.738
LIG_SH2_STAT5	57	60	PF00017	0.402
LIG_SH2_STAT5	71	74	PF00017	0.319
LIG_SH3_1	366	372	PF00018	0.725
LIG_SH3_1	417	423	PF00018	0.492
LIG_SH3_2	47	52	PF14604	0.446
LIG_SH3_3	103	109	PF00018	0.365
LIG_SH3_3	24	30	PF00018	0.362
LIG_SH3_3	296	302	PF00018	0.424
LIG_SH3_3	344	350	PF00018	0.469
LIG_SH3_3	353	359	PF00018	0.651
LIG_SH3_3	366	372	PF00018	0.680
LIG_SH3_3	399	405	PF00018	0.665
LIG_SH3_3	408	414	PF00018	0.639
LIG_SH3_3	416	422	PF00018	0.705
LIG_SH3_3	428	434	PF00018	0.615
LIG_SH3_3	44	50	PF00018	0.398
LIG_SUMO_SIM_par_1	23	28	PF11976	0.418
LIG_TRAF2_1	289	292	PF00917	0.421
LIG_TYR_ITIM	280	285	PF00017	0.218
LIG_UBA3_1	165	172	PF00899	0.398
LIG_WRPW_2	313	316	PF00400	0.466
MOD_CK1_1	245	251	PF00069	0.350
MOD_CK2_1	286	292	PF00069	0.399
MOD_Cter_Amidation	37	40	PF01082	0.504
MOD_GlcNHglycan	144	147	PF01048	0.266
MOD_GlcNHglycan	190	193	PF01048	0.366
MOD_GlcNHglycan	203	206	PF01048	0.218
MOD_GlcNHglycan	244	247	PF01048	0.279
MOD_GlcNHglycan	252	255	PF01048	0.269
MOD_GSK3_1	245	252	PF00069	0.352
MOD_GSK3_1	264	271	PF00069	0.295
MOD_GSK3_1	274	281	PF00069	0.281
MOD_GSK3_1	320	327	PF00069	0.391
MOD_GSK3_1	386	393	PF00069	0.654
MOD_GSK3_1	84	91	PF00069	0.363
MOD_GSK3_1	93	100	PF00069	0.388
MOD_LATS_1	170	176	PF00433	0.419
MOD_N-GLC_1	172	177	PF02516	0.421
MOD_N-GLC_1	234	239	PF02516	0.303
MOD_N-GLC_1	324	329	PF02516	0.449
MOD_N-GLC_1	69	74	PF02516	0.344
MOD_NEK2_1	142	147	PF00069	0.253
MOD_NEK2_1	268	273	PF00069	0.329
MOD_NEK2_1	274	279	PF00069	0.294
MOD_NEK2_1	304	309	PF00069	0.276
MOD_NEK2_1	390	395	PF00069	0.666
MOD_NEK2_1	41	46	PF00069	0.486
MOD_NEK2_1	88	93	PF00069	0.290
MOD_PIKK_1	395	401	PF00454	0.721
MOD_PK_1	172	178	PF00069	0.419
MOD_PKA_2	154	160	PF00069	0.382
MOD_PKA_2	193	199	PF00069	0.269
MOD_PKA_2	249	255	PF00069	0.190
MOD_Plk_1	324	330	PF00069	0.421
MOD_Plk_1	83	89	PF00069	0.411
MOD_Plk_4	12	18	PF00069	0.574
MOD_Plk_4	172	178	PF00069	0.394
MOD_Plk_4	203	209	PF00069	0.275
MOD_Plk_4	278	284	PF00069	0.240
MOD_Plk_4	324	330	PF00069	0.459
MOD_Plk_4	84	90	PF00069	0.442
MOD_ProDKin_1	368	374	PF00069	0.633
MOD_ProDKin_1	427	433	PF00069	0.708
TRG_DiLeu_BaEn_1	101	106	PF01217	0.281
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.501
TRG_ENDOCYTIC_2	282	285	PF00928	0.301
TRG_ENDOCYTIC_2	313	316	PF00928	0.490
TRG_ENDOCYTIC_2	71	74	PF00928	0.429
TRG_ER_diArg_1	231	233	PF00400	0.366
TRG_ER_diArg_1	39	41	PF00400	0.513
TRG_NLS_MonoExtC_3	293	298	PF00514	0.421
TRG_NLS_MonoExtN_4	294	299	PF00514	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW49	Leptomonas seymouri	49%	95%
A0A0N1P9F5	Leptomonas seymouri	44%	100%
A0A0N1PDW0	Leptomonas seymouri	74%	100%
A0A0S4IS06	Bodo saltans	43%	100%
A0A0S4J2H4	Bodo saltans	53%	95%
A0A1X0NMB0	Trypanosomatidae	49%	100%
A0A1X0NMU0	Trypanosomatidae	50%	100%
A0A1X0P5R0	Trypanosomatidae	65%	100%
A0A3Q8IG58	Leishmania donovani	96%	99%
A0A422N5J3	Trypanosoma rangeli	50%	100%
A0A422NQE5	Trypanosoma rangeli	64%	94%
A1CL82	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	37%	100%
A1CQZ0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	37%	100%
A1D3V4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	37%	100%
A1D611	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	37%	100%
A2QU58	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	38%	99%
A2RB75	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	100%
A3LSY7	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	37%	100%
A4HMH9	Leishmania braziliensis	83%	100%
A4IB59	Leishmania infantum	94%	97%
A4QTY2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	36%	100%
A5D9W7	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	37%	100%
A5DZS4	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	36%	97%
A6R7B8	Ajellomyces capsulatus (strain NAm1 / WU24)	37%	100%
A6SDT7	Botryotinia fuckeliana (strain B05.10)	35%	100%
A6ZP43	Saccharomyces cerevisiae (strain YJM789)	36%	100%
A7F075	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	36%	100%
B0XPP3	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	37%	100%
B0Y081	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	37%	100%
C9ZQB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZQB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZZG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	88%
D0A1S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B636	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
O74477	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P0CM58	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	35%	94%
P0CM59	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	35%	94%
Q08601	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
Q0CQL9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	37%	100%
Q0CTN3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	36%	100%
Q1E0A3	Coccidioides immitis (strain RS)	38%	94%
Q2UCB7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	37%	100%
Q2UN81	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	100%
Q2VLK6	Trypanosoma cruzi (strain CL Brener)	46%	100%
Q2VLK8	Trypanosoma cruzi (strain CL Brener)	63%	98%
Q4PEQ5	Ustilago maydis (strain 521 / FGSC 9021)	40%	100%
Q4WJA1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	100%
Q4WYT0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	100%
Q585F3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	49%	100%
Q5ANA8	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	97%
Q6BH13	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	37%	99%
Q6C2Y6	Yarrowia lipolytica (strain CLIB 122 / E 150)	37%	94%
Q6CLS0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	100%
Q6FPX9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	36%	100%
Q75B43	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	96%
Q7S232	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	96%
Q7S4N5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	38%	100%
Q7XJE6	Arabidopsis thaliana	31%	100%
Q8IEW1	Trypanosoma brucei brucei	57%	87%
Q8J140	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q8T8E5	Trypanosoma brucei brucei	41%	100%
Q8T8E6	Trypanosoma brucei brucei	49%	100%
Q8T8E7	Trypanosoma brucei brucei	49%	100%
V5BTK1	Trypanosoma cruzi	62%	98%